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The map label for this gene is mltA [H]

Identifier: 83594936

GI number: 83594936

Start: 4147125

End: 4148321

Strand: Reverse

Name: mltA [H]

Synonym: Rru_A3607

Alternate gene names: 83594936

Gene position: 4148321-4147125 (Counterclockwise)

Preceding gene: 83594937

Following gene: 83594935

Centisome position: 95.3

GC content: 69.84

Gene sequence:

>1197_bases
ATGGGCGCGATGAACGGCACGTCCGGGCGGCGGCTGTCGACGGCAACCCGGGTCGCCGCGATGGCCGGGGTTCTGCTGCT
GGCGGCCTGCGGCGGTCCGTCGTCGCGTCCGGGCCTGGTCAGCCGGCCGGCGGGCGTTGCCGGACCGGTCTCCTATCAGC
GCGTCGCCATCGAAGGGCTGCCCGGCTGGTCGACCGACCGCGTCGCCGATGCCCTACCGGTGTTCCGGCGGTCGTGCGAG
CGGCTGCGCGCGGTTTCCCCGAATTCCATGGTCGGACCCTCGGTCTGGGGATCGCGGGCAAGCGATTGGCAGGCGGCCTG
TGCCGTCGCCGCCCGCCTTCCGGCCTTCGATGACGACGCGGCCCGGCGGTTCTTCGCCGAGCGCTTCCAGGCTTGGCAGG
TGACCGGGGCGGGCGATCCCACCGGTTTGTTCACCGGCTATTACGAAGCCGCCCTTGATGGCTCGCTTTCGCCCAGCGCC
GTCTATTCCACCCCGATCTACGGCGTGCCGCTTGATCTACGCATGGAAGGCGGCAAGGGCATGCGGGTATCGGGGGGGCG
CAGTCTGCCCTATCCCGATCGCGCCGCCATCGAGGAGGGCGCCATTTCCGGTGTCGCCCCGGTGATCATGTGGGCGCGCG
ATCCGGTGGACGTGTTCATGCTCCATATCCAGGGCTCGGGACAGGTCCGCCTGCCCGATGGCCGGATCCAACGCATCGGC
TATGCCGCCAACAACGGTCATCCCTTTGTCGGCATCGGCGCCATCATGCGCGATCGCGGCCTGGGCGACGGGTCGTCGAT
GATCGCCATCCGCGCTTGGTTGCGCGCCAATCCGGCCGAGGGCCGCGCCCTGATGCGCGAAAACCCGCGCTTCATCTTTT
TCCGCCCGATCGAGGGCGAAGGACCGATCGGCGCCCAGGGTCTGCCTTTGACCGGCGGGCGCAGTCTGGCCGTTGATCCG
TCCAGCGTTCCCTTGGGCGCCCCGGTGTGGCTGGCGACCTCGGATGCCCACGGCGAAACCGTCAACCGCCTGATGGTCGC
CCAGGATACGGGCAGCGCCATCAAGGGCGCGGTGCGCGGCGATTTCTTCTGGGGAAGCGGCGAGGAGGCGCTTTACCACG
CCGGCGGCATGAAGTCGGCCGGGCGGTACTGGGTGCTTGTCCCGCGCGGCGGGCGCAACGCGGTTGCGCAAAACTAG

Upstream 100 bases:

>100_bases
GAGGTCACTGATATCTGGACCTTCCGCCGCGATACCGTGTCGAACGATCCCAATTGGGACCTGATCGCCACCCAAGTCCC
CGAGGAATGAGTTCCCGGGC

Downstream 100 bases:

>100_bases
GGCTTGGATTTCTTGTCAAAGGCCCGCCATCGGGCCATTCTGCCCAATGGGAGTGGCCAGGACCCTGGCGGGGAAGGCTC
CATGAGCCCCCGCCGCTGGC

Product: murein degrading transglycosylase protein

Products: Muramic Acid Residue [C]

Alternate protein names: Murein hydrolase A [H]

Number of amino acids: Translated: 398; Mature: 397

Protein sequence:

>398_residues
MGAMNGTSGRRLSTATRVAAMAGVLLLAACGGPSSRPGLVSRPAGVAGPVSYQRVAIEGLPGWSTDRVADALPVFRRSCE
RLRAVSPNSMVGPSVWGSRASDWQAACAVAARLPAFDDDAARRFFAERFQAWQVTGAGDPTGLFTGYYEAALDGSLSPSA
VYSTPIYGVPLDLRMEGGKGMRVSGGRSLPYPDRAAIEEGAISGVAPVIMWARDPVDVFMLHIQGSGQVRLPDGRIQRIG
YAANNGHPFVGIGAIMRDRGLGDGSSMIAIRAWLRANPAEGRALMRENPRFIFFRPIEGEGPIGAQGLPLTGGRSLAVDP
SSVPLGAPVWLATSDAHGETVNRLMVAQDTGSAIKGAVRGDFFWGSGEEALYHAGGMKSAGRYWVLVPRGGRNAVAQN

Sequences:

>Translated_398_residues
MGAMNGTSGRRLSTATRVAAMAGVLLLAACGGPSSRPGLVSRPAGVAGPVSYQRVAIEGLPGWSTDRVADALPVFRRSCE
RLRAVSPNSMVGPSVWGSRASDWQAACAVAARLPAFDDDAARRFFAERFQAWQVTGAGDPTGLFTGYYEAALDGSLSPSA
VYSTPIYGVPLDLRMEGGKGMRVSGGRSLPYPDRAAIEEGAISGVAPVIMWARDPVDVFMLHIQGSGQVRLPDGRIQRIG
YAANNGHPFVGIGAIMRDRGLGDGSSMIAIRAWLRANPAEGRALMRENPRFIFFRPIEGEGPIGAQGLPLTGGRSLAVDP
SSVPLGAPVWLATSDAHGETVNRLMVAQDTGSAIKGAVRGDFFWGSGEEALYHAGGMKSAGRYWVLVPRGGRNAVAQN
>Mature_397_residues
GAMNGTSGRRLSTATRVAAMAGVLLLAACGGPSSRPGLVSRPAGVAGPVSYQRVAIEGLPGWSTDRVADALPVFRRSCER
LRAVSPNSMVGPSVWGSRASDWQAACAVAARLPAFDDDAARRFFAERFQAWQVTGAGDPTGLFTGYYEAALDGSLSPSAV
YSTPIYGVPLDLRMEGGKGMRVSGGRSLPYPDRAAIEEGAISGVAPVIMWARDPVDVFMLHIQGSGQVRLPDGRIQRIGY
AANNGHPFVGIGAIMRDRGLGDGSSMIAIRAWLRANPAEGRALMRENPRFIFFRPIEGEGPIGAQGLPLTGGRSLAVDPS
SVPLGAPVWLATSDAHGETVNRLMVAQDTGSAIKGAVRGDFFWGSGEEALYHAGGMKSAGRYWVLVPRGGRNAVAQN

Specific function: Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. Degrades murein glycan strands and insoluble, high-molecular weight murein sacculi [H]

COG id: COG2821

COG function: function code M; Membrane-bound lytic murein transglycosylase

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1789179, Length=305, Percent_Identity=33.4426229508197, Blast_Score=122, Evalue=5e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010611
- InterPro:   IPR014733
- InterPro:   IPR005300 [H]

Pfam domain/function: PF06725 3D; PF03562 MltA [H]

EC number: 3.2.1.- [C]

Molecular weight: Translated: 41835; Mature: 41704

Theoretical pI: Translated: 9.94; Mature: 9.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGAMNGTSGRRLSTATRVAAMAGVLLLAACGGPSSRPGLVSRPAGVAGPVSYQRVAIEGL
CCCCCCCCCCCHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCCCCCCEEEEEEECC
PGWSTDRVADALPVFRRSCERLRAVSPNSMVGPSVWGSRASDWQAACAVAARLPAFDDDA
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHH
ARRFFAERFQAWQVTGAGDPTGLFTGYYEAALDGSLSPSAVYSTPIYGVPLDLRMEGGKG
HHHHHHHHHHEEEEECCCCCCCHHHHHHHHHCCCCCCCCEEECCCEECCEEEEEECCCCC
MRVSGGRSLPYPDRAAIEEGAISGVAPVIMWARDPVDVFMLHIQGSGQVRLPDGRIQRIG
EEECCCCCCCCCCHHHHHHCCCCCCCEEEEECCCCCEEEEEEEECCCEEECCCCCEEEEE
YAANNGHPFVGIGAIMRDRGLGDGSSMIAIRAWLRANPAEGRALMRENPRFIFFRPIEGE
EECCCCCCEEEEHHHHHHCCCCCCCCEEEEEHHHHCCCCCCCHHHHCCCCEEEEEECCCC
GPIGAQGLPLTGGRSLAVDPSSVPLGAPVWLATSDAHGETVNRLMVAQDTGSAIKGAVRG
CCCCCCCCCCCCCCEEEECCCCCCCCCEEEEEECCCCCCCHHEEEEEECCCCHHHHCCCC
DFFWGSGEEALYHAGGMKSAGRYWVLVPRGGRNAVAQN
CEEECCCCCEEEECCCCCCCCCEEEEEECCCCCCCCCC
>Mature Secondary Structure 
GAMNGTSGRRLSTATRVAAMAGVLLLAACGGPSSRPGLVSRPAGVAGPVSYQRVAIEGL
CCCCCCCCCCHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCCCCCCEEEEEEECC
PGWSTDRVADALPVFRRSCERLRAVSPNSMVGPSVWGSRASDWQAACAVAARLPAFDDDA
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHH
ARRFFAERFQAWQVTGAGDPTGLFTGYYEAALDGSLSPSAVYSTPIYGVPLDLRMEGGKG
HHHHHHHHHHEEEEECCCCCCCHHHHHHHHHCCCCCCCCEEECCCEECCEEEEEECCCCC
MRVSGGRSLPYPDRAAIEEGAISGVAPVIMWARDPVDVFMLHIQGSGQVRLPDGRIQRIG
EEECCCCCCCCCCHHHHHHCCCCCCCEEEEECCCCCEEEEEEEECCCEEECCCCCEEEEE
YAANNGHPFVGIGAIMRDRGLGDGSSMIAIRAWLRANPAEGRALMRENPRFIFFRPIEGE
EECCCCCCEEEEHHHHHHCCCCCCCCEEEEEHHHHCCCCCCCHHHHCCCCEEEEEECCCC
GPIGAQGLPLTGGRSLAVDPSSVPLGAPVWLATSDAHGETVNRLMVAQDTGSAIKGAVRG
CCCCCCCCCCCCCCEEEECCCCCCCCCEEEEEECCCCCCCHHEEEEEECCCCHHHHCCCC
DFFWGSGEEALYHAGGMKSAGRYWVLVPRGGRNAVAQN
CEEECCCCCEEEECCCCCCCCCEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Muramic Acid Residue (N-Acetylmuramic Acid And N-Acetylglucosamine Residues) [C]

Specific reaction: Cleavage Of The Beta-1,4-Glycosidic [C]

General reaction: Cleavage Bond [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]