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The map label for this gene is pyrC [H]

Identifier: 83594521

GI number: 83594521

Start: 3680265

End: 3681563

Strand: Direct

Name: pyrC [H]

Synonym: Rru_A3191

Alternate gene names: 83594521

Gene position: 3680265-3681563 (Clockwise)

Preceding gene: 83594520

Following gene: 83594522

Centisome position: 84.55

GC content: 68.05

Gene sequence:

>1299_bases
ATGTCGCTGCGTTCCCCCGGTCGCGTCGCCTATGTCAACGCCCGCCTGCTCGATCCGGCCAGCGGCCTGGATCAAACGGG
CGCCCTGCTGGCCGATGGCGAGCATATCGTCGAAGTCCACCCCGGCGCCTTCACCGCCCCCGAGGACGCCGAGATCATCG
ACTGCCAGGGGGCCTGTCTCGCCCCCGGGCTGGTCGACATGCGCGTTCAGCTGCGCGAGCCGGGCGAGGAACATAAGGAA
AGCATGCGCAGCGCCGGTCAGGCGGCGGTGGCCGGCGGCATCACCTCGATGGTCTGCCTGCCCAACACCAATCCGCCGAT
GGACGACGAGGCGACCTTGGAATTCGTCGCCCGCCGCGCCCGTCTGGCCGGATTGGCCAAGGTCTATTGCTATGGCGCCT
GCACCAAGGGCCTGCGCGGCGAGGATCTGGCCGAGCTTGGCATCATGGCCGAAGCCGGGGCCCTGGCCTTCACCGATGGC
GTCAAGGCGATCGCCAACGCCCAGATGATGCGCCGGGTGCTGGCCTATGCCGCCACCTTCGACCTGCTGGTGATGCAGCA
TCCCGAAGAGCCGACCCTGGCCGGCGGCGTGATGAACGCCGGCGATCTGGCGACGCGCATGGGATTGTCGGGCATTCCGC
GCGAAGCCGAGATCATTTTGCTCGAACGCGATCTGCGGCTGGTCGCCATGACCGGCGGACGCTACCACGCCGCCCATATC
AGCACCGGCGAAAGCGTCGCGCTGATCCGCCGGGCCAAGGACCAGGGCCTGCGCGTCAGTTGCGATACGGCGCCGTTCTA
TTTCGCCCTCAACGAGCTGGCCGTCGGCGATTACCGGACCTTCGCCAAGCTGTCGCCGCCGTTGCGCGGCGAAAGCGACC
GCCGCGCCATCATCGAGGGATTGAAGGACGGGGTGATCGACGCCATCGCCTCCGATCACTCGCCCCAGGACCAGGACACC
AAGCGCCTGCCCTTCGCCCAGGCGGCCTTCGGCGCCGTCGGCCTGGAAACCCTGCTGTCGATCTCGCTCGAACTCCACCA
CAACGGCCATCTGTCGTTGCTCGAGGTGCTCAAGCGCCTGACCGTCGCCCCGGCCGGCCTGCTTGGCCTGGATGCCGGAC
GCCTGCGCCCGGGTGGCAAGGCCGACCTGCTGGTGTTCGATCCCTATCGCGCCGGCAAGGTCGACGCCACCCGCTTCCTG
TCGAAATCCAAAAACTCCCCCTTCGACGACCGCCCGGTGCAGGGTCGCGTTCTGCGTACCGTCGTCGATGGCCGCACGGT
GTTCCCCGCCAATGGCTGA

Upstream 100 bases:

>100_bases
AACGCAGCGTGATCCGGGAGCAGGTGGAAATGGGCGTCGCGGTGCGCATGGCGGTTCTCGAGGTGCTGTCGGGCAACCTC
GCCTCGATGGAGACCGCATA

Downstream 100 bases:

>100_bases
TCTTTCAACGCTGATGCCCGCCCTGGTTCTTGGGGTTTGCGCGCTGGCCGGCTACCTGCTGGGCTCGGTGCCCTTCGGGC
TGGTGCTGGTGCGTCTGGCC

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 432; Mature: 431

Protein sequence:

>432_residues
MSLRSPGRVAYVNARLLDPASGLDQTGALLADGEHIVEVHPGAFTAPEDAEIIDCQGACLAPGLVDMRVQLREPGEEHKE
SMRSAGQAAVAGGITSMVCLPNTNPPMDDEATLEFVARRARLAGLAKVYCYGACTKGLRGEDLAELGIMAEAGALAFTDG
VKAIANAQMMRRVLAYAATFDLLVMQHPEEPTLAGGVMNAGDLATRMGLSGIPREAEIILLERDLRLVAMTGGRYHAAHI
STGESVALIRRAKDQGLRVSCDTAPFYFALNELAVGDYRTFAKLSPPLRGESDRRAIIEGLKDGVIDAIASDHSPQDQDT
KRLPFAQAAFGAVGLETLLSISLELHHNGHLSLLEVLKRLTVAPAGLLGLDAGRLRPGGKADLLVFDPYRAGKVDATRFL
SKSKNSPFDDRPVQGRVLRTVVDGRTVFPANG

Sequences:

>Translated_432_residues
MSLRSPGRVAYVNARLLDPASGLDQTGALLADGEHIVEVHPGAFTAPEDAEIIDCQGACLAPGLVDMRVQLREPGEEHKE
SMRSAGQAAVAGGITSMVCLPNTNPPMDDEATLEFVARRARLAGLAKVYCYGACTKGLRGEDLAELGIMAEAGALAFTDG
VKAIANAQMMRRVLAYAATFDLLVMQHPEEPTLAGGVMNAGDLATRMGLSGIPREAEIILLERDLRLVAMTGGRYHAAHI
STGESVALIRRAKDQGLRVSCDTAPFYFALNELAVGDYRTFAKLSPPLRGESDRRAIIEGLKDGVIDAIASDHSPQDQDT
KRLPFAQAAFGAVGLETLLSISLELHHNGHLSLLEVLKRLTVAPAGLLGLDAGRLRPGGKADLLVFDPYRAGKVDATRFL
SKSKNSPFDDRPVQGRVLRTVVDGRTVFPANG
>Mature_431_residues
SLRSPGRVAYVNARLLDPASGLDQTGALLADGEHIVEVHPGAFTAPEDAEIIDCQGACLAPGLVDMRVQLREPGEEHKES
MRSAGQAAVAGGITSMVCLPNTNPPMDDEATLEFVARRARLAGLAKVYCYGACTKGLRGEDLAELGIMAEAGALAFTDGV
KAIANAQMMRRVLAYAATFDLLVMQHPEEPTLAGGVMNAGDLATRMGLSGIPREAEIILLERDLRLVAMTGGRYHAAHIS
TGESVALIRRAKDQGLRVSCDTAPFYFALNELAVGDYRTFAKLSPPLRGESDRRAIIEGLKDGVIDAIASDHSPQDQDTK
RLPFAQAAFGAVGLETLLSISLELHHNGHLSLLEVLKRLTVAPAGLLGLDAGRLRPGGKADLLVFDPYRAGKVDATRFLS
KSKNSPFDDRPVQGRVLRTVVDGRTVFPANG

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=393, Percent_Identity=28.498727735369, Blast_Score=119, Evalue=8e-27,
Organism=Escherichia coli, GI1786722, Length=403, Percent_Identity=27.5434243176179, Blast_Score=142, Evalue=6e-35,
Organism=Escherichia coli, GI87082175, Length=405, Percent_Identity=23.7037037037037, Blast_Score=79, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI193204318, Length=397, Percent_Identity=25.6926952141058, Blast_Score=107, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6322218, Length=425, Percent_Identity=27.2941176470588, Blast_Score=135, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24642586, Length=373, Percent_Identity=26.8096514745308, Blast_Score=118, Evalue=6e-27,
Organism=Drosophila melanogaster, GI18859883, Length=449, Percent_Identity=27.6169265033408, Blast_Score=97, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 46036; Mature: 45905

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: PS00626 RCC1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLRSPGRVAYVNARLLDPASGLDQTGALLADGEHIVEVHPGAFTAPEDAEIIDCQGACL
CCCCCCCCEEEEEEEEECCCCCCCCCCCEEECCCEEEEECCCCCCCCCCCCEEECCCCCC
APGLVDMRVQLREPGEEHKESMRSAGQAAVAGGITSMVCLPNTNPPMDDEATLEFVARRA
CCCCEEEHEEECCCCHHHHHHHHHCCCHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHH
RLAGLAKVYCYGACTKGLRGEDLAELGIMAEAGALAFTDGVKAIANAQMMRRVLAYAATF
HHHHHHHHEEEHHHCCCCCCCCHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHH
DLLVMQHPEEPTLAGGVMNAGDLATRMGLSGIPREAEIILLERDLRLVAMTGGRYHAAHI
HEEEEECCCCCCCCCCCCCCHHHHHHHCCCCCCCCCEEEEEECCCEEEEEECCEEEEEEE
STGESVALIRRAKDQGLRVSCDTAPFYFALNELAVGDYRTFAKLSPPLRGESDRRAIIEG
CCCCHHHHHHHHCCCCCEEEECCCCEEEEHHHHHCCCHHHHHHCCCCCCCCCHHHHHHHH
LKDGVIDAIASDHSPQDQDTKRLPFAQAAFGAVGLETLLSISLELHHNGHLSLLEVLKRL
HHHHHHHHHHCCCCCCCCCHHCCCHHHHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHH
TVAPAGLLGLDAGRLRPGGKADLLVFDPYRAGKVDATRFLSKSKNSPFDDRPVQGRVLRT
HCCCCCCEECCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHCCCCCCCCCCCCCHHEEE
VVDGRTVFPANG
ECCCCEEECCCC
>Mature Secondary Structure 
SLRSPGRVAYVNARLLDPASGLDQTGALLADGEHIVEVHPGAFTAPEDAEIIDCQGACL
CCCCCCCEEEEEEEEECCCCCCCCCCCEEECCCEEEEECCCCCCCCCCCCEEECCCCCC
APGLVDMRVQLREPGEEHKESMRSAGQAAVAGGITSMVCLPNTNPPMDDEATLEFVARRA
CCCCEEEHEEECCCCHHHHHHHHHCCCHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHH
RLAGLAKVYCYGACTKGLRGEDLAELGIMAEAGALAFTDGVKAIANAQMMRRVLAYAATF
HHHHHHHHEEEHHHCCCCCCCCHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHH
DLLVMQHPEEPTLAGGVMNAGDLATRMGLSGIPREAEIILLERDLRLVAMTGGRYHAAHI
HEEEEECCCCCCCCCCCCCCHHHHHHHCCCCCCCCCEEEEEECCCEEEEEECCEEEEEEE
STGESVALIRRAKDQGLRVSCDTAPFYFALNELAVGDYRTFAKLSPPLRGESDRRAIIEG
CCCCHHHHHHHHCCCCCEEEECCCCEEEEHHHHHCCCHHHHHHCCCCCCCCCHHHHHHHH
LKDGVIDAIASDHSPQDQDTKRLPFAQAAFGAVGLETLLSISLELHHNGHLSLLEVLKRL
HHHHHHHHHHCCCCCCCCCHHCCCHHHHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHH
TVAPAGLLGLDAGRLRPGGKADLLVFDPYRAGKVDATRFLSKSKNSPFDDRPVQGRVLRT
HCCCCCCEECCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHCCCCCCCCCCCCCHHEEE
VVDGRTVFPANG
ECCCCEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA