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The map label for this gene is ywrD [H]

Identifier: 83594647

GI number: 83594647

Start: 3827625

End: 3829229

Strand: Reverse

Name: ywrD [H]

Synonym: Rru_A3318

Alternate gene names: 83594647

Gene position: 3829229-3827625 (Counterclockwise)

Preceding gene: 83594649

Following gene: 83594645

Centisome position: 87.97

GC content: 72.21

Gene sequence:

>1605_bases
ATGCTGACCTCCAGGCTGGCCCGGCGCGGCATGGTGAGCGCGCCCCATCATCTGGCGGCCCAGGCGGGGCTTGACATCCT
GCGCGAGGGTGGGAACGCCATCGAGGCGATGATCGCCGCCGCCAGCGCCTGCGCGGTTCTTTATCCCCATATGACCGGCA
TCGGCGGCGATGGCTTCTGGATCATCCACGAGCCCGGGCGCCCGCCGCTGTCGATCGATGCCAGCGGCGCCGCCGGGGCC
GGGGCCAGCCTTGCCGTCTATCGCGAGCGCGGCCTTGCCCGGGTTCCCATCCATGGCGCCCTGGCCGCCTGCACGGTGGC
CGGCGCGCTGTCGGGCTGGCAATCGGCGCTTGATGTCTCCAGCCGCTGGGGCGGGCGCCTGCCCTTGTCGCGGCTGCTGG
GCGAGGCGGTGGGCTATGCCCGCGACGGCTTCGCCGTCTCCCATTCCCAGGAACGGGCCCTGCGCCGGCTGCTGGGCGGG
CTGAAGGATCAGCCGGGCTTCGCCGCCCAGTTCCTTGAAGCCGATGGCCGGGTTCCCCGCGCCGGGGCGCTCCAGCGCAA
TCGCCCCCTGGCCGAGACCCTGGAAACCCTGGCGGCGGACGGACTTGACAGCTTTTATCGCGGCGAGGTCGGCCAAAAGG
TCGCCGCCGCCCTCAAGGCGGTGGGCGCGCCGGTGACCGCGGGCGATCTCGCCCGCCACCGCTCGATCCGCCGGCGGCCC
TTGACCCTGGCCCTGGAAAGCGCCGTTCTCCATACCACGCCGCCGCCGACCCAGGGGCTGACGACGCTGATGCTGATCGG
CCTGTTCCAACGCGCCGGCTTGCGCGATGCCGAGGGCGCGGCCTTTGTTCACGCCATGGTCGAGGCCGCCAAGGTCGCCT
ATCGGGTGCGCGACGCCAAGATCTGCGATCCCCGCCATATGGGCGTTCATCCCGCCACCTATCTCTCGGCCCAGGTCCTT
GACGGCCTCGCCGGCGAGATCGCCCAGGGCGGGGGGACGCCGACCCCGGCGCTGAGCGCGGCGGGGGATACGGTGTGGAT
GGGCGCCGTGGATGGCGAGGGGCGGGCGGTCAGTTTCAGCCAAAGCCTGTGCCACGCCTTCGGCTCGGGGGTGATGCTCG
GCGACACCGGCATCCTGTGGCACAATCGGGGCGTGGCGTTCGCGCTGGGCGACCAGGCGGTCAATCCGCTGGTCCCCGGG
CGCAAGCCGATCCACGCCCTCAATCCGCTGCTGGCGCGGCTGCGCGATGGCAGGACCCTGGTGTTCGGCACCATGGGGGG
GGATGGCCAGCCGCAAACCCTGGCGGCGATCTTCGCCCGCCATGTGCTGTTTGGCCAGGACCCGCAGGCGGCGATCTCGG
CGCCGCGCTGGCTATTGACCGGTGGGCCGGGGGGGCGCGACGGCTTGCCGCTGGCCGCCCTGCGTCTGGAATCGCGCTTC
GATCCCCGGGTGGTCGAAGGCCTGCGCGCCCTTGGGCATTGCGTCACCCTGACCGATGCCTTCGACGAGGCGATGGGCCA
TGCCGGGGCGCTGATCCGCCATCCCGACGGCACCATCGAAGGCGCCTTCGATCCGCGCTCCGACGGCGGTCTCGCCGGCT
GGTGA

Upstream 100 bases:

>100_bases
ATCCCTGCGGCGATTTCCGATCAAGAAGGCTGGACGCGCCCCCCGGCGGTCGGGGATTATAAGGATCGTTCAAGGATTTG
CCGGGGAGTTTATCCAACCG

Downstream 100 bases:

>100_bases
CGGCTCCTTGCCGGGCGGCATAAAAAAATCCCCGGACGCGGGTCCGGGGAGGCTCATGGCGGCAAAACGGCAGAGGCGTC
GCGAAACGGCCTCTCAGCGG

Product: gamma-glutamyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 534; Mature: 534

Protein sequence:

>534_residues
MLTSRLARRGMVSAPHHLAAQAGLDILREGGNAIEAMIAAASACAVLYPHMTGIGGDGFWIIHEPGRPPLSIDASGAAGA
GASLAVYRERGLARVPIHGALAACTVAGALSGWQSALDVSSRWGGRLPLSRLLGEAVGYARDGFAVSHSQERALRRLLGG
LKDQPGFAAQFLEADGRVPRAGALQRNRPLAETLETLAADGLDSFYRGEVGQKVAAALKAVGAPVTAGDLARHRSIRRRP
LTLALESAVLHTTPPPTQGLTTLMLIGLFQRAGLRDAEGAAFVHAMVEAAKVAYRVRDAKICDPRHMGVHPATYLSAQVL
DGLAGEIAQGGGTPTPALSAAGDTVWMGAVDGEGRAVSFSQSLCHAFGSGVMLGDTGILWHNRGVAFALGDQAVNPLVPG
RKPIHALNPLLARLRDGRTLVFGTMGGDGQPQTLAAIFARHVLFGQDPQAAISAPRWLLTGGPGGRDGLPLAALRLESRF
DPRVVEGLRALGHCVTLTDAFDEAMGHAGALIRHPDGTIEGAFDPRSDGGLAGW

Sequences:

>Translated_534_residues
MLTSRLARRGMVSAPHHLAAQAGLDILREGGNAIEAMIAAASACAVLYPHMTGIGGDGFWIIHEPGRPPLSIDASGAAGA
GASLAVYRERGLARVPIHGALAACTVAGALSGWQSALDVSSRWGGRLPLSRLLGEAVGYARDGFAVSHSQERALRRLLGG
LKDQPGFAAQFLEADGRVPRAGALQRNRPLAETLETLAADGLDSFYRGEVGQKVAAALKAVGAPVTAGDLARHRSIRRRP
LTLALESAVLHTTPPPTQGLTTLMLIGLFQRAGLRDAEGAAFVHAMVEAAKVAYRVRDAKICDPRHMGVHPATYLSAQVL
DGLAGEIAQGGGTPTPALSAAGDTVWMGAVDGEGRAVSFSQSLCHAFGSGVMLGDTGILWHNRGVAFALGDQAVNPLVPG
RKPIHALNPLLARLRDGRTLVFGTMGGDGQPQTLAAIFARHVLFGQDPQAAISAPRWLLTGGPGGRDGLPLAALRLESRF
DPRVVEGLRALGHCVTLTDAFDEAMGHAGALIRHPDGTIEGAFDPRSDGGLAGW
>Mature_534_residues
MLTSRLARRGMVSAPHHLAAQAGLDILREGGNAIEAMIAAASACAVLYPHMTGIGGDGFWIIHEPGRPPLSIDASGAAGA
GASLAVYRERGLARVPIHGALAACTVAGALSGWQSALDVSSRWGGRLPLSRLLGEAVGYARDGFAVSHSQERALRRLLGG
LKDQPGFAAQFLEADGRVPRAGALQRNRPLAETLETLAADGLDSFYRGEVGQKVAAALKAVGAPVTAGDLARHRSIRRRP
LTLALESAVLHTTPPPTQGLTTLMLIGLFQRAGLRDAEGAAFVHAMVEAAKVAYRVRDAKICDPRHMGVHPATYLSAQVL
DGLAGEIAQGGGTPTPALSAAGDTVWMGAVDGEGRAVSFSQSLCHAFGSGVMLGDTGILWHNRGVAFALGDQAVNPLVPG
RKPIHALNPLLARLRDGRTLVFGTMGGDGQPQTLAAIFARHVLFGQDPQAAISAPRWLLTGGPGGRDGLPLAALRLESRF
DPRVVEGLRALGHCVTLTDAFDEAMGHAGALIRHPDGTIEGAFDPRSDGGLAGW

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=552, Percent_Identity=25.9057971014493, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI73915090, Length=552, Percent_Identity=25.9057971014493, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI73915096, Length=552, Percent_Identity=25.9057971014493, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI73915094, Length=552, Percent_Identity=25.9057971014493, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI113429324, Length=553, Percent_Identity=25.1356238698011, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI113429326, Length=556, Percent_Identity=24.6402877697842, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI109148539, Length=533, Percent_Identity=25.703564727955, Blast_Score=93, Evalue=8e-19,
Organism=Homo sapiens, GI153266885, Length=551, Percent_Identity=24.6823956442831, Blast_Score=80, Evalue=6e-15,
Organism=Homo sapiens, GI153266901, Length=552, Percent_Identity=24.6376811594203, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI153266907, Length=551, Percent_Identity=25.0453720508167, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1789856, Length=554, Percent_Identity=27.4368231046931, Blast_Score=190, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI193208245, Length=513, Percent_Identity=23.7816764132554, Blast_Score=119, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI193208247, Length=513, Percent_Identity=23.7816764132554, Blast_Score=118, Evalue=7e-27,
Organism=Caenorhabditis elegans, GI17506189, Length=484, Percent_Identity=24.3801652892562, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI18859893, Length=533, Percent_Identity=26.6416510318949, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI161077880, Length=554, Percent_Identity=23.6462093862816, Blast_Score=105, Evalue=1e-22,
Organism=Drosophila melanogaster, GI161077878, Length=554, Percent_Identity=23.6462093862816, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24642670, Length=554, Percent_Identity=23.6462093862816, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24642666, Length=554, Percent_Identity=23.6462093862816, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI45551474, Length=554, Percent_Identity=23.6462093862816, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI161077496, Length=463, Percent_Identity=23.5421166306695, Blast_Score=80, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 55520; Mature: 55520

Theoretical pI: Translated: 8.75; Mature: 8.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTSRLARRGMVSAPHHLAAQAGLDILREGGNAIEAMIAAASACAVLYPHMTGIGGDGFW
CCCHHHHHCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEE
IIHEPGRPPLSIDASGAAGAGASLAVYRERGLARVPIHGALAACTVAGALSGWQSALDVS
EEECCCCCCEEEECCCCCCCCCEEEEHHHCCCEECCHHHHHHHHHHHHHHHHHHHHHHHH
SRWGGRLPLSRLLGEAVGYARDGFAVSHSQERALRRLLGGLKDQPGFAAQFLEADGRVPR
HCCCCCCCHHHHHHHHHCCCCCCCEECCHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCC
AGALQRNRPLAETLETLAADGLDSFYRGEVGQKVAAALKAVGAPVTAGDLARHRSIRRRP
CCCCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCC
LTLALESAVLHTTPPPTQGLTTLMLIGLFQRAGLRDAEGAAFVHAMVEAAKVAYRVRDAK
CEEEEHHHHEECCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
ICDPRHMGVHPATYLSAQVLDGLAGEIAQGGGTPTPALSAAGDTVWMGAVDGEGRAVSFS
CCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECCCCCEEEHH
QSLCHAFGSGVMLGDTGILWHNRGVAFALGDQAVNPLVPGRKPIHALNPLLARLRDGRTL
HHHHHHHCCCEEECCCEEEEECCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCEE
VFGTMGGDGQPQTLAAIFARHVLFGQDPQAAISAPRWLLTGGPGGRDGLPLAALRLESRF
EEEECCCCCCHHHHHHHHHHHHHCCCCCHHHHCCCCEEEECCCCCCCCCCHHHHHHHCCC
DPRVVEGLRALGHCVTLTDAFDEAMGHAGALIRHPDGTIEGAFDPRSDGGLAGW
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCEECCCCCCCCCCCCCC
>Mature Secondary Structure
MLTSRLARRGMVSAPHHLAAQAGLDILREGGNAIEAMIAAASACAVLYPHMTGIGGDGFW
CCCHHHHHCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEE
IIHEPGRPPLSIDASGAAGAGASLAVYRERGLARVPIHGALAACTVAGALSGWQSALDVS
EEECCCCCCEEEECCCCCCCCCEEEEHHHCCCEECCHHHHHHHHHHHHHHHHHHHHHHHH
SRWGGRLPLSRLLGEAVGYARDGFAVSHSQERALRRLLGGLKDQPGFAAQFLEADGRVPR
HCCCCCCCHHHHHHHHHCCCCCCCEECCHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCC
AGALQRNRPLAETLETLAADGLDSFYRGEVGQKVAAALKAVGAPVTAGDLARHRSIRRRP
CCCCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCC
LTLALESAVLHTTPPPTQGLTTLMLIGLFQRAGLRDAEGAAFVHAMVEAAKVAYRVRDAK
CEEEEHHHHEECCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
ICDPRHMGVHPATYLSAQVLDGLAGEIAQGGGTPTPALSAAGDTVWMGAVDGEGRAVSFS
CCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECCCCCEEEHH
QSLCHAFGSGVMLGDTGILWHNRGVAFALGDQAVNPLVPGRKPIHALNPLLARLRDGRTL
HHHHHHHCCCEEECCCEEEEECCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCEE
VFGTMGGDGQPQTLAAIFARHVLFGQDPQAAISAPRWLLTGGPGGRDGLPLAALRLESRF
EEEECCCCCCHHHHHHHHHHHHHCCCCCHHHHCCCCEEEECCCCCCCCCCHHHHHHHCCC
DPRVVEGLRALGHCVTLTDAFDEAMGHAGALIRHPDGTIEGAFDPRSDGGLAGW
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]