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The map label for this gene is parE [H]

Identifier: 83719101

GI number: 83719101

Start: 1062217

End: 1064199

Strand: Direct

Name: parE [H]

Synonym: BTH_I0940

Alternate gene names: 83719101

Gene position: 1062217-1064199 (Clockwise)

Preceding gene: 83721453

Following gene: 83721285

Centisome position: 27.89

GC content: 66.62

Gene sequence:

>1983_bases
ATGTCCACGAAAAAGCCCGCAGCGGCCTATAGCGAAGCATCGATCAAGGTGCTGAAGGGCCTCGAGCCCGTCAAGCAGCG
GCCCGGCATGTATACGCGCACCGAGAATCCGCTGCACATCATCCAGGAAGTGATCGACAACGCGTCCGACGAGGCGTTGG
GCGGTTTCGGCAAGCAGATCACGGTCACGCTGCACCCCGATCAATCGGTGTCCGTCGAGGACGACGGGCGCGGCATTCCG
TTCGGGCTGCATCCGGAGGAGAAGGTGCCCGTCGTCGAGATCGTGTTCACGCGGCTGCACGCCGGCGGCAAGTTCGACAA
GGCGAAGGGCGGCGCGTATACGTTCTCGGGCGGCCTGCACGGCGTCGGCGTGTCGGTGACGAACGCGCTCGCGACGCGGC
TCGACGTGACCGTCTGGCGCGACGGCAAGATCGCGCAGCTCGGCTTCGCCGACGGCGACGTCGTCAAGCCGCTCGCGACG
CAAGGTGCGGGCCGCGGCGAGAAGAAATCCGGCACGCGCGTGACCGTGTGGCCGAATCCGAAGTACTTCGATTCGCCGAA
CCTGCCGCTCGGGGAACTGCAGCGGCTGCTGCGCTCGAAGGCGGTGCTGCTGCCGGGCGTCGAGGTCGTGCTCGTCAACG
AGAAGACGGGCGAGCGGCAGAGCTGGAAATACGAGGATGGCCTGCGCGGCTATCTGCTCGACGAGATGAACGGCAGCGAG
CTCCTGATCCCGCTCTTCGAAGGCGAGCGCTTCGCCGATTCGCGCTCGGGCGACGACACGTTCGCCGAGGGCGAGGGCGC
GTCGTGGGTCGTCGCGTGGAGCGAGGAAGGCTCGCTCGTGCGCGAGTCGTATGTGAACCTGATTCCGACACCCGCGGGCG
GCACGCACGAATCCGGCCTGCGCGACGGCCTCTATCAGGCGGTGAAGAGCTTCGTCGAGCTGCACAACCTGCAGCCGAAG
GGCGTGAAGCTGCTCGCGGAGGACGTGTTCGCGCGCGTGTCGTTCGTGCTGTCGGCGAAGGTGCTCGATCCGCAGTTCCA
AGGGCAGATCAAGGAGCGCCTGAACAGCCGCGACGCGGTGAAGCTCGTGTCGTCGTTCACGCGCCCGGCGCTCGAGCTGT
GGCTCAATCAGCACGTCGAGCACGGCAAGAAGCTCGCGGAGCTCGTGATCAAGCAGGCGCAGGCGCGCACGCGCGCGGGC
CAGAAAATCGAGAAGAAGAAGAGCTCCGGCGTCGCGGTGCTGCCCGGCAAGCTGACCGATTGCGAAACCGAGGACATCGC
GCGCAACGAGCTTTTCCTCGTCGAGGGCGATTCGGCGGGCGGCTCGGCGAAGATGGGCCGCGACAAGGAATATCAGGCGA
TCCTGCCGCTGCGCGGCAAGGTGCTCAACACGTGGGAGACCGAGCGCGACCGCCTGTTCGCGAACAACGAGGTGCACGAC
ATCTCGGTGGCGATCGGCGTCGATCCGCACGGCCCGGACGACAGCGTCGACGTGTCGAACCTGCGCTACGGCAAGATCTG
CATCCTGTCGGACGCGGACGTCGACGGCGCGCACATCCAGGTGTTGCTGCTCACGCTGTTCTTCAAGCATTTCCCGCAAC
TGATCGAGCGCGGCCACGTGTTCGTCGCGCGGCCGCCGCTTTTCCGGGTCGACGCGCCCGCGCGCGGCAAGAAGCCCGCG
CAGAAGCTCTACGCGCTCGACGAGGGCGAGCTCGAGGCGATCCTCGACAAGCTGCGCAAGGACGGCGTGCGCGAATCGCA
ATGGACGATCAGCCGCTTCAAGGGCTTGGGCGAGATGAGCGCCGAGCAGCTGTGGGACACGACGATGAACCCCGACACGC
GCCGCCTGATGCCCGTCGCGCTCGGCGAGCTCGACTTCGAGGCGACGGTGGCGCGGATGACGATGCTGATGGGCAAGGGC
GAAGCCGCCGCGCGCCGCAACTGGCTCGAGGAAAAGGGCAACGAAGTCGAAGCGGATATCTGA

Upstream 100 bases:

>100_bases
TTGTTTCGACTCGGATTTTTATCGAATTCAACGTTTTGTCCACGACGTTATCCACACGAGCTGGGGATAACGTCAAGGTG
AATGACGAACCTGAGCTTCT

Downstream 100 bases:

>100_bases
GCGCGGCCGGGCGCGCGCCCGGCTACGCACGCATCGCATATACGGACACGAAATCTAGATGGACGACAATACTCCCGATC
TTTTCGCCGAGCCGGCCGCG

Product: DNA topoisomerase IV subunit B

Products: NA

Alternate protein names: Topoisomerase IV subunit B [H]

Number of amino acids: Translated: 660; Mature: 659

Protein sequence:

>660_residues
MSTKKPAAAYSEASIKVLKGLEPVKQRPGMYTRTENPLHIIQEVIDNASDEALGGFGKQITVTLHPDQSVSVEDDGRGIP
FGLHPEEKVPVVEIVFTRLHAGGKFDKAKGGAYTFSGGLHGVGVSVTNALATRLDVTVWRDGKIAQLGFADGDVVKPLAT
QGAGRGEKKSGTRVTVWPNPKYFDSPNLPLGELQRLLRSKAVLLPGVEVVLVNEKTGERQSWKYEDGLRGYLLDEMNGSE
LLIPLFEGERFADSRSGDDTFAEGEGASWVVAWSEEGSLVRESYVNLIPTPAGGTHESGLRDGLYQAVKSFVELHNLQPK
GVKLLAEDVFARVSFVLSAKVLDPQFQGQIKERLNSRDAVKLVSSFTRPALELWLNQHVEHGKKLAELVIKQAQARTRAG
QKIEKKKSSGVAVLPGKLTDCETEDIARNELFLVEGDSAGGSAKMGRDKEYQAILPLRGKVLNTWETERDRLFANNEVHD
ISVAIGVDPHGPDDSVDVSNLRYGKICILSDADVDGAHIQVLLLTLFFKHFPQLIERGHVFVARPPLFRVDAPARGKKPA
QKLYALDEGELEAILDKLRKDGVRESQWTISRFKGLGEMSAEQLWDTTMNPDTRRLMPVALGELDFEATVARMTMLMGKG
EAAARRNWLEEKGNEVEADI

Sequences:

>Translated_660_residues
MSTKKPAAAYSEASIKVLKGLEPVKQRPGMYTRTENPLHIIQEVIDNASDEALGGFGKQITVTLHPDQSVSVEDDGRGIP
FGLHPEEKVPVVEIVFTRLHAGGKFDKAKGGAYTFSGGLHGVGVSVTNALATRLDVTVWRDGKIAQLGFADGDVVKPLAT
QGAGRGEKKSGTRVTVWPNPKYFDSPNLPLGELQRLLRSKAVLLPGVEVVLVNEKTGERQSWKYEDGLRGYLLDEMNGSE
LLIPLFEGERFADSRSGDDTFAEGEGASWVVAWSEEGSLVRESYVNLIPTPAGGTHESGLRDGLYQAVKSFVELHNLQPK
GVKLLAEDVFARVSFVLSAKVLDPQFQGQIKERLNSRDAVKLVSSFTRPALELWLNQHVEHGKKLAELVIKQAQARTRAG
QKIEKKKSSGVAVLPGKLTDCETEDIARNELFLVEGDSAGGSAKMGRDKEYQAILPLRGKVLNTWETERDRLFANNEVHD
ISVAIGVDPHGPDDSVDVSNLRYGKICILSDADVDGAHIQVLLLTLFFKHFPQLIERGHVFVARPPLFRVDAPARGKKPA
QKLYALDEGELEAILDKLRKDGVRESQWTISRFKGLGEMSAEQLWDTTMNPDTRRLMPVALGELDFEATVARMTMLMGKG
EAAARRNWLEEKGNEVEADI
>Mature_659_residues
STKKPAAAYSEASIKVLKGLEPVKQRPGMYTRTENPLHIIQEVIDNASDEALGGFGKQITVTLHPDQSVSVEDDGRGIPF
GLHPEEKVPVVEIVFTRLHAGGKFDKAKGGAYTFSGGLHGVGVSVTNALATRLDVTVWRDGKIAQLGFADGDVVKPLATQ
GAGRGEKKSGTRVTVWPNPKYFDSPNLPLGELQRLLRSKAVLLPGVEVVLVNEKTGERQSWKYEDGLRGYLLDEMNGSEL
LIPLFEGERFADSRSGDDTFAEGEGASWVVAWSEEGSLVRESYVNLIPTPAGGTHESGLRDGLYQAVKSFVELHNLQPKG
VKLLAEDVFARVSFVLSAKVLDPQFQGQIKERLNSRDAVKLVSSFTRPALELWLNQHVEHGKKLAELVIKQAQARTRAGQ
KIEKKKSSGVAVLPGKLTDCETEDIARNELFLVEGDSAGGSAKMGRDKEYQAILPLRGKVLNTWETERDRLFANNEVHDI
SVAIGVDPHGPDDSVDVSNLRYGKICILSDADVDGAHIQVLLLTLFFKHFPQLIERGHVFVARPPLFRVDAPARGKKPAQ
KLYALDEGELEAILDKLRKDGVRESQWTISRFKGLGEMSAEQLWDTTMNPDTRRLMPVALGELDFEATVARMTMLMGKGE
AAARRNWLEEKGNEVEADI

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0187

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type II topoisomerase family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=646, Percent_Identity=24.1486068111455, Blast_Score=129, Evalue=6e-30,
Organism=Homo sapiens, GI19913406, Length=652, Percent_Identity=23.7730061349693, Blast_Score=121, Evalue=2e-27,
Organism=Escherichia coli, GI1789408, Length=653, Percent_Identity=50.3828483920367, Blast_Score=645, Evalue=0.0,
Organism=Escherichia coli, GI48994957, Length=600, Percent_Identity=37.5, Blast_Score=358, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI17535065, Length=651, Percent_Identity=24.1167434715822, Blast_Score=109, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI212645845, Length=615, Percent_Identity=24.390243902439, Blast_Score=104, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI212645657, Length=213, Percent_Identity=29.1079812206573, Blast_Score=73, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6324241, Length=644, Percent_Identity=25.1552795031056, Blast_Score=132, Evalue=1e-31,
Organism=Drosophila melanogaster, GI17136538, Length=660, Percent_Identity=25.1515151515152, Blast_Score=127, Evalue=3e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR001241
- InterPro:   IPR013759
- InterPro:   IPR002288
- InterPro:   IPR013506
- InterPro:   IPR013760
- InterPro:   IPR018522
- InterPro:   IPR005737 [H]

Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c [H]

EC number: 5.99.1.-

Molecular weight: Translated: 72566; Mature: 72435

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: PS00177 TOPOISOMERASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTKKPAAAYSEASIKVLKGLEPVKQRPGMYTRTENPLHIIQEVIDNASDEALGGFGKQI
CCCCCCCCHHHHHHHHHHHCCCHHHHCCCCCCCCCCHHHHHHHHHCCCCCHHHCCCCCEE
TVTLHPDQSVSVEDDGRGIPFGLHPEEKVPVVEIVFTRLHAGGKFDKAKGGAYTFSGGLH
EEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEECCCCC
GVGVSVTNALATRLDVTVWRDGKIAQLGFADGDVVKPLATQGAGRGEKKSGTRVTVWPNP
CCCHHHHHHHHHHEEEEEECCCCEEEEECCCCCHHCHHHHCCCCCCCCCCCCEEEECCCC
KYFDSPNLPLGELQRLLRSKAVLLPGVEVVLVNEKTGERQSWKYEDGLRGYLLDEMNGSE
CCCCCCCCCHHHHHHHHHHCCEECCCEEEEEEECCCCCCCCCCCCCCCCEEEEECCCCCE
LLIPLFEGERFADSRSGDDTFAEGEGASWVVAWSEEGSLVRESYVNLIPTPAGGTHESGL
EEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHEECCCCCCCCCHHH
RDGLYQAVKSFVELHNLQPKGVKLLAEDVFARVSFVLSAKVLDPQFQGQIKERLNSRDAV
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHH
KLVSSFTRPALELWLNQHVEHGKKLAELVIKQAQARTRAGQKIEKKKSSGVAVLPGKLTD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCC
CETEDIARNELFLVEGDSAGGSAKMGRDKEYQAILPLRGKVLNTWETERDRLFANNEVHD
CCCHHCCCCEEEEEECCCCCCCCCCCCCCCCEEECCCCCEEECCCCCCHHHEECCCCEEE
ISVAIGVDPHGPDDSVDVSNLRYGKICILSDADVDGAHIQVLLLTLFFKHFPQLIERGHV
EEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCE
FVARPPLFRVDAPARGKKPAQKLYALDEGELEAILDKLRKDGVRESQWTISRFKGLGEMS
EEECCCCEEECCCCCCCCHHHHHHCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCHH
AEQLWDTTMNPDTRRLMPVALGELDFEATVARMTMLMGKGEAAARRNWLEEKGNEVEADI
HHHHHCCCCCCCHHEEHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEECCCC
>Mature Secondary Structure 
STKKPAAAYSEASIKVLKGLEPVKQRPGMYTRTENPLHIIQEVIDNASDEALGGFGKQI
CCCCCCCHHHHHHHHHHHCCCHHHHCCCCCCCCCCHHHHHHHHHCCCCCHHHCCCCCEE
TVTLHPDQSVSVEDDGRGIPFGLHPEEKVPVVEIVFTRLHAGGKFDKAKGGAYTFSGGLH
EEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEECCCCC
GVGVSVTNALATRLDVTVWRDGKIAQLGFADGDVVKPLATQGAGRGEKKSGTRVTVWPNP
CCCHHHHHHHHHHEEEEEECCCCEEEEECCCCCHHCHHHHCCCCCCCCCCCCEEEECCCC
KYFDSPNLPLGELQRLLRSKAVLLPGVEVVLVNEKTGERQSWKYEDGLRGYLLDEMNGSE
CCCCCCCCCHHHHHHHHHHCCEECCCEEEEEEECCCCCCCCCCCCCCCCEEEEECCCCCE
LLIPLFEGERFADSRSGDDTFAEGEGASWVVAWSEEGSLVRESYVNLIPTPAGGTHESGL
EEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHEECCCCCCCCCHHH
RDGLYQAVKSFVELHNLQPKGVKLLAEDVFARVSFVLSAKVLDPQFQGQIKERLNSRDAV
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHH
KLVSSFTRPALELWLNQHVEHGKKLAELVIKQAQARTRAGQKIEKKKSSGVAVLPGKLTD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCC
CETEDIARNELFLVEGDSAGGSAKMGRDKEYQAILPLRGKVLNTWETERDRLFANNEVHD
CCCHHCCCCEEEEEECCCCCCCCCCCCCCCCEEECCCCCEEECCCCCCHHHEECCCCEEE
ISVAIGVDPHGPDDSVDVSNLRYGKICILSDADVDGAHIQVLLLTLFFKHFPQLIERGHV
EEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCE
FVARPPLFRVDAPARGKKPAQKLYALDEGELEAILDKLRKDGVRESQWTISRFKGLGEMS
EEECCCCEEECCCCCCCCHHHHHHCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCHH
AEQLWDTTMNPDTRRLMPVALGELDFEATVARMTMLMGKGEAAARRNWLEEKGNEVEADI
HHHHHCCCCCCCHHEEHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2170028; 8388096; 9278503; 8227000; 8980775 [H]