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The map label for this gene is mutL

Identifier: 83594278

GI number: 83594278

Start: 3394939

End: 3396828

Strand: Reverse

Name: mutL

Synonym: Rru_A2946

Alternate gene names: 83594278

Gene position: 3396828-3394939 (Counterclockwise)

Preceding gene: 83594279

Following gene: 83594277

Centisome position: 78.04

GC content: 71.11

Gene sequence:

>1890_bases
ATGACGATCCGTTTGTTGCCGCCGGTCCTCGTCAACCGCATCGCCGCCGGCGAGGTGGTTGAACGTCCGGCCTCGGCGGT
CAAGGAACTGGTCGAGAACGCCATCGATGCGGGGGCCTCCCGCATCGATATCACCATGACCGACGGCGGCCGCGCCCGCA
TTCTGGTGGTCGACGACGGTCGGGGCATGGATCCCGGCGAATTATCGCTGGCGGTCGAACGCCATGCCACCTCGAAGCTG
CCCGGCGACGATCTGCTTGATATCCACACCCTGGGGTTTCGCGGCGAGGCCCTGCCGTCGATTGGCTCGGTCGCCCGCCT
GACCCTGACCAGCCGGGCGGCGGGGGCTGGCGACGCCTGGGCTTTGACGGTCGAGGGCGGCGCCAAGGGCGAGCCCGAAC
CGGCCAGCCATCCCCAGGGCACCCGGGTCGAGGTCCGCGACCTGTTCTATGCCACCCCGGCCCGGCTGAAATTCCTCAAG
GCGCCGCGCACCGAGCAGATGCACGCCGTCGATGTCGTCCACCGCTTGGCGATGGCCCATCCGGCGGTCGGCTTCACCCT
GTCGGACGGCACCCGCCAGCAGATCCGCCTGTCGGGCGCCCAGGGCGAATTGTTCGAAGCCCGGCTGACCCGCCTGGGCG
CCATTCTTGGCCGCGAGTTTTCCGATAACGCCATTGCCATCGAGGCCGAGCGCGAGGGCATCCGCCTGACCGGCCATGCC
GCCCTGCCGACCTATAACAAGGCGACCAGCGCCGGCCAGTACCTGTTCGTCAATGGCCGGCCGGTGCGCGACAAGTTGCT
GCACGGCGCGGTGCGCGGCGCCTATCAAGACGTGCTGGCCCACGACCGCAACGCCGTTCTGGCGCTTTATCTCGATCTGC
CGCCCGAGATGGTCGACGTCAACGTCCATCCGGCCAAGGCCGAGGTCCGCTTCCGCGATCCCGGTCTGGTGCGCGGGCTG
ATCATCGGCGCCCTGCGCCATGCCCTGGCCGCCGCCGGCCACCGGGCGAGCAGCACGGTCTCGCTGGCCGCCCTGGGGGC
CCTGCGCCCGGCCCAAGGATCGGGCGCTCCGGCCCTGCCCTGGGGGGCGGGCGGCTATGGCGGCGGAGCCTCCCATCCGG
GATTGGAGGAGCGCCGCAGCGCCTATGCCGCCCAGGCTCCGGCCGGAACGCCCGATCCTTGGGCCGGGCGGGGAATGGGG
GCCGGAGGTGGAAGCGGGCAGGCGGCGATGGCCTGGCTGGCCGGGGCGCCCCCGGCCGCCCCACGCCTGGCCGGCGAGCC
CGAAGCCCCGCCGACGGGGGCCGAGGATTTTCCCTTGGGCGCGGCGCGCGGTCAGATCCACGACACCTATATCATCGCCC
AAACCCGCGATGGCGTGGTCATCGTCGATCAGCACGCCGCCCATGAACGGCTGGTGATGGAGCGGATGAAGGCCGCCCTG
GCCGAGCGCGGCGAGGTCGCTCGCCAGATCCTGCTGCTGCCCGAAGTGGTCGAACTCGACGAACCGGGGGCGGTGCGGGT
GGCGACGGCGGCGGCCGAGTTGGCCAAGCTGGGGCTGGTGGTCGAAGGCTTCGGCCCCGGCGCCGTGGTGGTGCGCGAGG
TGCCGGCCCTGCTCGGCGATACCGACGTCAAGGGGCTGGTCGCCGATCTCGCCGAGGGGCTGGCCGAATGGGGCACCGCC
CAGGCCCTGGAGGACAGGCTGGGCGATGTGGTGGCGACCATGGCCTGTCACGGCTCGGTGCGGGCCGGCCGGCGGCTGCG
CATCGAGGAGATGAACGCCCTGTTGCGCGATATGGAGCGGACTCCGCGCGCCGGCCAATGCAATCATGGCCGACCGACTT
ATGTTGAGCTAAGATTGGGCGACATCGAACGGTTGTTCGGCCGGCGCTGA

Upstream 100 bases:

>100_bases
TCCCCGGCCCATGATAGTTCCACCAATGGCCTGATCGCGCTATATAGGGAGTTCAGCGCCGGGTAACCCCCAGATGTAGC
CCCCAGCGAGAGGGACGCCG

Downstream 100 bases:

>100_bases
GGCGGCGGAGGACGGCGGTTCTGGAACCGGGGAGGGGCCGCGCTTTTGGGGCGTGGTCTAAGGGGAATGGGATTTCGCGA
AAAAATGGGCCGCTCGTCAC

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 629; Mature: 628

Protein sequence:

>629_residues
MTIRLLPPVLVNRIAAGEVVERPASAVKELVENAIDAGASRIDITMTDGGRARILVVDDGRGMDPGELSLAVERHATSKL
PGDDLLDIHTLGFRGEALPSIGSVARLTLTSRAAGAGDAWALTVEGGAKGEPEPASHPQGTRVEVRDLFYATPARLKFLK
APRTEQMHAVDVVHRLAMAHPAVGFTLSDGTRQQIRLSGAQGELFEARLTRLGAILGREFSDNAIAIEAEREGIRLTGHA
ALPTYNKATSAGQYLFVNGRPVRDKLLHGAVRGAYQDVLAHDRNAVLALYLDLPPEMVDVNVHPAKAEVRFRDPGLVRGL
IIGALRHALAAAGHRASSTVSLAALGALRPAQGSGAPALPWGAGGYGGGASHPGLEERRSAYAAQAPAGTPDPWAGRGMG
AGGGSGQAAMAWLAGAPPAAPRLAGEPEAPPTGAEDFPLGAARGQIHDTYIIAQTRDGVVIVDQHAAHERLVMERMKAAL
AERGEVARQILLLPEVVELDEPGAVRVATAAAELAKLGLVVEGFGPGAVVVREVPALLGDTDVKGLVADLAEGLAEWGTA
QALEDRLGDVVATMACHGSVRAGRRLRIEEMNALLRDMERTPRAGQCNHGRPTYVELRLGDIERLFGRR

Sequences:

>Translated_629_residues
MTIRLLPPVLVNRIAAGEVVERPASAVKELVENAIDAGASRIDITMTDGGRARILVVDDGRGMDPGELSLAVERHATSKL
PGDDLLDIHTLGFRGEALPSIGSVARLTLTSRAAGAGDAWALTVEGGAKGEPEPASHPQGTRVEVRDLFYATPARLKFLK
APRTEQMHAVDVVHRLAMAHPAVGFTLSDGTRQQIRLSGAQGELFEARLTRLGAILGREFSDNAIAIEAEREGIRLTGHA
ALPTYNKATSAGQYLFVNGRPVRDKLLHGAVRGAYQDVLAHDRNAVLALYLDLPPEMVDVNVHPAKAEVRFRDPGLVRGL
IIGALRHALAAAGHRASSTVSLAALGALRPAQGSGAPALPWGAGGYGGGASHPGLEERRSAYAAQAPAGTPDPWAGRGMG
AGGGSGQAAMAWLAGAPPAAPRLAGEPEAPPTGAEDFPLGAARGQIHDTYIIAQTRDGVVIVDQHAAHERLVMERMKAAL
AERGEVARQILLLPEVVELDEPGAVRVATAAAELAKLGLVVEGFGPGAVVVREVPALLGDTDVKGLVADLAEGLAEWGTA
QALEDRLGDVVATMACHGSVRAGRRLRIEEMNALLRDMERTPRAGQCNHGRPTYVELRLGDIERLFGRR
>Mature_628_residues
TIRLLPPVLVNRIAAGEVVERPASAVKELVENAIDAGASRIDITMTDGGRARILVVDDGRGMDPGELSLAVERHATSKLP
GDDLLDIHTLGFRGEALPSIGSVARLTLTSRAAGAGDAWALTVEGGAKGEPEPASHPQGTRVEVRDLFYATPARLKFLKA
PRTEQMHAVDVVHRLAMAHPAVGFTLSDGTRQQIRLSGAQGELFEARLTRLGAILGREFSDNAIAIEAEREGIRLTGHAA
LPTYNKATSAGQYLFVNGRPVRDKLLHGAVRGAYQDVLAHDRNAVLALYLDLPPEMVDVNVHPAKAEVRFRDPGLVRGLI
IGALRHALAAAGHRASSTVSLAALGALRPAQGSGAPALPWGAGGYGGGASHPGLEERRSAYAAQAPAGTPDPWAGRGMGA
GGGSGQAAMAWLAGAPPAAPRLAGEPEAPPTGAEDFPLGAARGQIHDTYIIAQTRDGVVIVDQHAAHERLVMERMKAALA
ERGEVARQILLLPEVVELDEPGAVRVATAAAELAKLGLVVEGFGPGAVVVREVPALLGDTDVKGLVADLAEGLAEWGTAQ
ALEDRLGDVVATMACHGSVRAGRRLRIEEMNALLRDMERTPRAGQCNHGRPTYVELRLGDIERLFGRR

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family

Homologues:

Organism=Homo sapiens, GI4557757, Length=312, Percent_Identity=35.2564102564103, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI4505913, Length=342, Percent_Identity=26.6081871345029, Blast_Score=116, Evalue=7e-26,
Organism=Homo sapiens, GI310128478, Length=342, Percent_Identity=26.6081871345029, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI4505911, Length=331, Percent_Identity=26.8882175226586, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI189458898, Length=331, Percent_Identity=26.8882175226586, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI189458896, Length=319, Percent_Identity=25.705329153605, Blast_Score=103, Evalue=6e-22,
Organism=Homo sapiens, GI263191589, Length=218, Percent_Identity=30.2752293577982, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI310128480, Length=307, Percent_Identity=23.4527687296417, Blast_Score=78, Evalue=3e-14,
Organism=Homo sapiens, GI91992162, Length=275, Percent_Identity=26.1818181818182, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI91992160, Length=275, Percent_Identity=26.1818181818182, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI1790612, Length=574, Percent_Identity=37.4564459930314, Blast_Score=279, Evalue=5e-76,
Organism=Caenorhabditis elegans, GI71991825, Length=325, Percent_Identity=36.3076923076923, Blast_Score=169, Evalue=5e-42,
Organism=Caenorhabditis elegans, GI17562796, Length=334, Percent_Identity=24.8502994011976, Blast_Score=105, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6323819, Length=356, Percent_Identity=32.3033707865169, Blast_Score=176, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6324247, Length=334, Percent_Identity=27.5449101796407, Blast_Score=119, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6325093, Length=727, Percent_Identity=21.3204951856946, Blast_Score=109, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6323063, Length=364, Percent_Identity=26.3736263736264, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI17136968, Length=332, Percent_Identity=34.3373493975904, Blast_Score=181, Evalue=2e-45,
Organism=Drosophila melanogaster, GI17136970, Length=347, Percent_Identity=27.3775216138329, Blast_Score=86, Evalue=8e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUTL_RHORT (Q2RQ52)

Other databases:

- EMBL:   CP000230
- RefSeq:   YP_428030.1
- ProteinModelPortal:   Q2RQ52
- SMR:   Q2RQ52
- STRING:   Q2RQ52
- GeneID:   3836390
- GenomeReviews:   CP000230_GR
- KEGG:   rru:Rru_A2946
- eggNOG:   COG0323
- HOGENOM:   HBG520262
- OMA:   FLFINNR
- PhylomeDB:   Q2RQ52
- ProtClustDB:   PRK00095
- BioCyc:   RRUB269796:RRU_A2946-MONOMER
- HAMAP:   MF_00149
- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.565.10
- Gene3D:   G3DSA:3.30.230.10
- PANTHER:   PTHR10073
- SMART:   SM00387
- SMART:   SM00853
- TIGRFAMs:   TIGR00585

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C; SSF55874 ATP_bd_ATPase; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: NA

Molecular weight: Translated: 66132; Mature: 66001

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIRLLPPVLVNRIAAGEVVERPASAVKELVENAIDAGASRIDITMTDGGRARILVVDDG
CEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEEEECC
RGMDPGELSLAVERHATSKLPGDDLLDIHTLGFRGEALPSIGSVARLTLTSRAAGAGDAW
CCCCCCCEEEEEEHHHCCCCCCCCCEEEEECCCCCCCCCCCCCHHEEEEECCCCCCCCEE
ALTVEGGAKGEPEPASHPQGTRVEVRDLFYATPARLKFLKAPRTEQMHAVDVVHRLAMAH
EEEECCCCCCCCCCCCCCCCCEEEEHHHHHCCHHHHHEECCCCCCHHHHHHHHHHHHHHC
PAVGFTLSDGTRQQIRLSGAQGELFEARLTRLGAILGREFSDNAIAIEAEREGIRLTGHA
CCCEEEECCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCEEEEECC
ALPTYNKATSAGQYLFVNGRPVRDKLLHGAVRGAYQDVLAHDRNAVLALYLDLPPEMVDV
CCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEEE
NVHPAKAEVRFRDPGLVRGLIIGALRHALAAAGHRASSTVSLAALGALRPAQGSGAPALP
ECCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCCCCC
WGAGGYGGGASHPGLEERRSAYAAQAPAGTPDPWAGRGMGAGGGSGQAAMAWLAGAPPAA
CCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHEECCCCCCC
PRLAGEPEAPPTGAEDFPLGAARGQIHDTYIIAQTRDGVVIVDQHAAHERLVMERMKAAL
CCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCEEEEECCHHHHHHHHHHHHHHH
AERGEVARQILLLPEVVELDEPGAVRVATAAAELAKLGLVVEGFGPGAVVVREVPALLGD
HHHHHHHHHHHHCCHHHCCCCCCCEEEHHHHHHHHHHCEEEECCCCCHHHHHHHHHHHCC
TDVKGLVADLAEGLAEWGTAQALEDRLGDVVATMACHGSVRAGRRLRIEEMNALLRDMER
CCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHH
TPRAGQCNHGRPTYVELRLGDIERLFGRR
CCCCCCCCCCCCCEEEEEECCHHHHHCCC
>Mature Secondary Structure 
TIRLLPPVLVNRIAAGEVVERPASAVKELVENAIDAGASRIDITMTDGGRARILVVDDG
EEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEEEECC
RGMDPGELSLAVERHATSKLPGDDLLDIHTLGFRGEALPSIGSVARLTLTSRAAGAGDAW
CCCCCCCEEEEEEHHHCCCCCCCCCEEEEECCCCCCCCCCCCCHHEEEEECCCCCCCCEE
ALTVEGGAKGEPEPASHPQGTRVEVRDLFYATPARLKFLKAPRTEQMHAVDVVHRLAMAH
EEEECCCCCCCCCCCCCCCCCEEEEHHHHHCCHHHHHEECCCCCCHHHHHHHHHHHHHHC
PAVGFTLSDGTRQQIRLSGAQGELFEARLTRLGAILGREFSDNAIAIEAEREGIRLTGHA
CCCEEEECCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCEEEEECC
ALPTYNKATSAGQYLFVNGRPVRDKLLHGAVRGAYQDVLAHDRNAVLALYLDLPPEMVDV
CCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEEE
NVHPAKAEVRFRDPGLVRGLIIGALRHALAAAGHRASSTVSLAALGALRPAQGSGAPALP
ECCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCCCCC
WGAGGYGGGASHPGLEERRSAYAAQAPAGTPDPWAGRGMGAGGGSGQAAMAWLAGAPPAA
CCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHEECCCCCCC
PRLAGEPEAPPTGAEDFPLGAARGQIHDTYIIAQTRDGVVIVDQHAAHERLVMERMKAAL
CCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCEEEEECCHHHHHHHHHHHHHHH
AERGEVARQILLLPEVVELDEPGAVRVATAAAELAKLGLVVEGFGPGAVVVREVPALLGD
HHHHHHHHHHHHCCHHHCCCCCCCEEEHHHHHHHHHHCEEEECCCCCHHHHHHHHHHHCC
TDVKGLVADLAEGLAEWGTAQALEDRLGDVVATMACHGSVRAGRRLRIEEMNALLRDMER
CCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHH
TPRAGQCNHGRPTYVELRLGDIERLFGRR
CCCCCCCCCCCCCEEEEEECCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA