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The map label for this gene is glk [H]

Identifier: 83719951

GI number: 83719951

Start: 1749745

End: 1751670

Strand: Reverse

Name: glk [H]

Synonym: BTH_I1550

Alternate gene names: 83719951

Gene position: 1751670-1749745 (Counterclockwise)

Preceding gene: 83720394

Following gene: 83718424

Centisome position: 45.99

GC content: 68.64

Gene sequence:

>1926_bases
ATGTCTACTGGTGCGCAAACTAAGGCCGCCGAGGCGAGCCAGCACGCGGACGGGCCGCGCCTATTGGCCGACGTCGGCGG
CACGAACGCGCGCTTCGCGCTCGAGACGGGGCCTGGCGAGATCACGCAGATCCGCGTGTACCCCGGCGCCGAGTATCCGA
CGCTCACCGACGCGATCCGCAGGTATCTGAAAGACGTGAAGATCGGCCGCGTGAATCACGCGGCGATCGCGATCGCGAAC
CCCGTCGACGGCGATCAGGTCCGGATGACGAATCACAACTGGAGCTTCTCGATCGAGGCGACGCGCCGCGCGCTCGGCTT
CGACACGCTGCTCGTCGTCAACGATTTCACCGCGCTCGCGATGGCGCTGCCCGGCCTGACCGACGCGCAGCGCGTGCAGA
TCGGCGCCGGCGCGCGCAGGCAAAACAGCGTGATCGGCCTGATGGGGCCGGGCACGGGGCTCGGCGTGTCGGGCCTCATC
CCCGCCGACGACCGCTGGATCGCGCTCGGCAGCGAAGGCGGCCACGCGACGTTCGCGCCGATGGACGAGCGCGAGGATCT
CGTGCTGCAGTACGCGCGCCGCAAGTATCCGCACGTGTCGTTCGAGCGCGTGTGCGCGGGCCCGGGCATGGAGATCATCT
ACCGCGCGCTCGCCGCGCGCGACAAGAAACGCATCGCCGCGAACGTCGTCACGGCCGACATCGTCGAGCGCGCGCACGCG
GGCGATGCGCTCGCGCTCGAGGCGGTCGAGTGCTTCTGCGGAATTCTCGGCACGTTCGCGGGCAACCTCGCGGTGACGCT
CGGCGCATTGGGCGGCATCTATATCGGCGGCGGCGTCGTGCCGAAGCTGGGCGAGCTCTTCATGCGCTCGCCGTTTCGCG
CGCGCTTCGAGGCGAAGGGCCGCTTCGAGGCGTATCTCGCGAACATCCCGACCTACCTGATCACCGCCGAATATCCGGCG
TTCCTCGGCGTGTCGGCGATCCTCGCCGAGCAGTTGTCGAACCGCACGGGCGGCGCGTCGTCGGCCGTGTTCGAGCGCAT
CCGCCAGATGCGCGACGCGTTGACGCCCGCCGAGCGGCGCGTCGCCGATCTCGCGCTCAACCACCCGCGCTCGATCATCA
ACGATCCGATCGTCGACATCGCGCGCAAGGCCGACGTGAGCCAGCCGACCGTGATCCGCTTCTGCCGCTCGCTCGGCTGC
CAGGGGCTGTCGGACTTCAAGCTGAAGCTCGCCACAGGCTTGACGGGCACGATCCCGATGAGCCACAGCCAGGTGCATCT
CGGCGATACGGCCACCGATTTCGGCGCGAAGGTGCTCGACAACACCGTGTCGGCGATCCTTCAGTTGCGCGAGCACCTGA
ACTTCGAGCACGTCGAGCAGGCGATCGACATCCTGAACAACGCGCGGCGCATCGAGTTCTATGGGCTCGGCAATTCGAAC
ATCGTCGCGCAGGACGCGCATTACAAGTTCTTCCGCTTCGGGATTCCGACGATCGCGTACGGCGACCTGTACATGCAGGC
CGCGTCGGCCGCGCTCCTCGGCAAGGGCGACGTGATCGTCGCGGTGTCGAAGTCCGGACGCGCGCCGGAGCTGCTGCGCG
TGCTCGACGTCGCGATGCAGGCGGGCGCGAAGGTGATCGCGATCACGTCGAGCAACACGCCGCTCGCCAAGCGCGCGACG
GTGGCGCTCGAGACCGACCACATCGAGATGCGCGAGTCGCAGTTGTCGATGATCTCGCGAATCCTGCATCTCGTGATGAT
CGACATCCTCGCGGTCGGCGTCGCGATCCGCCGCGCCTCGCCGAACGCGGAGCTCGCGGAGGCGATGGCGCGCGCGAAAG
CGCGCGCGGGTGCGAGCGCGGGCGACGAAGCCGCGGACGTGCTCGACTGGCTGAGCCACGGCGCGGCGCCCGCGGCGAAG
GAGTGA

Upstream 100 bases:

>100_bases
ATCGCGGGAAGCCGCAAGCGCGAGGTGCTCGAGGCGGCCGCGGCCGCGCCGCAGAAGAACGCGATTTCGCAACTGGCCAA
CGACAAGGGGACGAAGCTCG

Downstream 100 bases:

>100_bases
CGCGCGCGTTGCGCGTCGCAGCTTGCAGCCATGCCGGAGCCTTCGCGCTCCGGCATTTTTTTGGGCGATCCGAAACGGAT
TCCACACTGCTCCCGCCCTT

Product: bifunctional glucokinase/RpiR family transcriptional regulator

Products: NA

Alternate protein names: Glucokinase; Glucose kinase; Putative HTH-type transcriptional regulator [H]

Number of amino acids: Translated: 641; Mature: 640

Protein sequence:

>641_residues
MSTGAQTKAAEASQHADGPRLLADVGGTNARFALETGPGEITQIRVYPGAEYPTLTDAIRRYLKDVKIGRVNHAAIAIAN
PVDGDQVRMTNHNWSFSIEATRRALGFDTLLVVNDFTALAMALPGLTDAQRVQIGAGARRQNSVIGLMGPGTGLGVSGLI
PADDRWIALGSEGGHATFAPMDEREDLVLQYARRKYPHVSFERVCAGPGMEIIYRALAARDKKRIAANVVTADIVERAHA
GDALALEAVECFCGILGTFAGNLAVTLGALGGIYIGGGVVPKLGELFMRSPFRARFEAKGRFEAYLANIPTYLITAEYPA
FLGVSAILAEQLSNRTGGASSAVFERIRQMRDALTPAERRVADLALNHPRSIINDPIVDIARKADVSQPTVIRFCRSLGC
QGLSDFKLKLATGLTGTIPMSHSQVHLGDTATDFGAKVLDNTVSAILQLREHLNFEHVEQAIDILNNARRIEFYGLGNSN
IVAQDAHYKFFRFGIPTIAYGDLYMQAASAALLGKGDVIVAVSKSGRAPELLRVLDVAMQAGAKVIAITSSNTPLAKRAT
VALETDHIEMRESQLSMISRILHLVMIDILAVGVAIRRASPNAELAEAMARAKARAGASAGDEAADVLDWLSHGAAPAAK
E

Sequences:

>Translated_641_residues
MSTGAQTKAAEASQHADGPRLLADVGGTNARFALETGPGEITQIRVYPGAEYPTLTDAIRRYLKDVKIGRVNHAAIAIAN
PVDGDQVRMTNHNWSFSIEATRRALGFDTLLVVNDFTALAMALPGLTDAQRVQIGAGARRQNSVIGLMGPGTGLGVSGLI
PADDRWIALGSEGGHATFAPMDEREDLVLQYARRKYPHVSFERVCAGPGMEIIYRALAARDKKRIAANVVTADIVERAHA
GDALALEAVECFCGILGTFAGNLAVTLGALGGIYIGGGVVPKLGELFMRSPFRARFEAKGRFEAYLANIPTYLITAEYPA
FLGVSAILAEQLSNRTGGASSAVFERIRQMRDALTPAERRVADLALNHPRSIINDPIVDIARKADVSQPTVIRFCRSLGC
QGLSDFKLKLATGLTGTIPMSHSQVHLGDTATDFGAKVLDNTVSAILQLREHLNFEHVEQAIDILNNARRIEFYGLGNSN
IVAQDAHYKFFRFGIPTIAYGDLYMQAASAALLGKGDVIVAVSKSGRAPELLRVLDVAMQAGAKVIAITSSNTPLAKRAT
VALETDHIEMRESQLSMISRILHLVMIDILAVGVAIRRASPNAELAEAMARAKARAGASAGDEAADVLDWLSHGAAPAAK
E
>Mature_640_residues
STGAQTKAAEASQHADGPRLLADVGGTNARFALETGPGEITQIRVYPGAEYPTLTDAIRRYLKDVKIGRVNHAAIAIANP
VDGDQVRMTNHNWSFSIEATRRALGFDTLLVVNDFTALAMALPGLTDAQRVQIGAGARRQNSVIGLMGPGTGLGVSGLIP
ADDRWIALGSEGGHATFAPMDEREDLVLQYARRKYPHVSFERVCAGPGMEIIYRALAARDKKRIAANVVTADIVERAHAG
DALALEAVECFCGILGTFAGNLAVTLGALGGIYIGGGVVPKLGELFMRSPFRARFEAKGRFEAYLANIPTYLITAEYPAF
LGVSAILAEQLSNRTGGASSAVFERIRQMRDALTPAERRVADLALNHPRSIINDPIVDIARKADVSQPTVIRFCRSLGCQ
GLSDFKLKLATGLTGTIPMSHSQVHLGDTATDFGAKVLDNTVSAILQLREHLNFEHVEQAIDILNNARRIEFYGLGNSNI
VAQDAHYKFFRFGIPTIAYGDLYMQAASAALLGKGDVIVAVSKSGRAPELLRVLDVAMQAGAKVIAITSSNTPLAKRATV
ALETDHIEMRESQLSMISRILHLVMIDILAVGVAIRRASPNAELAEAMARAKARAGASAGDEAADVLDWLSHGAAPAAKE

Specific function: Not Highly Important In E.Coli As Glucose Is Transported Into The Cell By The Pts System Already As Glucose 6-Phosphate. [C]

COG id: COG0837

COG function: function code G; Glucokinase

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain [H]

Homologues:

Organism=Escherichia coli, GI1788732, Length=316, Percent_Identity=45.8860759493671, Blast_Score=276, Evalue=2e-75,
Organism=Escherichia coli, GI1788159, Length=281, Percent_Identity=35.5871886120996, Blast_Score=186, Evalue=4e-48,
Organism=Escherichia coli, GI87082369, Length=263, Percent_Identity=28.1368821292776, Blast_Score=107, Evalue=3e-24,
Organism=Escherichia coli, GI1788767, Length=249, Percent_Identity=26.5060240963855, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI87082130, Length=226, Percent_Identity=28.7610619469027, Blast_Score=91, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003836
- InterPro:   IPR000843
- InterPro:   IPR000281
- InterPro:   IPR001347
- InterPro:   IPR011991 [H]

Pfam domain/function: PF02685 Glucokinase; PF01418 HTH_6; PF01380 SIS [H]

EC number: =2.7.1.2 [H]

Molecular weight: Translated: 68476; Mature: 68345

Theoretical pI: Translated: 7.71; Mature: 7.71

Prosite motif: PS00356 HTH_LACI_1 ; PS51071 HTH_RPIR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTGAQTKAAEASQHADGPRLLADVGGTNARFALETGPGEITQIRVYPGAEYPTLTDAIR
CCCCCCCCHHHHHHCCCCCEEEEECCCCCCEEEEECCCCCEEEEEEECCCCCCHHHHHHH
RYLKDVKIGRVNHAAIAIANPVDGDQVRMTNHNWSFSIEATRRALGFDTLLVVNDFTALA
HHHHHCCCCCCCCEEEEEECCCCCCEEEEECCCEEEEEHHHHHHHCCCEEEEHHHHHHHH
MALPGLTDAQRVQIGAGARRQNSVIGLMGPGTGLGVSGLIPADDRWIALGSEGGHATFAP
HHCCCCCCCCEEEECCCCCCCCCEEEEECCCCCCCCCCCCCCCCCEEEEECCCCCEEECC
MDEREDLVLQYARRKYPHVSFERVCAGPGMEIIYRALAARDKKRIAANVVTADIVERAHA
CCCHHHHHHHHHHHCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GDALALEAVECFCGILGTFAGNLAVTLGALGGIYIGGGVVPKLGELFMRSPFRARFEAKG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCHHHHHHHHHCCCCHHHHCCCC
RFEAYLANIPTYLITAEYPAFLGVSAILAEQLSNRTGGASSAVFERIRQMRDALTPAERR
CHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHH
VADLALNHPRSIINDPIVDIARKADVSQPTVIRFCRSLGCQGLSDFKLKLATGLTGTIPM
HHHHHHCCCHHHHCCHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCEEEEECCCCCCCCC
SHSQVHLGDTATDFGAKVLDNTVSAILQLREHLNFEHVEQAIDILNNARRIEFYGLGNSN
CCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCEEEEEECCCCC
IVAQDAHYKFFRFGIPTIAYGDLYMQAASAALLGKGDVIVAVSKSGRAPELLRVLDVAMQ
EEEECCCCEEEEECCCCEEEHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHH
AGAKVIAITSSNTPLAKRATVALETDHIEMRESQLSMISRILHLVMIDILAVGVAIRRAS
CCCEEEEEECCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PNAELAEAMARAKARAGASAGDEAADVLDWLSHGAAPAAKE
CCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
STGAQTKAAEASQHADGPRLLADVGGTNARFALETGPGEITQIRVYPGAEYPTLTDAIR
CCCCCCCHHHHHHCCCCCEEEEECCCCCCEEEEECCCCCEEEEEEECCCCCCHHHHHHH
RYLKDVKIGRVNHAAIAIANPVDGDQVRMTNHNWSFSIEATRRALGFDTLLVVNDFTALA
HHHHHCCCCCCCCEEEEEECCCCCCEEEEECCCEEEEEHHHHHHHCCCEEEEHHHHHHHH
MALPGLTDAQRVQIGAGARRQNSVIGLMGPGTGLGVSGLIPADDRWIALGSEGGHATFAP
HHCCCCCCCCEEEECCCCCCCCCEEEEECCCCCCCCCCCCCCCCCEEEEECCCCCEEECC
MDEREDLVLQYARRKYPHVSFERVCAGPGMEIIYRALAARDKKRIAANVVTADIVERAHA
CCCHHHHHHHHHHHCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GDALALEAVECFCGILGTFAGNLAVTLGALGGIYIGGGVVPKLGELFMRSPFRARFEAKG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCHHHHHHHHHCCCCHHHHCCCC
RFEAYLANIPTYLITAEYPAFLGVSAILAEQLSNRTGGASSAVFERIRQMRDALTPAERR
CHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHH
VADLALNHPRSIINDPIVDIARKADVSQPTVIRFCRSLGCQGLSDFKLKLATGLTGTIPM
HHHHHHCCCHHHHCCHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCEEEEECCCCCCCCC
SHSQVHLGDTATDFGAKVLDNTVSAILQLREHLNFEHVEQAIDILNNARRIEFYGLGNSN
CCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCEEEEEECCCCC
IVAQDAHYKFFRFGIPTIAYGDLYMQAASAALLGKGDVIVAVSKSGRAPELLRVLDVAMQ
EEEECCCCEEEEECCCCEEEHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHH
AGAKVIAITSSNTPLAKRATVALETDHIEMRESQLSMISRILHLVMIDILAVGVAIRRAS
CCCEEEEEECCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PNAELAEAMARAKARAGASAGDEAADVLDWLSHGAAPAAKE
CCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA