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The map label for this gene is galE [C]

Identifier: 83594438

GI number: 83594438

Start: 3578642

End: 3579628

Strand: Direct

Name: galE [C]

Synonym: Rru_A3108

Alternate gene names: 83594438

Gene position: 3578642-3579628 (Clockwise)

Preceding gene: 83594437

Following gene: 83594439

Centisome position: 82.21

GC content: 67.78

Gene sequence:

>987_bases
ATGACAGCCCTCACAGAGATCGATGCCCGCCATGCCGCTTGGCGTGGCCGGCGGGTGCTGGTCACCGGCGGCGCCGGCTT
CATCGGCGGCCATTTGTGCCGACGCCTGGTTGGCCTGGGGGCCGAGGTCGTCGTTCTTGACGACCTGAGCACCGGCCGCC
GCGACACGGTCCCCCGGGGGGTCCGCCTGATCGTCGGCTCGGTCACCGACCCGGCTCTGGTGCGCAAGGCGTTGCAAGGA
ACGGAAGGCTGCTTCCACCTTGCCGCCATCGCCTCGGTGCCGCTGTCGGTCAGCGCCCTGGTCGATTGCCATGCCGTCAA
CCAGACGGGAACCCTGCGCCTGATCGAAGGTCTGCGCGATAACGGCGGCGGGCGGTTGGTCTACGCCTCGAGTTCGGCGG
TCTTTGGCGATCCGGTCGCCCTGCCGCTGACCATGGCCTCGCCAACGCGGCCGATCTCGCCCTATGGCGTCGACAAGCTG
GCCTGTGAAGCCCACGCCCGGGTGGCCGGCGGGCTTTATGGGCTGAAAAGCTTCGGCCTGCGCTTCTTCAACGTTTATGG
CGAGGGGCAATCCGACGATTCGCCCTATAGCGGCGTCATCGCCCTCTTCAATCGCAAGCTCCGCGACGGTCAGCCGATCA
CCGTCTTTGGTGACGGCTCCCAAAGCCGCGACTTCGTCTATGTCGGCGATGTCATCGAGGGGCTGCTCGCCGCCTGGAAC
GAGGCCAGCGTCCGCGGACCGGTGGAAACCGTCGGCACCGGCTGCCCGACCACCGTGATGGATCTGGCCCGGACGATCAT
GGAGGTCCACGGCCGCAGCGTTCCCGTCGTTCACGCCCCGCCGCGCGAAGCCGATATCGAACATTCCTACGGCAAGGCCG
ATTTCCTGGCCCGCATCCTGCCCAAGCCGGCGGTGGCTTTGCGCGCCGGGTTGGCGCGGACGCTGTCGATCTCTCCCCCC
GCCGCAACCTTGGCCCCAACTCCATAG

Upstream 100 bases:

>100_bases
CCGGGCAGCGGACGATCCCCCCGGCGCGCCGCGGTAGATCCCAAACCAAGGGACAGCGGGACCGCGACGCGCAGGGACAA
AAAATCATAAGGAGATCACC

Downstream 100 bases:

>100_bases
GCGTCAGCACCGTGATCCCTTCCCCTTCCCCCCCCGTCCTGTCCGGTAGCGCCCAGTCCCCTTCCATGCCCGCCCCCCGC
TGGGCCACCATGGGCGCCAT

Product: NAD-dependent epimerase/dehydratase

Products: NA

Alternate protein names: Galactowaldenase; UDP-galactose 4-epimerase [H]

Number of amino acids: Translated: 328; Mature: 327

Protein sequence:

>328_residues
MTALTEIDARHAAWRGRRVLVTGGAGFIGGHLCRRLVGLGAEVVVLDDLSTGRRDTVPRGVRLIVGSVTDPALVRKALQG
TEGCFHLAAIASVPLSVSALVDCHAVNQTGTLRLIEGLRDNGGGRLVYASSSAVFGDPVALPLTMASPTRPISPYGVDKL
ACEAHARVAGGLYGLKSFGLRFFNVYGEGQSDDSPYSGVIALFNRKLRDGQPITVFGDGSQSRDFVYVGDVIEGLLAAWN
EASVRGPVETVGTGCPTTVMDLARTIMEVHGRSVPVVHAPPREADIEHSYGKADFLARILPKPAVALRAGLARTLSISPP
AATLAPTP

Sequences:

>Translated_328_residues
MTALTEIDARHAAWRGRRVLVTGGAGFIGGHLCRRLVGLGAEVVVLDDLSTGRRDTVPRGVRLIVGSVTDPALVRKALQG
TEGCFHLAAIASVPLSVSALVDCHAVNQTGTLRLIEGLRDNGGGRLVYASSSAVFGDPVALPLTMASPTRPISPYGVDKL
ACEAHARVAGGLYGLKSFGLRFFNVYGEGQSDDSPYSGVIALFNRKLRDGQPITVFGDGSQSRDFVYVGDVIEGLLAAWN
EASVRGPVETVGTGCPTTVMDLARTIMEVHGRSVPVVHAPPREADIEHSYGKADFLARILPKPAVALRAGLARTLSISPP
AATLAPTP
>Mature_327_residues
TALTEIDARHAAWRGRRVLVTGGAGFIGGHLCRRLVGLGAEVVVLDDLSTGRRDTVPRGVRLIVGSVTDPALVRKALQGT
EGCFHLAAIASVPLSVSALVDCHAVNQTGTLRLIEGLRDNGGGRLVYASSSAVFGDPVALPLTMASPTRPISPYGVDKLA
CEAHARVAGGLYGLKSFGLRFFNVYGEGQSDDSPYSGVIALFNRKLRDGQPITVFGDGSQSRDFVYVGDVIEGLLAAWNE
ASVRGPVETVGTGCPTTVMDLARTIMEVHGRSVPVVHAPPREADIEHSYGKADFLARILPKPAVALRAGLARTLSISPPA
ATLAPTP

Specific function: Galactose metabolism; third step. [C]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Homo sapiens, GI42516563, Length=265, Percent_Identity=32.0754716981132, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI56237023, Length=311, Percent_Identity=27.3311897106109, Blast_Score=101, Evalue=9e-22,
Organism=Homo sapiens, GI56118217, Length=311, Percent_Identity=27.3311897106109, Blast_Score=101, Evalue=9e-22,
Organism=Homo sapiens, GI189083684, Length=311, Percent_Identity=27.3311897106109, Blast_Score=101, Evalue=9e-22,
Organism=Homo sapiens, GI7657641, Length=265, Percent_Identity=29.0566037735849, Blast_Score=100, Evalue=2e-21,
Organism=Escherichia coli, GI1786974, Length=317, Percent_Identity=29.0220820189274, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI48994969, Length=276, Percent_Identity=28.2608695652174, Blast_Score=71, Evalue=9e-14,
Organism=Escherichia coli, GI1788353, Length=289, Percent_Identity=27.3356401384083, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17539532, Length=311, Percent_Identity=28.2958199356913, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI71982035, Length=313, Percent_Identity=26.8370607028754, Blast_Score=88, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI71982038, Length=315, Percent_Identity=26.984126984127, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17568069, Length=275, Percent_Identity=28.7272727272727, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI115532424, Length=301, Percent_Identity=24.2524916943522, Blast_Score=73, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6319493, Length=324, Percent_Identity=27.7777777777778, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI21356223, Length=313, Percent_Identity=29.7124600638978, Blast_Score=108, Evalue=4e-24,
Organism=Drosophila melanogaster, GI19923002, Length=330, Percent_Identity=27.5757575757576, Blast_Score=98, Evalue=7e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.2 [H]

Molecular weight: Translated: 34437; Mature: 34306

Theoretical pI: Translated: 8.49; Mature: 8.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTALTEIDARHAAWRGRRVLVTGGAGFIGGHLCRRLVGLGAEVVVLDDLSTGRRDTVPRG
CCCCHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCC
VRLIVGSVTDPALVRKALQGTEGCFHLAAIASVPLSVSALVDCHAVNQTGTLRLIEGLRD
EEEEEECCCCHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHEEEECCCCCHHHEEHHHHC
NGGGRLVYASSSAVFGDPVALPLTMASPTRPISPYGVDKLACEAHARVAGGLYGLKSFGL
CCCCEEEEECCCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCE
RFFNVYGEGQSDDSPYSGVIALFNRKLRDGQPITVFGDGSQSRDFVYVGDVIEGLLAAWN
EEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCEEEEHHHHHHHHHHCC
EASVRGPVETVGTGCPTTVMDLARTIMEVHGRSVPVVHAPPREADIEHSYGKADFLARIL
CCCCCCCHHHHCCCCCHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCHHHHHHHHC
PKPAVALRAGLARTLSISPPAATLAPTP
CCCHHHHHHCHHHEEECCCCCCCCCCCC
>Mature Secondary Structure 
TALTEIDARHAAWRGRRVLVTGGAGFIGGHLCRRLVGLGAEVVVLDDLSTGRRDTVPRG
CCCHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCC
VRLIVGSVTDPALVRKALQGTEGCFHLAAIASVPLSVSALVDCHAVNQTGTLRLIEGLRD
EEEEEECCCCHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHEEEECCCCCHHHEEHHHHC
NGGGRLVYASSSAVFGDPVALPLTMASPTRPISPYGVDKLACEAHARVAGGLYGLKSFGL
CCCCEEEEECCCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCE
RFFNVYGEGQSDDSPYSGVIALFNRKLRDGQPITVFGDGSQSRDFVYVGDVIEGLLAAWN
EEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCEEEEHHHHHHHHHHCC
EASVRGPVETVGTGCPTTVMDLARTIMEVHGRSVPVVHAPPREADIEHSYGKADFLARIL
CCCCCCCHHHHCCCCCHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCHHHHHHHHC
PKPAVALRAGLARTLSISPPAATLAPTP
CCCHHHHHHCHHHEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]