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The map label for this gene is hppD [H]

Identifier: 83720009

GI number: 83720009

Start: 3539703

End: 3540800

Strand: Direct

Name: hppD [H]

Synonym: BTH_I3106

Alternate gene names: 83720009

Gene position: 3539703-3540800 (Clockwise)

Preceding gene: 83719127

Following gene: 83721446

Centisome position: 92.93

GC content: 63.66

Gene sequence:

>1098_bases
ATGCAAATCCCCACCTGGGACAATCCCGTCGGCACCGACGGCTTCGAATTCATCGAATACACCGCCCCCGATCCGAAAGC
GCTCGGCCAACTGTTCGAGCGGATGGGCTTCACCGCGGTTGCGCGCCATCGCCATAAGGACGTGACGCTGTACCGCCAGG
GCGACATCAACTTCATCATCAACGCGGAACCGGATTCGTTCGCACAGCGCTTCGCGCGGCTGCACGGGCCGTCGATCTGC
GCGATCGCGTTTCGCGTGCAGGATGCCGCGAAGGCGTACAAGCACGCGCTCGAACTCGGCGCGTGGGGCTTCGACAACAA
GACGGGCCCGATGGAGCTGAACATCCCGGCGATCAAGGGCATCGGCGATTCGCTGATCTACTTCGTCGACCGCTGGCGCG
GCAAGAACGGCGCGAAGCCGGGCGCGATCGGCGACATCAGCATCTACGACGTCGACTTCGAGCCGATCCCGGGCGTCGAT
CCGAACCCGGTCGGCCACGGCCTCACGTACATCGACCATCTGACGCACAACGTCCACCGCGGCCGCATGCAGGAATGGGC
GGCGTTCTACGAGCGCCTGTTCAACTTCCGCGAAGTCCGCTACTTCGACATCGAAGGCAAGGTGACGGGCGTGAAGTCGA
AGGCAATGACGTCGCCGTGCGGCAAGATCCGGATTCCGATCAACGAGGAAGGCTCGGACACGGCCGGCCAGATCCAGGAA
TACCTCGACGCTTATCGCGGCGAAGGCATCCAGCACATCGCGCTCGGCGCGGCCGACATCTATCGGGCGGTCGACGGACT
GCGCGCGACGGGCGTGACGCTGCTCGACACGATCGACACGTACTACGAGCTCGTCGACCGCCGCGTGCCGAACCACGGAG
AGCCGCTCGACGAGCTCAGGAAGCGCAAGATCCTGATCGACGGCGCGCGCGACGAACTGCTGCTGCAGATCTTCACCGAG
AACCAGATCGGGCCGATCTTCTTCGAGATCATCCAGCGCAAGGGCAATCAGGGCTTCGGCGAAGGCAACTTCAAGGCGCT
GTTCGAATCGATCGAGCTCGACCAGATCCGCCGCGGCGTCGTGCAGGACAAGGCTTAA

Upstream 100 bases:

>100_bases
TTGCGCGATCAAGTTCGCAAGTTTTCACCCAGCCCTCCCCGCTACACTTTGCCGCAGACATTCATCAAGACGCGTGCCCC
ACCGAGGGCTAGGAGACGCC

Downstream 100 bases:

>100_bases
GCGAGCCGGCCCGGCACGCGGCCGGCCTCGCGCGCCGCGCGCCGCGCGCGGAGTCCGCAAATGGCCTGATAGACAGCCCT
GCAAGCGGACCAGTAAAGGA

Product: 4-hydroxyphenylpyruvate dioxygenase

Products: NA

Alternate protein names: 4HPPD; HPD; HPPDase [H]

Number of amino acids: Translated: 365; Mature: 365

Protein sequence:

>365_residues
MQIPTWDNPVGTDGFEFIEYTAPDPKALGQLFERMGFTAVARHRHKDVTLYRQGDINFIINAEPDSFAQRFARLHGPSIC
AIAFRVQDAAKAYKHALELGAWGFDNKTGPMELNIPAIKGIGDSLIYFVDRWRGKNGAKPGAIGDISIYDVDFEPIPGVD
PNPVGHGLTYIDHLTHNVHRGRMQEWAAFYERLFNFREVRYFDIEGKVTGVKSKAMTSPCGKIRIPINEEGSDTAGQIQE
YLDAYRGEGIQHIALGAADIYRAVDGLRATGVTLLDTIDTYYELVDRRVPNHGEPLDELRKRKILIDGARDELLLQIFTE
NQIGPIFFEIIQRKGNQGFGEGNFKALFESIELDQIRRGVVQDKA

Sequences:

>Translated_365_residues
MQIPTWDNPVGTDGFEFIEYTAPDPKALGQLFERMGFTAVARHRHKDVTLYRQGDINFIINAEPDSFAQRFARLHGPSIC
AIAFRVQDAAKAYKHALELGAWGFDNKTGPMELNIPAIKGIGDSLIYFVDRWRGKNGAKPGAIGDISIYDVDFEPIPGVD
PNPVGHGLTYIDHLTHNVHRGRMQEWAAFYERLFNFREVRYFDIEGKVTGVKSKAMTSPCGKIRIPINEEGSDTAGQIQE
YLDAYRGEGIQHIALGAADIYRAVDGLRATGVTLLDTIDTYYELVDRRVPNHGEPLDELRKRKILIDGARDELLLQIFTE
NQIGPIFFEIIQRKGNQGFGEGNFKALFESIELDQIRRGVVQDKA
>Mature_365_residues
MQIPTWDNPVGTDGFEFIEYTAPDPKALGQLFERMGFTAVARHRHKDVTLYRQGDINFIINAEPDSFAQRFARLHGPSIC
AIAFRVQDAAKAYKHALELGAWGFDNKTGPMELNIPAIKGIGDSLIYFVDRWRGKNGAKPGAIGDISIYDVDFEPIPGVD
PNPVGHGLTYIDHLTHNVHRGRMQEWAAFYERLFNFREVRYFDIEGKVTGVKSKAMTSPCGKIRIPINEEGSDTAGQIQE
YLDAYRGEGIQHIALGAADIYRAVDGLRATGVTLLDTIDTYYELVDRRVPNHGEPLDELRKRKILIDGARDELLLQIFTE
NQIGPIFFEIIQRKGNQGFGEGNFKALFESIELDQIRRGVVQDKA

Specific function: Unknown

COG id: COG3185

COG function: function code ER; 4-hydroxyphenylpyruvate dioxygenase and related hemolysins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 4HPPD family [H]

Homologues:

Organism=Homo sapiens, GI4504477, Length=351, Percent_Identity=28.7749287749288, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI285002264, Length=327, Percent_Identity=29.3577981651376, Blast_Score=112, Evalue=4e-25,
Organism=Homo sapiens, GI14249394, Length=378, Percent_Identity=24.3386243386243, Blast_Score=83, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17555220, Length=301, Percent_Identity=32.5581395348837, Blast_Score=137, Evalue=7e-33,
Organism=Caenorhabditis elegans, GI17550752, Length=223, Percent_Identity=30.9417040358744, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI21356105, Length=301, Percent_Identity=33.8870431893688, Blast_Score=139, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24667510, Length=301, Percent_Identity=33.8870431893688, Blast_Score=139, Evalue=3e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005956
- InterPro:   IPR004360 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: =1.13.11.27 [H]

Molecular weight: Translated: 41056; Mature: 41056

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQIPTWDNPVGTDGFEFIEYTAPDPKALGQLFERMGFTAVARHRHKDVTLYRQGDINFII
CCCCCCCCCCCCCCHHEEEECCCCHHHHHHHHHHHCHHHHHHHCCCCEEEEEECCEEEEE
NAEPDSFAQRFARLHGPSICAIAFRVQDAAKAYKHALELGAWGFDNKTGPMELNIPAIKG
ECCCHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCHHHC
IGDSLIYFVDRWRGKNGAKPGAIGDISIYDVDFEPIPGVDPNPVGHGLTYIDHLTHNVHR
CCHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHH
GRMQEWAAFYERLFNFREVRYFDIEGKVTGVKSKAMTSPCGKIRIPINEEGSDTAGQIQE
HHHHHHHHHHHHHHCHHHEEEEEECCEEECCCHHHHCCCCCEEEEECCCCCCCHHHHHHH
YLDAYRGEGIQHIALGAADIYRAVDGLRATGVTLLDTIDTYYELVDRRVPNHGEPLDELR
HHHHHHCCCCEEEHHHHHHHHHHHHCHHHCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
KRKILIDGARDELLLQIFTENQIGPIFFEIIQRKGNQGFGEGNFKALFESIELDQIRRGV
HCEEEEECCCHHEEEEEECCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHCHHHHHHHH
VQDKA
HCCCC
>Mature Secondary Structure
MQIPTWDNPVGTDGFEFIEYTAPDPKALGQLFERMGFTAVARHRHKDVTLYRQGDINFII
CCCCCCCCCCCCCCHHEEEECCCCHHHHHHHHHHHCHHHHHHHCCCCEEEEEECCEEEEE
NAEPDSFAQRFARLHGPSICAIAFRVQDAAKAYKHALELGAWGFDNKTGPMELNIPAIKG
ECCCHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCHHHC
IGDSLIYFVDRWRGKNGAKPGAIGDISIYDVDFEPIPGVDPNPVGHGLTYIDHLTHNVHR
CCHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHH
GRMQEWAAFYERLFNFREVRYFDIEGKVTGVKSKAMTSPCGKIRIPINEEGSDTAGQIQE
HHHHHHHHHHHHHHCHHHEEEEEECCEEECCCHHHHCCCCCEEEEECCCCCCCHHHHHHH
YLDAYRGEGIQHIALGAADIYRAVDGLRATGVTLLDTIDTYYELVDRRVPNHGEPLDELR
HHHHHHCCCCEEEHHHHHHHHHHHHCHHHCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
KRKILIDGARDELLLQIFTENQIGPIFFEIIQRKGNQGFGEGNFKALFESIELDQIRRGV
HCEEEEECCCHHEEEEEECCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHCHHHHHHHH
VQDKA
HCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1572351; 10467142 [H]