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The map label for this gene is ilvR [H]

Identifier: 83720528

GI number: 83720528

Start: 942710

End: 943672

Strand: Direct

Name: ilvR [H]

Synonym: BTH_I0828

Alternate gene names: 83720528

Gene position: 942710-943672 (Clockwise)

Preceding gene: 83718656

Following gene: 83721368

Centisome position: 24.75

GC content: 74.04

Gene sequence:

>963_bases
TTGACCCCCGATCTGCGCCAATGGCGCTATTTCGTCGCCGTCGCCGACGAGCGACACTTCGGCCGCGCCGCCGAGCGGCT
TTCGATGACGCAGCCGCCGCTGTCGCAGGCGATCCGCGCGCTCGAGGACGCGCTCGGCGTCGCGCTGTTCGCGCGCACCA
AGCGCTCGGTCGAGCTGACCGCGGTCGGCGCGGCGCTGCTGCCCGACGTGCGGCGGCTGATCGCCGCGGCCGACGCGCTG
CCGCCGCTCGCGCAGAGCCTCGCGCGCGGCGAGGCGGGATCGCTCGCGCTCGCGTTCGTATCGACGGCCGATTACGGGCT
GCTGCCGCAACTGTTGCGCGAGTTCGGCGCGCGCTATCCGCACGTGCGGCTGCAACTGACCGAGGCGACGAGCGACGTGC
AGATCGAGGAGCTCGTCGCGGGCCGCATCGACGCGGGGCTCGTGATTCCGCCCGTGCCGCCGCGGCATGCGGCGTCGCTG
TCGTATCTGCCGGTGCTGCGCGAGCCGCTCGTCGTCGCGATGCCGGCCGACGCCGCGGAGGCGGCGGGGGACGCGCCGGT
GCGCATCGCCGACATCGCGTCGCTGCCGCTCGTCATCTTTCCGCGTCGTTTGGCGCCCGGCTTTTATGACATCATTACGG
GCTGCTACGGCGCGGCGGGCGTCGCGCCGCGCATCGGCCAGGAGGCGATCCAGATGCAGACGATCGTCAGCCTCGTGTCC
GCGGGCATGGGTGTCGCGCTCGTGCCGCAATCGCTGCGTAACCTGCGGCGCACGGGCGTCGTCTACCGCGCGCTCGCCGA
TCCGGCGCCCGTCGTCGAAACGGGCCTCGTGTGGCGCACGGACGACGTGAGTCCGGTGCTCGCGGGCTTCATCGACGTCG
TGCGCGGCGCGGCGCGGCCCGCGCCGTCCTCGCGGCCGGATTCGACGCCGGGCGCGGGCGGGCGTGCGGCGACGCGGCCG
TGA

Upstream 100 bases:

>100_bases
AGAATGCAGTTTCTGTTAGAGAATGTCCAATATATTATTCATCGCCTATTAGGTCGGCATGCATATTAATCGGTGTGCCG
ACGACGATGCGGAGCCTGAT

Downstream 100 bases:

>100_bases
ACGTTCGTGCGGCGCGTGCGTCGAATCGCGGTCGCAACGCGTTTTCGCGGTGGCGGCGGACGTCGCCGGGCATGCCGTAT
CGATTCAGAACCTTCAACGC

Product: isoleucine biosynthesis transcriptional activator

Products: NA

Alternate protein names: Isoleucine biosynthesis transcriptional activator [H]

Number of amino acids: Translated: 320; Mature: 319

Protein sequence:

>320_residues
MTPDLRQWRYFVAVADERHFGRAAERLSMTQPPLSQAIRALEDALGVALFARTKRSVELTAVGAALLPDVRRLIAAADAL
PPLAQSLARGEAGSLALAFVSTADYGLLPQLLREFGARYPHVRLQLTEATSDVQIEELVAGRIDAGLVIPPVPPRHAASL
SYLPVLREPLVVAMPADAAEAAGDAPVRIADIASLPLVIFPRRLAPGFYDIITGCYGAAGVAPRIGQEAIQMQTIVSLVS
AGMGVALVPQSLRNLRRTGVVYRALADPAPVVETGLVWRTDDVSPVLAGFIDVVRGAARPAPSSRPDSTPGAGGRAATRP

Sequences:

>Translated_320_residues
MTPDLRQWRYFVAVADERHFGRAAERLSMTQPPLSQAIRALEDALGVALFARTKRSVELTAVGAALLPDVRRLIAAADAL
PPLAQSLARGEAGSLALAFVSTADYGLLPQLLREFGARYPHVRLQLTEATSDVQIEELVAGRIDAGLVIPPVPPRHAASL
SYLPVLREPLVVAMPADAAEAAGDAPVRIADIASLPLVIFPRRLAPGFYDIITGCYGAAGVAPRIGQEAIQMQTIVSLVS
AGMGVALVPQSLRNLRRTGVVYRALADPAPVVETGLVWRTDDVSPVLAGFIDVVRGAARPAPSSRPDSTPGAGGRAATRP
>Mature_319_residues
TPDLRQWRYFVAVADERHFGRAAERLSMTQPPLSQAIRALEDALGVALFARTKRSVELTAVGAALLPDVRRLIAAADALP
PLAQSLARGEAGSLALAFVSTADYGLLPQLLREFGARYPHVRLQLTEATSDVQIEELVAGRIDAGLVIPPVPPRHAASLS
YLPVLREPLVVAMPADAAEAAGDAPVRIADIASLPLVIFPRRLAPGFYDIITGCYGAAGVAPRIGQEAIQMQTIVSLVSA
GMGVALVPQSLRNLRRTGVVYRALADPAPVVETGLVWRTDDVSPVLAGFIDVVRGAARPAPSSRPDSTPGAGGRAATRP

Specific function: Positively regulates the expression of the ilvD gene while negatively autoregulating its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787879, Length=292, Percent_Identity=39.041095890411, Blast_Score=183, Evalue=2e-47,
Organism=Escherichia coli, GI1788887, Length=296, Percent_Identity=33.1081081081081, Blast_Score=150, Evalue=9e-38,
Organism=Escherichia coli, GI2367136, Length=291, Percent_Identity=32.3024054982818, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI1790399, Length=283, Percent_Identity=30.0353356890459, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI145693105, Length=177, Percent_Identity=31.0734463276836, Blast_Score=98, Evalue=8e-22,
Organism=Escherichia coli, GI1788748, Length=250, Percent_Identity=29.6, Blast_Score=95, Evalue=5e-21,
Organism=Escherichia coli, GI157672245, Length=244, Percent_Identity=30.327868852459, Blast_Score=88, Evalue=6e-19,
Organism=Escherichia coli, GI1787806, Length=296, Percent_Identity=27.027027027027, Blast_Score=84, Evalue=8e-18,
Organism=Escherichia coli, GI1787530, Length=246, Percent_Identity=28.4552845528455, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1790208, Length=255, Percent_Identity=29.4117647058824, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1787589, Length=137, Percent_Identity=36.4963503649635, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1788297, Length=253, Percent_Identity=25.296442687747, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1786713, Length=121, Percent_Identity=35.5371900826446, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI87081904, Length=146, Percent_Identity=32.8767123287671, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1789204, Length=144, Percent_Identity=33.3333333333333, Blast_Score=68, Evalue=8e-13,
Organism=Escherichia coli, GI48994962, Length=71, Percent_Identity=46.4788732394366, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1788296, Length=231, Percent_Identity=26.4069264069264, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1789173, Length=133, Percent_Identity=35.3383458646617, Blast_Score=61, Evalue=8e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33773; Mature: 33642

Theoretical pI: Translated: 9.00; Mature: 9.00

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPDLRQWRYFVAVADERHFGRAAERLSMTQPPLSQAIRALEDALGVALFARTKRSVELT
CCCCHHHHEEEEEEECCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEE
AVGAALLPDVRRLIAAADALPPLAQSLARGEAGSLALAFVSTADYGLLPQLLREFGARYP
HHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHCCCCC
HVRLQLTEATSDVQIEELVAGRIDAGLVIPPVPPRHAASLSYLPVLREPLVVAMPADAAE
EEEEEEECCCCCCHHHHHHHCCCCCCEEECCCCCCHHCCCHHHHHHHCCEEEEECCCHHH
AAGDAPVRIADIASLPLVIFPRRLAPGFYDIITGCYGAAGVAPRIGQEAIQMQTIVSLVS
HCCCCCEEEHHHHCCCCEEECHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
AGMGVALVPQSLRNLRRTGVVYRALADPAPVVETGLVWRTDDVSPVLAGFIDVVRGAARP
CCCCCEEHHHHHHHHHHHHHHHHHHCCCCCHHHCCCEEECCCCHHHHHHHHHHHHHCCCC
APSSRPDSTPGAGGRAATRP
CCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TPDLRQWRYFVAVADERHFGRAAERLSMTQPPLSQAIRALEDALGVALFARTKRSVELT
CCCHHHHEEEEEEECCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEE
AVGAALLPDVRRLIAAADALPPLAQSLARGEAGSLALAFVSTADYGLLPQLLREFGARYP
HHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHCCCCC
HVRLQLTEATSDVQIEELVAGRIDAGLVIPPVPPRHAASLSYLPVLREPLVVAMPADAAE
EEEEEEECCCCCCHHHHHHHCCCCCCEEECCCCCCHHCCCHHHHHHHCCEEEEECCCHHH
AAGDAPVRIADIASLPLVIFPRRLAPGFYDIITGCYGAAGVAPRIGQEAIQMQTIVSLVS
HCCCCCEEEHHHHCCCCEEECHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
AGMGVALVPQSLRNLRRTGVVYRALADPAPVVETGLVWRTDDVSPVLAGFIDVVRGAARP
CCCCCEEHHHHHHHHHHHHHHHHHHCCCCCHHHCCCEEECCCCHHHHHHHHHHHHHCCCC
APSSRPDSTPGAGGRAATRP
CCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8113165; 11259647 [H]