BacMap

Definition	Burkholderia thailandensis E264 chromosome chromosome I, complete sequence.
Accession	NC_007651
Length	3,809,201

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The map label for this gene is cpnA [H]

Identifier: 83719818

GI number: 83719818

Start: 2779648

End: 2780394

Strand: Reverse

Name: cpnA [H]

Synonym: BTH_I2430

Alternate gene names: 83719818

Gene position: 2780394-2779648 (Counterclockwise)

Preceding gene: 83719138

Following gene: 83720554

Centisome position: 72.99

GC content: 73.09

Gene sequence:

>747_bases
ATGAGCGTCGCTTTCGATTTCAATGGCCGGTCGTTCCTCGTGACGGGCGCATCGAGCGGGATCGGCCGCGCCGCGGTCGT
CGCGCTGCGCGGCTGCGGCGCGCGCGTCGTCGCGGCCGCGCGCAACGTGCGCGAGCTCGATCGGCTGGCCGGCGAGACGG
GCTGCGAGCCGCTCGAGCTCGACGTCGGCCGCGATGCGTCGGTGAGCGCGGCGTTTTCCGGCGAGCGGATGCGCGACGCG
TTCGACGGGCTCGTCAACTGCGCGGGCGTGACGAGCCTCGCCGCGGCGATCGACGCGACGGCCGACGAATTCGACCGCGT
GATGGCCGTCAACGCGCGCGGCGCGATGCTGGTCGCGCGGCATGTCGCGCGCGCGATGATCAGCGCGGGGCGGGGCGGCA
GCATCGTCAACGTGTCGAGCCAGGCGGCGCTCGTCGCGCTGCCGTCGCATCTCGCCTATTGCGCGTCGAAGGCGGCGCTC
GACGCGATGACGCGCGTGCTGTGTGTCGAGCTCGGGCCGCACGGGGTTCGCGTGAACAGCGTCAATCCGACCGTCACGCT
CACGCCGATGGCCGAGCGCGCATGGAGCGATCCCGACGCGAGCGGGCCGATGCTCGCGGCGATTCCGCTCGGGCGCTTCG
CGAGCGTCGCGGACGTCGTCGGGCCGATCCTGTTCCTGTTGAGCGACGCGGCCGCGATGGTGAGCGGCGTCGCGCTGCCC
GTCGACGGGGGCTACACCGCGCGATAG

Upstream 100 bases:

>100_bases
GCCCCGACGCGCGGCACGCGGCGTTGCACGACGCGCGCTTCGCGCTGTACGCCGGGCTCTATCCGGCGCTCAAACCCTTC
ATGCACGGATTGCAGACATC

Downstream 100 bases:

>100_bases
CCGCCCGCCGTTCGCGGGCGCCGCGCGCGCGGGCGGGCTTCGCGGCGGGGCGTCATCGGGCCGGCAATCTCGCGAGCCGC
AATCTCGAGCCGGCAGATCG

Product: short chain dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 248; Mature: 247

Protein sequence:

>248_residues
MSVAFDFNGRSFLVTGASSGIGRAAVVALRGCGARVVAAARNVRELDRLAGETGCEPLELDVGRDASVSAAFSGERMRDA
FDGLVNCAGVTSLAAAIDATADEFDRVMAVNARGAMLVARHVARAMISAGRGGSIVNVSSQAALVALPSHLAYCASKAAL
DAMTRVLCVELGPHGVRVNSVNPTVTLTPMAERAWSDPDASGPMLAAIPLGRFASVADVVGPILFLLSDAAAMVSGVALP
VDGGYTAR

Sequences:

>Translated_248_residues
MSVAFDFNGRSFLVTGASSGIGRAAVVALRGCGARVVAAARNVRELDRLAGETGCEPLELDVGRDASVSAAFSGERMRDA
FDGLVNCAGVTSLAAAIDATADEFDRVMAVNARGAMLVARHVARAMISAGRGGSIVNVSSQAALVALPSHLAYCASKAAL
DAMTRVLCVELGPHGVRVNSVNPTVTLTPMAERAWSDPDASGPMLAAIPLGRFASVADVVGPILFLLSDAAAMVSGVALP
VDGGYTAR
>Mature_247_residues
SVAFDFNGRSFLVTGASSGIGRAAVVALRGCGARVVAAARNVRELDRLAGETGCEPLELDVGRDASVSAAFSGERMRDAF
DGLVNCAGVTSLAAAIDATADEFDRVMAVNARGAMLVARHVARAMISAGRGGSIVNVSSQAALVALPSHLAYCASKAALD
AMTRVLCVELGPHGVRVNSVNPTVTLTPMAERAWSDPDASGPMLAAIPLGRFASVADVVGPILFLLSDAAAMVSGVALPV
DGGYTAR

Specific function: Reduces cyclopentanol to cyclopentanone. The enzyme also shows considerable activity toward cyclohexanol [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI7705925, Length=240, Percent_Identity=47.5, Blast_Score=203, Evalue=9e-53,
Organism=Homo sapiens, GI15277342, Length=246, Percent_Identity=34.9593495934959, Blast_Score=112, Evalue=4e-25,
Organism=Homo sapiens, GI32483357, Length=244, Percent_Identity=30.7377049180328, Blast_Score=95, Evalue=5e-20,
Organism=Homo sapiens, GI40254992, Length=234, Percent_Identity=31.6239316239316, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI10190704, Length=247, Percent_Identity=34.0080971659919, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI66933014, Length=245, Percent_Identity=30.2040816326531, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI126723750, Length=247, Percent_Identity=27.9352226720648, Blast_Score=78, Evalue=6e-15,
Organism=Homo sapiens, GI4503817, Length=202, Percent_Identity=30.6930693069307, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI5031737, Length=247, Percent_Identity=29.9595141700405, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI19923817, Length=254, Percent_Identity=26.7716535433071, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI7706318, Length=183, Percent_Identity=32.2404371584699, Blast_Score=72, Evalue=4e-13,
Organism=Escherichia coli, GI1789208, Length=258, Percent_Identity=29.8449612403101, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI87082160, Length=250, Percent_Identity=30.8, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1788459, Length=242, Percent_Identity=32.2314049586777, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI2367175, Length=243, Percent_Identity=33.3333333333333, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1787335, Length=245, Percent_Identity=32.2448979591837, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1786812, Length=250, Percent_Identity=32.4, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI87082100, Length=252, Percent_Identity=33.7301587301587, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1790717, Length=251, Percent_Identity=28.6852589641434, Blast_Score=98, Evalue=5e-22,
Organism=Escherichia coli, GI2367365, Length=247, Percent_Identity=31.5789473684211, Blast_Score=78, Evalue=5e-16,
Organism=Escherichia coli, GI1789057, Length=245, Percent_Identity=28.1632653061224, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI1787905, Length=245, Percent_Identity=30.2040816326531, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1787545, Length=259, Percent_Identity=28.1853281853282, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1787526, Length=248, Percent_Identity=27.4193548387097, Blast_Score=64, Evalue=9e-12,
Organism=Escherichia coli, GI1786701, Length=207, Percent_Identity=29.4685990338164, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1789378, Length=251, Percent_Identity=27.8884462151394, Blast_Score=61, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI115534694, Length=251, Percent_Identity=46.2151394422311, Blast_Score=202, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI71994604, Length=245, Percent_Identity=32.2448979591837, Blast_Score=106, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17555706, Length=242, Percent_Identity=30.5785123966942, Blast_Score=101, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17562906, Length=267, Percent_Identity=32.9588014981273, Blast_Score=97, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI17531453, Length=264, Percent_Identity=34.0909090909091, Blast_Score=94, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI25147288, Length=247, Percent_Identity=30.7692307692308, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI71994600, Length=249, Percent_Identity=29.3172690763052, Blast_Score=91, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17562908, Length=266, Percent_Identity=31.9548872180451, Blast_Score=91, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI193204405, Length=260, Percent_Identity=30.7692307692308, Blast_Score=87, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17536025, Length=251, Percent_Identity=28.6852589641434, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17536651, Length=253, Percent_Identity=28.0632411067194, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17560220, Length=260, Percent_Identity=31.9230769230769, Blast_Score=84, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17561402, Length=253, Percent_Identity=26.8774703557312, Blast_Score=84, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI72000259, Length=264, Percent_Identity=31.4393939393939, Blast_Score=81, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17562990, Length=265, Percent_Identity=31.3207547169811, Blast_Score=80, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17560676, Length=244, Percent_Identity=26.6393442622951, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17561272, Length=233, Percent_Identity=27.0386266094421, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17560150, Length=269, Percent_Identity=31.5985130111524, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17544670, Length=262, Percent_Identity=27.8625954198473, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17563726, Length=199, Percent_Identity=30.6532663316583, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17538480, Length=267, Percent_Identity=29.9625468164794, Blast_Score=77, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17562904, Length=264, Percent_Identity=26.8939393939394, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17559104, Length=265, Percent_Identity=28.3018867924528, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17551412, Length=265, Percent_Identity=27.5471698113208, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17560332, Length=269, Percent_Identity=28.6245353159851, Blast_Score=70, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI71982365, Length=213, Percent_Identity=28.169014084507, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17562910, Length=265, Percent_Identity=27.5471698113208, Blast_Score=68, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6322067, Length=173, Percent_Identity=34.1040462427746, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6324126, Length=257, Percent_Identity=26.8482490272374, Blast_Score=69, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24643142, Length=243, Percent_Identity=41.5637860082305, Blast_Score=168, Evalue=4e-42,
Organism=Drosophila melanogaster, GI21357041, Length=252, Percent_Identity=36.9047619047619, Blast_Score=135, Evalue=2e-32,
Organism=Drosophila melanogaster, GI28571526, Length=253, Percent_Identity=37.9446640316205, Blast_Score=134, Evalue=5e-32,
Organism=Drosophila melanogaster, GI24644339, Length=252, Percent_Identity=34.9206349206349, Blast_Score=125, Evalue=3e-29,
Organism=Drosophila melanogaster, GI23397609, Length=246, Percent_Identity=35.7723577235772, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24639444, Length=243, Percent_Identity=35.3909465020576, Blast_Score=111, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24644337, Length=174, Percent_Identity=38.5057471264368, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI21355319, Length=252, Percent_Identity=29.7619047619048, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21356301, Length=203, Percent_Identity=32.0197044334975, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17737361, Length=194, Percent_Identity=32.9896907216495, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21358495, Length=197, Percent_Identity=29.9492385786802, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.163 [H]

Molecular weight: Translated: 25229; Mature: 25098

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVAFDFNGRSFLVTGASSGIGRAAVVALRGCGARVVAAARNVRELDRLAGETGCEPLEL
CEEEEECCCCEEEEECCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCEEE
DVGRDASVSAAFSGERMRDAFDGLVNCAGVTSLAAAIDATADEFDRVMAVNARGAMLVAR
ECCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHEEEECCCCHHHHHH
HVARAMISAGRGGSIVNVSSQAALVALPSHLAYCASKAALDAMTRVLCVELGPHGVRVNS
HHHHHHHHCCCCCCEEEECCCEEEEEHHHHHHHHHHHHHHHHHHHHHHEEECCCCEEEEC
VNPTVTLTPMAERAWSDPDASGPMLAAIPLGRFASVADVVGPILFLLSDAAAMVSGVALP
CCCEEEECCCHHHCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEE
VDGGYTAR
CCCCCCCC
>Mature Secondary Structure 
SVAFDFNGRSFLVTGASSGIGRAAVVALRGCGARVVAAARNVRELDRLAGETGCEPLEL
EEEEECCCCEEEEECCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCEEE
DVGRDASVSAAFSGERMRDAFDGLVNCAGVTSLAAAIDATADEFDRVMAVNARGAMLVAR
ECCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHEEEECCCCHHHHHH
HVARAMISAGRGGSIVNVSSQAALVALPSHLAYCASKAALDAMTRVLCVELGPHGVRVNS
HHHHHHHHCCCCCCEEEECCCEEEEEHHHHHHHHHHHHHHHHHHHHHHEEECCCCEEEEC
VNPTVTLTPMAERAWSDPDASGPMLAAIPLGRFASVADVVGPILFLLSDAAAMVSGVALP
CCCEEEECCCHHHCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEE
VDGGYTAR
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12406764 [H]