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The map label for this gene is cobD [H]

Identifier: 83594711

GI number: 83594711

Start: 3898851

End: 3899861

Strand: Reverse

Name: cobD [H]

Synonym: Rru_A3382

Alternate gene names: 83594711

Gene position: 3899861-3898851 (Counterclockwise)

Preceding gene: 83594718

Following gene: 83594707

Centisome position: 89.59

GC content: 70.13

Gene sequence:

>1011_bases
ATGGTCAGCCTGTTCTCCGTCGCCCCCATGGGCCTTACCGATCCGCTTGTTTTGGTCCTGCTCGCCCTGGTGTTTGACGC
CTATCTGGGGGGAATGGGGCCGTTGTTTCGCCTGATCCCCCACCCGGTGGTGGTGATGGGCGGGGCGATCGACGCCCTGG
AACAACGCCTGAACCGCGCCGAGCGCGACGACGCCACCCGCAAGCGCCGGGGCGTCTTCACCGTGATCGTTCTCGTCGGC
GCGGCGATCGGCCTGGGCGTCGCCTTGCAGGCCCTGGCCAGCGTTCTGGCGGTCGGCTGGGTTCTGGAACTGCTCCTGGC
CGTCGCCCTGCTCGCCCAGCGCGAACTCCACGATCACGTGGCCGCCGTCGCCGACGGGTTGGAGACGGGGGGCATCGACG
CCGGCCGCGAGGCGGTCTCCCATATCGTCGGCCGCGATCCGGCCTTGCTTGATCATGCCGGCGTCGGGCGCGGGGCGCTG
GAAAGTTTGGCCGAGAATTTCTCCGATGGCGTGGTCGCCCCGGTCTTCTGGTTCGTGCTCTTCGGCCTGCCCGGCCTGCT
CGCCTATAAGATGATCAACACCATGGACAGCATGATCGGCCACCGCACCCCGCGGCTGCGCGCCTTCGGCTGGGCGGCGG
CGCGGCTGGACGATGGCGTCAATCTGATCCCGGCGCGGCTGTCGGGCCTGCTGCTGATCGCCGCCGCCCTGACCAAGCCC
TGGGCCGACGCGCGCGCCGCCTTTGTCGTCATGCTACGCGATGCCGGCAAGCACCGCTCGCCCAATGCCGGCTGGCCGGA
AGGGGCGATGGCCGGGGCCCTTGGCCTGCGGCTGTCGGGACCGCGCGTTTATAAGGGCGAGGCGCCGCGCGACGAACCCT
ATGTCGGCGACGGCCGGGCGGGGGTGACGCCCAAGGACATCCGTCGCGGTCTGGCGCTGTTTCGGAGCGCCTGCCTGATC
GAAGGCGCGCTGATCGCCCTGCTGGCCATCGCCCTCGCCGTCTTGCGCTGA

Upstream 100 bases:

>100_bases
TAAGGGCTGCCGCCAAGCCGGGGCAAATCTTAAGGTCGGCCTTGGGCCGTAGGGCGAAACGGCCCTTGCCCGCAGGGAGG
CGCCGGGGCAGGATCGCACC

Downstream 100 bases:

>100_bases
CCTGCTTTTCAAGCCCGTTCAGGGCGCGGCCAGGGCGAGCAGGCGGTCGAGGGCGACATGGCGTTCCAGGTGATCGGCCA
GGGCGTCGAGGGTCGCCTCG

Product: adenosylcobinamide-phosphate synthase

Products: ADP; phosphate; Adenosyl cobinamide phosphate; Adenosyl cobinamide

Alternate protein names: NA

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MVSLFSVAPMGLTDPLVLVLLALVFDAYLGGMGPLFRLIPHPVVVMGGAIDALEQRLNRAERDDATRKRRGVFTVIVLVG
AAIGLGVALQALASVLAVGWVLELLLAVALLAQRELHDHVAAVADGLETGGIDAGREAVSHIVGRDPALLDHAGVGRGAL
ESLAENFSDGVVAPVFWFVLFGLPGLLAYKMINTMDSMIGHRTPRLRAFGWAAARLDDGVNLIPARLSGLLLIAAALTKP
WADARAAFVVMLRDAGKHRSPNAGWPEGAMAGALGLRLSGPRVYKGEAPRDEPYVGDGRAGVTPKDIRRGLALFRSACLI
EGALIALLAIALAVLR

Sequences:

>Translated_336_residues
MVSLFSVAPMGLTDPLVLVLLALVFDAYLGGMGPLFRLIPHPVVVMGGAIDALEQRLNRAERDDATRKRRGVFTVIVLVG
AAIGLGVALQALASVLAVGWVLELLLAVALLAQRELHDHVAAVADGLETGGIDAGREAVSHIVGRDPALLDHAGVGRGAL
ESLAENFSDGVVAPVFWFVLFGLPGLLAYKMINTMDSMIGHRTPRLRAFGWAAARLDDGVNLIPARLSGLLLIAAALTKP
WADARAAFVVMLRDAGKHRSPNAGWPEGAMAGALGLRLSGPRVYKGEAPRDEPYVGDGRAGVTPKDIRRGLALFRSACLI
EGALIALLAIALAVLR
>Mature_336_residues
MVSLFSVAPMGLTDPLVLVLLALVFDAYLGGMGPLFRLIPHPVVVMGGAIDALEQRLNRAERDDATRKRRGVFTVIVLVG
AAIGLGVALQALASVLAVGWVLELLLAVALLAQRELHDHVAAVADGLETGGIDAGREAVSHIVGRDPALLDHAGVGRGAL
ESLAENFSDGVVAPVFWFVLFGLPGLLAYKMINTMDSMIGHRTPRLRAFGWAAARLDDGVNLIPARLSGLLLIAAALTKP
WADARAAFVVMLRDAGKHRSPNAGWPEGAMAGALGLRLSGPRVYKGEAPRDEPYVGDGRAGVTPKDIRRGLALFRSACLI
EGALIALLAIALAVLR

Specific function: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group [H]

COG id: COG1270

COG function: function code H; Cobalamin biosynthesis protein CobD/CbiB

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CobD/CbiB family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004485 [H]

Pfam domain/function: PF03186 CobD_Cbib [H]

EC number: 6.3.1.10

Molecular weight: Translated: 35348; Mature: 35348

Theoretical pI: Translated: 9.08; Mature: 9.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSLFSVAPMGLTDPLVLVLLALVFDAYLGGMGPLFRLIPHPVVVMGGAIDALEQRLNRA
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHCCCCCEEECCHHHHHHHHHHHH
ERDDATRKRRGVFTVIVLVGAAIGLGVALQALASVLAVGWVLELLLAVALLAQRELHDHV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAVADGLETGGIDAGREAVSHIVGRDPALLDHAGVGRGALESLAENFSDGVVAPVFWFVL
HHHHHCHHCCCCCHHHHHHHHHHCCCCCHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHH
FGLPGLLAYKMINTMDSMIGHRTPRLRAFGWAAARLDDGVNLIPARLSGLLLIAAALTKP
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCC
WADARAAFVVMLRDAGKHRSPNAGWPEGAMAGALGLRLSGPRVYKGEAPRDEPYVGDGRA
HHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHEEECCCEEECCCCCCCCCCCCCCCC
GVTPKDIRRGLALFRSACLIEGALIALLAIALAVLR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MVSLFSVAPMGLTDPLVLVLLALVFDAYLGGMGPLFRLIPHPVVVMGGAIDALEQRLNRA
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHCCCCCEEECCHHHHHHHHHHHH
ERDDATRKRRGVFTVIVLVGAAIGLGVALQALASVLAVGWVLELLLAVALLAQRELHDHV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAVADGLETGGIDAGREAVSHIVGRDPALLDHAGVGRGALESLAENFSDGVVAPVFWFVL
HHHHHCHHCCCCCHHHHHHHHHHCCCCCHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHH
FGLPGLLAYKMINTMDSMIGHRTPRLRAFGWAAARLDDGVNLIPARLSGLLLIAAALTKP
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCC
WADARAAFVVMLRDAGKHRSPNAGWPEGAMAGALGLRLSGPRVYKGEAPRDEPYVGDGRA
HHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHEEECCCEEECCCCCCCCCCCCCCCC
GVTPKDIRRGLALFRSACLIEGALIALLAIALAVLR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; adenosylcobyric acid; (R)-1-aminopropan-2-yl phosphate; (R)-1-aminopropan-2-ol

Specific reaction: (1) ATP + adenosylcobyric acid + (R)-1-aminopropan-2-yl phosphate = ADP + phosphate + adenosylcobinamide phosphate; (2) ATP + adenosylcobyric acid + (R)-1-aminopropan-2-ol = ADP + phosphate + adenosylcobinamide

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 2211520 [H]