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The map label for this gene is ghrA [H]

Identifier: 83720502

GI number: 83720502

Start: 345831

End: 346772

Strand: Reverse

Name: ghrA [H]

Synonym: BTH_I0314

Alternate gene names: 83720502

Gene position: 346772-345831 (Counterclockwise)

Preceding gene: 83721621

Following gene: 83720769

Centisome position: 9.1

GC content: 72.61

Gene sequence:

>942_bases
ATGCGCATTCTGCTCTACACGCCGCATCAGGACGCGCAGGACTGGAAGCGCGACATCGAGCGCGCGCTGCCCGGCGCGCA
ACTGCGCGCATGGACGCCGGGCGACGACGCGAGCGCCGATTACGCGCTCGTGTGGCGCGCACCGCGCGAGTTCTTCGCGC
CGCGCGCCGATCTGAAGGCGGTGTTCAATCTCGGCGCGGGCGTCGACGCGATACTCGCGCTCGAGCGCGCGCATCCGGGC
CTGCTGCCGCGCGACGTGCCGCTCGTGCGCCTCGAGGACGCCGGGATGGCGCAGCAGATGGTCGAATACGCGACGCACGC
GGCGCTGCGCTATCTGCGCCGCTTCGACGAATACGCGCTGCTGCAGCGCGAGCGCCGCTGGCAGGTGCTCGAGCCGCATT
CGCGCGAGACCTTCGTCGTCGGCGTGCTCGGGCTCGGCGCGCTCGGCGCCGAAGTCGCGCGAGCGCTCGCCGCGCTCGGG
CTGCCGGTGCGCGGCTTCAGCCGCGCGCCGAAAACGCTCGACGGCGTCACGACGTTCGCGGGCGCAGCACAGCTCGACGC
ATTCCTCGGCGGCGTGAAGCTGCTCGTGAACCTGCTGCCGAGCACGGCGGACACCGACGGCATCCTGAACGCGCGCACGT
TCTCGCAGCTCGCGCACGGCGCGTATCTCGTGAATCTCGCGCGCGGCGCGCATCTCGTCGAAGCGGATCTGCTCGACGCG
CTCGCGAGCGGCCGCATCGCCGCCGCGACGCTCGACGTGTTCGCGACCGAGCCGCTGCCGGCCGATCACCCGTTCTGGCG
CGAGCCGCGCATCGCGGTCACACCGCACTGCTCGGCCGACACGCTGCGCGCGGAGGCGGTCGAGCAGATCGCCGCGAAGA
TCGGCGCGCTCGAGCGCGGCGAGCCGATCGGCGGCATCGTCGAGCGCGATCGCGGCTACTGA

Upstream 100 bases:

>100_bases
GTCGGCGAGCAGGCGACGATGTTCTTCGTCGATCCGTGCGGCAACGCGCTGGAATTCAAGGCCTTCGCCGACATCGGCCA
GCTGTTCGCGAAATAGGCGC

Downstream 100 bases:

>100_bases
ACGCGGCCCGCGAACGCGCGCCGGAAAGCCGCATGCCACGATACATTCGATGCATTCATCAGAAGACAGGAATCAGGAGA
CCCGGATGACGCTCCCCCAA

Product: 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: 2-ketoacid reductase [H]

Number of amino acids: Translated: 313; Mature: 313

Protein sequence:

>313_residues
MRILLYTPHQDAQDWKRDIERALPGAQLRAWTPGDDASADYALVWRAPREFFAPRADLKAVFNLGAGVDAILALERAHPG
LLPRDVPLVRLEDAGMAQQMVEYATHAALRYLRRFDEYALLQRERRWQVLEPHSRETFVVGVLGLGALGAEVARALAALG
LPVRGFSRAPKTLDGVTTFAGAAQLDAFLGGVKLLVNLLPSTADTDGILNARTFSQLAHGAYLVNLARGAHLVEADLLDA
LASGRIAAATLDVFATEPLPADHPFWREPRIAVTPHCSADTLRAEAVEQIAAKIGALERGEPIGGIVERDRGY

Sequences:

>Translated_313_residues
MRILLYTPHQDAQDWKRDIERALPGAQLRAWTPGDDASADYALVWRAPREFFAPRADLKAVFNLGAGVDAILALERAHPG
LLPRDVPLVRLEDAGMAQQMVEYATHAALRYLRRFDEYALLQRERRWQVLEPHSRETFVVGVLGLGALGAEVARALAALG
LPVRGFSRAPKTLDGVTTFAGAAQLDAFLGGVKLLVNLLPSTADTDGILNARTFSQLAHGAYLVNLARGAHLVEADLLDA
LASGRIAAATLDVFATEPLPADHPFWREPRIAVTPHCSADTLRAEAVEQIAAKIGALERGEPIGGIVERDRGY
>Mature_313_residues
MRILLYTPHQDAQDWKRDIERALPGAQLRAWTPGDDASADYALVWRAPREFFAPRADLKAVFNLGAGVDAILALERAHPG
LLPRDVPLVRLEDAGMAQQMVEYATHAALRYLRRFDEYALLQRERRWQVLEPHSRETFVVGVLGLGALGAEVARALAALG
LPVRGFSRAPKTLDGVTTFAGAAQLDAFLGGVKLLVNLLPSTADTDGILNARTFSQLAHGAYLVNLARGAHLVEADLLDA
LASGRIAAATLDVFATEPLPADHPFWREPRIAVTPHCSADTLRAEAVEQIAAKIGALERGEPIGGIVERDRGY

Specific function: Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively [H]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrA subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=263, Percent_Identity=28.5171102661597, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI23308577, Length=266, Percent_Identity=28.5714285714286, Blast_Score=84, Evalue=1e-16,
Organism=Escherichia coli, GI87081824, Length=313, Percent_Identity=51.1182108626198, Blast_Score=317, Evalue=9e-88,
Organism=Escherichia coli, GI87082289, Length=156, Percent_Identity=28.8461538461538, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17532191, Length=270, Percent_Identity=26.6666666666667, Blast_Score=74, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6324980, Length=171, Percent_Identity=29.2397660818713, Blast_Score=66, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6324964, Length=171, Percent_Identity=29.2397660818713, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6322116, Length=182, Percent_Identity=25.2747252747253, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320925, Length=182, Percent_Identity=25.2747252747253, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI28574286, Length=235, Percent_Identity=28.0851063829787, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24585516, Length=147, Percent_Identity=31.2925170068027, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24585514, Length=238, Percent_Identity=26.890756302521, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI28574282, Length=238, Percent_Identity=26.890756302521, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI28574284, Length=238, Percent_Identity=26.890756302521, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI45552429, Length=238, Percent_Identity=26.890756302521, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI45551003, Length=238, Percent_Identity=26.890756302521, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI28571528, Length=156, Percent_Identity=31.4102564102564, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI19921140, Length=203, Percent_Identity=27.0935960591133, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.79; =1.1.1.81 [H]

Molecular weight: Translated: 33999; Mature: 33999

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILLYTPHQDAQDWKRDIERALPGAQLRAWTPGDDASADYALVWRAPREFFAPRADLKA
CEEEEECCCCCHHHHHHHHHHHCCCCCEEEECCCCCCCCCEEEEEECCHHHHCCHHHHHH
VFNLGAGVDAILALERAHPGLLPRDVPLVRLEDAGMAQQMVEYATHAALRYLRRFDEYAL
HHHCCCCHHHHHHHHHCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LQRERRWQVLEPHSRETFVVGVLGLGALGAEVARALAALGLPVRGFSRAPKTLDGVTTFA
HHHHHCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHH
GAAQLDAFLGGVKLLVNLLPSTADTDGILNARTFSQLAHGAYLVNLARGAHLVEADLLDA
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHEEHHHCCCHHHHHHHHHH
LASGRIAAATLDVFATEPLPADHPFWREPRIAVTPHCSADTLRAEAVEQIAAKIGALERG
HHCCCEEEEEEHHHCCCCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHCCCCCC
EPIGGIVERDRGY
CCCCCCCCCCCCC
>Mature Secondary Structure
MRILLYTPHQDAQDWKRDIERALPGAQLRAWTPGDDASADYALVWRAPREFFAPRADLKA
CEEEEECCCCCHHHHHHHHHHHCCCCCEEEECCCCCCCCCEEEEEECCHHHHCCHHHHHH
VFNLGAGVDAILALERAHPGLLPRDVPLVRLEDAGMAQQMVEYATHAALRYLRRFDEYAL
HHHCCCCHHHHHHHHHCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LQRERRWQVLEPHSRETFVVGVLGLGALGAEVARALAALGLPVRGFSRAPKTLDGVTTFA
HHHHHCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHH
GAAQLDAFLGGVKLLVNLLPSTADTDGILNARTFSQLAHGAYLVNLARGAHLVEADLLDA
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHEEHHHCCCHHHHHHHHHH
LASGRIAAATLDVFATEPLPADHPFWREPRIAVTPHCSADTLRAEAVEQIAAKIGALERG
HHCCCEEEEEEHHHCCCCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHCCCCCC
EPIGGIVERDRGY
CCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA