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The map label for this gene is ykpB [H]

Identifier: 83594847

GI number: 83594847

Start: 4050517

End: 4051434

Strand: Reverse

Name: ykpB [H]

Synonym: Rru_A3518

Alternate gene names: 83594847

Gene position: 4051434-4050517 (Counterclockwise)

Preceding gene: 83594848

Following gene: 83594846

Centisome position: 93.08

GC content: 67.97

Gene sequence:

>918_bases
ATGCGCTGTCTTATTCTGGGTGCGGGGGGCATTGGTGGCTATTTCGGCGGACGGCTGCTGGCCGCCGGCCGCGATGTCAC
TTTTCTGGTTCGCCCGGCCCGCGCCGCCCGGCTGGCCCAAGGGCTGAGGATCATCAGCCCGCGCGGTGATCTCGCCCTGC
CGGCGCCGCCGCTGGTCACCAGCCAAACCCTGACCGGGACCTATGATGTGGTCATGGTGTCGTGCAAGGCCTATGACCTG
GAGAACGCCATCGACACCATCGCCCCGGCGGTCGGGCGCGAAACCGTCATCGTGCCGCTGCTCAACGGCTTTGGTCATCT
TGATACTTTACGCGCCCGCTTCGGGGCGGAACGGGTGCTGGGTGGCTATTGCCTGATTTCGGTCACCCTTGATGGCGAGG
GCGGCATCGCTCACTTCAATCAGGCCGATGTTCTGCGCCTGGGCGAGATCGCCGGCGGCCCGTCCGAACGCGTGCGGGCG
ATCGGCGCGATGCTGGGCGGGGCCGGCTTCGACTTCGCGGTCAGCGACGATATCGTTCAGGAAATGTGGGAGAAATGGGT
GTTCATCGCCACGACGGCCAGCGCCACCTGCCTGATGCGCGCCGCCATCGGCGATATCATCGGCGCCGGCGCCGGCGATG
TGACGCTTGGCCTGTTGGCGGAATGCGAGGCGATCGCCAGCGATAACGGTCATCCGCCGGGCGAGGCGGCGCGCAAGCGG
GCCCGCGACCAACTTACCGACGCGACCTCGCCGATCATGGCCTCGATGCTGCGTGATATCGAGCGCGGCGGGCCGGTGGA
GGCCGACGCCATCCAGGGCGAGATGCTGCGCCGGGCCGGCGATCGTCCAGCGCCGCTGCTTCGTCTCGCCCATGCCCATC
TGCGCGCCTATGAAGCGCGCCGCGCCCGCCAATCCTGA

Upstream 100 bases:

>100_bases
CGCAAACCGATCTCGGCCCCTGTCCTCGGCCCCCTCCTGCGGCCCCGTCCTCGGCGGCCGTTTCCTAACCATGGCTTTTT
TTTCACAAACGGAGACCGTG

Downstream 100 bases:

>100_bases
TCCCCCCCTATGCCCAGCCAAAGCGGCCGGGCGGAGAGCGCCGATGCCGACCAAACGCCCGCCCGCCGGTCTGCACTACG
CCTGGATCGTCGCCGCCGTC

Product: 2-dehydropantoate 2-reductase

Products: 2-dehydropantoate; NADPH; H+

Alternate protein names: NA

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MRCLILGAGGIGGYFGGRLLAAGRDVTFLVRPARAARLAQGLRIISPRGDLALPAPPLVTSQTLTGTYDVVMVSCKAYDL
ENAIDTIAPAVGRETVIVPLLNGFGHLDTLRARFGAERVLGGYCLISVTLDGEGGIAHFNQADVLRLGEIAGGPSERVRA
IGAMLGGAGFDFAVSDDIVQEMWEKWVFIATTASATCLMRAAIGDIIGAGAGDVTLGLLAECEAIASDNGHPPGEAARKR
ARDQLTDATSPIMASMLRDIERGGPVEADAIQGEMLRRAGDRPAPLLRLAHAHLRAYEARRARQS

Sequences:

>Translated_305_residues
MRCLILGAGGIGGYFGGRLLAAGRDVTFLVRPARAARLAQGLRIISPRGDLALPAPPLVTSQTLTGTYDVVMVSCKAYDL
ENAIDTIAPAVGRETVIVPLLNGFGHLDTLRARFGAERVLGGYCLISVTLDGEGGIAHFNQADVLRLGEIAGGPSERVRA
IGAMLGGAGFDFAVSDDIVQEMWEKWVFIATTASATCLMRAAIGDIIGAGAGDVTLGLLAECEAIASDNGHPPGEAARKR
ARDQLTDATSPIMASMLRDIERGGPVEADAIQGEMLRRAGDRPAPLLRLAHAHLRAYEARRARQS
>Mature_305_residues
MRCLILGAGGIGGYFGGRLLAAGRDVTFLVRPARAARLAQGLRIISPRGDLALPAPPLVTSQTLTGTYDVVMVSCKAYDL
ENAIDTIAPAVGRETVIVPLLNGFGHLDTLRARFGAERVLGGYCLISVTLDGEGGIAHFNQADVLRLGEIAGGPSERVRA
IGAMLGGAGFDFAVSDDIVQEMWEKWVFIATTASATCLMRAAIGDIIGAGAGDVTLGLLAECEAIASDNGHPPGEAARKR
ARDQLTDATSPIMASMLRDIERGGPVEADAIQGEMLRRAGDRPAPLLRLAHAHLRAYEARRARQS

Specific function: Catalyzes The NADPH-Dependent Reduction Of Ketopantoate Into Pantoic Acid. [C]

COG id: COG1893

COG function: function code H; Ketopantoate reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketopantoate reductase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR003710
- InterPro:   IPR013752
- InterPro:   IPR013332
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02558 ApbA; PF08546 ApbA_C [H]

EC number: 1.1.1.169

Molecular weight: Translated: 32079; Mature: 32079

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRCLILGAGGIGGYFGGRLLAAGRDVTFLVRPARAARLAQGLRIISPRGDLALPAPPLVT
CEEEEEECCCCCHHHCCEEEECCCCEEEEECCHHHHHHHCCCEEECCCCCCCCCCCCCCC
SQTLTGTYDVVMVSCKAYDLENAIDTIAPAVGRETVIVPLLNGFGHLDTLRARFGAERVL
CCCCCCCEEEEEEEEHHHCHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHCHHHHC
GGYCLISVTLDGEGGIAHFNQADVLRLGEIAGGPSERVRAIGAMLGGAGFDFAVSDDIVQ
CCEEEEEEEECCCCCEECCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCHHHHH
EMWEKWVFIATTASATCLMRAAIGDIIGAGAGDVTLGLLAECEAIASDNGHPPGEAARKR
HHHHCEEEEEECCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHH
ARDQLTDATSPIMASMLRDIERGGPVEADAIQGEMLRRAGDRPAPLLRLAHAHLRAYEAR
HHHHHHHCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
RARQS
HHCCC
>Mature Secondary Structure
MRCLILGAGGIGGYFGGRLLAAGRDVTFLVRPARAARLAQGLRIISPRGDLALPAPPLVT
CEEEEEECCCCCHHHCCEEEECCCCEEEEECCHHHHHHHCCCEEECCCCCCCCCCCCCCC
SQTLTGTYDVVMVSCKAYDLENAIDTIAPAVGRETVIVPLLNGFGHLDTLRARFGAERVL
CCCCCCCEEEEEEEEHHHCHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHCHHHHC
GGYCLISVTLDGEGGIAHFNQADVLRLGEIAGGPSERVRAIGAMLGGAGFDFAVSDDIVQ
CCEEEEEEEECCCCCEECCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCHHHHH
EMWEKWVFIATTASATCLMRAAIGDIIGAGAGDVTLGLLAECEAIASDNGHPPGEAARKR
HHHHCEEEEEECCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHH
ARDQLTDATSPIMASMLRDIERGGPVEADAIQGEMLRRAGDRPAPLLRLAHAHLRAYEAR
HHHHHHHCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
RARQS
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 4.0 {NADPH}} [C]

Substrates: (R)-pantoate; NADP+

Specific reaction: (R)-pantoate + NADP+ = 2-dehydropantoate + NADPH + H+

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]