Click here to switch to the map view.

The map label for this gene is lon [H]

Identifier: 83719717

GI number: 83719717

Start: 2395065

End: 2397485

Strand: Direct

Name: lon [H]

Synonym: BTH_I2122

Alternate gene names: 83719717

Gene position: 2395065-2397485 (Clockwise)

Preceding gene: 83721081

Following gene: 83721437

Centisome position: 62.88

GC content: 63.86

Gene sequence:

>2421_bases
ATGTCAGGCACCCAACTTCTCCCGTCGGAACGCACTACGCTCCCGCTGCTGCCGCTGCGGGATGTCGTCGTTTTCCCGCA
CATGGTGATTCCGCTCTTCGTGGGCCGGCCGAAGTCGATCAAGGCCCTCGAAGTGGCGATGGAAGGCGGCAAGCACATCA
TGCTCGTCGCGCAGAAGACCGCCGCGAAGGATGAGCCGACCGAAAAGGACATGTACGACGTCGGCTGCATCGCGAACATC
CTGCAGATGCTGAAGCTGCCCGACGGCACCGTGAAGGTGCTCGTCGAGGGCTTGCAGCGCGCGCAGGCGCTGTCGATCGA
GGAGCAGGAGACGCAGTTCTCGTGCGAGGTGATGCCGCTCGAACCGGACCACGCCGACAGCGCCGAAACCGAGGCGCTGC
GCCGCGCGATCGTGTCGCAGTTCGATCAGTACGTGAAACTGAACAAGAAGATTCCGCCCGAGATCCTGACGTCGCTGTCG
GGTATCGACGAGGCGGGCCGCCTTGCCGACACGATCGCCGCGCATCTGCCGCTGAAGCTCGATCAGAAGCAGCACATCCT
CGAGATGTTCCCGGTCATCGAGCGTCTCGAGCACCTGCTCGCGCAGCTCGAGGCCGAGATCGACATTCTGCAGGTCGAAA
AGCGCATCCGCGGGCGCGTGAAGCGCCAGATGGAAAAGAGCCAGCGCGAGTACTACCTGAACGAGCAGGTCAAGGCGATC
CAGAAGGAACTGGGCGAGGGCGAGGAAGGCGCGGATCTCGAGGAGCTCGAGAAGCGCATCAACGCCGCGCGCATGCCGAA
GGAAGCGAAGAAGAAGGCCGATGCCGAGCTCAAGAAGCTGAAGCTGATGTCGCCGATGTCGGCCGAGGCGACCGTCGTAC
GCAACTACATCGACACGCTGATCGCGCTGCCGTGGCGCAAGAAGAGCAAGGTCAACAATGATCTGTCGAACGCCGAGAAG
GTGCTCGACGAGGATCACTACGGCCTTGAGAAGGTCAAGGAACGGATCCTCGAGTATCTTGCGGTGCAGCAACGCGTCGA
CAAGGTGAAGGCGCCGATCCTCTGCCTCGTCGGGCCTCCGGGCGTCGGCAAGACCTCGCTCGGCCAGTCGATCGCGCGCG
CGACGAACCGCAAGTTCGTCCGGATGGCGCTGGGCGGCGTGCGTGACGAGGCCGAGATCCGCGGTCACCGCCGAACCTAC
ATCGGTTCGATGCCGGGCAAGATCCTGCAGAGCCTGTCGAAGGTCGGTGTGCGCAATCCGCTCTTCCTGCTCGACGAAGT
CGACAAGATGGGGATGGATTTCCGCGGCGATCCGTCGTCGGCGCTGCTCGAAGTGCTCGATCCGGAGCAGAACCACACGT
TCGCCGACCACTACGTCGAGGTCGATTTCGACCTGTCGGACGTGATGTTCGTCGCGACGTCGAACTCGCTGAACATTCCG
CCGCCGCTGCTCGACCGGATGGAAGTGATCCGCCTGTCGGGTTATACCGAGGACGAGAAGGTCAGTATCGCGCAGCGCTA
CCTGCTGCCGAAGCAGAAGAAGAACAACGGCCTGAAGGAAGGCGAGATCGAGGTTGCCGAGCAGGCGATCCGCGACATCA
TCCGCTACTACACGCGCGAAGCCGGTGTGCGTTCGCTCGAGCGCGAGGTGTCGAAGATCTGCCGCAAGGTCGTGAAGATG
CTGCTGCTGAAGAAGGCATCGGGCGCGATCAAGGTCGACGGCGAGAACCTCGACACGTTCCTCGGCGTGCGCAAGTACGA
CTTCGGTCTTGCCGCGAAGGAGAACCAGGTCGGTCAGGTCACGGGTCTCGCATGGACCGAAGTGGGCGGCGATCTGCTGA
CGATCGAGGCGGCCGTGATGCCCGGCAAGGGCAACGTGATCCGCACGGGCTCGCTTGGCGACGTGATGAAGGAATCGGTC
GAGGCCGCGCGCTCGGTCGTGCGCTCGCGCTCGCGCCGGCTCGGCATCAAGGATGAGGCGTTCGAGAAGCAGGACATCCA
CATCCACGTGCCGGAAGGCGCGACGCCGAAGGACGGTCCGTCCGCCGGCATCGCGATGACGACGGCGCTCGTGTCGGTGC
TCACGGGCATTCCGGTGCGCGCCGACGTCGCGATGACGGGCGAGATCACGCTGCGCGGCGAAGTGCTGCCGATCGGCGGG
CTGAAGGAGAAGCTGCTCGCCGCGCACCGCGGCGGCATCAAGCTCGTGCTGATTCCGGAAGAGAACGTGAAGGATCTCGC
TGACATTCCGGACAACGTGAAGAACGCGATCGAAATCGTGCCGGTCCGCTGGATCGACAAGGTGCTCGAACTCGCGCTCG
AACGTCTGCCGAATGCGCTGCCCGAGGAAGAGGCGAAGGCGGCGGCGCCTGTCGCGGAACCCGCGAAGGATGCCGGCTCG
ACGGAAGTCGTCAAGCACTGA

Upstream 100 bases:

>100_bases
GGTAACTTTTTTACTGAATATTTCCCACGCGCTGAAGGCTTGCAATCCGCTGTGCCGGCCTTACTTACCGAACAATTGAT
TCCACTCATGGGGAAATGAA

Downstream 100 bases:

>100_bases
GCGCACGCGCAAGCGCTTGCGTGTCCTCGCGAACAAGCCCACGGCCGAGAGGCCGTGGGCTTTGTTTTTGCACGGGGCGA
CGGGTTGGCGGCGGTGTTGT

Product: ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 806; Mature: 805

Protein sequence:

>806_residues
MSGTQLLPSERTTLPLLPLRDVVVFPHMVIPLFVGRPKSIKALEVAMEGGKHIMLVAQKTAAKDEPTEKDMYDVGCIANI
LQMLKLPDGTVKVLVEGLQRAQALSIEEQETQFSCEVMPLEPDHADSAETEALRRAIVSQFDQYVKLNKKIPPEILTSLS
GIDEAGRLADTIAAHLPLKLDQKQHILEMFPVIERLEHLLAQLEAEIDILQVEKRIRGRVKRQMEKSQREYYLNEQVKAI
QKELGEGEEGADLEELEKRINAARMPKEAKKKADAELKKLKLMSPMSAEATVVRNYIDTLIALPWRKKSKVNNDLSNAEK
VLDEDHYGLEKVKERILEYLAVQQRVDKVKAPILCLVGPPGVGKTSLGQSIARATNRKFVRMALGGVRDEAEIRGHRRTY
IGSMPGKILQSLSKVGVRNPLFLLDEVDKMGMDFRGDPSSALLEVLDPEQNHTFADHYVEVDFDLSDVMFVATSNSLNIP
PPLLDRMEVIRLSGYTEDEKVSIAQRYLLPKQKKNNGLKEGEIEVAEQAIRDIIRYYTREAGVRSLEREVSKICRKVVKM
LLLKKASGAIKVDGENLDTFLGVRKYDFGLAAKENQVGQVTGLAWTEVGGDLLTIEAAVMPGKGNVIRTGSLGDVMKESV
EAARSVVRSRSRRLGIKDEAFEKQDIHIHVPEGATPKDGPSAGIAMTTALVSVLTGIPVRADVAMTGEITLRGEVLPIGG
LKEKLLAAHRGGIKLVLIPEENVKDLADIPDNVKNAIEIVPVRWIDKVLELALERLPNALPEEEAKAAAPVAEPAKDAGS
TEVVKH

Sequences:

>Translated_806_residues
MSGTQLLPSERTTLPLLPLRDVVVFPHMVIPLFVGRPKSIKALEVAMEGGKHIMLVAQKTAAKDEPTEKDMYDVGCIANI
LQMLKLPDGTVKVLVEGLQRAQALSIEEQETQFSCEVMPLEPDHADSAETEALRRAIVSQFDQYVKLNKKIPPEILTSLS
GIDEAGRLADTIAAHLPLKLDQKQHILEMFPVIERLEHLLAQLEAEIDILQVEKRIRGRVKRQMEKSQREYYLNEQVKAI
QKELGEGEEGADLEELEKRINAARMPKEAKKKADAELKKLKLMSPMSAEATVVRNYIDTLIALPWRKKSKVNNDLSNAEK
VLDEDHYGLEKVKERILEYLAVQQRVDKVKAPILCLVGPPGVGKTSLGQSIARATNRKFVRMALGGVRDEAEIRGHRRTY
IGSMPGKILQSLSKVGVRNPLFLLDEVDKMGMDFRGDPSSALLEVLDPEQNHTFADHYVEVDFDLSDVMFVATSNSLNIP
PPLLDRMEVIRLSGYTEDEKVSIAQRYLLPKQKKNNGLKEGEIEVAEQAIRDIIRYYTREAGVRSLEREVSKICRKVVKM
LLLKKASGAIKVDGENLDTFLGVRKYDFGLAAKENQVGQVTGLAWTEVGGDLLTIEAAVMPGKGNVIRTGSLGDVMKESV
EAARSVVRSRSRRLGIKDEAFEKQDIHIHVPEGATPKDGPSAGIAMTTALVSVLTGIPVRADVAMTGEITLRGEVLPIGG
LKEKLLAAHRGGIKLVLIPEENVKDLADIPDNVKNAIEIVPVRWIDKVLELALERLPNALPEEEAKAAAPVAEPAKDAGS
TEVVKH
>Mature_805_residues
SGTQLLPSERTTLPLLPLRDVVVFPHMVIPLFVGRPKSIKALEVAMEGGKHIMLVAQKTAAKDEPTEKDMYDVGCIANIL
QMLKLPDGTVKVLVEGLQRAQALSIEEQETQFSCEVMPLEPDHADSAETEALRRAIVSQFDQYVKLNKKIPPEILTSLSG
IDEAGRLADTIAAHLPLKLDQKQHILEMFPVIERLEHLLAQLEAEIDILQVEKRIRGRVKRQMEKSQREYYLNEQVKAIQ
KELGEGEEGADLEELEKRINAARMPKEAKKKADAELKKLKLMSPMSAEATVVRNYIDTLIALPWRKKSKVNNDLSNAEKV
LDEDHYGLEKVKERILEYLAVQQRVDKVKAPILCLVGPPGVGKTSLGQSIARATNRKFVRMALGGVRDEAEIRGHRRTYI
GSMPGKILQSLSKVGVRNPLFLLDEVDKMGMDFRGDPSSALLEVLDPEQNHTFADHYVEVDFDLSDVMFVATSNSLNIPP
PLLDRMEVIRLSGYTEDEKVSIAQRYLLPKQKKNNGLKEGEIEVAEQAIRDIIRYYTREAGVRSLEREVSKICRKVVKML
LLKKASGAIKVDGENLDTFLGVRKYDFGLAAKENQVGQVTGLAWTEVGGDLLTIEAAVMPGKGNVIRTGSLGDVMKESVE
AARSVVRSRSRRLGIKDEAFEKQDIHIHVPEGATPKDGPSAGIAMTTALVSVLTGIPVRADVAMTGEITLRGEVLPIGGL
KEKLLAAHRGGIKLVLIPEENVKDLADIPDNVKNAIEIVPVRWIDKVLELALERLPNALPEEEAKAAAPVAEPAKDAGST
EVVKH

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=568, Percent_Identity=46.6549295774648, Blast_Score=521, Evalue=1e-148,
Organism=Homo sapiens, GI21396489, Length=683, Percent_Identity=40.8491947291362, Blast_Score=508, Evalue=1e-144,
Organism=Escherichia coli, GI1786643, Length=773, Percent_Identity=69.987063389392, Blast_Score=1088, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=692, Percent_Identity=39.8843930635838, Blast_Score=481, Evalue=1e-136,
Organism=Caenorhabditis elegans, GI17556486, Length=540, Percent_Identity=41.2962962962963, Blast_Score=436, Evalue=1e-122,
Organism=Saccharomyces cerevisiae, GI6319449, Length=720, Percent_Identity=40.5555555555556, Blast_Score=516, Evalue=1e-147,
Organism=Drosophila melanogaster, GI24666867, Length=689, Percent_Identity=41.6545718432511, Blast_Score=513, Evalue=1e-145,
Organism=Drosophila melanogaster, GI221513036, Length=689, Percent_Identity=41.6545718432511, Blast_Score=513, Evalue=1e-145,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 89179; Mature: 89047

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGTQLLPSERTTLPLLPLRDVVVFPHMVIPLFVGRPKSIKALEVAMEGGKHIMLVAQKT
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCEEEEEEECC
AAKDEPTEKDMYDVGCIANILQMLKLPDGTVKVLVEGLQRAQALSIEEQETQFSCEVMPL
CCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHCCCEEEEEEEC
EPDHADSAETEALRRAIVSQFDQYVKLNKKIPPEILTSLSGIDEAGRLADTIAAHLPLKL
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCC
DQKQHILEMFPVIERLEHLLAQLEAEIDILQVEKRIRGRVKRQMEKSQREYYLNEQVKAI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QKELGEGEEGADLEELEKRINAARMPKEAKKKADAELKKLKLMSPMSAEATVVRNYIDTL
HHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
IALPWRKKSKVNNDLSNAEKVLDEDHYGLEKVKERILEYLAVQQRVDKVKAPILCLVGPP
HHCCCCHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCC
GVGKTSLGQSIARATNRKFVRMALGGVRDEAEIRGHRRTYIGSMPGKILQSLSKVGVRNP
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHCCCCHHHHHHHHHHCCCCCC
LFLLDEVDKMGMDFRGDPSSALLEVLDPEQNHTFADHYVEVDFDLSDVMFVATSNSLNIP
HHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCEEECCEEEEEECCCCEEEEEECCCCCCC
PPLLDRMEVIRLSGYTEDEKVSIAQRYLLPKQKKNNGLKEGEIEVAEQAIRDIIRYYTRE
CHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHH
AGVRSLEREVSKICRKVVKMLLLKKASGAIKVDGENLDTFLGVRKYDFGLAAKENQVGQV
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHCCHHHCCCCCCCCCCCCCE
TGLAWTEVGGDLLTIEAAVMPGKGNVIRTGSLGDVMKESVEAARSVVRSRSRRLGIKDEA
ECEEHHHCCCCEEEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCHHC
FEKQDIHIHVPEGATPKDGPSAGIAMTTALVSVLTGIPVRADVAMTGEITLRGEVLPIGG
CCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEECEEEECEEEEECEEEECCC
LKEKLLAAHRGGIKLVLIPEENVKDLADIPDNVKNAIEIVPVRWIDKVLELALERLPNAL
HHHHHHHHHCCCEEEEEECCCCHHHHHCCCHHHHHHHEEECHHHHHHHHHHHHHHCCCCC
PEEEAKAAAPVAEPAKDAGSTEVVKH
CCHHHHHCCCCCCCHHCCCCCHHCCC
>Mature Secondary Structure 
SGTQLLPSERTTLPLLPLRDVVVFPHMVIPLFVGRPKSIKALEVAMEGGKHIMLVAQKT
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCEEEEEEECC
AAKDEPTEKDMYDVGCIANILQMLKLPDGTVKVLVEGLQRAQALSIEEQETQFSCEVMPL
CCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHCCCEEEEEEEC
EPDHADSAETEALRRAIVSQFDQYVKLNKKIPPEILTSLSGIDEAGRLADTIAAHLPLKL
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCC
DQKQHILEMFPVIERLEHLLAQLEAEIDILQVEKRIRGRVKRQMEKSQREYYLNEQVKAI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QKELGEGEEGADLEELEKRINAARMPKEAKKKADAELKKLKLMSPMSAEATVVRNYIDTL
HHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
IALPWRKKSKVNNDLSNAEKVLDEDHYGLEKVKERILEYLAVQQRVDKVKAPILCLVGPP
HHCCCCHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCC
GVGKTSLGQSIARATNRKFVRMALGGVRDEAEIRGHRRTYIGSMPGKILQSLSKVGVRNP
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHCCCCHHHHHHHHHHCCCCCC
LFLLDEVDKMGMDFRGDPSSALLEVLDPEQNHTFADHYVEVDFDLSDVMFVATSNSLNIP
HHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCEEECCEEEEEECCCCEEEEEECCCCCCC
PPLLDRMEVIRLSGYTEDEKVSIAQRYLLPKQKKNNGLKEGEIEVAEQAIRDIIRYYTRE
CHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHH
AGVRSLEREVSKICRKVVKMLLLKKASGAIKVDGENLDTFLGVRKYDFGLAAKENQVGQV
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHCCHHHCCCCCCCCCCCCCE
TGLAWTEVGGDLLTIEAAVMPGKGNVIRTGSLGDVMKESVEAARSVVRSRSRRLGIKDEA
ECEEHHHCCCCEEEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCHHC
FEKQDIHIHVPEGATPKDGPSAGIAMTTALVSVLTGIPVRADVAMTGEITLRGEVLPIGG
CCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEECEEEECEEEEECEEEECCC
LKEKLLAAHRGGIKLVLIPEENVKDLADIPDNVKNAIEIVPVRWIDKVLELALERLPNAL
HHHHHHHHHCCCEEEEEECCCCHHHHHCCCHHHHHHHEEECHHHHHHHHHHHHHHCCCCC
PEEEAKAAAPVAEPAKDAGSTEVVKH
CCHHHHHCCCCCCCHHCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8981986; 12620739 [H]