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The map label for this gene is pepA [H]

Identifier: 83718913

GI number: 83718913

Start: 937527

End: 939038

Strand: Direct

Name: pepA [H]

Synonym: BTH_I0823

Alternate gene names: 83718913

Gene position: 937527-939038 (Clockwise)

Preceding gene: 83718676

Following gene: 83721052

Centisome position: 24.61

GC content: 66.8

Gene sequence:

>1512_bases
ATGGACTTTAGCATAAAAGGCTGTGATTGGAGCAAAGGCTCGGCGAAGGGTTTCCTGACGGGGAAATCGGACTGCATCGT
GCTGGGCGTGTTCGAGGCGCAAACCTTGTCCGGCGCGGCGCTCGACATCGACGAAGCGGCGAAGGGCCTCGTCTCGCGCG
TGATCAAGGCGGGCGACATCGACGGCAAGCTCGGCAAGACCTTGTTTTTGCACGAGGTTTCGGGAATCGGCGCGTCGCGC
GTGCTGCTCGTCGGCCTGGGCAAGCAGGATGCTTTCAGCCAGAAAGCCTACAACGACGCGGTGAAGGCCGCCTGGCGCGC
GCTGCTCGGCACGAAAGTGGTCCAGGTCACCTTCACGCTCGCGCAGTTGCCCGTGCCCGAGCGCGCGTCCGACTGGGGCG
TGCGCGCGGCGATTCTCGCGCTGCGCAATGAGACGTACAAGTTCACGCAGATGAAGAGCAAGCCGGACGCGAGCGCGCCG
GCGCTCAAGCGCATCGTGTTCAGCGTCGATCCGGCCGACGAGAAGGCAGCGAAGATCGCCGCGAAGCAGGCGGTCGCGCT
CGCGAACGGGATGGACCTCACGCGCGACCTCGGCAATCTGCCGGGCAACGTCTGCACGCCGACCTACCTCGCGAACACCG
CGAAGAAGCTCGCGAAGGACTGGGGCCTGAAAGCCGACGTGCTCGGCCTCAAGCAGATCCAGGCGCTCAAGATGAGCTCG
TTCCTGTCGGTGGCGAAGGGCTCGGTCGAGCCGCCGCAGTTCATCGTGCTGCACTATCAGGGCGCGGCTGCGAAGGCGGC
GCCCGTCGTGCTCGTCGGCAAGGGCATCACGTTCGACTCGGGCGGCATTTCGCTGAAGCCGGGCGAGGGCATGGACGAGA
TGAAGTACGACATGTGCGGCGCGGGCTCGGTGCTCGGCACGATCCGCGCGGTCGCCGAAATGGGCCTGAAGATCAATGTC
GTCGCGATCGTGCCGACCTGCGAGAACATGCCGGCCGGCAACGCGAACAAGCCGGGCGATATCGTCACGAGCATGAAGGG
CCTGACGATCGAGGTGCTCAACACCGACGCGGAAGGCCGTCTCATCCTGTGCGACGCGCTCACGTACGCGGAGCGCTTCA
AGCCGGCCGCGGTGATCGACGTCGCGACGCTGACGGGCGCGTGCATCATCGCGCTCGGCCATCACAACACCGGCCTCTTC
TCGAAGGACGACGCGCTCGCGGGCGAACTGCTCGACGCGTCGCGCGAGGCGGGCGACCCGGCGTGGCGCCTGCCGCTCGA
CGACGAGTATCAGGATCAGCTGAAGTCGAACTTCGCGGATCTCGCGAACATCGGCGGACGCCCGGCCGGCAGCGTGACGG
CCGCGTGCTTCCTGTCGCGCTTCGCGGAAAACTATCCGTGGGCGCACCTCGACATCGCGGGCACCGCGTGGAAGAGTGGC
GCGGCGAAGGGGGCGACGGGCCGTCCCGTGCCGCTTCTCGCGCAATTCCTGATCGACCGCGCCGGCGCGTGA

Upstream 100 bases:

>100_bases
GAAACAGCGCACGAGTGGGGGGCGCTCACGCCGCACGGGAAAAATAGCGGATAATTGCGGCTTTCATCCTTAGCCCAGAT
TTTATCCGAGGACAAGCGCG

Downstream 100 bases:

>100_bases
TGGCGCAAGGTTCGGCAAACGGCGCGGCAGGGCGCGGCGAGCGATGACGCGGATCGATTTCCATACGAACGTCGGCGATT
CGCTCGCATACGCGTGCCGG

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 503; Mature: 503

Protein sequence:

>503_residues
MDFSIKGCDWSKGSAKGFLTGKSDCIVLGVFEAQTLSGAALDIDEAAKGLVSRVIKAGDIDGKLGKTLFLHEVSGIGASR
VLLVGLGKQDAFSQKAYNDAVKAAWRALLGTKVVQVTFTLAQLPVPERASDWGVRAAILALRNETYKFTQMKSKPDASAP
ALKRIVFSVDPADEKAAKIAAKQAVALANGMDLTRDLGNLPGNVCTPTYLANTAKKLAKDWGLKADVLGLKQIQALKMSS
FLSVAKGSVEPPQFIVLHYQGAAAKAAPVVLVGKGITFDSGGISLKPGEGMDEMKYDMCGAGSVLGTIRAVAEMGLKINV
VAIVPTCENMPAGNANKPGDIVTSMKGLTIEVLNTDAEGRLILCDALTYAERFKPAAVIDVATLTGACIIALGHHNTGLF
SKDDALAGELLDASREAGDPAWRLPLDDEYQDQLKSNFADLANIGGRPAGSVTAACFLSRFAENYPWAHLDIAGTAWKSG
AAKGATGRPVPLLAQFLIDRAGA

Sequences:

>Translated_503_residues
MDFSIKGCDWSKGSAKGFLTGKSDCIVLGVFEAQTLSGAALDIDEAAKGLVSRVIKAGDIDGKLGKTLFLHEVSGIGASR
VLLVGLGKQDAFSQKAYNDAVKAAWRALLGTKVVQVTFTLAQLPVPERASDWGVRAAILALRNETYKFTQMKSKPDASAP
ALKRIVFSVDPADEKAAKIAAKQAVALANGMDLTRDLGNLPGNVCTPTYLANTAKKLAKDWGLKADVLGLKQIQALKMSS
FLSVAKGSVEPPQFIVLHYQGAAAKAAPVVLVGKGITFDSGGISLKPGEGMDEMKYDMCGAGSVLGTIRAVAEMGLKINV
VAIVPTCENMPAGNANKPGDIVTSMKGLTIEVLNTDAEGRLILCDALTYAERFKPAAVIDVATLTGACIIALGHHNTGLF
SKDDALAGELLDASREAGDPAWRLPLDDEYQDQLKSNFADLANIGGRPAGSVTAACFLSRFAENYPWAHLDIAGTAWKSG
AAKGATGRPVPLLAQFLIDRAGA
>Mature_503_residues
MDFSIKGCDWSKGSAKGFLTGKSDCIVLGVFEAQTLSGAALDIDEAAKGLVSRVIKAGDIDGKLGKTLFLHEVSGIGASR
VLLVGLGKQDAFSQKAYNDAVKAAWRALLGTKVVQVTFTLAQLPVPERASDWGVRAAILALRNETYKFTQMKSKPDASAP
ALKRIVFSVDPADEKAAKIAAKQAVALANGMDLTRDLGNLPGNVCTPTYLANTAKKLAKDWGLKADVLGLKQIQALKMSS
FLSVAKGSVEPPQFIVLHYQGAAAKAAPVVLVGKGITFDSGGISLKPGEGMDEMKYDMCGAGSVLGTIRAVAEMGLKINV
VAIVPTCENMPAGNANKPGDIVTSMKGLTIEVLNTDAEGRLILCDALTYAERFKPAAVIDVATLTGACIIALGHHNTGLF
SKDDALAGELLDASREAGDPAWRLPLDDEYQDQLKSNFADLANIGGRPAGSVTAACFLSRFAENYPWAHLDIAGTAWKSG
AAKGATGRPVPLLAQFLIDRAGA

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=494, Percent_Identity=38.8663967611336, Blast_Score=278, Evalue=6e-75,
Organism=Homo sapiens, GI47155554, Length=329, Percent_Identity=32.2188449848024, Blast_Score=128, Evalue=1e-29,
Organism=Escherichia coli, GI1790710, Length=506, Percent_Identity=50.395256916996, Blast_Score=513, Evalue=1e-147,
Organism=Escherichia coli, GI87082123, Length=319, Percent_Identity=42.6332288401254, Blast_Score=213, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI17556903, Length=314, Percent_Identity=33.7579617834395, Blast_Score=144, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17565172, Length=249, Percent_Identity=30.1204819277108, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI20129969, Length=521, Percent_Identity=31.0940499040307, Blast_Score=217, Evalue=2e-56,
Organism=Drosophila melanogaster, GI24662227, Length=510, Percent_Identity=30.9803921568627, Blast_Score=212, Evalue=5e-55,
Organism=Drosophila melanogaster, GI21355725, Length=345, Percent_Identity=35.6521739130435, Blast_Score=209, Evalue=3e-54,
Organism=Drosophila melanogaster, GI24661038, Length=351, Percent_Identity=35.042735042735, Blast_Score=209, Evalue=4e-54,
Organism=Drosophila melanogaster, GI161077148, Length=503, Percent_Identity=31.013916500994, Blast_Score=204, Evalue=9e-53,
Organism=Drosophila melanogaster, GI20130057, Length=503, Percent_Identity=31.013916500994, Blast_Score=204, Evalue=9e-53,
Organism=Drosophila melanogaster, GI21355645, Length=490, Percent_Identity=31.4285714285714, Blast_Score=204, Evalue=1e-52,
Organism=Drosophila melanogaster, GI24662223, Length=490, Percent_Identity=31.4285714285714, Blast_Score=204, Evalue=1e-52,
Organism=Drosophila melanogaster, GI20129963, Length=503, Percent_Identity=29.6222664015905, Blast_Score=188, Evalue=6e-48,
Organism=Drosophila melanogaster, GI19922386, Length=482, Percent_Identity=30.7053941908714, Blast_Score=185, Evalue=5e-47,
Organism=Drosophila melanogaster, GI221379063, Length=312, Percent_Identity=31.7307692307692, Blast_Score=136, Evalue=3e-32,
Organism=Drosophila melanogaster, GI221379062, Length=312, Percent_Identity=31.7307692307692, Blast_Score=136, Evalue=3e-32,
Organism=Drosophila melanogaster, GI21357381, Length=312, Percent_Identity=31.7307692307692, Blast_Score=136, Evalue=3e-32,
Organism=Drosophila melanogaster, GI24646701, Length=311, Percent_Identity=27.0096463022508, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24646703, Length=311, Percent_Identity=27.0096463022508, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI21358201, Length=311, Percent_Identity=27.0096463022508, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 52731; Mature: 52731

Theoretical pI: Translated: 8.19; Mature: 8.19

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFSIKGCDWSKGSAKGFLTGKSDCIVLGVFEAQTLSGAALDIDEAAKGLVSRVIKAGDI
CCCCCCCCCCCCCCCCEEEECCCCEEEEEEEECCCCCCCEECHHHHHHHHHHHHHHCCCC
DGKLGKTLFLHEVSGIGASRVLLVGLGKQDAFSQKAYNDAVKAAWRALLGTKVVQVTFTL
CCCCCCEEEEEECCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCHHEEEEEHH
AQLPVPERASDWGVRAAILALRNETYKFTQMKSKPDASAPALKRIVFSVDPADEKAAKIA
HHCCCCCCCCCCCHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHEEECCCCHHHHHHHH
AKQAVALANGMDLTRDLGNLPGNVCTPTYLANTAKKLAKDWGLKADVLGLKQIQALKMSS
HHHHHHHHCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
FLSVAKGSVEPPQFIVLHYQGAAAKAAPVVLVGKGITFDSGGISLKPGEGMDEMKYDMCG
HHHHHCCCCCCCEEEEEEECCCCCCCCCEEEEECCEEECCCCEEECCCCCHHHHHHHHCC
AGSVLGTIRAVAEMGLKINVVAIVPTCENMPAGNANKPGDIVTSMKGLTIEVLNTDAEGR
CCHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCCCCCCCHHHHHCCCCEEEEEECCCCCC
LILCDALTYAERFKPAAVIDVATLTGACIIALGHHNTGLFSKDDALAGELLDASREAGDP
EEEEEHHHHHHHCCCCCEEEHHHHCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCC
AWRLPLDDEYQDQLKSNFADLANIGGRPAGSVTAACFLSRFAENYPWAHLDIAGTAWKSG
EEECCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCC
AAKGATGRPVPLLAQFLIDRAGA
CCCCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MDFSIKGCDWSKGSAKGFLTGKSDCIVLGVFEAQTLSGAALDIDEAAKGLVSRVIKAGDI
CCCCCCCCCCCCCCCCEEEECCCCEEEEEEEECCCCCCCEECHHHHHHHHHHHHHHCCCC
DGKLGKTLFLHEVSGIGASRVLLVGLGKQDAFSQKAYNDAVKAAWRALLGTKVVQVTFTL
CCCCCCEEEEEECCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCHHEEEEEHH
AQLPVPERASDWGVRAAILALRNETYKFTQMKSKPDASAPALKRIVFSVDPADEKAAKIA
HHCCCCCCCCCCCHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHEEECCCCHHHHHHHH
AKQAVALANGMDLTRDLGNLPGNVCTPTYLANTAKKLAKDWGLKADVLGLKQIQALKMSS
HHHHHHHHCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
FLSVAKGSVEPPQFIVLHYQGAAAKAAPVVLVGKGITFDSGGISLKPGEGMDEMKYDMCG
HHHHHCCCCCCCEEEEEEECCCCCCCCCEEEEECCEEECCCCEEECCCCCHHHHHHHHCC
AGSVLGTIRAVAEMGLKINVVAIVPTCENMPAGNANKPGDIVTSMKGLTIEVLNTDAEGR
CCHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCCCCCCCHHHHHCCCCEEEEEECCCCCC
LILCDALTYAERFKPAAVIDVATLTGACIIALGHHNTGLFSKDDALAGELLDASREAGDP
EEEEEHHHHHHHCCCCCEEEHHHHCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCC
AWRLPLDDEYQDQLKSNFADLANIGGRPAGSVTAACFLSRFAENYPWAHLDIAGTAWKSG
EEECCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCC
AAKGATGRPVPLLAQFLIDRAGA
CCCCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA