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The map label for this gene is loxA [H]

Identifier: 83719086

GI number: 83719086

Start: 2650433

End: 2652520

Strand: Direct

Name: loxA [H]

Synonym: BTH_I2353

Alternate gene names: 83719086

Gene position: 2650433-2652520 (Clockwise)

Preceding gene: 83718721

Following gene: 83720185

Centisome position: 69.58

GC content: 59.96

Gene sequence:

>2088_bases
TTGGTCAATCACAAAACCGGGTCAAATATGAACCGAAGGGATTTAATTAAATTCTTGAGCTTCGCCGCCAGCGGAACCGC
GTTTGCGGGGCTCGTCAGGTCGACTCTGTCGTCACCGGCCGCGTCGTCGATCACCGCAAGCCCTCGCACGCTCGACGCCG
GCATCGGCATTTCGTCGCCGCAGGCGGTTCGCGCAGCCGCGCCGGTGCTGCCGCAAAAAGACACGGCCGCAGGCAGGATC
GCACGGGCGGGTTTTCTCGCCACGCAAAGACTGAGTTACATCTGGACGGAACATGTGCCGACCGCGAGCGGCATTCCACT
TGCGCTGGTCACGCCGCAAGATCTTCCAACCATTGAATGGCTGATCAAATTCATCGCGATCGTTGTGGGCGTCATCGAGA
ATTTTCTCGGCTCCGCACCCGCGACGGCGGTTGCCCTCTGGCGCGATCAGTTCGCCAAGATCAGGGTGGATCTGCTTTCC
CTCGAAAACCTGTATTCGGATCTCACCCACGATCCGAACTTGCAAGACCCGGTTGCCATTGCTCAGGCAGCGAGCATTCA
GGCGGCCTTGATCGCGCTGTTGGCGAACGTCGGCGTCTTGTCGAAGGACATCATTTCAAGATTGGGCGAAATCGTCTCCA
ACCACGACACTCGAAGCGAAGAGAACTTCAAGGCGCTGTTTTCCACCTTCCCGCTTCCCGACATCTCCGCCGCGTACCAG
CGGGACGATCATTTCGCGTCTCTCCGGGTTGCCGGCCAGAATCCGGTGTTGATCAAGCGCATCTCCGGCTTGCCGTCGAA
GTTCCCACTGACGAACGCTCAATTCCAGCAAGTCATGGGGCCCGCCGACAATCTCGTCAGCGCCGCCGCGGAGAATCGGC
TGTATCTCCTCGATTACGTCGACAACGGTCTGTTGGCGACGTCGCGGGCCGTGGCCAAACCACTCACGGGCATCGGCTAC
TCCTATGCGCCCATCGCACTTTTCGCGCTGCCGAGGGGCGGCGCGTCCCTCGTTCCCGTGGCGATTCAATGCGATCAGGA
TCCCGCGACGAATCCCCTGTTCCTCCCTGCCGATCCCAGTCAGGAATCCGCCTATTGGGCGTGGCAAATGGCCAAGACGG
TCGTTCAATGCGCGGAGGAAAACTATCACGAGATGTTTGTTCATCTCGCGCGAACGCACCTGGTGACCGGCGCGATTTGC
GTCGCCACTCACCGGAATCTCGCGTCGACGCATCCGCTCTACGCGCTTCTGATGCCGCACTTCGAGGGCACTTTGTACAT
CAACGAACTCGCCGCGCTCACGCTGCTTCCACCGTTGATGTTCATCGATACGCTGTTTGCCGCGCCCATCCAGCAGACGC
AACAGATGGTCGCAAGCGATCGGCTCGCGTTCGATTTCTACGATCACATGTTGCCCAACGACATCGAAATGCGCGGAGTC
GGCGCGGCCAACCTGCCGGACTATCCGTATCGCGACGACGGCCTCCTGATTTGGAACGCCATCGCCGAATGGGCGAAGGC
GTATGTCGATGTCTATTACAAGTCCGATCAGGATGTCGTCGATGACTACGAGCTCAGGTCCTGGGCCGCCGACATCATCG
CCAACGGCAAGGTCAAGGGATTCCGGCCGGTGCGTTCGAAGGCGCAATTGATCGACGTGCTGACCATGATCATCTTTACC
GCAAGCGCCCAGCACGCCGCCGTCAACTTCTCGCAGTCGGATTTTTCGACCTACGCGCCCGCGCTTTCCGCACTGCTGTC
CGCGCCGGCCCCGACAAGCGCCGTGGGAAAAAGCAAGGCCGATTGGCTGAAGATGCTCCCTCCCCTCGTTTCAGGGATCG
AGCGGGTTGCGATCTACGAGATCTTGGCGGGCGTCCAGCACAGCGCGTTGGGCCAGTATCGCAGCAACGTATTTCCATAT
CGGCCGCTCATCACGGACCCCGCGATCACCGGAAGCAACGGGCCGCTCGAGCATTTCCGACAGGCGCTCGGCGACGTCGA
ATCGCAGATCAACGCTCGCAACAGCATACGCAAGACGCCTTATGAATATCTGCTGCCGAGCCGGATTCCGGCAAGCACGA
ACATTTGA

Upstream 100 bases:

>100_bases
ATGGGCGATGAAATGAGGGGCGGCGCATGCTCCGAATATCGATGCGCCAGATATCAGCTGGATTTGATTTTATTTCAACG
GCCGATTCCGTGCGGCCTCG

Downstream 100 bases:

>100_bases
TCCGCCGCTCGGAGGCGGGACGAGTCAACGCCCTCCTCTTCGCAACCGCATTCCCGGACGCGTCTCCCCGCAACGGGTTC
AACACGCAATCTCATTTTGA

Product: arachidonate 15-lipoxygenase

Products: NA

Alternate protein names: 15-LOX [H]

Number of amino acids: Translated: 695; Mature: 695

Protein sequence:

>695_residues
MVNHKTGSNMNRRDLIKFLSFAASGTAFAGLVRSTLSSPAASSITASPRTLDAGIGISSPQAVRAAAPVLPQKDTAAGRI
ARAGFLATQRLSYIWTEHVPTASGIPLALVTPQDLPTIEWLIKFIAIVVGVIENFLGSAPATAVALWRDQFAKIRVDLLS
LENLYSDLTHDPNLQDPVAIAQAASIQAALIALLANVGVLSKDIISRLGEIVSNHDTRSEENFKALFSTFPLPDISAAYQ
RDDHFASLRVAGQNPVLIKRISGLPSKFPLTNAQFQQVMGPADNLVSAAAENRLYLLDYVDNGLLATSRAVAKPLTGIGY
SYAPIALFALPRGGASLVPVAIQCDQDPATNPLFLPADPSQESAYWAWQMAKTVVQCAEENYHEMFVHLARTHLVTGAIC
VATHRNLASTHPLYALLMPHFEGTLYINELAALTLLPPLMFIDTLFAAPIQQTQQMVASDRLAFDFYDHMLPNDIEMRGV
GAANLPDYPYRDDGLLIWNAIAEWAKAYVDVYYKSDQDVVDDYELRSWAADIIANGKVKGFRPVRSKAQLIDVLTMIIFT
ASAQHAAVNFSQSDFSTYAPALSALLSAPAPTSAVGKSKADWLKMLPPLVSGIERVAIYEILAGVQHSALGQYRSNVFPY
RPLITDPAITGSNGPLEHFRQALGDVESQINARNSIRKTPYEYLLPSRIPASTNI

Sequences:

>Translated_695_residues
MVNHKTGSNMNRRDLIKFLSFAASGTAFAGLVRSTLSSPAASSITASPRTLDAGIGISSPQAVRAAAPVLPQKDTAAGRI
ARAGFLATQRLSYIWTEHVPTASGIPLALVTPQDLPTIEWLIKFIAIVVGVIENFLGSAPATAVALWRDQFAKIRVDLLS
LENLYSDLTHDPNLQDPVAIAQAASIQAALIALLANVGVLSKDIISRLGEIVSNHDTRSEENFKALFSTFPLPDISAAYQ
RDDHFASLRVAGQNPVLIKRISGLPSKFPLTNAQFQQVMGPADNLVSAAAENRLYLLDYVDNGLLATSRAVAKPLTGIGY
SYAPIALFALPRGGASLVPVAIQCDQDPATNPLFLPADPSQESAYWAWQMAKTVVQCAEENYHEMFVHLARTHLVTGAIC
VATHRNLASTHPLYALLMPHFEGTLYINELAALTLLPPLMFIDTLFAAPIQQTQQMVASDRLAFDFYDHMLPNDIEMRGV
GAANLPDYPYRDDGLLIWNAIAEWAKAYVDVYYKSDQDVVDDYELRSWAADIIANGKVKGFRPVRSKAQLIDVLTMIIFT
ASAQHAAVNFSQSDFSTYAPALSALLSAPAPTSAVGKSKADWLKMLPPLVSGIERVAIYEILAGVQHSALGQYRSNVFPY
RPLITDPAITGSNGPLEHFRQALGDVESQINARNSIRKTPYEYLLPSRIPASTNI
>Mature_695_residues
MVNHKTGSNMNRRDLIKFLSFAASGTAFAGLVRSTLSSPAASSITASPRTLDAGIGISSPQAVRAAAPVLPQKDTAAGRI
ARAGFLATQRLSYIWTEHVPTASGIPLALVTPQDLPTIEWLIKFIAIVVGVIENFLGSAPATAVALWRDQFAKIRVDLLS
LENLYSDLTHDPNLQDPVAIAQAASIQAALIALLANVGVLSKDIISRLGEIVSNHDTRSEENFKALFSTFPLPDISAAYQ
RDDHFASLRVAGQNPVLIKRISGLPSKFPLTNAQFQQVMGPADNLVSAAAENRLYLLDYVDNGLLATSRAVAKPLTGIGY
SYAPIALFALPRGGASLVPVAIQCDQDPATNPLFLPADPSQESAYWAWQMAKTVVQCAEENYHEMFVHLARTHLVTGAIC
VATHRNLASTHPLYALLMPHFEGTLYINELAALTLLPPLMFIDTLFAAPIQQTQQMVASDRLAFDFYDHMLPNDIEMRGV
GAANLPDYPYRDDGLLIWNAIAEWAKAYVDVYYKSDQDVVDDYELRSWAADIIANGKVKGFRPVRSKAQLIDVLTMIIFT
ASAQHAAVNFSQSDFSTYAPALSALLSAPAPTSAVGKSKADWLKMLPPLVSGIERVAIYEILAGVQHSALGQYRSNVFPY
RPLITDPAITGSNGPLEHFRQALGDVESQINARNSIRKTPYEYLLPSRIPASTNI

Specific function: Converts arachidonic acid to 15S- hydroperoxyeicosatetraenoic acid (HpETE) which is rapidly reduced to hydroxyeicosatetraenoic acid (HETE). Could act on exogenous human-derived substrates to potentially modulate the local inflammatory responses during P.a

COG id: NA

COG function: NA

Gene ontology:

Cell location: Periplasm. Secreted, extracellular space. Note=Periplasmic with some activity further secreted to the extracellular milieu [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 lipoxygenase domain [H]

Homologues:

Organism=Homo sapiens, GI85067501, Length=493, Percent_Identity=32.657200811359, Blast_Score=221, Evalue=2e-57,
Organism=Homo sapiens, GI182765464, Length=551, Percent_Identity=30.8529945553539, Blast_Score=216, Evalue=5e-56,
Organism=Homo sapiens, GI260166612, Length=551, Percent_Identity=30.8529945553539, Blast_Score=216, Evalue=5e-56,
Organism=Homo sapiens, GI4502057, Length=467, Percent_Identity=32.5481798715203, Blast_Score=214, Evalue=3e-55,
Organism=Homo sapiens, GI4502053, Length=473, Percent_Identity=30.6553911205074, Blast_Score=196, Evalue=7e-50,
Organism=Homo sapiens, GI85067499, Length=493, Percent_Identity=31.0344827586207, Blast_Score=189, Evalue=1e-47,
Organism=Homo sapiens, GI154426292, Length=479, Percent_Identity=28.8100208768267, Blast_Score=167, Evalue=3e-41,
Organism=Homo sapiens, GI40316937, Length=482, Percent_Identity=28.8381742738589, Blast_Score=160, Evalue=5e-39,
Organism=Homo sapiens, GI85067503, Length=488, Percent_Identity=28.4836065573771, Blast_Score=146, Evalue=8e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000907
- InterPro:   IPR013819
- InterPro:   IPR020834
- InterPro:   IPR020833 [H]

Pfam domain/function: PF00305 Lipoxygenase [H]

EC number: =1.13.11.33 [H]

Molecular weight: Translated: 75474; Mature: 75474

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVNHKTGSNMNRRDLIKFLSFAASGTAFAGLVRSTLSSPAASSITASPRTLDAGIGISSP
CCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCEEECCCCCCCC
QAVRAAAPVLPQKDTAAGRIARAGFLATQRLSYIWTEHVPTASGIPLALVTPQDLPTIEW
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCHHHH
LIKFIAIVVGVIENFLGSAPATAVALWRDQFAKIRVDLLSLENLYSDLTHDPNLQDPVAI
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
AQAASIQAALIALLANVGVLSKDIISRLGEIVSNHDTRSEENFKALFSTFPLPDISAAYQ
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCHHHHH
RDDHFASLRVAGQNPVLIKRISGLPSKFPLTNAQFQQVMGPADNLVSAAAENRLYLLDYV
CCCCEEEEEECCCCCEEHHHHCCCCCCCCCCHHHHHHHHCCHHHHHHHHHCCCEEEEEEC
DNGLLATSRAVAKPLTGIGYSYAPIALFALPRGGASLVPVAIQCDQDPATNPLFLPADPS
CCCHHHHHHHHHCCHHHCCCCHHCEEEEEECCCCCCEEEEEEEECCCCCCCCEEECCCCC
QESAYWAWQMAKTVVQCAEENYHEMFVHLARTHLVTGAICVATHRNLASTHPLYALLMPH
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHC
FEGTLYINELAALTLLPPLMFIDTLFAAPIQQTQQMVASDRLAFDFYDHMLPNDIEMRGV
CCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCC
GAANLPDYPYRDDGLLIWNAIAEWAKAYVDVYYKSDQDVVDDYELRSWAADIIANGKVKG
CCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCC
FRPVRSKAQLIDVLTMIIFTASAQHAAVNFSQSDFSTYAPALSALLSAPAPTSAVGKSKA
CHHHHHHHHHHHHHHHHHHHCCCCHHEEECCCHHHHHHHHHHHHHHCCCCCCHHHCCCHH
DWLKMLPPLVSGIERVAIYEILAGVQHSALGQYRSNVFPYRPLITDPAITGSNGPLEHFR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHH
QALGDVESQINARNSIRKTPYEYLLPSRIPASTNI
HHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCC
>Mature Secondary Structure
MVNHKTGSNMNRRDLIKFLSFAASGTAFAGLVRSTLSSPAASSITASPRTLDAGIGISSP
CCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCEEECCCCCCCC
QAVRAAAPVLPQKDTAAGRIARAGFLATQRLSYIWTEHVPTASGIPLALVTPQDLPTIEW
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCHHHH
LIKFIAIVVGVIENFLGSAPATAVALWRDQFAKIRVDLLSLENLYSDLTHDPNLQDPVAI
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
AQAASIQAALIALLANVGVLSKDIISRLGEIVSNHDTRSEENFKALFSTFPLPDISAAYQ
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCHHHHH
RDDHFASLRVAGQNPVLIKRISGLPSKFPLTNAQFQQVMGPADNLVSAAAENRLYLLDYV
CCCCEEEEEECCCCCEEHHHHCCCCCCCCCCHHHHHHHHCCHHHHHHHHHCCCEEEEEEC
DNGLLATSRAVAKPLTGIGYSYAPIALFALPRGGASLVPVAIQCDQDPATNPLFLPADPS
CCCHHHHHHHHHCCHHHCCCCHHCEEEEEECCCCCCEEEEEEEECCCCCCCCEEECCCCC
QESAYWAWQMAKTVVQCAEENYHEMFVHLARTHLVTGAICVATHRNLASTHPLYALLMPH
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHC
FEGTLYINELAALTLLPPLMFIDTLFAAPIQQTQQMVASDRLAFDFYDHMLPNDIEMRGV
CCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCC
GAANLPDYPYRDDGLLIWNAIAEWAKAYVDVYYKSDQDVVDDYELRSWAADIIANGKVKG
CCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCC
FRPVRSKAQLIDVLTMIIFTASAQHAAVNFSQSDFSTYAPALSALLSAPAPTSAVGKSKA
CHHHHHHHHHHHHHHHHHHHCCCCHHEEECCCHHHHHHHHHHHHHHCCCCCCHHHCCCHH
DWLKMLPPLVSGIERVAIYEILAGVQHSALGQYRSNVFPYRPLITDPAITGSNGPLEHFR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHH
QALGDVESQINARNSIRKTPYEYLLPSRIPASTNI
HHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]