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The map label for this gene is hsrA [H]

Identifier: 83594386

GI number: 83594386

Start: 3518796

End: 3520256

Strand: Reverse

Name: hsrA [H]

Synonym: Rru_A3056

Alternate gene names: 83594386

Gene position: 3520256-3518796 (Counterclockwise)

Preceding gene: 83594387

Following gene: 83594385

Centisome position: 80.87

GC content: 67.56

Gene sequence:

>1461_bases
ATGTCCGCCGTTCCCCCCGCCGTTCCCCCGTCTTCGCCTTCTCCCGTGCCGTCTTCCGCCCCCCGATCCGCGCCGACCTC
GGCCGCCTTGTCCTATCTGGTGGCCGGCGCCTTTTTCATGGAAGCCCTGGACGGCACGGTGGTCATCACCGCCCTGCCGC
AGATGGCGGCATCCTTCGGCGCCGCGCCGGTCGATCTCAATATCGGCGTTTCGGCCTATATCCTGACCGTCGCCATCCTG
ATCCCGGCCAGCGGCTGGGCGGCCGAGCGCTTTGGGGCGCGGACGGTCTTCGCCCTGGCGATCACCGTCTTCACCCTGGC
CTCGATCCTTTGCGGTCTCAGCCAGGACCTGTGGTCGTTCGTCGCCGCGCGCATCTTGCAAGGGGTGGGCGGGGCGATGA
TGGTGCCGGTCGGCCGGCTGGTCGTGCTGCGCGATACCCAAAAATCCGGGCTGATGCGGGCGATCGCCATCATCACCTGG
CCCGGTCTGGTCGCCCCGGTGCTGGGGCCGCCGATCGGCGGCTTCCTGGCCACCCATGCGTCCTGGCACTGGATCTTCTT
TCTGAATGTGCCGCTGGGGATCCTGGCGCTGATCCTGACCCTGGTTCTGGTGCCGCGCGGCCGCCGTGATAGCCCCGGCC
CCTTCGATGGCCTGGGCTTTGTTCTCAGCGGTACGGCCTGTTTCTGCCTGATCTACGGCCTGGATCTGATCAGCCGGGGC
GAGGTCTGGACCTCGGGGGCGCTTTGTTTGGTCGGATTGCTTGGCGGTTTTCTCGCCTTGCGCCATTCCCGCCACCACGA
GCGGCCGCTGATCGACCTGTGGGCGATGCGCCAGCGAAGCTTCGCCGTGACCATTTTCGGCGGCACGCTGTTTCGCCTGA
CGCTGAGCGCCACGCCGTTCTTGCTGGCGCTGCTGTTTCAGTTGTCCTTCGGCATGGACGCCTTCGCCTCGGGCCTGCTG
GTTCTGGCGATTTTCGTCGGCAATCTGGCGATGAAGCTGCTGACCTCGCCGATTCTGCGCCGCTTCAGCTTTCGCGCCAC
CTTGCTGGTCAATGGCGGGCTGAACGCCCTGACCATCTTCGCCTGCGCCCTGCTTGACGCCGCAACGCCGACGGCGGTGA
TCCTGGGCCTGCTGTTCGTCAGCGGGCTGACGCGCTCGCTGCAGTTCACCGCGCTCAACACCTTGGCCTTCGCCGATGTG
CCCCAGGAGCGGATGACCGGCGCCAATACCCTGGCCAATGTCGCCCAACGCATGAGCGGGGCGCTGGGCGTGGCCTGTGG
CGCCGTGGCCCTGCGGCTGGCCGGGGCGATCGGCGAGGGCGCCGCCACGCCCCTTGAGCTGGCCGATTTCCGCTTCGCCT
TCGTGCTGATCGGGGTGATTTCCCTGCTCGGGCTGCTTGATGTCATCGGTTTGCGTCGCGATGCCGGCGACGAGGTGCGC
GGCGTCATCGCCGCGCGCTGA

Upstream 100 bases:

>100_bases
TCGGCCGAGGCGGTTCTCGCCCTGCTATAAGGTTTTGCTCATCGTCACCGGCCGCGTCCTTGGAGAAGGGGGCGGCCGGG
TTCATGGATCGTGTCCCCCG

Downstream 100 bases:

>100_bases
CGGGGGGGGCGCTGACGGGGGCGGTGACGGCCAAGAACGGGCGGTATAAGGTGCCGCTCCGCCGCGTTCCCACCGTTCCG
TCTCGAGGTTCCCCATCTTG

Product: major facilitator transporter

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: High-copy suppressor of rspA [H]

Number of amino acids: Translated: 486; Mature: 485

Protein sequence:

>486_residues
MSAVPPAVPPSSPSPVPSSAPRSAPTSAALSYLVAGAFFMEALDGTVVITALPQMAASFGAAPVDLNIGVSAYILTVAIL
IPASGWAAERFGARTVFALAITVFTLASILCGLSQDLWSFVAARILQGVGGAMMVPVGRLVVLRDTQKSGLMRAIAIITW
PGLVAPVLGPPIGGFLATHASWHWIFFLNVPLGILALILTLVLVPRGRRDSPGPFDGLGFVLSGTACFCLIYGLDLISRG
EVWTSGALCLVGLLGGFLALRHSRHHERPLIDLWAMRQRSFAVTIFGGTLFRLTLSATPFLLALLFQLSFGMDAFASGLL
VLAIFVGNLAMKLLTSPILRRFSFRATLLVNGGLNALTIFACALLDAATPTAVILGLLFVSGLTRSLQFTALNTLAFADV
PQERMTGANTLANVAQRMSGALGVACGAVALRLAGAIGEGAATPLELADFRFAFVLIGVISLLGLLDVIGLRRDAGDEVR
GVIAAR

Sequences:

>Translated_486_residues
MSAVPPAVPPSSPSPVPSSAPRSAPTSAALSYLVAGAFFMEALDGTVVITALPQMAASFGAAPVDLNIGVSAYILTVAIL
IPASGWAAERFGARTVFALAITVFTLASILCGLSQDLWSFVAARILQGVGGAMMVPVGRLVVLRDTQKSGLMRAIAIITW
PGLVAPVLGPPIGGFLATHASWHWIFFLNVPLGILALILTLVLVPRGRRDSPGPFDGLGFVLSGTACFCLIYGLDLISRG
EVWTSGALCLVGLLGGFLALRHSRHHERPLIDLWAMRQRSFAVTIFGGTLFRLTLSATPFLLALLFQLSFGMDAFASGLL
VLAIFVGNLAMKLLTSPILRRFSFRATLLVNGGLNALTIFACALLDAATPTAVILGLLFVSGLTRSLQFTALNTLAFADV
PQERMTGANTLANVAQRMSGALGVACGAVALRLAGAIGEGAATPLELADFRFAFVLIGVISLLGLLDVIGLRRDAGDEVR
GVIAAR
>Mature_485_residues
SAVPPAVPPSSPSPVPSSAPRSAPTSAALSYLVAGAFFMEALDGTVVITALPQMAASFGAAPVDLNIGVSAYILTVAILI
PASGWAAERFGARTVFALAITVFTLASILCGLSQDLWSFVAARILQGVGGAMMVPVGRLVVLRDTQKSGLMRAIAIITWP
GLVAPVLGPPIGGFLATHASWHWIFFLNVPLGILALILTLVLVPRGRRDSPGPFDGLGFVLSGTACFCLIYGLDLISRGE
VWTSGALCLVGLLGGFLALRHSRHHERPLIDLWAMRQRSFAVTIFGGTLFRLTLSATPFLLALLFQLSFGMDAFASGLLV
LAIFVGNLAMKLLTSPILRRFSFRATLLVNGGLNALTIFACALLDAATPTAVILGLLFVSGLTRSLQFTALNTLAFADVP
QERMTGANTLANVAQRMSGALGVACGAVALRLAGAIGEGAATPLELADFRFAFVLIGVISLLGLLDVIGLRRDAGDEVRG
VIAAR

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1790195, Length=453, Percent_Identity=36.644591611479, Blast_Score=275, Evalue=3e-75,
Organism=Escherichia coli, GI1788392, Length=415, Percent_Identity=36.6265060240964, Blast_Score=226, Evalue=3e-60,
Organism=Escherichia coli, GI1788710, Length=432, Percent_Identity=26.6203703703704, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI1789042, Length=401, Percent_Identity=25.6857855361596, Blast_Score=119, Evalue=6e-28,
Organism=Escherichia coli, GI87081983, Length=407, Percent_Identity=28.009828009828, Blast_Score=105, Evalue=8e-24,
Organism=Escherichia coli, GI1790146, Length=169, Percent_Identity=27.810650887574, Blast_Score=66, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6325455, Length=138, Percent_Identity=29.7101449275362, Blast_Score=71, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6322958, Length=166, Percent_Identity=30.7228915662651, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 50746; Mature: 50615

Theoretical pI: Translated: 9.84; Mature: 9.84

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAVPPAVPPSSPSPVPSSAPRSAPTSAALSYLVAGAFFMEALDGTVVITALPQMAASFG
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHCC
AAPVDLNIGVSAYILTVAILIPASGWAAERFGARTVFALAITVFTLASILCGLSQDLWSF
CCCEEECCCHHHHHHHHHHHHCCCCCHHHHHCHHHHHHHHHHHHHHHHHHHCCCHHHHHH
VAARILQGVGGAMMVPVGRLVVLRDTQKSGLMRAIAIITWPGLVAPVLGPPIGGFLATHA
HHHHHHHHCCCEEEECCCCEEEEECCCHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHCC
SWHWIFFLNVPLGILALILTLVLVPRGRRDSPGPFDGLGFVLSGTACFCLIYGLDLISRG
CEEEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
EVWTSGALCLVGLLGGFLALRHSRHHERPLIDLWAMRQRSFAVTIFGGTLFRLTLSATPF
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCEEEEEECCEEEEHHHCCHHH
LLALLFQLSFGMDAFASGLLVLAIFVGNLAMKLLTSPILRRFSFRATLLVNGGLNALTIF
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCHHHHHH
ACALLDAATPTAVILGLLFVSGLTRSLQFTALNTLAFADVPQERMTGANTLANVAQRMSG
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHCC
ALGVACGAVALRLAGAIGEGAATPLELADFRFAFVLIGVISLLGLLDVIGLRRDAGDEVR
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
GVIAAR
HHHCCC
>Mature Secondary Structure 
SAVPPAVPPSSPSPVPSSAPRSAPTSAALSYLVAGAFFMEALDGTVVITALPQMAASFG
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHCC
AAPVDLNIGVSAYILTVAILIPASGWAAERFGARTVFALAITVFTLASILCGLSQDLWSF
CCCEEECCCHHHHHHHHHHHHCCCCCHHHHHCHHHHHHHHHHHHHHHHHHHCCCHHHHHH
VAARILQGVGGAMMVPVGRLVVLRDTQKSGLMRAIAIITWPGLVAPVLGPPIGGFLATHA
HHHHHHHHCCCEEEECCCCEEEEECCCHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHCC
SWHWIFFLNVPLGILALILTLVLVPRGRRDSPGPFDGLGFVLSGTACFCLIYGLDLISRG
CEEEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
EVWTSGALCLVGLLGGFLALRHSRHHERPLIDLWAMRQRSFAVTIFGGTLFRLTLSATPF
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCEEEEEECCEEEEHHHCCHHH
LLALLFQLSFGMDAFASGLLVLAIFVGNLAMKLLTSPILRRFSFRATLLVNGGLNALTIF
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCHHHHHH
ACALLDAATPTAVILGLLFVSGLTRSLQFTALNTLAFADVPQERMTGANTLANVAQRMSG
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHCC
ALGVACGAVALRLAGAIGEGAATPLELADFRFAFVLIGVISLLGLLDVIGLRRDAGDEVR
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
GVIAAR
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7686882; 9278503 [H]