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The map label for this gene is aphA [H]

Identifier: 83718534

GI number: 83718534

Start: 1069730

End: 1070752

Strand: Direct

Name: aphA [H]

Synonym: BTH_I0946

Alternate gene names: 83718534

Gene position: 1069730-1070752 (Clockwise)

Preceding gene: 83720004

Following gene: 83721335

Centisome position: 28.08

GC content: 69.4

Gene sequence:

>1023_bases
ATGCTGACGTACTTCCATCCCGACCAATCGCTGCATCATCCGCGCACGTACTTTTCGCGCGGCAGGATGCGCACGCCGCA
GGAGGTGCCCGAGCGCGCGGCGCAACTCGTCGCGGCCGCGCTCGCGATGGGTTTTTCCGTGCGCGAGCCGGACGACTTCG
GCATCGCGCCGATCGCGGCCGTGCACGACATGAGCTACCTGCGCTTTCTCGAGACCGTGCATCGCGAATGGAAGAAGATG
CCGCAGGACTGGGGCGATGAAGCGATGTTGAACATCTTCGTGCGAGCGCCGAACGCGCTGCGCGGCATGCTTGCGCAAGC
CGCCCGCCATCTCGCGGACGGCAGTCGCCCGGCCGGCGAGCACACGTGGCGGGCCGCGTACGGGTCCGCGCAGAGCGCGC
TCGCCGCGGCGGCGGTGCGCGACGGCGCGCCCGAAGCGTACGCGCTGTGCCGGTCGCCGGGCCACCATGCGCGCGCGGAC
GCCGCGGGCGGGTTCTGCTATCTGAACAACGCGGCGATCGCTGCGCAGGCGCTGCGCGCGCGCCACGCACGCGTCGCGAT
CCTCGACGCCGACATGCACCACGGGCAGGGTATCCAGGAGATCTTCTACGCGCGGCGCGACGTGCCGTACGTGTCGATCC
ACGGCGATCCGACGAACTTCTATCCGGCCGTGGCGGGCTTCGACGACGAGCGCGGCTCGGGCGACGGCTACGGCTACAAC
GTGAATCTGCCGATGCCGCACGGCTCGGGCGAGGCGGCGTTCTTCGAGCGCGCCGACGATGCACTGCGCGAACTGCGGCG
CTTCGCGCCGGATGCGCTTGTGCTGTCGTTCGGCTTCGGCATTTATCGCGACGATCCGCAATCGCAGGTTGCTGTGACGA
CGCCGGGTTTCGGCCGGTTAGGCAACCTGATCGGCGCGCTGCGGCTGCCGACCGTGATCGTGCAGGAGGGCGGCTATCAC
ATCGAGCGCCTCGAGGCGAACGCGCGGTCGTTCTTCGACGGATTCGGCGCGATGGGCGCTTGA

Upstream 100 bases:

>100_bases
GAGTGCCGAACGCCGAACGCCGAACGCCGAATGCGGCCCGCCCCCCACAAACCGATAACGGGCGACCCGCTCTCCGCCCA
TGCGACCCGAGGAAATCGAG

Downstream 100 bases:

>100_bases
TGCGGCGTCGAGACGCACGCAGCCGAAGGCGTGCGGCCGGCAACGTGCGTTCGGCGCGACATGCGTTGTGGCGACGCGCA
TCGAGCTGCGCATGCGAAGC

Product: acetylpolyamine aminohydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 340; Mature: 340

Protein sequence:

>340_residues
MLTYFHPDQSLHHPRTYFSRGRMRTPQEVPERAAQLVAAALAMGFSVREPDDFGIAPIAAVHDMSYLRFLETVHREWKKM
PQDWGDEAMLNIFVRAPNALRGMLAQAARHLADGSRPAGEHTWRAAYGSAQSALAAAAVRDGAPEAYALCRSPGHHARAD
AAGGFCYLNNAAIAAQALRARHARVAILDADMHHGQGIQEIFYARRDVPYVSIHGDPTNFYPAVAGFDDERGSGDGYGYN
VNLPMPHGSGEAAFFERADDALRELRRFAPDALVLSFGFGIYRDDPQSQVAVTTPGFGRLGNLIGALRLPTVIVQEGGYH
IERLEANARSFFDGFGAMGA

Sequences:

>Translated_340_residues
MLTYFHPDQSLHHPRTYFSRGRMRTPQEVPERAAQLVAAALAMGFSVREPDDFGIAPIAAVHDMSYLRFLETVHREWKKM
PQDWGDEAMLNIFVRAPNALRGMLAQAARHLADGSRPAGEHTWRAAYGSAQSALAAAAVRDGAPEAYALCRSPGHHARAD
AAGGFCYLNNAAIAAQALRARHARVAILDADMHHGQGIQEIFYARRDVPYVSIHGDPTNFYPAVAGFDDERGSGDGYGYN
VNLPMPHGSGEAAFFERADDALRELRRFAPDALVLSFGFGIYRDDPQSQVAVTTPGFGRLGNLIGALRLPTVIVQEGGYH
IERLEANARSFFDGFGAMGA
>Mature_340_residues
MLTYFHPDQSLHHPRTYFSRGRMRTPQEVPERAAQLVAAALAMGFSVREPDDFGIAPIAAVHDMSYLRFLETVHREWKKM
PQDWGDEAMLNIFVRAPNALRGMLAQAARHLADGSRPAGEHTWRAAYGSAQSALAAAAVRDGAPEAYALCRSPGHHARAD
AAGGFCYLNNAAIAAQALRARHARVAILDADMHHGQGIQEIFYARRDVPYVSIHGDPTNFYPAVAGFDDERGSGDGYGYN
VNLPMPHGSGEAAFFERADDALRELRRFAPDALVLSFGFGIYRDDPQSQVAVTTPGFGRLGNLIGALRLPTVIVQEGGYH
IERLEANARSFFDGFGAMGA

Specific function: Acts on many types of acetylpolyamines has high affinity towards acetylputrescine, acetylcadaverine, acetylspermidine, and acetylspermine [H]

COG id: COG0123

COG function: function code BQ; Deacetylases, including yeast histone deacetylase and acetoin utilization protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histone deacetylase family [H]

Homologues:

Organism=Homo sapiens, GI8923769, Length=299, Percent_Identity=28.4280936454849, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI20070354, Length=218, Percent_Identity=37.6146788990826, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI262073088, Length=206, Percent_Identity=31.5533980582524, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI17158039, Length=203, Percent_Identity=33.4975369458128, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI30795204, Length=201, Percent_Identity=33.3333333333333, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI30795202, Length=201, Percent_Identity=33.3333333333333, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI153085395, Length=161, Percent_Identity=36.0248447204969, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI148539870, Length=224, Percent_Identity=34.8214285714286, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI169234807, Length=176, Percent_Identity=37.5, Blast_Score=95, Evalue=8e-20,
Organism=Homo sapiens, GI13128864, Length=199, Percent_Identity=33.1658291457286, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI13128860, Length=312, Percent_Identity=23.3974358974359, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI226529806, Length=221, Percent_Identity=34.841628959276, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI262073092, Length=236, Percent_Identity=27.5423728813559, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI13128862, Length=171, Percent_Identity=28.6549707602339, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI62750349, Length=199, Percent_Identity=33.6683417085427, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI62750347, Length=199, Percent_Identity=33.6683417085427, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI293336691, Length=125, Percent_Identity=34.4, Blast_Score=76, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17540334, Length=222, Percent_Identity=36.4864864864865, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17540332, Length=222, Percent_Identity=36.4864864864865, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI193206283, Length=222, Percent_Identity=36.4864864864865, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17508561, Length=310, Percent_Identity=26.1290322580645, Blast_Score=98, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17561978, Length=247, Percent_Identity=28.3400809716599, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI193209491, Length=217, Percent_Identity=31.3364055299539, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17537347, Length=216, Percent_Identity=31.9444444444444, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17534739, Length=171, Percent_Identity=28.0701754385965, Blast_Score=78, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI25154022, Length=193, Percent_Identity=27.979274611399, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI25154020, Length=193, Percent_Identity=27.979274611399, Blast_Score=68, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6324307, Length=206, Percent_Identity=36.8932038834951, Blast_Score=115, Evalue=7e-27,
Organism=Saccharomyces cerevisiae, GI6323999, Length=171, Percent_Identity=29.8245614035088, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6321244, Length=168, Percent_Identity=27.9761904761905, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6325325, Length=148, Percent_Identity=28.3783783783784, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI281360799, Length=178, Percent_Identity=39.8876404494382, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI281360801, Length=178, Percent_Identity=39.8876404494382, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24641720, Length=178, Percent_Identity=39.8876404494382, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24642144, Length=181, Percent_Identity=38.121546961326, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24642142, Length=181, Percent_Identity=38.121546961326, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24642146, Length=181, Percent_Identity=38.121546961326, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI281360899, Length=181, Percent_Identity=38.121546961326, Blast_Score=95, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24644244, Length=171, Percent_Identity=32.1637426900585, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24657891, Length=312, Percent_Identity=24.6794871794872, Blast_Score=91, Evalue=8e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000286 [H]

Pfam domain/function: PF00850 Hist_deacetyl [H]

EC number: NA

Molecular weight: Translated: 37137; Mature: 37137

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTYFHPDQSLHHPRTYFSRGRMRTPQEVPERAAQLVAAALAMGFSVREPDDFGIAPIAA
CCEEECCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHH
VHDMSYLRFLETVHREWKKMPQDWGDEAMLNIFVRAPNALRGMLAQAARHLADGSRPAGE
HHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHCCCCCCCC
HTWRAAYGSAQSALAAAAVRDGAPEAYALCRSPGHHARADAAGGFCYLNNAAIAAQALRA
CHHHHHHCCHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCCCCEEEECCHHHHHHHHHH
RHARVAILDADMHHGQGIQEIFYARRDVPYVSIHGDPTNFYPAVAGFDDERGSGDGYGYN
HCCEEEEEECCCCCCCCHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCEEE
VNLPMPHGSGEAAFFERADDALRELRRFAPDALVLSFGFGIYRDDPQSQVAVTTPGFGRL
EEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEHHHCCCEECCCCCCCEEEECCCHHHH
GNLIGALRLPTVIVQEGGYHIERLEANARSFFDGFGAMGA
HHHHHHHHCCEEEEECCCCEEEHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MLTYFHPDQSLHHPRTYFSRGRMRTPQEVPERAAQLVAAALAMGFSVREPDDFGIAPIAA
CCEEECCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHH
VHDMSYLRFLETVHREWKKMPQDWGDEAMLNIFVRAPNALRGMLAQAARHLADGSRPAGE
HHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHCCCCCCCC
HTWRAAYGSAQSALAAAAVRDGAPEAYALCRSPGHHARADAAGGFCYLNNAAIAAQALRA
CHHHHHHCCHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCCCCEEEECCHHHHHHHHHH
RHARVAILDADMHHGQGIQEIFYARRDVPYVSIHGDPTNFYPAVAGFDDERGSGDGYGYN
HCCEEEEEECCCCCCCCHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCEEE
VNLPMPHGSGEAAFFERADDALRELRRFAPDALVLSFGFGIYRDDPQSQVAVTTPGFGRL
EEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEHHHCCCEECCCCCCCEEEECCCHHHH
GNLIGALRLPTVIVQEGGYHIERLEANARSFFDGFGAMGA
HHHHHHHHCCEEEEECCCCEEEHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8824626; 3207420 [H]