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The map label for this gene is ald [H]

Identifier: 83595015

GI number: 83595015

Start: 4233317

End: 4234435

Strand: Direct

Name: ald [H]

Synonym: Rru_A3686

Alternate gene names: 83595015

Gene position: 4233317-4234435 (Clockwise)

Preceding gene: 83595012

Following gene: 83595023

Centisome position: 97.25

GC content: 68.36

Gene sequence:

>1119_bases
ATGCGTATCGGTGTTCCCAAGGAAATCAAGAATCACGAATACCGGGTCGGCCTGACCCCCAATAGCGTTCATGAATTCGT
CGACCACGGTCACGCCGTGGTGGTGGAAAGCGGCGCTGGCCTGGGCATCGGCTCGACCGACGCCGATTACATCAAGGCCG
GCGCCACCATCGCTGCGACGGCGGCCGAGGTGTTCGCCGGCGCCGAGATGGTGATCAAGGTCAAGGAGCCCCAGGCGGTT
GAATGCGCCATGCTGCGCCCCGGCCAGATCCTTTACACCTATCTGCACCTCGCCCCCGATCCCGAGCAGACCCGCGCCCT
GATCGCCTCGGGCGCCACCTGCATCGCCTATGAGACGGTGACCGACGCCAAGGGCGGCCTGCCGCTGCTGGCGCCGATGT
CCCAGGTGGCCGGTCGCATGGCGATCCAGGCCGGCGCCCATTGCCTGGAAAAGGCCCATGGCGGCGAAGGCGTGCTGTTG
GGCGGCGTGCCCGGGGTCGCCCCGGCCAAGGTGGCGATCATCGGCGGCGGCGTGGTCGGCGAGAACGCCGCGCAGATCGC
CCTGGGCATCGGCGCCGAGGTCACGGTGCTTGATCGCTCGCTCGACGCCCTCGCCCGGCTGTCGGCGCGCTTTGGCGCCG
GCCTCAAGACCGTCTATTCAACCCGGGCGGCGCTGGAGCAAACGGTGCTCGAGTCCGATCTGGTGATCGGCGCGGTGCTG
GTGAAGGGCGCCGCTACCCCCAAGCTGGTGACTCGCGCCATGCTGGGCCGCATGCGCCCCGGCGCGGTGCTGGTCGATGT
GGCGATCGATCAGGGCGGCTGCTTCGAGACATCAAAGGCGACCACCCACGACGCGCCGACCTATGTCGTCGATGGCGTGG
TTCATTACTGCGTGGCCAATATGCCCGGCGCCGTCGCCCGCACCTCGACCTATGCGCTCACCAACGCCACCCTGCCCTAT
GGTCTGGCGATCGCCACCAAGGGCTGGAAGGCGGCGCTGGCCGATGATCCCGGCTTGCTCGAAGGGCTGAACGTCCACGC
CGGCAAGGTCACCTGCGCCCCGGTCGCCGCCGAATTGGGTTATGAGCACACCCCGGCGGCGTCGGTGCTGGGCGCGTAA

Upstream 100 bases:

>100_bases
TAGGCCCTGGTCGTTTCGCAAGCACATTTCACCGAATCCGGCGCAGAGTTTTGATCTCTCGTCACCATCCCCCGCCGCGC
GGGCCTTGAAGGATTGTCGC

Downstream 100 bases:

>100_bases
CCCGGCTAAGATCCGGGCGGGGGGATGGGCGCGCCTGGGACGGCGGCCCTCAGGGCGTTTTGCCGGGCGCCGTTTGGTCA
AGCGCCACGTCCATCCCCCG

Product: L-alanine dehydrogenase

Products: NA

Alternate protein names: 40 kDa antigen; TB43 [H]

Number of amino acids: Translated: 372; Mature: 372

Protein sequence:

>372_residues
MRIGVPKEIKNHEYRVGLTPNSVHEFVDHGHAVVVESGAGLGIGSTDADYIKAGATIAATAAEVFAGAEMVIKVKEPQAV
ECAMLRPGQILYTYLHLAPDPEQTRALIASGATCIAYETVTDAKGGLPLLAPMSQVAGRMAIQAGAHCLEKAHGGEGVLL
GGVPGVAPAKVAIIGGGVVGENAAQIALGIGAEVTVLDRSLDALARLSARFGAGLKTVYSTRAALEQTVLESDLVIGAVL
VKGAATPKLVTRAMLGRMRPGAVLVDVAIDQGGCFETSKATTHDAPTYVVDGVVHYCVANMPGAVARTSTYALTNATLPY
GLAIATKGWKAALADDPGLLEGLNVHAGKVTCAPVAAELGYEHTPAASVLGA

Sequences:

>Translated_372_residues
MRIGVPKEIKNHEYRVGLTPNSVHEFVDHGHAVVVESGAGLGIGSTDADYIKAGATIAATAAEVFAGAEMVIKVKEPQAV
ECAMLRPGQILYTYLHLAPDPEQTRALIASGATCIAYETVTDAKGGLPLLAPMSQVAGRMAIQAGAHCLEKAHGGEGVLL
GGVPGVAPAKVAIIGGGVVGENAAQIALGIGAEVTVLDRSLDALARLSARFGAGLKTVYSTRAALEQTVLESDLVIGAVL
VKGAATPKLVTRAMLGRMRPGAVLVDVAIDQGGCFETSKATTHDAPTYVVDGVVHYCVANMPGAVARTSTYALTNATLPY
GLAIATKGWKAALADDPGLLEGLNVHAGKVTCAPVAAELGYEHTPAASVLGA
>Mature_372_residues
MRIGVPKEIKNHEYRVGLTPNSVHEFVDHGHAVVVESGAGLGIGSTDADYIKAGATIAATAAEVFAGAEMVIKVKEPQAV
ECAMLRPGQILYTYLHLAPDPEQTRALIASGATCIAYETVTDAKGGLPLLAPMSQVAGRMAIQAGAHCLEKAHGGEGVLL
GGVPGVAPAKVAIIGGGVVGENAAQIALGIGAEVTVLDRSLDALARLSARFGAGLKTVYSTRAALEQTVLESDLVIGAVL
VKGAATPKLVTRAMLGRMRPGAVLVDVAIDQGGCFETSKATTHDAPTYVVDGVVHYCVANMPGAVARTSTYALTNATLPY
GLAIATKGWKAALADDPGLLEGLNVHAGKVTCAPVAAELGYEHTPAASVLGA

Specific function: May play a role in cell wall synthesis as L-alanine is an important constituent of the peptidoglycan layer [H]

COG id: COG0686

COG function: function code E; Alanine dehydrogenase

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=343, Percent_Identity=29.7376093294461, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI122939153, Length=343, Percent_Identity=29.7376093294461, Blast_Score=123, Evalue=3e-28,
Organism=Escherichia coli, GI1787887, Length=298, Percent_Identity=32.5503355704698, Blast_Score=124, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17550456, Length=341, Percent_Identity=29.6187683284457, Blast_Score=119, Evalue=3e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR008143
- InterPro:   IPR007886
- InterPro:   IPR008141 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.4.1.1 [H]

Molecular weight: Translated: 37881; Mature: 37881

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS00837 ALADH_PNT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIGVPKEIKNHEYRVGLTPNSVHEFVDHGHAVVVESGAGLGIGSTDADYIKAGATIAAT
CCCCCCCHHCCCCEEEECCHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHCCCCHHHH
AAEVFAGAEMVIKVKEPQAVECAMLRPGQILYTYLHLAPDPEQTRALIASGATCIAYETV
HHHHHCCCEEEEEECCCCCEEEEECCCCCEEEEEEEECCCHHHHHHHHHCCCEEEEEEEE
TDAKGGLPLLAPMSQVAGRMAIQAGAHCLEKAHGGEGVLLGGVPGVAPAKVAIIGGGVVG
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCEEEEEECCEEC
ENAAQIALGIGAEVTVLDRSLDALARLSARFGAGLKTVYSTRAALEQTVLESDLVIGAVL
CCCEEEEEECCCEEEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHEEHHH
VKGAATPKLVTRAMLGRMRPGAVLVDVAIDQGGCFETSKATTHDAPTYVVDGVVHYCVAN
HCCCCCHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHC
MPGAVARTSTYALTNATLPYGLAIATKGWKAALADDPGLLEGLNVHAGKVTCAPVAAELG
CCCCHHCCCEEEEECCCCCCEEEEECCCCEEECCCCCCCCCCCCCCCCEEEEHHHHHHCC
YEHTPAASVLGA
CCCCCHHHHCCC
>Mature Secondary Structure
MRIGVPKEIKNHEYRVGLTPNSVHEFVDHGHAVVVESGAGLGIGSTDADYIKAGATIAAT
CCCCCCCHHCCCCEEEECCHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHCCCCHHHH
AAEVFAGAEMVIKVKEPQAVECAMLRPGQILYTYLHLAPDPEQTRALIASGATCIAYETV
HHHHHCCCEEEEEECCCCCEEEEECCCCCEEEEEEEECCCHHHHHHHHHCCCEEEEEEEE
TDAKGGLPLLAPMSQVAGRMAIQAGAHCLEKAHGGEGVLLGGVPGVAPAKVAIIGGGVVG
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCEEEEEECCEEC
ENAAQIALGIGAEVTVLDRSLDALARLSARFGAGLKTVYSTRAALEQTVLESDLVIGAVL
CCCEEEEEECCCEEEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHEEHHH
VKGAATPKLVTRAMLGRMRPGAVLVDVAIDQGGCFETSKATTHDAPTYVVDGVVHYCVAN
HCCCCCHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHC
MPGAVARTSTYALTNATLPYGLAIATKGWKAALADDPGLLEGLNVHAGKVTCAPVAAELG
CCCCHHCCCEEEEECCCCCCEEEEECCCCEEECCCCCCCCCCCCCCCCEEEEHHHHHHCC
YEHTPAASVLGA
CCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1587598; 9634230; 12218036; 7822223 [H]