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The map label for this gene is guaA [H]

Identifier: 83719399

GI number: 83719399

Start: 2331652

End: 2333451

Strand: Direct

Name: guaA [H]

Synonym: BTH_I2058

Alternate gene names: 83719399

Gene position: 2331652-2333451 (Clockwise)

Preceding gene: 83719758

Following gene: 83720892

Centisome position: 61.21

GC content: 65.56

Gene sequence:

>1800_bases
ATGCTGCGACGAGCAAGTTCGGCGACGCGGCGCGGCCGCCGTCGCAACCGTGATCGGCACGGCTCTCCCGACTGTCAGGC
CGCCGCGTGTCGCGGCGGCGCGATCGCCCGGCTACGTATTCGATGCAGCGCCTCGTGCGCTGCTTTTGTTATTCCATTGT
TCTTTTCTCCGTCCGCTGCCATGCACGACAAAATCCTGATTCTCGACTTCGGTTCGCAAGTCACTCAACTGATTGCGCGG
CGCGTCCGCGAAGCGCACGTCTACTGCGAGATCCACCCGAACGACGTCTCCGACGACTTCGTCCGCGAATTCGCACCGAA
GGGCGTGATTCTGTCCGGCAGCCACGCGAGCACCTATGAGGACCACCAACTGCGCGCGCCGCAGGCGGTGTGGGATCTCG
GCGTGCCCGTGCTCGGCATTTGTTACGGGATGCAGACGATGGCCGTGCAGTTGGGCGGCAAGGTCGAGTGGAGCGATCAT
CGCGAGTTCGGCTATGCGGAAGTGCGCGCGCACGGCCACACGCGCCTGCTCGACGGCATCCAGGATTTCGCGACGCCGGA
AGGCCACGGAATGCTGAAGGTGTGGATGAGTCATGGCGACAAGGTCGCCGCGATGCCGCCGGGCTTCGCGCTGATGGCGT
CGACGCCGAGCTGCCCGATCGCCGGCATGGCCGACGAGGCGCGCGGCTACTACGCGGTGCAGTTCCATCCGGAAGTCACG
CACACGGTGCAGGGCCGCAAGCTGCTCGAGCGCTTCGTGCTCGACATCGCCGGCGCGAAACCCGACTGGATCATGCGTGA
CCACATCGAAGAGGCGGTCGCGCGGATTCGCGAGCAAGTCGGCGACGAGGAGGTGATTCTCGGCCTGTCGGGCGGCGTGG
ATTCGAGCGTCGCGGCGGCGCTGATCCACCGCGCGATCGGCGATCAACTGACCTGCGTGTTCGTCGATCACGGCCTGCTG
CGCCTGAACGAAGGCAAGATGGTGCTCGACATGTTCGAAGGCCGGCTCCATGCGAAGGTGGTCCATGTCGACGCGTCCGA
GCAGTTCCTGGGCCATCTCGCGGGCGTCGCCGATCCGGAGCACAAGCGCAAGATCATTGGCCGCGAGTTCGTCGAGGTGT
TCCAGGCCGAGGCGAAGAAGCTGACGAACGCGAAGTGGCTCGCGCAGGGCACGATCTATCCGGACGTAATCGAATCGGGC
GGCGCAAAGACGAAGAAGGCGACGACGATCAAGAGCCATCACAATGTCGGCGGCCTGCCGGAGACGCTCGGCCTGAAACT
GCTCGAGCCGTTGCGCGACCTGTTCAAGGATGAAGTGCGCGAACTCGGCGTCGCGCTCGGCTTGCCCGAGGAGATGGTGT
ATCGGCATCCGTTCCCGGGCCCGGGCCTCGGCGTGCGGATTCTGGGCGAAGTGAAGCGAGACTACGCGGATCTGCTGCGC
CGCGCGGATGCGATCTTCATCGAAGAGCTTCGCGGCACGTTGGCGACCGAGCAGGACGCGGCGGCGGGCCTTTGCGAGCC
GTCGCAGGTCGGCAAGAGCTGGTATGACCTGACGAGCCAGGCGTTCGCGGTGTTCCTGCCGGTGAAGTCGGTCGGCGTGA
TGGGCGATGGCCGCACGTACGACTACGTGACCGCGCTGCGCGCCGTGCAGACGACCGACTTCATGACCGCGCACTGGGCG
CATCTGCCGTATGCGCTGCTCGGCCGCGCGTCGAACCGAATCATCAACGAAGTGCGCGGCATCAACCGGGTCGTGTACGA
CGTGTCGGGCAAGCCGCCGGCGACGATCGAGTGGGAATGA

Upstream 100 bases:

>100_bases
GCCGCGCGGATCGAGCCGAGCGTGTCGCGCGCGGGTGAGGCGGCCGGATCGCCGGGCGTCGCATCGGGCACGAGCGCCGC
GGCGCCCGCCGAGCGCACGG

Downstream 100 bases:

>100_bases
TCCGACGTCCGCCACCGGCTGGCATCGTCTGCTGGTAAGCAACGCCTAAGCCCGCGATTTCGCGGGCTTTTTTGTGCTTT
CGTCGGGCAATGGTTGGTAC

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 599; Mature: 599

Protein sequence:

>599_residues
MLRRASSATRRGRRRNRDRHGSPDCQAAACRGGAIARLRIRCSASCAAFVIPLFFSPSAAMHDKILILDFGSQVTQLIAR
RVREAHVYCEIHPNDVSDDFVREFAPKGVILSGSHASTYEDHQLRAPQAVWDLGVPVLGICYGMQTMAVQLGGKVEWSDH
REFGYAEVRAHGHTRLLDGIQDFATPEGHGMLKVWMSHGDKVAAMPPGFALMASTPSCPIAGMADEARGYYAVQFHPEVT
HTVQGRKLLERFVLDIAGAKPDWIMRDHIEEAVARIREQVGDEEVILGLSGGVDSSVAAALIHRAIGDQLTCVFVDHGLL
RLNEGKMVLDMFEGRLHAKVVHVDASEQFLGHLAGVADPEHKRKIIGREFVEVFQAEAKKLTNAKWLAQGTIYPDVIESG
GAKTKKATTIKSHHNVGGLPETLGLKLLEPLRDLFKDEVRELGVALGLPEEMVYRHPFPGPGLGVRILGEVKRDYADLLR
RADAIFIEELRGTLATEQDAAAGLCEPSQVGKSWYDLTSQAFAVFLPVKSVGVMGDGRTYDYVTALRAVQTTDFMTAHWA
HLPYALLGRASNRIINEVRGINRVVYDVSGKPPATIEWE

Sequences:

>Translated_599_residues
MLRRASSATRRGRRRNRDRHGSPDCQAAACRGGAIARLRIRCSASCAAFVIPLFFSPSAAMHDKILILDFGSQVTQLIAR
RVREAHVYCEIHPNDVSDDFVREFAPKGVILSGSHASTYEDHQLRAPQAVWDLGVPVLGICYGMQTMAVQLGGKVEWSDH
REFGYAEVRAHGHTRLLDGIQDFATPEGHGMLKVWMSHGDKVAAMPPGFALMASTPSCPIAGMADEARGYYAVQFHPEVT
HTVQGRKLLERFVLDIAGAKPDWIMRDHIEEAVARIREQVGDEEVILGLSGGVDSSVAAALIHRAIGDQLTCVFVDHGLL
RLNEGKMVLDMFEGRLHAKVVHVDASEQFLGHLAGVADPEHKRKIIGREFVEVFQAEAKKLTNAKWLAQGTIYPDVIESG
GAKTKKATTIKSHHNVGGLPETLGLKLLEPLRDLFKDEVRELGVALGLPEEMVYRHPFPGPGLGVRILGEVKRDYADLLR
RADAIFIEELRGTLATEQDAAAGLCEPSQVGKSWYDLTSQAFAVFLPVKSVGVMGDGRTYDYVTALRAVQTTDFMTAHWA
HLPYALLGRASNRIINEVRGINRVVYDVSGKPPATIEWE
>Mature_599_residues
MLRRASSATRRGRRRNRDRHGSPDCQAAACRGGAIARLRIRCSASCAAFVIPLFFSPSAAMHDKILILDFGSQVTQLIAR
RVREAHVYCEIHPNDVSDDFVREFAPKGVILSGSHASTYEDHQLRAPQAVWDLGVPVLGICYGMQTMAVQLGGKVEWSDH
REFGYAEVRAHGHTRLLDGIQDFATPEGHGMLKVWMSHGDKVAAMPPGFALMASTPSCPIAGMADEARGYYAVQFHPEVT
HTVQGRKLLERFVLDIAGAKPDWIMRDHIEEAVARIREQVGDEEVILGLSGGVDSSVAAALIHRAIGDQLTCVFVDHGLL
RLNEGKMVLDMFEGRLHAKVVHVDASEQFLGHLAGVADPEHKRKIIGREFVEVFQAEAKKLTNAKWLAQGTIYPDVIESG
GAKTKKATTIKSHHNVGGLPETLGLKLLEPLRDLFKDEVRELGVALGLPEEMVYRHPFPGPGLGVRILGEVKRDYADLLR
RADAIFIEELRGTLATEQDAAAGLCEPSQVGKSWYDLTSQAFAVFLPVKSVGVMGDGRTYDYVTALRAVQTTDFMTAHWA
HLPYALLGRASNRIINEVRGINRVVYDVSGKPPATIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=563, Percent_Identity=34.6358792184725, Blast_Score=276, Evalue=6e-74,
Organism=Escherichia coli, GI1788854, Length=536, Percent_Identity=64.365671641791, Blast_Score=694, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71992710, Length=580, Percent_Identity=35.5172413793103, Blast_Score=290, Evalue=2e-78,
Organism=Caenorhabditis elegans, GI71992717, Length=580, Percent_Identity=35.5172413793103, Blast_Score=290, Evalue=2e-78,
Organism=Caenorhabditis elegans, GI133901714, Length=580, Percent_Identity=35.5172413793103, Blast_Score=289, Evalue=2e-78,
Organism=Saccharomyces cerevisiae, GI6323873, Length=550, Percent_Identity=47.8181818181818, Blast_Score=499, Evalue=1e-142,
Organism=Drosophila melanogaster, GI281365319, Length=560, Percent_Identity=35.3571428571429, Blast_Score=283, Evalue=2e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 65920; Mature: 65920

Theoretical pI: Translated: 7.17; Mature: 7.17

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRRASSATRRGRRRNRDRHGSPDCQAAACRGGAIARLRIRCSASCAAFVIPLFFSPSAA
CCCCCHHHHHHHHHCCCCCCCCCCCHHHHCCCCCEEEEEEEECCCHHHHHHHHHCCCCCH
MHDKILILDFGSQVTQLIARRVREAHVYCEIHPNDVSDDFVREFAPKGVILSGSHASTYE
HCCEEEEEECCHHHHHHHHHHHHHCEEEEEECCCCCCHHHHHHHCCCCEEEECCCCCCCC
DHQLRAPQAVWDLGVPVLGICYGMQTMAVQLGGKVEWSDHREFGYAEVRAHGHTRLLDGI
CCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHCCEEEECCCCCCCCHHHHHCCCHHHHHHH
QDFATPEGHGMLKVWMSHGDKVAAMPPGFALMASTPSCPIAGMADEARGYYAVQFHPEVT
HHHCCCCCCCEEEEEECCCCEEEECCCCEEEEECCCCCCCCCCCCCCCCEEEEEECCCHH
HTVQGRKLLERFVLDIAGAKPDWIMRDHIEEAVARIREQVGDEEVILGLSGGVDSSVAAA
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHH
LIHRAIGDQLTCVFVDHGLLRLNEGKMVLDMFEGRLHAKVVHVDASEQFLGHLAGVADPE
HHHHHHCCCEEEEEEECCEEEECCCCEEEEHHCCCEEEEEEEECCHHHHHHHHHCCCCHH
HKRKIIGREFVEVFQAEAKKLTNAKWLAQGTIYPDVIESGGAKTKKATTIKSHHNVGGLP
HHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHCCCCCCCHHEEECCCCCCCCCC
ETLGLKLLEPLRDLFKDEVRELGVALGLPEEMVYRHPFPGPGLGVRILGEVKRDYADLLR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHH
RADAIFIEELRGTLATEQDAAAGLCEPSQVGKSWYDLTSQAFAVFLPVKSVGVMGDGRTY
HHHHHHHHHHHHHHCCCCHHHCCCCCHHHHCHHHHHHHHHHEEEEEEHHHHCCCCCCCCH
DYVTALRAVQTTDFMTAHWAHLPYALLGRASNRIINEVRGINRVVYDVSGKPPATIEWE
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCEEECC
>Mature Secondary Structure
MLRRASSATRRGRRRNRDRHGSPDCQAAACRGGAIARLRIRCSASCAAFVIPLFFSPSAA
CCCCCHHHHHHHHHCCCCCCCCCCCHHHHCCCCCEEEEEEEECCCHHHHHHHHHCCCCCH
MHDKILILDFGSQVTQLIARRVREAHVYCEIHPNDVSDDFVREFAPKGVILSGSHASTYE
HCCEEEEEECCHHHHHHHHHHHHHCEEEEEECCCCCCHHHHHHHCCCCEEEECCCCCCCC
DHQLRAPQAVWDLGVPVLGICYGMQTMAVQLGGKVEWSDHREFGYAEVRAHGHTRLLDGI
CCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHCCEEEECCCCCCCCHHHHHCCCHHHHHHH
QDFATPEGHGMLKVWMSHGDKVAAMPPGFALMASTPSCPIAGMADEARGYYAVQFHPEVT
HHHCCCCCCCEEEEEECCCCEEEECCCCEEEEECCCCCCCCCCCCCCCCEEEEEECCCHH
HTVQGRKLLERFVLDIAGAKPDWIMRDHIEEAVARIREQVGDEEVILGLSGGVDSSVAAA
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHH
LIHRAIGDQLTCVFVDHGLLRLNEGKMVLDMFEGRLHAKVVHVDASEQFLGHLAGVADPE
HHHHHHCCCEEEEEEECCEEEECCCCEEEEHHCCCEEEEEEEECCHHHHHHHHHCCCCHH
HKRKIIGREFVEVFQAEAKKLTNAKWLAQGTIYPDVIESGGAKTKKATTIKSHHNVGGLP
HHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHCCCCCCCHHEEECCCCCCCCCC
ETLGLKLLEPLRDLFKDEVRELGVALGLPEEMVYRHPFPGPGLGVRILGEVKRDYADLLR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHH
RADAIFIEELRGTLATEQDAAAGLCEPSQVGKSWYDLTSQAFAVFLPVKSVGVMGDGRTY
HHHHHHHHHHHHHHCCCCHHHCCCCCHHHHCHHHHHHHHHHEEEEEEHHHHCCCCCCCCH
DYVTALRAVQTTDFMTAHWAHLPYALLGRASNRIINEVRGINRVVYDVSGKPPATIEWE
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA