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The map label for this gene is phhA [H]

Identifier: 83720102

GI number: 83720102

Start: 3800766

End: 3801659

Strand: Direct

Name: phhA [H]

Synonym: BTH_I3337

Alternate gene names: 83720102

Gene position: 3800766-3801659 (Clockwise)

Preceding gene: 83721396

Following gene: 83721004

Centisome position: 99.78

GC content: 67.9

Gene sequence:

>894_bases
ATGTCCACCGTCGTCACCGCGAAACTGAAGGAACAGTTCGACGCGGGCCTCGAAACCCGCGCCGATTTCACCATCGATCA
GCCGCTCGCCCGTTACGGCGACCTCGACCACGCGGTGTGGAGGCAACTGTACGCGCGGCAGGCATCGCTGCTGCGCGGCC
GCGCGTGCGACGCGTTCATCGGCGGCCTCGCGCGCATCGGTCTCGCGCCCGATCGCGTGCCGTCGTTCGCCGACGTGAAC
CGCCGGCTCGAGCCCGCAACCGGCTGGCGCATCGTCGCGGTGCCGGGCCTCGTGCCGGACGCCGTCTTCTTCGAGCATCT
CGCGAACCGGCGGTTTCCGGTCACCTGGTGGATGCGTCGCCCGGATCAGCTCGATTATCTGCAGGAGCCGGACTGCTTCC
ACGATCTGTTCGGCCACGTGCCGCTGCTGATCGATCCCGTATTCGCCGACTACATGCACGCGTACGGCCGCGCGGCGCTC
GGCGTCGCCGACGATCCGCGCGCGCTCGCGCTTCTCGCACGCCTCTATTGGTATACGGTCGAATTCGGCCTGATCCGCGG
CGCGCGCGGTGAAAACGGGCTGCGGATCTACGGCGCGGGCATCGTGTCGAGCAAGGGCGAGACGCTCTACAGCCTTGAAA
GCGCGTCGCCGAACCGGATCGGCTTCGATCTCGAGCGCGTGATGCGGACCCGTTACCGGATCGACACGCTCCAGAAGACC
TACTTCGTGATCGACGATTTCGCGCAACTCTTCGCGCTCGCCGACATCGACGCGCGCACGCTTGCCGCGCGGCTCGCCAA
CGCGCCCGAGCACGCGGCGGGCGCCGTGCTTGACGGCGATCATGTGCTCACGCGCGGCACGGGTGAAGGTTGGGCAACCG
ATGCAGACGCCTGA

Upstream 100 bases:

>100_bases
ATTCATAGGCGAATGCGCGCCTACTTTGCGCCCAATCCGCGCGAGCCCCGCTCTACACTTGCATGCATCCCCACCACCGA
TGCAAAGCAAGGCGTTCACC

Downstream 100 bases:

>100_bases
CGAACAATTATGAAAGAATGGCCGATACGGCGCGCCGTCGCGCGAACGGGCGCGGCCGCGCCGCCATCGGACGAGGTATG
AAAATGATTCACAAGCTCAC

Product: phenylalanine 4-monooxygenase

Products: NA

Alternate protein names: PAH; Phe-4-monooxygenase [H]

Number of amino acids: Translated: 297; Mature: 296

Protein sequence:

>297_residues
MSTVVTAKLKEQFDAGLETRADFTIDQPLARYGDLDHAVWRQLYARQASLLRGRACDAFIGGLARIGLAPDRVPSFADVN
RRLEPATGWRIVAVPGLVPDAVFFEHLANRRFPVTWWMRRPDQLDYLQEPDCFHDLFGHVPLLIDPVFADYMHAYGRAAL
GVADDPRALALLARLYWYTVEFGLIRGARGENGLRIYGAGIVSSKGETLYSLESASPNRIGFDLERVMRTRYRIDTLQKT
YFVIDDFAQLFALADIDARTLAARLANAPEHAAGAVLDGDHVLTRGTGEGWATDADA

Sequences:

>Translated_297_residues
MSTVVTAKLKEQFDAGLETRADFTIDQPLARYGDLDHAVWRQLYARQASLLRGRACDAFIGGLARIGLAPDRVPSFADVN
RRLEPATGWRIVAVPGLVPDAVFFEHLANRRFPVTWWMRRPDQLDYLQEPDCFHDLFGHVPLLIDPVFADYMHAYGRAAL
GVADDPRALALLARLYWYTVEFGLIRGARGENGLRIYGAGIVSSKGETLYSLESASPNRIGFDLERVMRTRYRIDTLQKT
YFVIDDFAQLFALADIDARTLAARLANAPEHAAGAVLDGDHVLTRGTGEGWATDADA
>Mature_296_residues
STVVTAKLKEQFDAGLETRADFTIDQPLARYGDLDHAVWRQLYARQASLLRGRACDAFIGGLARIGLAPDRVPSFADVNR
RLEPATGWRIVAVPGLVPDAVFFEHLANRRFPVTWWMRRPDQLDYLQEPDCFHDLFGHVPLLIDPVFADYMHAYGRAALG
VADDPRALALLARLYWYTVEFGLIRGARGENGLRIYGAGIVSSKGETLYSLESASPNRIGFDLERVMRTRYRIDTLQKTY
FVIDDFAQLFALADIDARTLAARLANAPEHAAGAVLDGDHVLTRGTGEGWATDADA

Specific function: Unknown

COG id: COG3186

COG function: function code E; Phenylalanine-4-hydroxylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family [H]

Homologues:

Organism=Homo sapiens, GI88900503, Length=226, Percent_Identity=35.8407079646018, Blast_Score=132, Evalue=3e-31,
Organism=Homo sapiens, GI88900505, Length=226, Percent_Identity=35.8407079646018, Blast_Score=132, Evalue=4e-31,
Organism=Homo sapiens, GI88900501, Length=226, Percent_Identity=35.8407079646018, Blast_Score=132, Evalue=4e-31,
Organism=Homo sapiens, GI4557819, Length=227, Percent_Identity=34.3612334801762, Blast_Score=125, Evalue=3e-29,
Organism=Homo sapiens, GI31795563, Length=229, Percent_Identity=32.7510917030568, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI4759248, Length=224, Percent_Identity=32.1428571428571, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17531391, Length=225, Percent_Identity=38.2222222222222, Blast_Score=135, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI71980736, Length=219, Percent_Identity=32.4200913242009, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI115533973, Length=236, Percent_Identity=31.3559322033898, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI115532103, Length=236, Percent_Identity=31.3559322033898, Blast_Score=116, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI71980731, Length=150, Percent_Identity=30.6666666666667, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI62472054, Length=224, Percent_Identity=34.375, Blast_Score=124, Evalue=9e-29,
Organism=Drosophila melanogaster, GI24660393, Length=224, Percent_Identity=34.375, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI17136776, Length=225, Percent_Identity=30.2222222222222, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI17136774, Length=225, Percent_Identity=30.2222222222222, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24654994, Length=271, Percent_Identity=30.6273062730627, Blast_Score=109, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001273
- InterPro:   IPR018301
- InterPro:   IPR019774
- InterPro:   IPR005960 [H]

Pfam domain/function: PF00351 Biopterin_H [H]

EC number: =1.14.16.1 [H]

Molecular weight: Translated: 33069; Mature: 32938

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: PS00367 BIOPTERIN_HYDROXYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTVVTAKLKEQFDAGLETRADFTIDQPLARYGDLDHAVWRQLYARQASLLRGRACDAFI
CCCEEHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHH
GGLARIGLAPDRVPSFADVNRRLEPATGWRIVAVPGLVPDAVFFEHLANRRFPVTWWMRR
HHHHHHCCCHHCCCCHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCCCEEEECCC
PDQLDYLQEPDCFHDLFGHVPLLIDPVFADYMHAYGRAALGVADDPRALALLARLYWYTV
CCCCCCCCCCCHHHHHHCCCCCEEHHHHHHHHHHHCCEECCCCCCHHHHHHHHHHHHHHH
EFGLIRGARGENGLRIYGAGIVSSKGETLYSLESASPNRIGFDLERVMRTRYRIDTLQKT
HHHHEECCCCCCCEEEEEECEECCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHH
YFVIDDFAQLFALADIDARTLAARLANAPEHAAGAVLDGDHVLTRGTGEGWATDADA
HHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHCCCEECCCEEEECCCCCCCCCCCCC
>Mature Secondary Structure 
STVVTAKLKEQFDAGLETRADFTIDQPLARYGDLDHAVWRQLYARQASLLRGRACDAFI
CCEEHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHH
GGLARIGLAPDRVPSFADVNRRLEPATGWRIVAVPGLVPDAVFFEHLANRRFPVTWWMRR
HHHHHHCCCHHCCCCHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCCCEEEECCC
PDQLDYLQEPDCFHDLFGHVPLLIDPVFADYMHAYGRAALGVADDPRALALLARLYWYTV
CCCCCCCCCCCHHHHHHCCCCCEEHHHHHHHHHHHCCEECCCCCCHHHHHHHHHHHHHHH
EFGLIRGARGENGLRIYGAGIVSSKGETLYSLESASPNRIGFDLERVMRTRYRIDTLQKT
HHHHEECCCCCCCEEEEEECEECCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHH
YFVIDDFAQLFALADIDARTLAARLANAPEHAAGAVLDGDHVLTRGTGEGWATDADA
HHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHCCCEECCCEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]