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The map label for this gene is arpR [H]

Identifier: 83718398

GI number: 83718398

Start: 778719

End: 779354

Strand: Reverse

Name: arpR [H]

Synonym: BTH_I0679

Alternate gene names: 83718398

Gene position: 779354-778719 (Counterclockwise)

Preceding gene: 83719943

Following gene: 83719526

Centisome position: 20.46

GC content: 67.77

Gene sequence:

>636_bases
ATGGCCAGACGCACGAAGGAGGAAGCGCTCGCGACGCGCGACCGCATCCTCGACGCCGCCGAGCACGTCTTCTTCGAGAA
AGGCGTGTCGCACACGTCGCTCGCCGACATCGCCCAGCACGCGGGCGTCACGCGCGGCGCGATCTATTGGCATTTCGCGA
GCAAGAGCGAACTCTTCGACGCGATGTTCGACCGCGTGCTGCTGCCGATCGACGAGCTGAAGGCCGGCACGGGCGAGCCG
CACGCGGATCCGCTCGGCCGGGTCCGCGAGATCCTGATCTGGTGCCTGCTCGGCGCGGCGCGCGATCCGCAGTTGCGGCG
CGTGTTCAGCATCCTGTTCATGAAGTGCGAGTACGTCGCGGACATGGGGCCGCTCCTGCAGCGCAACCGCGAAGGCATGC
GCGACGCGCTGCGCAACATCGAAGCGGATCTCGCCCAGGGCGTCGCGAACGGCCAGTTGCCGGCCGATCTCGACACGTGG
CGCGCGACGCTGATGCTGCATACGCTCGTGAGCGGCTTCGTGCGCGACATGCTGATGCTGCCGGGCGAGATCGATGCGGA
GCGGCATGCGGAAAAGCTCGTCGACGGCTGCTTCGACATGCTGCGCACGAGCCCCGCGATGCACAAGGACGGCTGA

Upstream 100 bases:

>100_bases
TACGGCACGTAAGCAAAAAGGGCGTCCGTTGGACGACGCCTGCGATGCAACCCTTATTATTCACGCAATGACCCCGATCT
TGCACACGATGAGCTGTTGA

Downstream 100 bases:

>100_bases
GCGCGGCGCAACGATGCGCGCGGCGGCGCACGGAGCGCCCGCGTGCGCGGCAATCCGGCAGGAAGGAATGCAAAAAAGAA
GGAGGGAAGCGCGGCACCCG

Product: TetR family transcriptional regulator

Products: NA

Alternate protein names: Antibiotic efflux pump ArpABC operon regulator [H]

Number of amino acids: Translated: 211; Mature: 210

Protein sequence:

>211_residues
MARRTKEEALATRDRILDAAEHVFFEKGVSHTSLADIAQHAGVTRGAIYWHFASKSELFDAMFDRVLLPIDELKAGTGEP
HADPLGRVREILIWCLLGAARDPQLRRVFSILFMKCEYVADMGPLLQRNREGMRDALRNIEADLAQGVANGQLPADLDTW
RATLMLHTLVSGFVRDMLMLPGEIDAERHAEKLVDGCFDMLRTSPAMHKDG

Sequences:

>Translated_211_residues
MARRTKEEALATRDRILDAAEHVFFEKGVSHTSLADIAQHAGVTRGAIYWHFASKSELFDAMFDRVLLPIDELKAGTGEP
HADPLGRVREILIWCLLGAARDPQLRRVFSILFMKCEYVADMGPLLQRNREGMRDALRNIEADLAQGVANGQLPADLDTW
RATLMLHTLVSGFVRDMLMLPGEIDAERHAEKLVDGCFDMLRTSPAMHKDG
>Mature_210_residues
ARRTKEEALATRDRILDAAEHVFFEKGVSHTSLADIAQHAGVTRGAIYWHFASKSELFDAMFDRVLLPIDELKAGTGEPH
ADPLGRVREILIWCLLGAARDPQLRRVFSILFMKCEYVADMGPLLQRNREGMRDALRNIEADLAQGVANGQLPADLDTWR
ATLMLHTLVSGFVRDMLMLPGEIDAERHAEKLVDGCFDMLRTSPAMHKDG

Specific function: Probable regulatory protein for the antibiotic efflux pump arpABC operon. May function as a repressor [H]

COG id: COG1309

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786669, Length=208, Percent_Identity=38.4615384615385, Blast_Score=138, Evalue=2e-34,
Organism=Escherichia coli, GI1789664, Length=209, Percent_Identity=35.8851674641148, Blast_Score=102, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR015893
- InterPro:   IPR011075
- InterPro:   IPR013572
- InterPro:   IPR001647 [H]

Pfam domain/function: PF08361 TetR_C_2; PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 23654; Mature: 23522

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: PS01081 HTH_TETR_1 ; PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARRTKEEALATRDRILDAAEHVFFEKGVSHTSLADIAQHAGVTRGAIYWHFASKSELFD
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCEEEEECCHHHHHH
AMFDRVLLPIDELKAGTGEPHADPLGRVREILIWCLLGAARDPQLRRVFSILFMKCEYVA
HHHHHHHCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
DMGPLLQRNREGMRDALRNIEADLAQGVANGQLPADLDTWRATLMLHTLVSGFVRDMLML
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
PGEIDAERHAEKLVDGCFDMLRTSPAMHKDG
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
ARRTKEEALATRDRILDAAEHVFFEKGVSHTSLADIAQHAGVTRGAIYWHFASKSELFD
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCEEEEECCHHHHHH
AMFDRVLLPIDELKAGTGEPHADPLGRVREILIWCLLGAARDPQLRRVFSILFMKCEYVA
HHHHHHHCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
DMGPLLQRNREGMRDALRNIEADLAQGVANGQLPADLDTWRATLMLHTLVSGFVRDMLML
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
PGEIDAERHAEKLVDGCFDMLRTSPAMHKDG
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11160799 [H]