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The map label for this gene is oprM [H]

Identifier: 83719194

GI number: 83719194

Start: 20337

End: 21956

Strand: Reverse

Name: oprM [H]

Synonym: BTH_I0019

Alternate gene names: 83719194

Gene position: 21956-20337 (Counterclockwise)

Preceding gene: 83718605

Following gene: 83720261

Centisome position: 0.58

GC content: 72.65

Gene sequence:

>1620_bases
ATGCCGCAAGTCCCACATCCGCGCGCGCGCCGCGCGCTGAGCGCCGCCGTCGCCGCAGCGGCAGCCGTGCTGCTCGCCGG
CTGCGCGGTCGGGCCCGACTATCACCGCCCCGACGCGGCGATTCCCGCCGCATACAAGGAAGCGCCGCCCGGCTGGAAGG
TCGCGCAGCCGGCGGACCGTGCGGACCGCGGCCCGTGGTGGTCGATCTATGACGATCCGCAACTGAACGCGCTCGTCGAC
AAGCTCAACGCGTCGAACCAGACCGTCGCGCAATATGCGGCCGCGTACCGGCAGGCGCGTGCGCTCGTCGCCCAGGCGCG
CGCGTCGTACTTCCCGACGCTCGGGCTGACCGCGAGCGAATCGCGCGCGTCGAGCGCGCTGTCGTCGGGCACCACGACGC
GCACGATCGGCAACACCTACAACGTCGGCCTGGATGCGTCGTGGGAGCCGGACCTGTGGGGCAAGGTGAGCCGCACGGTC
GGCGCGCAGAAGGCGGGGGAAGCGGCCGCGGCCGCCGATCTCGCGAACGCGCGGCTGTCCGCGCAGGCAACGCTCGCGCA
GACCTATTTCCAATTGCGCGCCGCGGACGCGACGCAAAAACTCCTCGACGACACCGTCGCGTCGTACCAGAAATCGCTGC
AGCTCACGCAGAACCAGTACGCACAGGGCGTCGCCGCGCGCTCGGACGTGATCCAGGCGCAAACGCAGTTGCAATCGGCG
CAGGCCGCCGCGATCGACAACGGCATCGCGCGCGCGCAGTACGAGCACGCGATCGCGACGCTCGTCGGCGAGCCGGCGTC
GACGTTCTCGCTGCCGCCGATGCCGCTCACGGCCGAACCGCCCGCGATGCCGATCGATGTGCCGTCGGCGATTCTCGAGC
GGCGGCCCGACGTCGCCGCCGCCGAGCGGCGCGCGGCCGCCGCGAACGAGCAGATCGGCGTCGCGATCGCCGCGTTCTTC
CCCACGCTCACGCTGTCCGCGTCGGGCGGCTTCCAGAGCTCGGTGTGGTCGCAGCTCTTCACGCTGCCCGCGCGCTTCTG
GTCGGTCGGCCCGCAGCTCGCCGCGACGCTGTTCGACGCCGGTCTGCGCGCCGCGCAGACGGAAGCCGCGCGCGCGACCT
ACGACCAGGACGTCGCCGCGTACCGGGCCGCCGTGCTGTCCGCGTTTCAGGACGTCGAGGACAACCTCGCGTCGCAGCGC
ATCCTCGAGCAGGAAATCGCCGTGCAGCGGCAGGCGGTCGAATCCGCGCGGCATGCGCTCGACATCACGCTCAACCAGTA
CAAGGCGGGCACGGTCGCCTACCTGAACGTGCTGACCGCGCAGACGACCGCATTCAGCGCGCAGCAGAAGCTCTCGACGA
TTTCCGGGCAGCGGATGGTGTCGTCGGTCGGGCTCGTGAAGGCGCTGGGCGGCGGATGGGACGTGTCGCAGATCGCGCGC
GAGACGGGCAGCATGCAGGCGCCCGCCGCGCCGCAGCCTGCGTCTGGGCCGGCTGCGGCGGTTGCGCCGGCGGCCACGCC
CGCCGCGGCCGTTGGGCCGGCGGCCCGATCGGCGGCCGTGGTCGCGACGGCCTCGGCCAATGCGTCGGCCGTCCGTCCGG
CCGCCACGCCCACGCAATGA

Upstream 100 bases:

>100_bases
CCGCACCCGTCAGTTACCATTTCGGCCACGCCGTCAGCGTTTCGGCCGCATCGCCCGCTCGTCCGGTCCACCGGCGGCCG
CCTCGACAGGAATCCAGAAC

Downstream 100 bases:

>100_bases
CGGGGCCGGCCGGGAACTGCCGGTCGTCGCACCGGCGATTCGCCGGCACCGCCGGCATCAACGTCGACGTGCATCCGGCG
GCCGGCCCCAAGTCGGCCAA

Product: RND efflux system outer membrane lipoprotein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 539; Mature: 538

Protein sequence:

>539_residues
MPQVPHPRARRALSAAVAAAAAVLLAGCAVGPDYHRPDAAIPAAYKEAPPGWKVAQPADRADRGPWWSIYDDPQLNALVD
KLNASNQTVAQYAAAYRQARALVAQARASYFPTLGLTASESRASSALSSGTTTRTIGNTYNVGLDASWEPDLWGKVSRTV
GAQKAGEAAAAADLANARLSAQATLAQTYFQLRAADATQKLLDDTVASYQKSLQLTQNQYAQGVAARSDVIQAQTQLQSA
QAAAIDNGIARAQYEHAIATLVGEPASTFSLPPMPLTAEPPAMPIDVPSAILERRPDVAAAERRAAAANEQIGVAIAAFF
PTLTLSASGGFQSSVWSQLFTLPARFWSVGPQLAATLFDAGLRAAQTEAARATYDQDVAAYRAAVLSAFQDVEDNLASQR
ILEQEIAVQRQAVESARHALDITLNQYKAGTVAYLNVLTAQTTAFSAQQKLSTISGQRMVSSVGLVKALGGGWDVSQIAR
ETGSMQAPAAPQPASGPAAAVAPAATPAAAVGPAARSAAVVATASANASAVRPAATPTQ

Sequences:

>Translated_539_residues
MPQVPHPRARRALSAAVAAAAAVLLAGCAVGPDYHRPDAAIPAAYKEAPPGWKVAQPADRADRGPWWSIYDDPQLNALVD
KLNASNQTVAQYAAAYRQARALVAQARASYFPTLGLTASESRASSALSSGTTTRTIGNTYNVGLDASWEPDLWGKVSRTV
GAQKAGEAAAAADLANARLSAQATLAQTYFQLRAADATQKLLDDTVASYQKSLQLTQNQYAQGVAARSDVIQAQTQLQSA
QAAAIDNGIARAQYEHAIATLVGEPASTFSLPPMPLTAEPPAMPIDVPSAILERRPDVAAAERRAAAANEQIGVAIAAFF
PTLTLSASGGFQSSVWSQLFTLPARFWSVGPQLAATLFDAGLRAAQTEAARATYDQDVAAYRAAVLSAFQDVEDNLASQR
ILEQEIAVQRQAVESARHALDITLNQYKAGTVAYLNVLTAQTTAFSAQQKLSTISGQRMVSSVGLVKALGGGWDVSQIAR
ETGSMQAPAAPQPASGPAAAVAPAATPAAAVGPAARSAAVVATASANASAVRPAATPTQ
>Mature_538_residues
PQVPHPRARRALSAAVAAAAAVLLAGCAVGPDYHRPDAAIPAAYKEAPPGWKVAQPADRADRGPWWSIYDDPQLNALVDK
LNASNQTVAQYAAAYRQARALVAQARASYFPTLGLTASESRASSALSSGTTTRTIGNTYNVGLDASWEPDLWGKVSRTVG
AQKAGEAAAAADLANARLSAQATLAQTYFQLRAADATQKLLDDTVASYQKSLQLTQNQYAQGVAARSDVIQAQTQLQSAQ
AAAIDNGIARAQYEHAIATLVGEPASTFSLPPMPLTAEPPAMPIDVPSAILERRPDVAAAERRAAAANEQIGVAIAAFFP
TLTLSASGGFQSSVWSQLFTLPARFWSVGPQLAATLFDAGLRAAQTEAARATYDQDVAAYRAAVLSAFQDVEDNLASQRI
LEQEIAVQRQAVESARHALDITLNQYKAGTVAYLNVLTAQTTAFSAQQKLSTISGQRMVSSVGLVKALGGGWDVSQIARE
TGSMQAPAAPQPASGPAAAVAPAATPAAAVGPAARSAAVVATASANASAVRPAATPTQ

Specific function: The ability to export antibiotics and solvents is dramatically decreased in the presence of the proton conductor carbonyl cyanide m-chlorophenylhydrazone (CCCP), showing that an energized inner membrane is required for efflux. It is thought that the mexB

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor. Note=Attached to the outer membrane by a lipid anchor and via the transmembrane beta-barrel. The membrane anchor is not necessary for antibiotic efflux. In one report (PubMed:10889211) the Cys-18- Gly mutant is reported

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

Organism=Escherichia coli, GI1786785, Length=462, Percent_Identity=27.7056277056277, Blast_Score=166, Evalue=3e-42,
Organism=Escherichia coli, GI2367348, Length=478, Percent_Identity=26.5690376569038, Blast_Score=119, Evalue=5e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423
- InterPro:   IPR010131 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 55907; Mature: 55776

Theoretical pI: Translated: 8.34; Mature: 8.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPQVPHPRARRALSAAVAAAAAVLLAGCAVGPDYHRPDAAIPAAYKEAPPGWKVAQPADR
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCC
ADRGPWWSIYDDPQLNALVDKLNASNQTVAQYAAAYRQARALVAQARASYFPTLGLTASE
CCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCH
SRASSALSSGTTTRTIGNTYNVGLDASWEPDLWGKVSRTVGAQKAGEAAAAADLANARLS
HHHHHHHHCCCCEEECCCCEECCCCCCCCCCHHHHHHHHHCHHHCCHHHHHHHHHHHHHH
AQATLAQTYFQLRAADATQKLLDDTVASYQKSLQLTQNQYAQGVAARSDVIQAQTQLQSA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QAAAIDNGIARAQYEHAIATLVGEPASTFSLPPMPLTAEPPAMPIDVPSAILERRPDVAA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCHHH
AERRAAAANEQIGVAIAAFFPTLTLSASGGFQSSVWSQLFTLPARFWSVGPQLAATLFDA
HHHHHHHCCCCCCCHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
GLRAAQTEAARATYDQDVAAYRAAVLSAFQDVEDNLASQRILEQEIAVQRQAVESARHAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHE
DITLNQYKAGTVAYLNVLTAQTTAFSAQQKLSTISGQRMVSSVGLVKALGGGWDVSQIAR
EEEHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
ETGSMQAPAAPQPASGPAAAVAPAATPAAAVGPAARSAAVVATASANASAVRPAATPTQ
HHCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCHHCCCEEEEECCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PQVPHPRARRALSAAVAAAAAVLLAGCAVGPDYHRPDAAIPAAYKEAPPGWKVAQPADR
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCC
ADRGPWWSIYDDPQLNALVDKLNASNQTVAQYAAAYRQARALVAQARASYFPTLGLTASE
CCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCH
SRASSALSSGTTTRTIGNTYNVGLDASWEPDLWGKVSRTVGAQKAGEAAAAADLANARLS
HHHHHHHHCCCCEEECCCCEECCCCCCCCCCHHHHHHHHHCHHHCCHHHHHHHHHHHHHH
AQATLAQTYFQLRAADATQKLLDDTVASYQKSLQLTQNQYAQGVAARSDVIQAQTQLQSA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QAAAIDNGIARAQYEHAIATLVGEPASTFSLPPMPLTAEPPAMPIDVPSAILERRPDVAA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCHHH
AERRAAAANEQIGVAIAAFFPTLTLSASGGFQSSVWSQLFTLPARFWSVGPQLAATLFDA
HHHHHHHCCCCCCCHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
GLRAAQTEAARATYDQDVAAYRAAVLSAFQDVEDNLASQRILEQEIAVQRQAVESARHAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHE
DITLNQYKAGTVAYLNVLTAQTTAFSAQQKLSTISGQRMVSSVGLVKALGGGWDVSQIAR
EEEHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
ETGSMQAPAAPQPASGPAAAVAPAATPAAAVGPAARSAAVVATASANASAVRPAATPTQ
HHCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCHHCCCEEEEECCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8226684; 10889211; 10984043; 7968531; 8540696; 9401051; 9603892; 10952562 [H]