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The map label for this gene is pyrD [H]

Identifier: 83720052

GI number: 83720052

Start: 2864043

End: 2865080

Strand: Direct

Name: pyrD [H]

Synonym: BTH_I2511

Alternate gene names: 83720052

Gene position: 2864043-2865080 (Clockwise)

Preceding gene: 83720286

Following gene: 83719983

Centisome position: 75.19

GC content: 68.59

Gene sequence:

>1038_bases
GTGTTCAGCTCCCTCTATCCGCTTGCCCGTGCATCCCTCTTCAAGATGGATGCGGAGGACGCCCATCATCTGACCCTGCG
CATGCTCGGCGCCGCGGGCCGCACCGGCCTCGCACGCGCGCTGTCGTCCCGCGTGCCCGACGCGCCGCGCACCGTGATGG
GGCTCACGTTCCGCAATCCGGTCGGGCTTGCGGCCGGTCTCGACAAGGACGGCGCGGCGATCGACGGCTTCGCCGCGCTC
GGCTTCGGCTTCATCGAGGTCGGCACGGTCACGCCGCGCGCGCAGCCCGGCAACCCGCGCCCGCGGATGTTCCGGTTGCC
CGAGGCCGGCGCGATCATCAACCGGATGGGCTTCAACAACAGCGGCGTCGATCAGTTCGTGAAGAACGTGCAGGCGGCGC
GCTACCGCGGCGTGCTCGGCCTGAACATCGGCAAGAATGCCGATACGCCGATCGAGCGCGCGGCCGACGATTACCTGTAC
TGCCTCGAGCGCGTCTACCCGTTCGCAAGCTACGTGACGATCAACATCTCGTCGCCGAACACGAAGAATCTGCGACAGCT
CCAGGGCGCGGGCGAGCTCGACGCGCTGCTTGCCGCGCTGAAGAACAAGCAGCAGCGCCTCGCCGACCTGCACGGCAAGC
TCGTGCCGCTCGCGCTGAAGATCGCGCCCGATCTCGACGACGAGCAGGTGAAGGACATCGCCGCGACGCTGCTGCGCCAC
AACATCGAAGGCGTGATCGCGACCAACACCACGCTGTCGCGCGACGCGGTGAAGGGCCTGCCTCATGCCGACGAGGCGGG
CGGGCTGTCCGGGCGCCCCGTGTTCGACGCGTCGAACGCGGTGATCCGCAAGCTGCATGCGGAGCTCGGCGACGCCGTGC
CGATCATCGGCGTGGGCGGCATCTTCTCCGGAGACGACGCGCGTGCGAAACTCGCCGCGGGCGCGTCGCTCGTCCAGCTG
TATACGGGCTTCATCTATCGCGGTCCGGCGCTCGTCGCCGAATGCGTGAAGGCGATCGCTCGCGGGCAAACACGGTGA

Upstream 100 bases:

>100_bases
CGCGGCCGCACCCGTCGCCGCGCGCCCGACGAAGGCGCGCCGGCGCTTCTCGGCTAAAATAGCGGGTTGTCAATTTTTCG
GCCGCCGCCGCCCCTTTTTC

Downstream 100 bases:

>100_bases
TATAGAAATAAACAAACGATATTTAGACATCGATTGTTATTTCACTATCATTGGGCGATCGATCTCAAGGCCTCATCGAA
GGCCCCATCCCAGGCAAGGA

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 345; Mature: 345

Protein sequence:

>345_residues
MFSSLYPLARASLFKMDAEDAHHLTLRMLGAAGRTGLARALSSRVPDAPRTVMGLTFRNPVGLAAGLDKDGAAIDGFAAL
GFGFIEVGTVTPRAQPGNPRPRMFRLPEAGAIINRMGFNNSGVDQFVKNVQAARYRGVLGLNIGKNADTPIERAADDYLY
CLERVYPFASYVTINISSPNTKNLRQLQGAGELDALLAALKNKQQRLADLHGKLVPLALKIAPDLDDEQVKDIAATLLRH
NIEGVIATNTTLSRDAVKGLPHADEAGGLSGRPVFDASNAVIRKLHAELGDAVPIIGVGGIFSGDDARAKLAAGASLVQL
YTGFIYRGPALVAECVKAIARGQTR

Sequences:

>Translated_345_residues
MFSSLYPLARASLFKMDAEDAHHLTLRMLGAAGRTGLARALSSRVPDAPRTVMGLTFRNPVGLAAGLDKDGAAIDGFAAL
GFGFIEVGTVTPRAQPGNPRPRMFRLPEAGAIINRMGFNNSGVDQFVKNVQAARYRGVLGLNIGKNADTPIERAADDYLY
CLERVYPFASYVTINISSPNTKNLRQLQGAGELDALLAALKNKQQRLADLHGKLVPLALKIAPDLDDEQVKDIAATLLRH
NIEGVIATNTTLSRDAVKGLPHADEAGGLSGRPVFDASNAVIRKLHAELGDAVPIIGVGGIFSGDDARAKLAAGASLVQL
YTGFIYRGPALVAECVKAIARGQTR
>Mature_345_residues
MFSSLYPLARASLFKMDAEDAHHLTLRMLGAAGRTGLARALSSRVPDAPRTVMGLTFRNPVGLAAGLDKDGAAIDGFAAL
GFGFIEVGTVTPRAQPGNPRPRMFRLPEAGAIINRMGFNNSGVDQFVKNVQAARYRGVLGLNIGKNADTPIERAADDYLY
CLERVYPFASYVTINISSPNTKNLRQLQGAGELDALLAALKNKQQRLADLHGKLVPLALKIAPDLDDEQVKDIAATLLRH
NIEGVIATNTTLSRDAVKGLPHADEAGGLSGRPVFDASNAVIRKLHAELGDAVPIIGVGGIFSGDDARAKLAAGASLVQL
YTGFIYRGPALVAECVKAIARGQTR

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI45006951, Length=337, Percent_Identity=44.213649851632, Blast_Score=249, Evalue=2e-66,
Organism=Escherichia coli, GI1787177, Length=334, Percent_Identity=56.8862275449102, Blast_Score=391, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI17509475, Length=326, Percent_Identity=42.3312883435583, Blast_Score=230, Evalue=9e-61,
Organism=Drosophila melanogaster, GI281361352, Length=296, Percent_Identity=44.9324324324324, Blast_Score=237, Evalue=9e-63,
Organism=Drosophila melanogaster, GI17137316, Length=296, Percent_Identity=44.9324324324324, Blast_Score=237, Evalue=9e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.5.2 [H]

Molecular weight: Translated: 36633; Mature: 36633

Theoretical pI: Translated: 9.82; Mature: 9.82

Prosite motif: PS00911 DHODEHASE_1 ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSSLYPLARASLFKMDAEDAHHLTLRMLGAAGRTGLARALSSRVPDAPRTVMGLTFRNP
CCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCEEEEEECCC
VGLAAGLDKDGAAIDGFAALGFGFIEVGTVTPRAQPGNPRPRMFRLPEAGAIINRMGFNN
CCCCCCCCCCCCCCCHHHHHCCCCEEECCCCCCCCCCCCCCCEEECCCHHHHHHHCCCCC
SGVDQFVKNVQAARYRGVLGLNIGKNADTPIERAADDYLYCLERVYPFASYVTINISSPN
CCHHHHHHHHHHHHHCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCC
TKNLRQLQGAGELDALLAALKNKQQRLADLHGKLVPLALKIAPDLDDEQVKDIAATLLRH
CHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHH
NIEGVIATNTTLSRDAVKGLPHADEAGGLSGRPVFDASNAVIRKLHAELGDAVPIIGVGG
CCCEEEEECCCCCHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEECC
IFSGDDARAKLAAGASLVQLYTGFIYRGPALVAECVKAIARGQTR
EECCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MFSSLYPLARASLFKMDAEDAHHLTLRMLGAAGRTGLARALSSRVPDAPRTVMGLTFRNP
CCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCEEEEEECCC
VGLAAGLDKDGAAIDGFAALGFGFIEVGTVTPRAQPGNPRPRMFRLPEAGAIINRMGFNN
CCCCCCCCCCCCCCCHHHHHCCCCEEECCCCCCCCCCCCCCCEEECCCHHHHHHHCCCCC
SGVDQFVKNVQAARYRGVLGLNIGKNADTPIERAADDYLYCLERVYPFASYVTINISSPN
CCHHHHHHHHHHHHHCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCC
TKNLRQLQGAGELDALLAALKNKQQRLADLHGKLVPLALKIAPDLDDEQVKDIAATLLRH
CHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHH
NIEGVIATNTTLSRDAVKGLPHADEAGGLSGRPVFDASNAVIRKLHAELGDAVPIIGVGG
CCCEEEEECCCCCHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEECC
IFSGDDARAKLAAGASLVQLYTGFIYRGPALVAECVKAIARGQTR
EECCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA