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The map label for this gene is ispD [H]

Identifier: 83719809

GI number: 83719809

Start: 2367630

End: 2368340

Strand: Direct

Name: ispD [H]

Synonym: BTH_I2089

Alternate gene names: 83719809

Gene position: 2367630-2368340 (Clockwise)

Preceding gene: 83721234

Following gene: 83718714

Centisome position: 62.16

GC content: 70.89

Gene sequence:

>711_bases
GTGACCTCCCGACTCTTCGCCCTGATTCCGTGCGCCGGCACCGGCAGCCGCTCCGGCTCGGCATTGCCGAAGCAATACCG
CACGCTCGCCGGCCGCGCGCTCCTGCATTACACGCTCGCCGCGTTCGACGCGTGCAGCGAGTTCGCGCAAACGCTCGTCG
TGATTTCCCCCGACGACGCCCACTTCGACGCCCGCCGCTTTGCCGGTCTGCGCTTCGCGGTGCGGCGCTGCGGCGGCGCG
TCCCGACAGGCGTCGGTGATGAACGGGCTGATCCAGCTCGCCGAATTCGGCGCGACGGACGCCGACTGGGTGCTCGTGCA
CGACGCCGCGCGCCCCGGCATCACGCCGGCGCTGATCCGCACGCTGATCGGCGCGCTGAAGGACGACCCCGTCGGCGGCA
TCGTCGCGCTGCCGGTCGCCGATACGCTCAAGCGCGTGCCGGCGGGCGGCGACGCGATCGAGCGCACCGAATCGCGCAAC
GGCCTCTGGCAGGCGCAGACGCCGCAGATGTTCCGCATCGGCATGCTGCGCGACGCGATCCAGCGCGCGCAGCTCGAAGG
TCGCGATCTGACCGACGAAGCGAGCGCGATCGAATGGGCGGGCCATACGCCGCGCGTCGTGCAGGGCAGTCTGCGCAACT
TCAAGGTCACGTACCCGGAGGATTTCGACCTCGCGGAGGCGATTCTCGCGCATCCGGCGCGCGCCAGTTGA

Upstream 100 bases:

>100_bases
GCGAGCGCCGGATGGCGGACGAGCGTGGCGCGGCTCATCACGGCGAAAGACGTATTATAAAATCCGTCTTTCGATTTCAT
CTTCCCGGCGTTTCCTTTCC

Downstream 100 bases:

>100_bases
ACCGCATCTTCACCATCGCATCACACTCGGATCGAATCACATGGATTTCAGAATCGGACAAGGCTACGACGTGCACCAGC
TCGTTCCCGGACGGCCGCTC

Product: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase

Products: NA

Alternate protein names: 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT [H]

Number of amino acids: Translated: 236; Mature: 235

Protein sequence:

>236_residues
MTSRLFALIPCAGTGSRSGSALPKQYRTLAGRALLHYTLAAFDACSEFAQTLVVISPDDAHFDARRFAGLRFAVRRCGGA
SRQASVMNGLIQLAEFGATDADWVLVHDAARPGITPALIRTLIGALKDDPVGGIVALPVADTLKRVPAGGDAIERTESRN
GLWQAQTPQMFRIGMLRDAIQRAQLEGRDLTDEASAIEWAGHTPRVVQGSLRNFKVTYPEDFDLAEAILAHPARAS

Sequences:

>Translated_236_residues
MTSRLFALIPCAGTGSRSGSALPKQYRTLAGRALLHYTLAAFDACSEFAQTLVVISPDDAHFDARRFAGLRFAVRRCGGA
SRQASVMNGLIQLAEFGATDADWVLVHDAARPGITPALIRTLIGALKDDPVGGIVALPVADTLKRVPAGGDAIERTESRN
GLWQAQTPQMFRIGMLRDAIQRAQLEGRDLTDEASAIEWAGHTPRVVQGSLRNFKVTYPEDFDLAEAILAHPARAS
>Mature_235_residues
TSRLFALIPCAGTGSRSGSALPKQYRTLAGRALLHYTLAAFDACSEFAQTLVVISPDDAHFDARRFAGLRFAVRRCGGAS
RQASVMNGLIQLAEFGATDADWVLVHDAARPGITPALIRTLIGALKDDPVGGIVALPVADTLKRVPAGGDAIERTESRNG
LWQAQTPQMFRIGMLRDAIQRAQLEGRDLTDEASAIEWAGHTPRVVQGSLRNFKVTYPEDFDLAEAILAHPARAS

Specific function: Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) [H]

COG id: COG1211

COG function: function code I; 4-diphosphocytidyl-2-methyl-D-erithritol synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ispD family [H]

Homologues:

Organism=Homo sapiens, GI157412259, Length=232, Percent_Identity=24.5689655172414, Blast_Score=74, Evalue=1e-13,
Organism=Escherichia coli, GI1789104, Length=223, Percent_Identity=41.2556053811659, Blast_Score=155, Evalue=3e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001228
- InterPro:   IPR018294 [H]

Pfam domain/function: PF01128 IspD [H]

EC number: =2.7.7.60 [H]

Molecular weight: Translated: 25393; Mature: 25262

Theoretical pI: Translated: 8.10; Mature: 8.10

Prosite motif: PS01295 ISPD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSRLFALIPCAGTGSRSGSALPKQYRTLAGRALLHYTLAAFDACSEFAQTLVVISPDDA
CCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCC
HFDARRFAGLRFAVRRCGGASRQASVMNGLIQLAEFGATDADWVLVHDAARPGITPALIR
CHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHH
TLIGALKDDPVGGIVALPVADTLKRVPAGGDAIERTESRNGLWQAQTPQMFRIGMLRDAI
HHHHHHCCCCCCCEEEECHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
QRAQLEGRDLTDEASAIEWAGHTPRVVQGSLRNFKVTYPEDFDLAEAILAHPARAS
HHHHCCCCCCCCHHHHHHCCCCCCHHHHCCCCCEEEECCCCCHHHHHHHCCCCCCC
>Mature Secondary Structure 
TSRLFALIPCAGTGSRSGSALPKQYRTLAGRALLHYTLAAFDACSEFAQTLVVISPDDA
CCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCC
HFDARRFAGLRFAVRRCGGASRQASVMNGLIQLAEFGATDADWVLVHDAARPGITPALIR
CHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHH
TLIGALKDDPVGGIVALPVADTLKRVPAGGDAIERTESRNGLWQAQTPQMFRIGMLRDAI
HHHHHHCCCCCCCEEEECHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
QRAQLEGRDLTDEASAIEWAGHTPRVVQGSLRNFKVTYPEDFDLAEAILAHPARAS
HHHHCCCCCCCCHHHHHHCCCCCCHHHHCCCCCEEEECCCCCHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA