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The map label for this gene is hbd [H]

Identifier: 83720341

GI number: 83720341

Start: 3222156

End: 3223322

Strand: Reverse

Name: hbd [H]

Synonym: BTH_I2807

Alternate gene names: 83720341

Gene position: 3223322-3222156 (Counterclockwise)

Preceding gene: 83720809

Following gene: 83719453

Centisome position: 84.62

GC content: 70.35

Gene sequence:

>1167_bases
GTGTCCGGCGCGCGCCGGGACGCACGCGATGCGTGCCGCTCGCGCCGCCGCTCGCCTGCGCGGTCGGGCCGCGCGAATCG
AAACAGCCGCATGACGCTTCGGCACTCATGCGGTTTTTTTGCGCCGGGCGGATGCGCGCGAGCGGCCTCGCGCATCCGGC
GGCGGCCGACGGACTCGGCCGCGCAGCGCAACCATGGCGGTTCGATGCGACAATCGTTCGCACATTCGAACACCTTGGAG
ACCCCGCCCATGGAGATTCAACGGATCGCCGTCGTCGGCGCCGGCGTGATCGGCGCGAGCTGGACCGCGTTCTATTTGTC
GAAGGGCTTCGACGTCGCCGTGACCGATCCGGCGCCCGACGCGCGCACGCGCCTCGACGCCTCGCTCGCGAATTTCCTCG
GCGAGCGCGCCGGGACGCTCGCGCCACGCGTCGCATTCGAGCCGACGCTCGACGCGGCGCTCGACGGCGCGGACTTCGTG
CAGGAGAGCGGCCCCGAGCGCCTCGACTTCAAGCGCGAGCTGTATCGCCGGATCGACGCGCGGCTGCCCGCGCACGTGCT
CGTCGCATCGAGCTCGTCCGGGCTCAAGATGTCGGACATCCAGACCGCGTGCGACGCGCATCCCGAGCGCTGCCTGATCG
CGCATCCGTTCAATCCGCCGCATCTGATCCCGCTCGTCGAACTCGTCGGCGGCGCGGCGACGTCCGCCGGCGCGATCGCG
CAGGCGAAGCGCTTCTACGACGGCCTCGGCAAGGTGACGATCGTGCTCAACAAGGAGATGGCGGGCCATGTCGCGAACCG
GCTCGCGGCCGCGCTATTTCGCGAGGTGTATCACCTGGTCGGCGAAGGCGTCGTGAGCGTCGAGGACGCGGACAAGGCGG
TGTCGTGGGGGCCGGGCCTGCGCTGGGGGCTGATGGGGCAGAGCCTCATCTACCATCTCGGCGGCGGCGAAGGCGGCATC
GCGCATTTTCTCGAACACCTGTCGGGCCCGATGGCGGAGTGGTGGCGCGATCTTGGCTCGCCGTCGTTCTCGCCCGACGT
CGATCGCCAACTGATCGACGCGCTGCGCGAGATCCAGGGCGCGCATTCGATGCGCGAACTCGGCGCGGAGCGCGACCGCC
TGCTCGTCGAGCTGATCGACGCGCGGCGCGACAGCTTCCTGCCGTGA

Upstream 100 bases:

>100_bases
CGCTCGCCGAAACGAAGGCGAAGATCGAAGCCAGGCTCGGCGACTGAGCGACGCGGCAACCCGGCAACTCGGCGGCGACG
CGGCCGAGCCGGCGCGCGCC

Downstream 100 bases:

>100_bases
GCGTCGCGCGCAGGCGGTCGTGCGACGCCGGCGGCGTGTCGGGAGCCGGCATCGATCGCGCGCGCCTTCTTTGATTCCAC
GGTTGCTGCTCGCGCGCCCA

Product: 3-hydroxyacyl-CoA dehydrogenase family protein

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 388; Mature: 387

Protein sequence:

>388_residues
MSGARRDARDACRSRRRSPARSGRANRNSRMTLRHSCGFFAPGGCARAASRIRRRPTDSAAQRNHGGSMRQSFAHSNTLE
TPPMEIQRIAVVGAGVIGASWTAFYLSKGFDVAVTDPAPDARTRLDASLANFLGERAGTLAPRVAFEPTLDAALDGADFV
QESGPERLDFKRELYRRIDARLPAHVLVASSSSGLKMSDIQTACDAHPERCLIAHPFNPPHLIPLVELVGGAATSAGAIA
QAKRFYDGLGKVTIVLNKEMAGHVANRLAAALFREVYHLVGEGVVSVEDADKAVSWGPGLRWGLMGQSLIYHLGGGEGGI
AHFLEHLSGPMAEWWRDLGSPSFSPDVDRQLIDALREIQGAHSMRELGAERDRLLVELIDARRDSFLP

Sequences:

>Translated_388_residues
MSGARRDARDACRSRRRSPARSGRANRNSRMTLRHSCGFFAPGGCARAASRIRRRPTDSAAQRNHGGSMRQSFAHSNTLE
TPPMEIQRIAVVGAGVIGASWTAFYLSKGFDVAVTDPAPDARTRLDASLANFLGERAGTLAPRVAFEPTLDAALDGADFV
QESGPERLDFKRELYRRIDARLPAHVLVASSSSGLKMSDIQTACDAHPERCLIAHPFNPPHLIPLVELVGGAATSAGAIA
QAKRFYDGLGKVTIVLNKEMAGHVANRLAAALFREVYHLVGEGVVSVEDADKAVSWGPGLRWGLMGQSLIYHLGGGEGGI
AHFLEHLSGPMAEWWRDLGSPSFSPDVDRQLIDALREIQGAHSMRELGAERDRLLVELIDARRDSFLP
>Mature_387_residues
SGARRDARDACRSRRRSPARSGRANRNSRMTLRHSCGFFAPGGCARAASRIRRRPTDSAAQRNHGGSMRQSFAHSNTLET
PPMEIQRIAVVGAGVIGASWTAFYLSKGFDVAVTDPAPDARTRLDASLANFLGERAGTLAPRVAFEPTLDAALDGADFVQ
ESGPERLDFKRELYRRIDARLPAHVLVASSSSGLKMSDIQTACDAHPERCLIAHPFNPPHLIPLVELVGGAATSAGAIAQ
AKRFYDGLGKVTIVLNKEMAGHVANRLAAALFREVYHLVGEGVVSVEDADKAVSWGPGLRWGLMGQSLIYHLGGGEGGIA
HFLEHLSGPMAEWWRDLGSPSFSPDVDRQLIDALREIQGAHSMRELGAERDRLLVELIDARRDSFLP

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI115430219, Length=272, Percent_Identity=33.4558823529412, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI20127408, Length=223, Percent_Identity=28.2511210762332, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI296179429, Length=234, Percent_Identity=27.7777777777778, Blast_Score=73, Evalue=4e-13,
Organism=Escherichia coli, GI1787661, Length=243, Percent_Identity=28.3950617283951, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1788682, Length=137, Percent_Identity=32.1167883211679, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790281, Length=137, Percent_Identity=30.6569343065693, Blast_Score=62, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI115533614, Length=247, Percent_Identity=31.5789473684211, Blast_Score=122, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI193203623, Length=247, Percent_Identity=32.7935222672065, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17549919, Length=234, Percent_Identity=24.7863247863248, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI25144276, Length=210, Percent_Identity=27.1428571428571, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17508953, Length=210, Percent_Identity=27.1428571428571, Blast_Score=76, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17508951, Length=210, Percent_Identity=27.1428571428571, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17553560, Length=229, Percent_Identity=24.4541484716157, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17558304, Length=210, Percent_Identity=26.6666666666667, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI20129993, Length=315, Percent_Identity=29.5238095238095, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI45549573, Length=304, Percent_Identity=28.2894736842105, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI19921000, Length=233, Percent_Identity=26.6094420600858, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24583077, Length=233, Percent_Identity=26.6094420600858, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24583079, Length=233, Percent_Identity=26.6094420600858, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 42057; Mature: 41926

Theoretical pI: Translated: 9.01; Mature: 9.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGARRDARDACRSRRRSPARSGRANRNSRMTLRHSCGFFAPGGCARAASRIRRRPTDSA
CCCCCHHHHHHHHHHHCCCHHCCCCCCCCCEEEHHCCCCCCCCHHHHHHHHHHCCCCCHH
AQRNHGGSMRQSFAHSNTLETPPMEIQRIAVVGAGVIGASWTAFYLSKGFDVAVTDPAPD
HHHCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEECCCCCC
ARTRLDASLANFLGERAGTLAPRVAFEPTLDAALDGADFVQESGPERLDFKRELYRRIDA
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCHHHHHHCCCCCCHHHHHHHHHHHH
RLPAHVLVASSSSGLKMSDIQTACDAHPERCLIAHPFNPPHLIPLVELVGGAATSAGAIA
CCCCEEEEECCCCCCCHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHCCCCCHHHHHH
QAKRFYDGLGKVTIVLNKEMAGHVANRLAAALFREVYHLVGEGVVSVEDADKAVSWGPGL
HHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHCCCCCC
RWGLMGQSLIYHLGGGEGGIAHFLEHLSGPMAEWWRDLGSPSFSPDVDRQLIDALREIQG
HHHHHHHHHHEECCCCCCHHHHHHHHHCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
AHSMRELGAERDRLLVELIDARRDSFLP
HHHHHHHCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SGARRDARDACRSRRRSPARSGRANRNSRMTLRHSCGFFAPGGCARAASRIRRRPTDSA
CCCCHHHHHHHHHHHCCCHHCCCCCCCCCEEEHHCCCCCCCCHHHHHHHHHHCCCCCHH
AQRNHGGSMRQSFAHSNTLETPPMEIQRIAVVGAGVIGASWTAFYLSKGFDVAVTDPAPD
HHHCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEECCCCCC
ARTRLDASLANFLGERAGTLAPRVAFEPTLDAALDGADFVQESGPERLDFKRELYRRIDA
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCHHHHHHCCCCCCHHHHHHHHHHHH
RLPAHVLVASSSSGLKMSDIQTACDAHPERCLIAHPFNPPHLIPLVELVGGAATSAGAIA
CCCCEEEEECCCCCCCHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHCCCCCHHHHHH
QAKRFYDGLGKVTIVLNKEMAGHVANRLAAALFREVYHLVGEGVVSVEDADKAVSWGPGL
HHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHCCCCCC
RWGLMGQSLIYHLGGGEGGIAHFLEHLSGPMAEWWRDLGSPSFSPDVDRQLIDALREIQG
HHHHHHHHHHEECCCCCCHHHHHHHHHCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
AHSMRELGAERDRLLVELIDARRDSFLP
HHHHHHHCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8655474; 11466286 [H]