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The map label for this gene is ipdC [H]

Identifier: 83594051

GI number: 83594051

Start: 3144087

End: 3145748

Strand: Direct

Name: ipdC [H]

Synonym: Rru_A2719

Alternate gene names: 83594051

Gene position: 3144087-3145748 (Clockwise)

Preceding gene: 83594050

Following gene: 83594053

Centisome position: 72.23

GC content: 69.19

Gene sequence:

>1662_bases
ATGCCCACCATCGCCACGGCCTTGCTTGACGCGTTGAAGGCCCATGGGGCGACCCGGATCTTCGGCATTCCCGGCGATTT
CGCCCTGCCGTTCTTCCGGGTGGCCGAACAAAGCGCCCTCTTGCCGCTGTACACCCTGAGCCACGAACCCGGAGTCGGCT
TCGCCGCCGACGCCTGCGCCCGCATGGGGCGCGGCCTCGGGGTGGCGGCGGTCACTTACGGCGCCGGGGCCTTGAACATG
GTCAATCCGGTGGCCGGGGCTTGGTCGGAGAAATCACCCCTGGTGGTGATTTCCGGCGCCCCCGGCGTCGCCGAATCCGC
CGGCGGCCTGCTGCTCCACCATCAGGCCAAAACCCTCGACAGCCAGTGGCGGATCTTTGAAGAGATCACCTGCGCCCGCA
CCCGCCTTGATGACCCGCTGACCGCCCCCGGGGAAATCGCCCGGGTGTTGCGGGCCTGCCTTGAACACTCCCGCCCCGTC
TATATCGAAATCCCCCGCGACATCGTCGATGCGCCCTGCGCCGCCGTGGACCGCCTGCCGCCCACCCCGGTCGATGGCGA
AGCGGTCGAAGCCGCCGCCGGCGAGATCATGGCCCGCTTGGCTGCGGCCAGCGCCCCGGCGCTGCTGCTGGGGGTCGAGG
TCCGTCGCCACGGCATCGAAGCCGATGTCGCCGAACTGGCCCGCCGCCTGGGCCTGCCCATCGCCACCACCTTCATGGGC
CGGGGTCTGTTATCCGAGGAGGGCGCGGCCGGCGGCGCGCCCGACAGCCTGATGGGCACCTATCTGGGGCTGGCCGGCCG
CCCCGAGGTGCGCGCCGTCATCGAAGACTCCGATGGCCTGCTGATGCTCGGCGTCATCTTGTCCGACACCAATTTCGGCG
TTTCGGGCAAGCGCATCGACCTGCGCCGCGCCATGCTCGCCGCCGACCGTCAGGTCGCCCTGGGCTTTCATACCTATAAC
GATATCCCGCTGGCCGATCTGGTCGCCGCCCTGCTGCGTCAGGCCGAGGGCTTCGCCCGCCAGGACGCCAAGGCCCTACC
CAAGCCGACCGCCCTGCCCCGGGACATGATCGCCGATGGGGCGCCGATCGGCCCGATGGATATCGCCGCGGCCATCAACG
ATCTATTCTCGGCCCATGGGGTGATGCCGATCGCCTCGGATATGGGCGATTGCCTGTTCACCGCCCTTGATACCACCCAT
GCGCCGCTGGTCGCCCCGGGCTATTACGCCACCATGGGCTTTGGCGTGCCGGCGGGATTGGGCGTTCAGGCCAGCTGTGG
CCGCCGGCCGCTGATCCTGGTCGGCGACGGCGCCTTTCAGATGACCGGTTGGGAGTTGGGCAATTGCGCCCGCTACGGCT
GGGACCCGATCGTCATCGTCTTCAACAACGCCAGTTGGGAGATGCTGCGCACCTTCCAACCCGACACCGCCTATAACGAT
CTGGCCGATTGGCGATTCGCCGATCTGGCCGCCGGCCTGGGCGGCGTTGGTCACCGTTGCCAAACCCGCGCCGATCTGGC
CCGGGCCCTGGATCGGGCGGCCCGCGAACCGGGGCGCTTTCACCTGATCGAGGCGGTTCTGGCGCGCGGGGCGATCTCGG
ACACCCTCCAGCGCTTCGTCACCACGATGAAAGGCCGCCACGCCGCGGCGGCCGATGCCTGA

Upstream 100 bases:

>100_bases
AAAAAGGCCGAAGCCGCCCAGGCGGACGCCGAGGCCGAGGTCGCCGCGCCGACGGAGCCGCGCGAAGACTAGCGCGATCG
GCGTTTCCCGGAGCCGCCCC

Downstream 100 bases:

>100_bases
AGCCCCCCGGCACCCGCCCTTCGATCAAGGACGGGCGCCCCTGATACCCGTCGCGTCACGCCTTGACGATGCATTCCACC
GGACAGACCGGCACGCATTG

Product: phenylpyruvate decarboxylase

Products: NA

Alternate protein names: Indolepyruvate decarboxylase [H]

Number of amino acids: Translated: 553; Mature: 552

Protein sequence:

>553_residues
MPTIATALLDALKAHGATRIFGIPGDFALPFFRVAEQSALLPLYTLSHEPGVGFAADACARMGRGLGVAAVTYGAGALNM
VNPVAGAWSEKSPLVVISGAPGVAESAGGLLLHHQAKTLDSQWRIFEEITCARTRLDDPLTAPGEIARVLRACLEHSRPV
YIEIPRDIVDAPCAAVDRLPPTPVDGEAVEAAAGEIMARLAAASAPALLLGVEVRRHGIEADVAELARRLGLPIATTFMG
RGLLSEEGAAGGAPDSLMGTYLGLAGRPEVRAVIEDSDGLLMLGVILSDTNFGVSGKRIDLRRAMLAADRQVALGFHTYN
DIPLADLVAALLRQAEGFARQDAKALPKPTALPRDMIADGAPIGPMDIAAAINDLFSAHGVMPIASDMGDCLFTALDTTH
APLVAPGYYATMGFGVPAGLGVQASCGRRPLILVGDGAFQMTGWELGNCARYGWDPIVIVFNNASWEMLRTFQPDTAYND
LADWRFADLAAGLGGVGHRCQTRADLARALDRAAREPGRFHLIEAVLARGAISDTLQRFVTTMKGRHAAAADA

Sequences:

>Translated_553_residues
MPTIATALLDALKAHGATRIFGIPGDFALPFFRVAEQSALLPLYTLSHEPGVGFAADACARMGRGLGVAAVTYGAGALNM
VNPVAGAWSEKSPLVVISGAPGVAESAGGLLLHHQAKTLDSQWRIFEEITCARTRLDDPLTAPGEIARVLRACLEHSRPV
YIEIPRDIVDAPCAAVDRLPPTPVDGEAVEAAAGEIMARLAAASAPALLLGVEVRRHGIEADVAELARRLGLPIATTFMG
RGLLSEEGAAGGAPDSLMGTYLGLAGRPEVRAVIEDSDGLLMLGVILSDTNFGVSGKRIDLRRAMLAADRQVALGFHTYN
DIPLADLVAALLRQAEGFARQDAKALPKPTALPRDMIADGAPIGPMDIAAAINDLFSAHGVMPIASDMGDCLFTALDTTH
APLVAPGYYATMGFGVPAGLGVQASCGRRPLILVGDGAFQMTGWELGNCARYGWDPIVIVFNNASWEMLRTFQPDTAYND
LADWRFADLAAGLGGVGHRCQTRADLARALDRAAREPGRFHLIEAVLARGAISDTLQRFVTTMKGRHAAAADA
>Mature_552_residues
PTIATALLDALKAHGATRIFGIPGDFALPFFRVAEQSALLPLYTLSHEPGVGFAADACARMGRGLGVAAVTYGAGALNMV
NPVAGAWSEKSPLVVISGAPGVAESAGGLLLHHQAKTLDSQWRIFEEITCARTRLDDPLTAPGEIARVLRACLEHSRPVY
IEIPRDIVDAPCAAVDRLPPTPVDGEAVEAAAGEIMARLAAASAPALLLGVEVRRHGIEADVAELARRLGLPIATTFMGR
GLLSEEGAAGGAPDSLMGTYLGLAGRPEVRAVIEDSDGLLMLGVILSDTNFGVSGKRIDLRRAMLAADRQVALGFHTYND
IPLADLVAALLRQAEGFARQDAKALPKPTALPRDMIADGAPIGPMDIAAAINDLFSAHGVMPIASDMGDCLFTALDTTHA
PLVAPGYYATMGFGVPAGLGVQASCGRRPLILVGDGAFQMTGWELGNCARYGWDPIVIVFNNASWEMLRTFQPDTAYNDL
ADWRFADLAAGLGGVGHRCQTRADLARALDRAAREPGRFHLIEAVLARGAISDTLQRFVTTMKGRHAAAADA

Specific function: Valine and isoleucine biosynthesis; first step. [C]

COG id: COG3961

COG function: function code GHR; Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Escherichia coli, GI1790104, Length=549, Percent_Identity=25.1366120218579, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI87081685, Length=561, Percent_Identity=23.8859180035651, Blast_Score=89, Evalue=8e-19,
Organism=Saccharomyces cerevisiae, GI6323073, Length=551, Percent_Identity=25.7713248638838, Blast_Score=164, Evalue=4e-41,
Organism=Saccharomyces cerevisiae, GI6323163, Length=552, Percent_Identity=25.5434782608696, Blast_Score=162, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6321524, Length=549, Percent_Identity=25.6830601092896, Blast_Score=159, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6320123, Length=527, Percent_Identity=23.9089184060721, Blast_Score=159, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6320588, Length=546, Percent_Identity=22.8937728937729, Blast_Score=118, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6323755, Length=558, Percent_Identity=23.2974910394265, Blast_Score=94, Evalue=7e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017765
- InterPro:   IPR012110
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =4.1.1.74 [H]

Molecular weight: Translated: 58126; Mature: 57995

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTIATALLDALKAHGATRIFGIPGDFALPFFRVAEQSALLPLYTLSHEPGVGFAADACA
CCHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHH
RMGRGLGVAAVTYGAGALNMVNPVAGAWSEKSPLVVISGAPGVAESAGGLLLHHQAKTLD
HHCCCCCEEEEEECCCHHHHHCHHCCCCCCCCCEEEEECCCCCCCCCCCEEEECHHHHHH
SQWRIFEEITCARTRLDDPLTAPGEIARVLRACLEHSRPVYIEIPRDIVDAPCAAVDRLP
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCEEEECCHHHHHCCHHHHHCCC
PTPVDGEAVEAAAGEIMARLAAASAPALLLGVEVRRHGIEADVAELARRLGLPIATTFMG
CCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHCCCCHHHHHHHHHHCCCHHHHHHC
RGLLSEEGAAGGAPDSLMGTYLGLAGRPEVRAVIEDSDGLLMLGVILSDTNFGVSGKRID
CCCCCCCCCCCCCCHHHHHHHHCCCCCCCEEEEEECCCCEEEEEEEEECCCCCCCCCCHH
LRRAMLAADRQVALGFHTYNDIPLADLVAALLRQAEGFARQDAKALPKPTALPRDMIADG
HHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCC
APIGPMDIAAAINDLFSAHGVMPIASDMGDCLFTALDTTHAPLVAPGYYATMGFGVPAGL
CCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCEECCCHHHHHCCCCCCCC
GVQASCGRRPLILVGDGAFQMTGWELGNCARYGWDPIVIVFNNASWEMLRTFQPDTAYND
CCCCCCCCCCEEEEECCCEEECCCCCCCCHHCCCCEEEEEECCCCHHHHHHCCCCCCHHH
LADWRFADLAAGLGGVGHRCQTRADLARALDRAAREPGRFHLIEAVLARGAISDTLQRFV
HHCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHH
TTMKGRHAAAADA
HHHCCCCCCCCCC
>Mature Secondary Structure 
PTIATALLDALKAHGATRIFGIPGDFALPFFRVAEQSALLPLYTLSHEPGVGFAADACA
CHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHH
RMGRGLGVAAVTYGAGALNMVNPVAGAWSEKSPLVVISGAPGVAESAGGLLLHHQAKTLD
HHCCCCCEEEEEECCCHHHHHCHHCCCCCCCCCEEEEECCCCCCCCCCCEEEECHHHHHH
SQWRIFEEITCARTRLDDPLTAPGEIARVLRACLEHSRPVYIEIPRDIVDAPCAAVDRLP
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCEEEECCHHHHHCCHHHHHCCC
PTPVDGEAVEAAAGEIMARLAAASAPALLLGVEVRRHGIEADVAELARRLGLPIATTFMG
CCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHCCCCHHHHHHHHHHCCCHHHHHHC
RGLLSEEGAAGGAPDSLMGTYLGLAGRPEVRAVIEDSDGLLMLGVILSDTNFGVSGKRID
CCCCCCCCCCCCCCHHHHHHHHCCCCCCCEEEEEECCCCEEEEEEEEECCCCCCCCCCHH
LRRAMLAADRQVALGFHTYNDIPLADLVAALLRQAEGFARQDAKALPKPTALPRDMIADG
HHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCC
APIGPMDIAAAINDLFSAHGVMPIASDMGDCLFTALDTTHAPLVAPGYYATMGFGVPAGL
CCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCEECCCHHHHHCCCCCCCC
GVQASCGRRPLILVGDGAFQMTGWELGNCARYGWDPIVIVFNNASWEMLRTFQPDTAYND
CCCCCCCCCCEEEEECCCEEECCCCCCCCHHCCCCEEEEEECCCCHHHHHHCCCCCCHHH
LADWRFADLAAGLGGVGHRCQTRADLARALDRAAREPGRFHLIEAVLARGAISDTLQRFV
HHCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHH
TTMKGRHAAAADA
HHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8202090 [H]