Click here to switch to the map view.

The map label for this gene is lpxB [H]

Identifier: 83719655

GI number: 83719655

Start: 2311827

End: 2312993

Strand: Direct

Name: lpxB [H]

Synonym: BTH_I2040

Alternate gene names: 83719655

Gene position: 2311827-2312993 (Clockwise)

Preceding gene: 83720787

Following gene: 83721502

Centisome position: 60.69

GC content: 68.81

Gene sequence:

>1167_bases
ATGGCGTTCCAACCCACACCGCTGCGCGTCGCGCTCGTCGCGGGCGAACCGTCGGGCGACCTGCTCGGCGCGTCGCTCCT
CGGCGGGCTGCACGCGCAGTTGCCCGCATCGTCCCGCTATTACGGGATCGGCGGGCCGCGCATGACCGCCGTGGATTTCG
ACGCGCACTGGCCGATGGAAAAGCTCGCGGTGCGCGGCTACGTCGAGGCGCTCAAGCACATTCCCGAGATCCTGCGCATT
CGCGGCGAACTCAAGCGCCAGTTGCTCGCTGAACCGCCCGACGCGTTCATCGGCATCGACGCGCCCGATTTCAACTTCGG
CCTCGAGCAGGCGCTGCGCGGCGCCGGCATTCCGACGGTCCATTTCGTCTGCCCGTCGATCTGGGCATGGCGCGGCGGCC
GGATCAAGAAGATCGTCAAGGCCGTCGACCACATGCTGTGCCTGTTCCCGTTCGAGCCCGAACTGCTCGAGAAGGCCGGC
GTCGCGGCGACGTTCGTCGGCCATCCGCTCGCCGACGAGATTCCGCTCGAACCCGACATGCACGGCGCGCGAATCGCGCT
CGGCCTGCCGGATAGCGGCCCCGTGATCGCGGTGCTGCCGGGCAGCCGCCGCTCGGAGATCGAGCTGATCGGCCCGACGT
TCTTCGACGCGATGGCGTTGATGCAGCAGCGCGAGCCCGGCGTGCGCTTCGTCGTGCCGGCCGCGACGCCCGCGCTGCGC
GAGTTGCTGCAGCCGCTCGTCGACGCGCACCCGTTGCTGTCGGTCACGCTGACCGAAGGCCGCGCGCAGGTCGCGATGAC
GGCGGCCGATGCGATCCTCGTGAAGAGCGGCACCGTGACGCTCGAAGCGGCGCTGCTCAAGAAACCGATGGTGATCTCGT
ACAAGGTGCCGTGGCTCACGGGGCAGATCATGCGCCGGCAGGGCTATCTGCCGTACGTCGGATTGCCGAACATCCTCGCG
GGCCGTTTCGTCGTGCCTGAGCTGCTGCAGCATTTCGCGACGCCCGAGGCGCTCGCCGACGCGACGCTCACGCAACTGCG
CGACGATGCGAACCGCCGCACGCTCACTGGTATTTTCACCGACATGCATCTCGCGTTGCGCCAGAACACCGCGCAGCGCG
CGGCCGAGGCCGTCGCGCGCGTGATCGACAGCAGGAAGCCGCACTGA

Upstream 100 bases:

>100_bases
GCTGAGCGAGCTCGCGCAGGCGGGCGGCGACGGCGACGCGGCCGTGAAGGCGCTCGTCGACTTCGTCGAGTCGTCGCAGC
GCGGCATCATTCGCTGAACG

Downstream 100 bases:

>100_bases
TGGCGACGGCTCGCAAACCCCGCGGCGGCGCCGGTGGCGCGGCCCAGCCCGCGCTCGATTTCGACGCGCCGGGCGAGATC
GTCTGCGGCGTCGACGAAGC

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 388; Mature: 387

Protein sequence:

>388_residues
MAFQPTPLRVALVAGEPSGDLLGASLLGGLHAQLPASSRYYGIGGPRMTAVDFDAHWPMEKLAVRGYVEALKHIPEILRI
RGELKRQLLAEPPDAFIGIDAPDFNFGLEQALRGAGIPTVHFVCPSIWAWRGGRIKKIVKAVDHMLCLFPFEPELLEKAG
VAATFVGHPLADEIPLEPDMHGARIALGLPDSGPVIAVLPGSRRSEIELIGPTFFDAMALMQQREPGVRFVVPAATPALR
ELLQPLVDAHPLLSVTLTEGRAQVAMTAADAILVKSGTVTLEAALLKKPMVISYKVPWLTGQIMRRQGYLPYVGLPNILA
GRFVVPELLQHFATPEALADATLTQLRDDANRRTLTGIFTDMHLALRQNTAQRAAEAVARVIDSRKPH

Sequences:

>Translated_388_residues
MAFQPTPLRVALVAGEPSGDLLGASLLGGLHAQLPASSRYYGIGGPRMTAVDFDAHWPMEKLAVRGYVEALKHIPEILRI
RGELKRQLLAEPPDAFIGIDAPDFNFGLEQALRGAGIPTVHFVCPSIWAWRGGRIKKIVKAVDHMLCLFPFEPELLEKAG
VAATFVGHPLADEIPLEPDMHGARIALGLPDSGPVIAVLPGSRRSEIELIGPTFFDAMALMQQREPGVRFVVPAATPALR
ELLQPLVDAHPLLSVTLTEGRAQVAMTAADAILVKSGTVTLEAALLKKPMVISYKVPWLTGQIMRRQGYLPYVGLPNILA
GRFVVPELLQHFATPEALADATLTQLRDDANRRTLTGIFTDMHLALRQNTAQRAAEAVARVIDSRKPH
>Mature_387_residues
AFQPTPLRVALVAGEPSGDLLGASLLGGLHAQLPASSRYYGIGGPRMTAVDFDAHWPMEKLAVRGYVEALKHIPEILRIR
GELKRQLLAEPPDAFIGIDAPDFNFGLEQALRGAGIPTVHFVCPSIWAWRGGRIKKIVKAVDHMLCLFPFEPELLEKAGV
AATFVGHPLADEIPLEPDMHGARIALGLPDSGPVIAVLPGSRRSEIELIGPTFFDAMALMQQREPGVRFVVPAATPALRE
LLQPLVDAHPLLSVTLTEGRAQVAMTAADAILVKSGTVTLEAALLKKPMVISYKVPWLTGQIMRRQGYLPYVGLPNILAG
RFVVPELLQHFATPEALADATLTQLRDDANRRTLTGIFTDMHLALRQNTAQRAAEAVARVIDSRKPH

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family [H]

Homologues:

Organism=Escherichia coli, GI1786379, Length=373, Percent_Identity=42.3592493297587, Blast_Score=287, Evalue=1e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003835 [H]

Pfam domain/function: PF02684 LpxB [H]

EC number: =2.4.1.182 [H]

Molecular weight: Translated: 42129; Mature: 41998

Theoretical pI: Translated: 7.81; Mature: 7.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFQPTPLRVALVAGEPSGDLLGASLLGGLHAQLPASSRYYGIGGPRMTAVDFDAHWPME
CCCCCCCEEEEEEECCCCCCHHHHHHHCCHHHCCCCCCCEEECCCCEEEEEECCCCCCHH
KLAVRGYVEALKHIPEILRIRGELKRQLLAEPPDAFIGIDAPDFNFGLEQALRGAGIPTV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCHHHHHHCCCCCEE
HFVCPSIWAWRGGRIKKIVKAVDHMLCLFPFEPELLEKAGVAATFVGHPLADEIPLEPDM
EHHCCHHHHCCCCHHHHHHHHHHHHEEECCCCHHHHHHCCCEEEECCCCCCCCCCCCCCC
HGARIALGLPDSGPVIAVLPGSRRSEIELIGPTFFDAMALMQQREPGVRFVVPAATPALR
CCCEEEEECCCCCCEEEEECCCCCCCEEEECHHHHHHHHHHHHCCCCCEEEECCCCHHHH
ELLQPLVDAHPLLSVTLTEGRAQVAMTAADAILVKSGTVTLEAALLKKPMVISYKVPWLT
HHHHHHHCCCCEEEEEEECCCEEEEEEECCEEEEECCCEEEEHHHHCCCEEEEEECCHHH
GQIMRRQGYLPYVGLPNILAGRFVVPELLQHFATPEALADATLTQLRDDANRRTLTGIFT
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEHHHH
DMHLALRQNTAQRAAEAVARVIDSRKPH
HHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
AFQPTPLRVALVAGEPSGDLLGASLLGGLHAQLPASSRYYGIGGPRMTAVDFDAHWPME
CCCCCCEEEEEEECCCCCCHHHHHHHCCHHHCCCCCCCEEECCCCEEEEEECCCCCCHH
KLAVRGYVEALKHIPEILRIRGELKRQLLAEPPDAFIGIDAPDFNFGLEQALRGAGIPTV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCHHHHHHCCCCCEE
HFVCPSIWAWRGGRIKKIVKAVDHMLCLFPFEPELLEKAGVAATFVGHPLADEIPLEPDM
EHHCCHHHHCCCCHHHHHHHHHHHHEEECCCCHHHHHHCCCEEEECCCCCCCCCCCCCCC
HGARIALGLPDSGPVIAVLPGSRRSEIELIGPTFFDAMALMQQREPGVRFVVPAATPALR
CCCEEEEECCCCCCEEEEECCCCCCCEEEECHHHHHHHHHHHHCCCCCEEEECCCCHHHH
ELLQPLVDAHPLLSVTLTEGRAQVAMTAADAILVKSGTVTLEAALLKKPMVISYKVPWLT
HHHHHHHCCCCEEEEEEECCCEEEEEEECCEEEEECCCEEEEHHHHCCCEEEEEECCHHH
GQIMRRQGYLPYVGLPNILAGRFVVPELLQHFATPEALADATLTQLRDDANRRTLTGIFT
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEHHHH
DMHLALRQNTAQRAAEAVARVIDSRKPH
HHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA