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The map label for this gene is serA [H]

Identifier: 83720197

GI number: 83720197

Start: 3318665

End: 3319939

Strand: Reverse

Name: serA [H]

Synonym: BTH_I2885

Alternate gene names: 83720197

Gene position: 3319939-3318665 (Counterclockwise)

Preceding gene: 83721126

Following gene: 83721613

Centisome position: 87.16

GC content: 65.65

Gene sequence:

>1275_bases
ATGGCGACGTGCGCGCACCGCGCCGGGATTTCCGGCTTCCGCTACGATTCGACCACCACGCTAGGTAACATGACTTCCGT
TCTCCTCCTCGAAAACATTCACGACAGCGCGTCCCGGCATTTCGCCGACGCGAATGTCGACATCGAGCGGCGCAAGGGCG
CGCTCGCCGGCGACGAGCTTCAGCGCGCGCTGCTGCAGCATCAATTGATCGGCATTCGCTCCGCGACGCATCTGACGCGC
AACGAGATCGACGCCGCGCGTCATCTGCTCGCGATCGGGTGTTTCTGCATCGGCACGTCGCAGGTCGATTTGTCGGCTGC
CGCGCATCACGGCATTCCGGTGTTCAACGCGCCGTTCTCGAATACGCGGTCGGTCGCGGAGCTCGTGATCGCCGAGGCGA
TCCTGTTGCTGAGGCGCGTGCCGGAGAAGAGTGTCCTCGCGCATGCGGGGGAATGGGCGAAAGGTGCGGGCGGATCGTTC
GAGGCGCGCGGCAAGACGATCGCGATCGTCGGCTACGGCAACATCGGCGCGCAAGTCGGCGTGCTTGCCGAGGCGCTCGG
CATGAAGGTCGTCTATTACGACGTGCAGGCGAAGCTGTCGCTCGGTTCCGCGCGGCCGGCGCGTTCGCTGGGCGAAGCGA
TCGCGCTCGCGGACGTCGTCACGCTGCACGTGCCCGCAACCGCGACGACGCACAACATGATCGACGCGAGTGTCCTCGCG
CAGTTCAAATCGAATGCGATCCTGATCAATGCGTCGCGCGGCACCGTCGTCGATATCGATGCGCTGCGCGATGCGCTCGT
GCGGAAGCACCTGAGCGGTGCGGCGATCGACGTGTTTCCGCGCGAGCCGAAGAGCAACGCGGACCGCTTCGAATCCGTGC
TGCAGGGGTTGCCGAACGTGATCCTGACGCCGCATATCGGCGGCAGCACGCAGGAAGCGCAGGAGAACATCGGCGCGGAG
GTGTCGTCGAAGCTTGTCGCGTTCCTGACGCGCGGCGATACCGCGGGCGCCGTCAATTTCCCGCAGGTGAGCCCGGGCGA
TTGCACGTCGGCCGCGCGGCTCTTGAACGTGCACGGCAACGCGCCGGGCGTGCTCGCGGTGCTCAACACGCTGCTCGCGC
AAGAGGGCGCGAATGTCGTAGCGCAGCATCTGCAAACGCGCGGCGATATCGGCTATGTGGTGACCGATCTCGACCGCGTG
CCGTCCGACGCGTTTCTTGAAAAGCTGAGCGGCAACCGCGCATTTACTCGCAGCCGGCTGCTTCGCAGCGCATGA

Upstream 100 bases:

>100_bases
GGTCATGCCGGCCGGCTTGTGTCGAGCATCCGCCAGGCATACGATTTTTGAACGGTGACGCGACATGCGTCGCGTGCCGT
GCGATCGGCGCGAACGCCGC

Downstream 100 bases:

>100_bases
TGCGCCGCGCGGGCCGCCGGCAAGCGGTTCGCGCGCGACGTGCGCCGCGCGCTTGATGCGCTGCCGCACCCTGTCGATTT
TGACAGCGTTGGATTTCTCG

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 424; Mature: 423

Protein sequence:

>424_residues
MATCAHRAGISGFRYDSTTTLGNMTSVLLLENIHDSASRHFADANVDIERRKGALAGDELQRALLQHQLIGIRSATHLTR
NEIDAARHLLAIGCFCIGTSQVDLSAAAHHGIPVFNAPFSNTRSVAELVIAEAILLLRRVPEKSVLAHAGEWAKGAGGSF
EARGKTIAIVGYGNIGAQVGVLAEALGMKVVYYDVQAKLSLGSARPARSLGEAIALADVVTLHVPATATTHNMIDASVLA
QFKSNAILINASRGTVVDIDALRDALVRKHLSGAAIDVFPREPKSNADRFESVLQGLPNVILTPHIGGSTQEAQENIGAE
VSSKLVAFLTRGDTAGAVNFPQVSPGDCTSAARLLNVHGNAPGVLAVLNTLLAQEGANVVAQHLQTRGDIGYVVTDLDRV
PSDAFLEKLSGNRAFTRSRLLRSA

Sequences:

>Translated_424_residues
MATCAHRAGISGFRYDSTTTLGNMTSVLLLENIHDSASRHFADANVDIERRKGALAGDELQRALLQHQLIGIRSATHLTR
NEIDAARHLLAIGCFCIGTSQVDLSAAAHHGIPVFNAPFSNTRSVAELVIAEAILLLRRVPEKSVLAHAGEWAKGAGGSF
EARGKTIAIVGYGNIGAQVGVLAEALGMKVVYYDVQAKLSLGSARPARSLGEAIALADVVTLHVPATATTHNMIDASVLA
QFKSNAILINASRGTVVDIDALRDALVRKHLSGAAIDVFPREPKSNADRFESVLQGLPNVILTPHIGGSTQEAQENIGAE
VSSKLVAFLTRGDTAGAVNFPQVSPGDCTSAARLLNVHGNAPGVLAVLNTLLAQEGANVVAQHLQTRGDIGYVVTDLDRV
PSDAFLEKLSGNRAFTRSRLLRSA
>Mature_423_residues
ATCAHRAGISGFRYDSTTTLGNMTSVLLLENIHDSASRHFADANVDIERRKGALAGDELQRALLQHQLIGIRSATHLTRN
EIDAARHLLAIGCFCIGTSQVDLSAAAHHGIPVFNAPFSNTRSVAELVIAEAILLLRRVPEKSVLAHAGEWAKGAGGSFE
ARGKTIAIVGYGNIGAQVGVLAEALGMKVVYYDVQAKLSLGSARPARSLGEAIALADVVTLHVPATATTHNMIDASVLAQ
FKSNAILINASRGTVVDIDALRDALVRKHLSGAAIDVFPREPKSNADRFESVLQGLPNVILTPHIGGSTQEAQENIGAEV
SSKLVAFLTRGDTAGAVNFPQVSPGDCTSAARLLNVHGNAPGVLAVLNTLLAQEGANVVAQHLQTRGDIGYVVTDLDRVP
SDAFLEKLSGNRAFTRSRLLRSA

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=319, Percent_Identity=32.2884012539185, Blast_Score=158, Evalue=8e-39,
Organism=Homo sapiens, GI145580578, Length=292, Percent_Identity=30.1369863013699, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI4557499, Length=292, Percent_Identity=30.1369863013699, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI145580575, Length=292, Percent_Identity=30.1369863013699, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI4557497, Length=304, Percent_Identity=27.9605263157895, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI61743967, Length=304, Percent_Identity=27.9605263157895, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI6912396, Length=309, Percent_Identity=26.2135922330097, Blast_Score=80, Evalue=4e-15,
Organism=Escherichia coli, GI1789279, Length=397, Percent_Identity=53.904282115869, Blast_Score=404, Evalue=1e-114,
Organism=Escherichia coli, GI87082289, Length=262, Percent_Identity=31.6793893129771, Blast_Score=102, Evalue=6e-23,
Organism=Escherichia coli, GI1787645, Length=252, Percent_Identity=26.984126984127, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1788660, Length=262, Percent_Identity=28.6259541984733, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17532191, Length=289, Percent_Identity=35.2941176470588, Blast_Score=154, Evalue=8e-38,
Organism=Caenorhabditis elegans, GI25147481, Length=300, Percent_Identity=27, Blast_Score=93, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6322116, Length=415, Percent_Identity=45.5421686746988, Blast_Score=349, Evalue=4e-97,
Organism=Saccharomyces cerevisiae, GI6320925, Length=415, Percent_Identity=45.0602409638554, Blast_Score=344, Evalue=2e-95,
Organism=Saccharomyces cerevisiae, GI6324964, Length=276, Percent_Identity=27.1739130434783, Blast_Score=85, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6324055, Length=227, Percent_Identity=25.5506607929515, Blast_Score=81, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6321253, Length=193, Percent_Identity=27.4611398963731, Blast_Score=73, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6325144, Length=175, Percent_Identity=29.7142857142857, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI19921140, Length=312, Percent_Identity=29.8076923076923, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24646446, Length=309, Percent_Identity=29.4498381877023, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24646448, Length=309, Percent_Identity=29.4498381877023, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24646452, Length=309, Percent_Identity=29.4498381877023, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24646450, Length=309, Percent_Identity=29.4498381877023, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI62472511, Length=309, Percent_Identity=29.4498381877023, Blast_Score=108, Evalue=5e-24,
Organism=Drosophila melanogaster, GI28574286, Length=244, Percent_Identity=26.2295081967213, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI45552429, Length=247, Percent_Identity=25.1012145748988, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI45551003, Length=247, Percent_Identity=25.1012145748988, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24585514, Length=247, Percent_Identity=25.1012145748988, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI28574282, Length=247, Percent_Identity=25.1012145748988, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI28574284, Length=247, Percent_Identity=25.1012145748988, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI28571528, Length=251, Percent_Identity=25.8964143426295, Blast_Score=72, Evalue=6e-13,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 44708; Mature: 44577

Theoretical pI: Translated: 7.76; Mature: 7.76

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATCAHRAGISGFRYDSTTTLGNMTSVLLLENIHDSASRHFADANVDIERRKGALAGDEL
CCCCCCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCHHHH
QRALLQHQLIGIRSATHLTRNEIDAARHLLAIGCFCIGTSQVDLSAAAHHGIPVFNAPFS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCEECCCCC
NTRSVAELVIAEAILLLRRVPEKSVLAHAGEWAKGAGGSFEARGKTIAIVGYGNIGAQVG
CHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCEECCCCEEEEEECCCCCHHHH
VLAEALGMKVVYYDVQAKLSLGSARPARSLGEAIALADVVTLHVPATATTHNMIDASVLA
HHHHHHCCEEEEEEEEEEEECCCCCCHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHH
QFKSNAILINASRGTVVDIDALRDALVRKHLSGAAIDVFPREPKSNADRFESVLQGLPNV
HHCCCEEEEECCCCCEEEHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHCCCCE
ILTPHIGGSTQEAQENIGAEVSSKLVAFLTRGDTAGAVNFPQVSPGDCTSAARLLNVHGN
EEECCCCCCHHHHHHHHCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHEECCCC
APGVLAVLNTLLAQEGANVVAQHLQTRGDIGYVVTDLDRVPSDAFLEKLSGNRAFTRSRL
CCHHHHHHHHHHHHCCHHHHHHHHHHCCCCCEEEECHHHCCHHHHHHHHCCCHHHHHHHH
LRSA
HHCC
>Mature Secondary Structure 
ATCAHRAGISGFRYDSTTTLGNMTSVLLLENIHDSASRHFADANVDIERRKGALAGDEL
CCCCCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCHHHH
QRALLQHQLIGIRSATHLTRNEIDAARHLLAIGCFCIGTSQVDLSAAAHHGIPVFNAPFS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCEECCCCC
NTRSVAELVIAEAILLLRRVPEKSVLAHAGEWAKGAGGSFEARGKTIAIVGYGNIGAQVG
CHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCEECCCCEEEEEECCCCCHHHH
VLAEALGMKVVYYDVQAKLSLGSARPARSLGEAIALADVVTLHVPATATTHNMIDASVLA
HHHHHHCCEEEEEEEEEEEECCCCCCHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHH
QFKSNAILINASRGTVVDIDALRDALVRKHLSGAAIDVFPREPKSNADRFESVLQGLPNV
HHCCCEEEEECCCCCEEEHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHCCCCE
ILTPHIGGSTQEAQENIGAEVSSKLVAFLTRGDTAGAVNFPQVSPGDCTSAARLLNVHGN
EEECCCCCCHHHHHHHHCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHEECCCC
APGVLAVLNTLLAQEGANVVAQHLQTRGDIGYVVTDLDRVPSDAFLEKLSGNRAFTRSRL
CCHHHHHHHHHHHHCCHHHHHHHHHHCCCCCEEEECHHHCCHHHHHHHHCCCHHHHHHHH
LRSA
HHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]