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The map label for this gene is nrdZ [H]

Identifier: 83594588

GI number: 83594588

Start: 3753674

End: 3756034

Strand: Direct

Name: nrdZ [H]

Synonym: Rru_A3258

Alternate gene names: 83594588

Gene position: 3753674-3756034 (Clockwise)

Preceding gene: 83594587

Following gene: 83594590

Centisome position: 86.24

GC content: 67.68

Gene sequence:

>2361_bases
ATGGACCGCCAGCCTATCGTCGAAAGCATCTGGCGGGAGAAGTACCGGCTGGTCGACCCCGATGGCTCGTCGCTTGAGCA
GGGTCCCGAAGACAGCTTCGCCCGGGTCTGCCGGGGCATCTATGCCCGCGACCCCCGGCGCGCCGTTCACGAGCCCCTGG
CCCTAGAGGCGATGAAGGCGCTGGAATGGTGCCCGGGTGGGCGCATTCACGCCGGAGCGGGCACCGATCGCCGAGTCACC
CTGATCAACTGCTTCGTCAATATGATCGTGCCCGACCGCATGGACGGCATCATGGAGGCGCTAACCCGCGCCGCCCTGAC
CATGCAGCAAGGCGGCGGCATCGGCACCGATTTCTCGACGCTGCGGCCGCGCGGCGCCAAGGTCCGGCGCACCGGATCGG
TGTCGTCGGGGCCGCTGTCGTTCATGGAGATCTGGCACGCCATGTGCGGCACGATCATGAGCGGCGGGGCGCGGCGCGGC
GCGATGATGGGCACGATGATTTGCGACCATCCCGACCTGCCGGCCTTCATCACCGCCAAGGCCCAGGCCGGACGGCTGAC
CAATTTCAACGTCTCGGTTCTGGTCACCGACGCCTTCATGCGCGCCGTTGACGAGGATGCGACCTGGGATCTGGGCTTTT
CCGTGCCGCCGGCCGATCCGGCCCGTTTGGTGGCGGTTACCGAGCGCAACGGCGAACCCTGGTACGTCTACGAGCGGCTG
TCGGCCCGCGCCCTGTGGGAAAAGATCATCCGCACCACCTATGATCACGCCGAGCCCGGAGTGATCTTCATCGACCGGGT
GAACGAGCGCAACAATCTGGCTTATTGCGAGACCATCTCGTGCACCAACCCCTGCGGTGAACAGCCGCTGCCGCCCAATG
GCGATTGCAACCTGGGTTGCGTCAATCTGGCGGTTCTGGTGCGCGATCCCTTCACCCCCCAAGCCCGGTTCGACGACGCG
CGTCTGGCCGAGGTGGCGGCGATCGGCGTGCGCTTCCTTGATAACGTGCTCGATGTCTCGAACTTCCCGGTCGAGGATCA
GGCCAAGGAGGCCCAGGCCAAGCGCCGGCTGGGGCTGGGGATCATGGGCCTGGGCAACGCCTTGCAGATGCTGGGTCTGC
GCTATGGTTCGCCGGCCGCCATCGCCGAAACCCGGCGGATCATGGCGCTCTTGCGCGATGCCGCCTATCGGGCTTCGGCC
GAGCTGGCGGGCGAGCGCGGCCCCTTCCCGCTTTATGACCGCGACCAGCTGCTGGCCCGCCCCTTCATTCAGGAGTTGCC
CGACGATCTTCGCGCCAAGATTGCTGAACAGGGCCTGCGCAATGGTGTGATGCTGACCATCGCCCCGACGGGGACGACGG
CGATCTATTACAACAACGTGTCGAGCGGTCTGGAGCCGACCTTCGGCTGGCGCTATTTCCGCAAGGTGCTGCGCCCCGAT
GGCGGCCACGACGAATTCGCCGTGATCGACGCCGGCTTTGAAAGCTGGTGCCGGACGCGGGGCCTTGATCCGGCCACGGC
GCCGCTCACCGGCCTGCCCGACTCGATGGTGACGGCGCTGGAGCTGTCGGTCGAGGATCACCTGCGCATGCAGGCCGCCT
GTCAGGAGTTCATCGACGCCTCGATCAGCAAGACGATCAACTGCCCGGCCGACATGAGCTACGACTCCTTCGCCGCCGTC
TACAAGCTGGCCTATGAGATGGGCTGCAAGGGCTGCACGACCTATCGCCCCTCGGGCACGCGCGGCTCGGTGCTGTCGCT
GGACGCGACGACGCCCGCCGCCGCCCCGGTCCAGAAGGCGCCGGCGCCGCGCACCCCGGCGCCGCCGATGCGGCCGGAGT
TTCTGGAGGGCCGCACCTATAAACTGCGCTGGCCGTTATCGGACGAGAACTTCTACGTCACCATCAACGATGTGCGCGAC
GAGGCCGGCGGCCGACGGCCCTTCGAGGTGTTCATCGCCTCGCGCTCGGCCGAACACGCCGAATTGCTTTCGGCGCTGAC
CGTCACCCTGTCGGCGGTGATGCGCCGCACCGACAACCCGGCCTTCCTGGTCGAAGATCTCGAACAGGTGCGCGGCGCCC
AGGGCGTTTGGGTCAAGGGCCGCTTCGTCAATGGCGTGGTCGCCCTGGTCGCCTCGGTGATGCGCCGCCACCTCGCCGAT
CTCGGCCTGATGGACCAGATCGCCGAGCGCGGCGCCCCCGAGGAGGAAACCGCCCCGGCCGCGCCATCGGCCGATGCCTC
GGCCCCTGCCTCGGCGGGGGCGCCGATCGGCGACCGCTGCCCGGCCTGCGGCCAGCCGACCTACTTCCGCCAGGAAGGCT
GCTCCAAATGCGCGAGCTGCGGCCATTCGACCTGCTCATAA

Upstream 100 bases:

>100_bases
ACCCTGGCGGCCCCGGCGGACCCGGCCCCGTCCCTGGGCGCCTGATCCCTTTTCAGACCCTTTCCTTTTCGCGTTTTTCC
CCCACCAAGGAGTTTCCCCC

Downstream 100 bases:

>100_bases
GCCTCCCGTCCGCCCGACCTTAGGGTCGGGCGGGTACGGCGCTTAGAGCGGCCTGCGGATTTCACGCGGGCCGCCCTAGG
CGGTCAACGGTGGCGAGCAG

Product: ribonucleotide reductase large subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 786; Mature: 786

Protein sequence:

>786_residues
MDRQPIVESIWREKYRLVDPDGSSLEQGPEDSFARVCRGIYARDPRRAVHEPLALEAMKALEWCPGGRIHAGAGTDRRVT
LINCFVNMIVPDRMDGIMEALTRAALTMQQGGGIGTDFSTLRPRGAKVRRTGSVSSGPLSFMEIWHAMCGTIMSGGARRG
AMMGTMICDHPDLPAFITAKAQAGRLTNFNVSVLVTDAFMRAVDEDATWDLGFSVPPADPARLVAVTERNGEPWYVYERL
SARALWEKIIRTTYDHAEPGVIFIDRVNERNNLAYCETISCTNPCGEQPLPPNGDCNLGCVNLAVLVRDPFTPQARFDDA
RLAEVAAIGVRFLDNVLDVSNFPVEDQAKEAQAKRRLGLGIMGLGNALQMLGLRYGSPAAIAETRRIMALLRDAAYRASA
ELAGERGPFPLYDRDQLLARPFIQELPDDLRAKIAEQGLRNGVMLTIAPTGTTAIYYNNVSSGLEPTFGWRYFRKVLRPD
GGHDEFAVIDAGFESWCRTRGLDPATAPLTGLPDSMVTALELSVEDHLRMQAACQEFIDASISKTINCPADMSYDSFAAV
YKLAYEMGCKGCTTYRPSGTRGSVLSLDATTPAAAPVQKAPAPRTPAPPMRPEFLEGRTYKLRWPLSDENFYVTINDVRD
EAGGRRPFEVFIASRSAEHAELLSALTVTLSAVMRRTDNPAFLVEDLEQVRGAQGVWVKGRFVNGVVALVASVMRRHLAD
LGLMDQIAERGAPEEETAPAAPSADASAPASAGAPIGDRCPACGQPTYFRQEGCSKCASCGHSTCS

Sequences:

>Translated_786_residues
MDRQPIVESIWREKYRLVDPDGSSLEQGPEDSFARVCRGIYARDPRRAVHEPLALEAMKALEWCPGGRIHAGAGTDRRVT
LINCFVNMIVPDRMDGIMEALTRAALTMQQGGGIGTDFSTLRPRGAKVRRTGSVSSGPLSFMEIWHAMCGTIMSGGARRG
AMMGTMICDHPDLPAFITAKAQAGRLTNFNVSVLVTDAFMRAVDEDATWDLGFSVPPADPARLVAVTERNGEPWYVYERL
SARALWEKIIRTTYDHAEPGVIFIDRVNERNNLAYCETISCTNPCGEQPLPPNGDCNLGCVNLAVLVRDPFTPQARFDDA
RLAEVAAIGVRFLDNVLDVSNFPVEDQAKEAQAKRRLGLGIMGLGNALQMLGLRYGSPAAIAETRRIMALLRDAAYRASA
ELAGERGPFPLYDRDQLLARPFIQELPDDLRAKIAEQGLRNGVMLTIAPTGTTAIYYNNVSSGLEPTFGWRYFRKVLRPD
GGHDEFAVIDAGFESWCRTRGLDPATAPLTGLPDSMVTALELSVEDHLRMQAACQEFIDASISKTINCPADMSYDSFAAV
YKLAYEMGCKGCTTYRPSGTRGSVLSLDATTPAAAPVQKAPAPRTPAPPMRPEFLEGRTYKLRWPLSDENFYVTINDVRD
EAGGRRPFEVFIASRSAEHAELLSALTVTLSAVMRRTDNPAFLVEDLEQVRGAQGVWVKGRFVNGVVALVASVMRRHLAD
LGLMDQIAERGAPEEETAPAAPSADASAPASAGAPIGDRCPACGQPTYFRQEGCSKCASCGHSTCS
>Mature_786_residues
MDRQPIVESIWREKYRLVDPDGSSLEQGPEDSFARVCRGIYARDPRRAVHEPLALEAMKALEWCPGGRIHAGAGTDRRVT
LINCFVNMIVPDRMDGIMEALTRAALTMQQGGGIGTDFSTLRPRGAKVRRTGSVSSGPLSFMEIWHAMCGTIMSGGARRG
AMMGTMICDHPDLPAFITAKAQAGRLTNFNVSVLVTDAFMRAVDEDATWDLGFSVPPADPARLVAVTERNGEPWYVYERL
SARALWEKIIRTTYDHAEPGVIFIDRVNERNNLAYCETISCTNPCGEQPLPPNGDCNLGCVNLAVLVRDPFTPQARFDDA
RLAEVAAIGVRFLDNVLDVSNFPVEDQAKEAQAKRRLGLGIMGLGNALQMLGLRYGSPAAIAETRRIMALLRDAAYRASA
ELAGERGPFPLYDRDQLLARPFIQELPDDLRAKIAEQGLRNGVMLTIAPTGTTAIYYNNVSSGLEPTFGWRYFRKVLRPD
GGHDEFAVIDAGFESWCRTRGLDPATAPLTGLPDSMVTALELSVEDHLRMQAACQEFIDASISKTINCPADMSYDSFAAV
YKLAYEMGCKGCTTYRPSGTRGSVLSLDATTPAAAPVQKAPAPRTPAPPMRPEFLEGRTYKLRWPLSDENFYVTINDVRD
EAGGRRPFEVFIASRSAEHAELLSALTVTLSAVMRRTDNPAFLVEDLEQVRGAQGVWVKGRFVNGVVALVASVMRRHLAD
LGLMDQIAERGAPEEETAPAAPSADASAPASAGAPIGDRCPACGQPTYFRQEGCSKCASCGHSTCS

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0209

COG function: function code F; Ribonucleotide reductase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-cone domain [H]

Homologues:

Organism=Homo sapiens, GI4506749, Length=629, Percent_Identity=25.7551669316375, Blast_Score=169, Evalue=8e-42,
Organism=Escherichia coli, GI1789030, Length=489, Percent_Identity=25.5623721881391, Blast_Score=104, Evalue=2e-23,
Organism=Escherichia coli, GI2367133, Length=500, Percent_Identity=23.4, Blast_Score=86, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17555242, Length=622, Percent_Identity=26.2057877813505, Blast_Score=173, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI6320914, Length=575, Percent_Identity=25.3913043478261, Blast_Score=145, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6322123, Length=577, Percent_Identity=25.1299826689775, Blast_Score=137, Evalue=5e-33,
Organism=Drosophila melanogaster, GI17352481, Length=643, Percent_Identity=24.4167962674961, Blast_Score=156, Evalue=5e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005144
- InterPro:   IPR013344
- InterPro:   IPR013509
- InterPro:   IPR000788
- InterPro:   IPR008926 [H]

Pfam domain/function: PF03477 ATP-cone; PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 85641; Mature: 85641

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRQPIVESIWREKYRLVDPDGSSLEQGPEDSFARVCRGIYARDPRRAVHEPLALEAMKA
CCCCCHHHHHHHHHCEEECCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHCHHHHHHHHH
LEWCPGGRIHAGAGTDRRVTLINCFVNMIVPDRMDGIMEALTRAALTMQQGGGIGTDFST
HHCCCCCEEECCCCCCCEEHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
LRPRGAKVRRTGSVSSGPLSFMEIWHAMCGTIMSGGARRGAMMGTMICDHPDLPAFITAK
CCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHEECCCCCCCEEEEEC
AQAGRLTNFNVSVLVTDAFMRAVDEDATWDLGFSVPPADPARLVAVTERNGEPWYVYERL
CCCCCCCCCCEEEEEHHHHHHHHCCCCCEECCCCCCCCCCCEEEEEEECCCCCEEEHHHH
SARALWEKIIRTTYDHAEPGVIFIDRVNERNNLAYCETISCTNPCGEQPLPPNGDCNLGC
HHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCC
VNLAVLVRDPFTPQARFDDARLAEVAAIGVRFLDNVLDVSNFPVEDQAKEAQAKRRLGLG
EEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCC
IMGLGNALQMLGLRYGSPAAIAETRRIMALLRDAAYRASAELAGERGPFPLYDRDQLLAR
EECHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHH
PFIQELPDDLRAKIAEQGLRNGVMLTIAPTGTTAIYYNNVSSGLEPTFGWRYFRKVLRPD
HHHHHCCHHHHHHHHHHHHHCCEEEEEECCCCEEEEECCCCCCCCCCHHHHHHHHHHCCC
GGHDEFAVIDAGFESWCRTRGLDPATAPLTGLPDSMVTALELSVEDHLRMQAACQEFIDA
CCCCCEEEEECCHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
SISKTINCPADMSYDSFAAVYKLAYEMGCKGCTTYRPSGTRGSVLSLDATTPAAAPVQKA
HHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCCCCCHHCC
PAPRTPAPPMRPEFLEGRTYKLRWPLSDENFYVTINDVRDEAGGRRPFEVFIASRSAEHA
CCCCCCCCCCCCHHHCCCEEEEECCCCCCCEEEEEECCHHCCCCCCCEEEEEECCCCHHH
ELLSALTVTLSAVMRRTDNPAFLVEDLEQVRGAQGVWVKGRFVNGVVALVASVMRRHLAD
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHHHHHH
LGLMDQIAERGAPEEETAPAAPSADASAPASAGAPIGDRCPACGQPTYFRQEGCSKCASC
CCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHC
GHSTCS
CCCCCC
>Mature Secondary Structure
MDRQPIVESIWREKYRLVDPDGSSLEQGPEDSFARVCRGIYARDPRRAVHEPLALEAMKA
CCCCCHHHHHHHHHCEEECCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHCHHHHHHHHH
LEWCPGGRIHAGAGTDRRVTLINCFVNMIVPDRMDGIMEALTRAALTMQQGGGIGTDFST
HHCCCCCEEECCCCCCCEEHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
LRPRGAKVRRTGSVSSGPLSFMEIWHAMCGTIMSGGARRGAMMGTMICDHPDLPAFITAK
CCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHEECCCCCCCEEEEEC
AQAGRLTNFNVSVLVTDAFMRAVDEDATWDLGFSVPPADPARLVAVTERNGEPWYVYERL
CCCCCCCCCCEEEEEHHHHHHHHCCCCCEECCCCCCCCCCCEEEEEEECCCCCEEEHHHH
SARALWEKIIRTTYDHAEPGVIFIDRVNERNNLAYCETISCTNPCGEQPLPPNGDCNLGC
HHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCC
VNLAVLVRDPFTPQARFDDARLAEVAAIGVRFLDNVLDVSNFPVEDQAKEAQAKRRLGLG
EEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCC
IMGLGNALQMLGLRYGSPAAIAETRRIMALLRDAAYRASAELAGERGPFPLYDRDQLLAR
EECHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHH
PFIQELPDDLRAKIAEQGLRNGVMLTIAPTGTTAIYYNNVSSGLEPTFGWRYFRKVLRPD
HHHHHCCHHHHHHHHHHHHHCCEEEEEECCCCEEEEECCCCCCCCCCHHHHHHHHHHCCC
GGHDEFAVIDAGFESWCRTRGLDPATAPLTGLPDSMVTALELSVEDHLRMQAACQEFIDA
CCCCCEEEEECCHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
SISKTINCPADMSYDSFAAVYKLAYEMGCKGCTTYRPSGTRGSVLSLDATTPAAAPVQKA
HHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCCCCCHHCC
PAPRTPAPPMRPEFLEGRTYKLRWPLSDENFYVTINDVRDEAGGRRPFEVFIASRSAEHA
CCCCCCCCCCCCHHHCCCEEEEECCCCCCCEEEEEECCHHCCCCCCCEEEEEECCCCHHH
ELLSALTVTLSAVMRRTDNPAFLVEDLEQVRGAQGVWVKGRFVNGVVALVASVMRRHLAD
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHHHHHH
LGLMDQIAERGAPEEETAPAAPSADASAPASAGAPIGDRCPACGQPTYFRQEGCSKCASC
CCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHC
GHSTCS
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]