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The map label for this gene is cobQ [H]

Identifier: 83594879

GI number: 83594879

Start: 4089637

End: 4091178

Strand: Direct

Name: cobQ [H]

Synonym: Rru_A3550

Alternate gene names: 83594879

Gene position: 4089637-4091178 (Clockwise)

Preceding gene: 83594878

Following gene: 83594880

Centisome position: 93.95

GC content: 70.36

Gene sequence:

>1542_bases
ATGACCGATGATCCGACGATCGCCTTTCAGCGGCTGAAAAACCCCCACCCCCTCCGGGCGCGCGGCCTGATGCTGCAGGG
CACGGCCTCCGATGTCGGCAAGTCGCTGCTGGTCGCCGGGCTGTGCCGGGCCTATACGCGGCGCGGTCTGGTGGTGCGCC
CGTTCAAGGCGCAGAACATGAGCAACAACGCCGCCGTGACCCTTGATGGCGAGCATCCGGGCCAGCGCGGCGAAATCGGC
CGGGCCCAGGCCCTGCAGGCCCGCGCCTGCAAGGCGCCCTGCTCGGTTCACATGAACCCGGTGCTGCTCAAGCCCGAAAG
CGACATCGATTGTCAGGTGGTGCTGCGCGGTCAGGTGCTCGGGCGCTGGTCGGCCAGCGCCTATCAGCGGCTAAAGCCCA
AACTGATGCCCGCCGTTCTCGACAGCCTTGAGCGCCTGGGCGCCGAAGCCGATCTGCTGGTGGTCGAAGGGGCGGGCTGC
GGCGCCGAACGCTATCTGCGCGCCCAGGACATCACCAATATGGCGCTGGCCGAGGCCGCCGATTTGGCCGTCTGCATCAT
CGCCGACGAGTCGCGCGGCGGGGTGATGGCGGCGCTGCTGGGCATGCACGGCCTGCTCGACCCCAGCGAACGCCAGCGGG
TGATCGGCTATATCGTCAATAAATTCCGTGGCGATCCCCGGGTTTTCGATCCGGCGGCCGAGGAGATCACCGCGCGCTCG
GGCTGGGCCAATCTGGGGCTGGTCGGCTGGTTCGACGCCGCCGGCCGCCTGCCGGCCGAGGATTCGCTGGCCCTGGCGCG
CCCCCGCGCCGCCGGCGCCGGAGCGCTGACGCTCGCCGTTCCCCGGCTGTCGCGCATCGCCAATTTCGACGACCTTGATC
CGTTGGCCGCCGAACCCGGGGTGCGGGTGATCTGGGTAGCGCCCGGTCAGCCGATCCCGCGCGACGCCGATGTCATCGTG
CTTCCCGGCTCGAAGGCGACGCGCGCCGATCTGGCGATGCTGCGAGCCGAGGGCTGGGATATCGACATCCTGGCCCATGT
CCGCCAGGGCGGCCGGGTCGTCGGGCTGTGCGCCGGCTTCCAGATGCTGGGCCAGGTGGTGCGTGATCCCCAAGGCATCG
AAGGACCGGCCGGCGAGAGCGCCGGGCTGGGCCTGCTCGATATCGAAACGGTGATCGGCGGCGAAAAGCGGCTGGTCGAT
CTGGCGGTGACCGAGCGCCGGAGCGGCTGCGCCCTGACCGGCTACGAGATGCACATGGGCACCACCCGGGGCCCCGGTCT
CGCCCGCCCCTGGCTGGTCTTCGACGATCACGGCGCCCCGCGCCCCCAGGGGGCGTGTTCGGCCGATGGGCGGGTGATGG
GCGCCTATGTCCACGGGATTTTCGCCGCCGACGGCTTTCGCGCCCATTGGCTGGGTCAGGTCGGCGCCCCCCCCTCGTCG
CTGCTGTTTGAAGACCGCATCGAAGGGGCGCTCGACGCCCTGGCCGACCACTGCGAGGCCGCTCTCGACCTTGATCGCCT
GTGGGAGCTGGCCCGCCGATGA

Upstream 100 bases:

>100_bases
GGCGCGCACCGAAACCGCGCTCGAGGCTTTGGCCGACCATCTGGAGGCCAATCTCGACCTCGACGCCCTGCTTGCCTTCG
CCCGCTGAGCGGAGGGGGCG

Downstream 100 bases:

>100_bases
ACCACGCACAGGTTTCTCCCCCCTCTCTTCGACGTGCCCCGTCTCAGCAAAGGATCCCTGCGCAATGATATTTCCCAACG
CGAGCCAGTCGGGCTCCTTC

Product: cobyric acid synthase

Products: ADP; phosphate; adenosylcobyric acid; L-glutamate

Alternate protein names: NA

Number of amino acids: Translated: 513; Mature: 512

Protein sequence:

>513_residues
MTDDPTIAFQRLKNPHPLRARGLMLQGTASDVGKSLLVAGLCRAYTRRGLVVRPFKAQNMSNNAAVTLDGEHPGQRGEIG
RAQALQARACKAPCSVHMNPVLLKPESDIDCQVVLRGQVLGRWSASAYQRLKPKLMPAVLDSLERLGAEADLLVVEGAGC
GAERYLRAQDITNMALAEAADLAVCIIADESRGGVMAALLGMHGLLDPSERQRVIGYIVNKFRGDPRVFDPAAEEITARS
GWANLGLVGWFDAAGRLPAEDSLALARPRAAGAGALTLAVPRLSRIANFDDLDPLAAEPGVRVIWVAPGQPIPRDADVIV
LPGSKATRADLAMLRAEGWDIDILAHVRQGGRVVGLCAGFQMLGQVVRDPQGIEGPAGESAGLGLLDIETVIGGEKRLVD
LAVTERRSGCALTGYEMHMGTTRGPGLARPWLVFDDHGAPRPQGACSADGRVMGAYVHGIFAADGFRAHWLGQVGAPPSS
LLFEDRIEGALDALADHCEAALDLDRLWELARR

Sequences:

>Translated_513_residues
MTDDPTIAFQRLKNPHPLRARGLMLQGTASDVGKSLLVAGLCRAYTRRGLVVRPFKAQNMSNNAAVTLDGEHPGQRGEIG
RAQALQARACKAPCSVHMNPVLLKPESDIDCQVVLRGQVLGRWSASAYQRLKPKLMPAVLDSLERLGAEADLLVVEGAGC
GAERYLRAQDITNMALAEAADLAVCIIADESRGGVMAALLGMHGLLDPSERQRVIGYIVNKFRGDPRVFDPAAEEITARS
GWANLGLVGWFDAAGRLPAEDSLALARPRAAGAGALTLAVPRLSRIANFDDLDPLAAEPGVRVIWVAPGQPIPRDADVIV
LPGSKATRADLAMLRAEGWDIDILAHVRQGGRVVGLCAGFQMLGQVVRDPQGIEGPAGESAGLGLLDIETVIGGEKRLVD
LAVTERRSGCALTGYEMHMGTTRGPGLARPWLVFDDHGAPRPQGACSADGRVMGAYVHGIFAADGFRAHWLGQVGAPPSS
LLFEDRIEGALDALADHCEAALDLDRLWELARR
>Mature_512_residues
TDDPTIAFQRLKNPHPLRARGLMLQGTASDVGKSLLVAGLCRAYTRRGLVVRPFKAQNMSNNAAVTLDGEHPGQRGEIGR
AQALQARACKAPCSVHMNPVLLKPESDIDCQVVLRGQVLGRWSASAYQRLKPKLMPAVLDSLERLGAEADLLVVEGAGCG
AERYLRAQDITNMALAEAADLAVCIIADESRGGVMAALLGMHGLLDPSERQRVIGYIVNKFRGDPRVFDPAAEEITARSG
WANLGLVGWFDAAGRLPAEDSLALARPRAAGAGALTLAVPRLSRIANFDDLDPLAAEPGVRVIWVAPGQPIPRDADVIVL
PGSKATRADLAMLRAEGWDIDILAHVRQGGRVVGLCAGFQMLGQVVRDPQGIEGPAGESAGLGLLDIETVIGGEKRLVDL
AVTERRSGCALTGYEMHMGTTRGPGLARPWLVFDDHGAPRPQGACSADGRVMGAYVHGIFAADGFRAHWLGQVGAPPSSL
LFEDRIEGALDALADHCEAALDLDRLWELARR

Specific function: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation [H]

COG id: COG1492

COG function: function code H; Cobyric acid synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GATase cobBQ-type domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002586
- InterPro:   IPR017929
- InterPro:   IPR004459
- InterPro:   IPR011698 [H]

Pfam domain/function: PF01656 CbiA; PF07685 GATase_3 [H]

EC number: 6.3.5.10

Molecular weight: Translated: 54643; Mature: 54512

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDDPTIAFQRLKNPHPLRARGLMLQGTASDVGKSLLVAGLCRAYTRRGLVVRPFKAQNM
CCCCHHHHHHHCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHCCCEEECHHCCCC
SNNAAVTLDGEHPGQRGEIGRAQALQARACKAPCSVHMNPVLLKPESDIDCQVVLRGQVL
CCCEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCEEEECCCCCCCEEEEEECCCC
GRWSASAYQRLKPKLMPAVLDSLERLGAEADLLVVEGAGCGAERYLRAQDITNMALAEAA
CCCCHHHHHHHCHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHC
DLAVCIIADESRGGVMAALLGMHGLLDPSERQRVIGYIVNKFRGDPRVFDPAAEEITARS
CEEEEEEEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCC
GWANLGLVGWFDAAGRLPAEDSLALARPRAAGAGALTLAVPRLSRIANFDDLDPLAAEPG
CCCCCCEEEEECCCCCCCCCCCCEEECCCCCCCCEEEEEHHHHHHHCCCCCCCCCCCCCC
VRVIWVAPGQPIPRDADVIVLPGSKATRADLAMLRAEGWDIDILAHVRQGGRVVGLCAGF
CEEEEECCCCCCCCCCCEEEECCCCCCHHHHHHHHHCCCCEEEHHHHHCCCCEEEEHHHH
QMLGQVVRDPQGIEGPAGESAGLGLLDIETVIGGEKRLVDLAVTERRSGCALTGYEMHMG
HHHHHHHCCCCCCCCCCCCCCCCCEEEEHHHHCCCCEEEEEEEECCCCCCEEEEEEEECC
TTRGPGLARPWLVFDDHGAPRPQGACSADGRVMGAYVHGIFAADGFRAHWLGQVGAPPSS
CCCCCCCCCCEEEECCCCCCCCCCCCCCCCCEEEEEEEEEHCCCCCCEEECCCCCCCHHH
LLFEDRIEGALDALADHCEAALDLDRLWELARR
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCC
>Mature Secondary Structure 
TDDPTIAFQRLKNPHPLRARGLMLQGTASDVGKSLLVAGLCRAYTRRGLVVRPFKAQNM
CCCHHHHHHHCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHCCCEEECHHCCCC
SNNAAVTLDGEHPGQRGEIGRAQALQARACKAPCSVHMNPVLLKPESDIDCQVVLRGQVL
CCCEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCEEEECCCCCCCEEEEEECCCC
GRWSASAYQRLKPKLMPAVLDSLERLGAEADLLVVEGAGCGAERYLRAQDITNMALAEAA
CCCCHHHHHHHCHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHC
DLAVCIIADESRGGVMAALLGMHGLLDPSERQRVIGYIVNKFRGDPRVFDPAAEEITARS
CEEEEEEEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCC
GWANLGLVGWFDAAGRLPAEDSLALARPRAAGAGALTLAVPRLSRIANFDDLDPLAAEPG
CCCCCCEEEEECCCCCCCCCCCCEEECCCCCCCCEEEEEHHHHHHHCCCCCCCCCCCCCC
VRVIWVAPGQPIPRDADVIVLPGSKATRADLAMLRAEGWDIDILAHVRQGGRVVGLCAGF
CEEEEECCCCCCCCCCCEEEECCCCCCHHHHHHHHHCCCCEEEHHHHHCCCCEEEEHHHH
QMLGQVVRDPQGIEGPAGESAGLGLLDIETVIGGEKRLVDLAVTERRSGCALTGYEMHMG
HHHHHHHCCCCCCCCCCCCCCCCCEEEEHHHHCCCCEEEEEEEECCCCCCEEEEEEEECC
TTRGPGLARPWLVFDDHGAPRPQGACSADGRVMGAYVHGIFAADGFRAHWLGQVGAPPSS
CCCCCCCCCCEEEECCCCCCCCCCCCCCCCCEEEEEEEEEHCCCCCCEEECCCCCCCHHH
LLFEDRIEGALDALADHCEAALDLDRLWELARR
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; adenosylcobyrinic acid a,c-diamide; L-glutamine; H2O

Specific reaction: 4 ATP + adenosylcobyrinic acid a,c-diamide + 4 L-glutamine + 4 H2O = 4 ADP + 4 phosphate + adenosylcobyric acid + 4 L-glutamate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA