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The map label for this gene is frmA [H]

Identifier: 83594734

GI number: 83594734

Start: 3921784

End: 3922902

Strand: Direct

Name: frmA [H]

Synonym: Rru_A3405

Alternate gene names: 83594734

Gene position: 3921784-3922902 (Clockwise)

Preceding gene: 83594733

Following gene: 83594735

Centisome position: 90.1

GC content: 64.7

Gene sequence:

>1119_bases
ATGATCGTCTCGCGCGCCGCTATCGCCTGGGAAGCTGGCAAACCCCTGTCCGTCGAAGAGGTCGAGGTGGCGCCGCCGCG
CCAAGGCGAGGTTCTGGTGCGCATCATCGCCACCGGTGTTTGCCATACGGATGCTTATACCCTGTCGGGCAGCGACCCCG
AGGGGGTGTTTCCGGCGATCCTGGGGCACGAGGGCGGCGGCATCGTCGAAGAGATCGGCCCCGGCGTCACCTCGGTGGCC
GTCGGCGATCACGTCATCCCGCTTTACACCCCGGAATGCGGCACCTGCAAATTCTGCCGCTCGGGCAAGACCAATCTGTG
TCAGGCCATCCGCGCCACCCAGGGCCAGGGCCTGATGCCCGATGGCACCAGCCGGTTTTCGATCAAGGGCCGCGAGATCC
GCCATTACATGGGCACCTCGACCTTCTCCGAATACACCGTGCTGCCCGAGATCGCCCTGGCCAAGGTCAACAAGGCGGCC
CCTTTGGAAAAGATCTGCCTGCTGGGCTGCGGCGTCACCACCGGCATGGGAGCGGTGCTCAATACGGCCAAGGTCGAGCC
GGGGGCGACGGTGGCGATCTTCGGCCTGGGCGGCATCGGCCTGTCGGCGATCATCGGCTGTGTCATGGCCGGGGCCGGGC
GGATCATCGGCGTTGACATCAATCCCGATAAATTCGAGATCGCCCGCCAGCTTGGCGCCACCGATGTGATCAATTCGCGC
GATTACGACCGGCCGATCCAGGAGGTGCTGATCGACATGACCGATGGCGGCGTCGATTATTCGTTCGAATGCATCGGCAA
TGTCGGGGTCATGCGCTCGGCCCTGGAATGCTGCCACAAGGGCTGGGGCCAGTCGGTGATCATCGGCGTCGCCGGCGCCG
GCCAGGAGATTTCCACCCGGCCCTTCCAACTGGTCACCGGCCGGGTGTGGCGGGGCTCGGCCTTTGGCGGGGTCAAGGGC
CGCTCGGAACTGCCCGCCCTGGTCGAACGCTATCTGGCGGGCGATTTCGAACTCGATACCTTCATCACCCATACCATGGG
GCTGGCCGACATCAACCACGCCTTCGAGCTGATGCACGAGGGCAAAAGCATCCGCTCGGTGATCCATTATGACCTGTGA

Upstream 100 bases:

>100_bases
GAGCGGCGGAGGGCGCGAAGGGTTTTCATCGGCGTCCTCGCATGCCATATGCGGGGTCTGACCTGTGTTTCCCCTCCCCC
TTTCCCCCAAGAGGTCCTTC

Downstream 100 bases:

>100_bases
TCTCCGCCGGTCGGAGGACCGGCAATGACCGGGGCCCCCCAGCTTGTCTCGGCCGCGTGCTGCTTTGGCGGCACCCAGGC
GCGTTATCGCCATTCCTCGG

Product: formaldehyde dehydrogenase (glutathione)

Products: NA

Alternate protein names: Alcohol dehydrogenase class-3; Alcohol dehydrogenase class-III; Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH; GSH-FDH [H]

Number of amino acids: Translated: 372; Mature: 372

Protein sequence:

>372_residues
MIVSRAAIAWEAGKPLSVEEVEVAPPRQGEVLVRIIATGVCHTDAYTLSGSDPEGVFPAILGHEGGGIVEEIGPGVTSVA
VGDHVIPLYTPECGTCKFCRSGKTNLCQAIRATQGQGLMPDGTSRFSIKGREIRHYMGTSTFSEYTVLPEIALAKVNKAA
PLEKICLLGCGVTTGMGAVLNTAKVEPGATVAIFGLGGIGLSAIIGCVMAGAGRIIGVDINPDKFEIARQLGATDVINSR
DYDRPIQEVLIDMTDGGVDYSFECIGNVGVMRSALECCHKGWGQSVIIGVAGAGQEISTRPFQLVTGRVWRGSAFGGVKG
RSELPALVERYLAGDFELDTFITHTMGLADINHAFELMHEGKSIRSVIHYDL

Sequences:

>Translated_372_residues
MIVSRAAIAWEAGKPLSVEEVEVAPPRQGEVLVRIIATGVCHTDAYTLSGSDPEGVFPAILGHEGGGIVEEIGPGVTSVA
VGDHVIPLYTPECGTCKFCRSGKTNLCQAIRATQGQGLMPDGTSRFSIKGREIRHYMGTSTFSEYTVLPEIALAKVNKAA
PLEKICLLGCGVTTGMGAVLNTAKVEPGATVAIFGLGGIGLSAIIGCVMAGAGRIIGVDINPDKFEIARQLGATDVINSR
DYDRPIQEVLIDMTDGGVDYSFECIGNVGVMRSALECCHKGWGQSVIIGVAGAGQEISTRPFQLVTGRVWRGSAFGGVKG
RSELPALVERYLAGDFELDTFITHTMGLADINHAFELMHEGKSIRSVIHYDL
>Mature_372_residues
MIVSRAAIAWEAGKPLSVEEVEVAPPRQGEVLVRIIATGVCHTDAYTLSGSDPEGVFPAILGHEGGGIVEEIGPGVTSVA
VGDHVIPLYTPECGTCKFCRSGKTNLCQAIRATQGQGLMPDGTSRFSIKGREIRHYMGTSTFSEYTVLPEIALAKVNKAA
PLEKICLLGCGVTTGMGAVLNTAKVEPGATVAIFGLGGIGLSAIIGCVMAGAGRIIGVDINPDKFEIARQLGATDVINSR
DYDRPIQEVLIDMTDGGVDYSFECIGNVGVMRSALECCHKGWGQSVIIGVAGAGQEISTRPFQLVTGRVWRGSAFGGVKG
RSELPALVERYLAGDFELDTFITHTMGLADINHAFELMHEGKSIRSVIHYDL

Specific function: Has High Formaldehyde Dehydrogenase Activity In The Presence Of Glutathione And Catalyzes The Oxidation Of Normal Alcohols In A Reaction That Is Not Gsh-Dependent. In Addition, Hemithiolacetals Other Than Those Formed From Gsh, Including Omega-Thiol Fatty

COG id: COG1062

COG function: function code C; Zn-dependent alcohol dehydrogenases, class III

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI71565154, Length=368, Percent_Identity=66.5760869565217, Blast_Score=521, Evalue=1e-148,
Organism=Homo sapiens, GI34577061, Length=372, Percent_Identity=52.1505376344086, Blast_Score=421, Evalue=1e-118,
Organism=Homo sapiens, GI4501929, Length=372, Percent_Identity=51.6129032258064, Blast_Score=412, Evalue=1e-115,
Organism=Homo sapiens, GI71565152, Length=375, Percent_Identity=53.3333333333333, Blast_Score=407, Evalue=1e-114,
Organism=Homo sapiens, GI4501933, Length=372, Percent_Identity=50.5376344086022, Blast_Score=405, Evalue=1e-113,
Organism=Homo sapiens, GI156523966, Length=368, Percent_Identity=50.2717391304348, Blast_Score=390, Evalue=1e-108,
Organism=Homo sapiens, GI262073058, Length=371, Percent_Identity=49.3261455525606, Blast_Score=387, Evalue=1e-107,
Organism=Homo sapiens, GI71743840, Length=371, Percent_Identity=49.3261455525606, Blast_Score=387, Evalue=1e-107,
Organism=Homo sapiens, GI4501939, Length=362, Percent_Identity=50.5524861878453, Blast_Score=385, Evalue=1e-107,
Organism=Escherichia coli, GI1786552, Length=367, Percent_Identity=68.3923705722071, Blast_Score=520, Evalue=1e-149,
Organism=Escherichia coli, GI87082125, Length=368, Percent_Identity=26.6304347826087, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1788073, Length=347, Percent_Identity=26.5129682997118, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1790045, Length=379, Percent_Identity=25.5936675461741, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI87081918, Length=345, Percent_Identity=28.9855072463768, Blast_Score=88, Evalue=7e-19,
Organism=Escherichia coli, GI1787863, Length=362, Percent_Identity=24.0331491712707, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1786825, Length=247, Percent_Identity=28.7449392712551, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1788075, Length=363, Percent_Identity=25.068870523416, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI226510992, Length=364, Percent_Identity=23.3516483516484, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI25146526, Length=375, Percent_Identity=57.6, Blast_Score=466, Evalue=1e-131,
Organism=Caenorhabditis elegans, GI71997431, Length=377, Percent_Identity=57.2944297082228, Blast_Score=461, Evalue=1e-130,
Organism=Caenorhabditis elegans, GI17565904, Length=343, Percent_Identity=57.4344023323615, Blast_Score=424, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI17562584, Length=371, Percent_Identity=28.0323450134771, Blast_Score=91, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI71988145, Length=250, Percent_Identity=28.8, Blast_Score=81, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17562582, Length=375, Percent_Identity=27.2, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17562878, Length=258, Percent_Identity=25.968992248062, Blast_Score=76, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6320033, Length=370, Percent_Identity=59.4594594594595, Blast_Score=463, Evalue=1e-131,
Organism=Saccharomyces cerevisiae, GI6319621, Length=366, Percent_Identity=28.4153005464481, Blast_Score=94, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6323729, Length=369, Percent_Identity=25.7452574525745, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6323099, Length=385, Percent_Identity=28.3116883116883, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6323961, Length=364, Percent_Identity=24.4505494505494, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6324486, Length=365, Percent_Identity=24.1095890410959, Blast_Score=81, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6319257, Length=283, Percent_Identity=25.4416961130742, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI17737895, Length=372, Percent_Identity=65.0537634408602, Blast_Score=524, Evalue=1e-149,
Organism=Drosophila melanogaster, GI17137530, Length=361, Percent_Identity=26.0387811634349, Blast_Score=82, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014183
- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.284; =1.1.1.1 [H]

Molecular weight: Translated: 39308; Mature: 39308

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVSRAAIAWEAGKPLSVEEVEVAPPRQGEVLVRIIATGVCHTDAYTLSGSDPEGVFPAI
CEECCCEEEECCCCCCCCCEEECCCCCCCCEEEEEEHHCCCCCCEEEECCCCCCCCCHHE
LGHEGGGIVEEIGPGVTSVAVGDHVIPLYTPECGTCKFCRSGKTNLCQAIRATQGQGLMP
ECCCCCCHHHHHCCCCEEEECCCEEEEEECCCCCCCHHHHCCCHHHHHHHHHCCCCCCCC
DGTSRFSIKGREIRHYMGTSTFSEYTVLPEIALAKVNKAAPLEKICLLGCGVTTGMGAVL
CCCCEEEECHHHHHHHHCCCCCCCEEECHHHHHHHCCCCCCHHHHHHHHCCHHHCHHHHH
NTAKVEPGATVAIFGLGGIGLSAIIGCVMAGAGRIIGVDINPDKFEIARQLGATDVINSR
HHCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHCCCHHCCCCC
DYDRPIQEVLIDMTDGGVDYSFECIGNVGVMRSALECCHKGWGQSVIIGVAGAGQEISTR
CCCCHHHHHHEECCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCC
PFQLVTGRVWRGSAFGGVKGRSELPALVERYLAGDFELDTFITHTMGLADINHAFELMHE
CEEEEECEEECCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHC
GKSIRSVIHYDL
CHHHHHHHHCCC
>Mature Secondary Structure
MIVSRAAIAWEAGKPLSVEEVEVAPPRQGEVLVRIIATGVCHTDAYTLSGSDPEGVFPAI
CEECCCEEEECCCCCCCCCEEECCCCCCCCEEEEEEHHCCCCCCEEEECCCCCCCCCHHE
LGHEGGGIVEEIGPGVTSVAVGDHVIPLYTPECGTCKFCRSGKTNLCQAIRATQGQGLMP
ECCCCCCHHHHHCCCCEEEECCCEEEEEECCCCCCCHHHHCCCHHHHHHHHHCCCCCCCC
DGTSRFSIKGREIRHYMGTSTFSEYTVLPEIALAKVNKAAPLEKICLLGCGVTTGMGAVL
CCCCEEEECHHHHHHHHCCCCCCCEEECHHHHHHHCCCCCCHHHHHHHHCCHHHCHHHHH
NTAKVEPGATVAIFGLGGIGLSAIIGCVMAGAGRIIGVDINPDKFEIARQLGATDVINSR
HHCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHCCCHHCCCCC
DYDRPIQEVLIDMTDGGVDYSFECIGNVGVMRSALECCHKGWGQSVIIGVAGAGQEISTR
CCCCHHHHHHEECCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCC
PFQLVTGRVWRGSAFGGVKGRSELPALVERYLAGDFELDTFITHTMGLADINHAFELMHE
CEEEEECEEECCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHC
GKSIRSVIHYDL
CHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]