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The map label for this gene is adk [H]

Identifier: 83593999

GI number: 83593999

Start: 3096775

End: 3097362

Strand: Reverse

Name: adk [H]

Synonym: Rru_A2667

Alternate gene names: 83593999

Gene position: 3097362-3096775 (Counterclockwise)

Preceding gene: 83594000

Following gene: 83593998

Centisome position: 71.16

GC content: 61.56

Gene sequence:

>588_bases
ATGACGGGCAAGCGCGTCATTTTCATGGGACCGCCGGGGGGCGGCAAAGGCACCCAGGCTCAGCGCCTTGAGAAGAAGTA
CCAGTTGAAGCAGCTTTCCACCGGCGACATGTTGCGCGCCGCCGTGGCCGCCGGCACCGATCTTGGCCGTCAGGCCAAGG
CGATCATCGATGCGGGCAAGCTGGTTTCCGACGATATCATGGTCGGCATGATCGCCGAGCGAATCGACGAGACGGATTGC
GCGAACGGTTTCGTTCTTGACGGATTCCCGCGCACCGTTCCCCAGGCCGAAGCCCTTGACGTCATGCTTGCCGACAAGGG
TCTGAAACTCGACGCGGTGATCGAATTGCGGGTGGATGATTCCATCTTGTTCGATCGCATCCGCAAACGGGCGGCCGAGG
CCGACGCGGGTAGCGTTCGCGCCGATGACAACGAAGACACCCTGCGCAAGCGCCTTGATATCTATCACGGCATGACGGCG
CCCATCCTGCCTTACTACGGGCAGAAGGGCCTGCTTCACGTGGTCGACGGCACCTTGCCGGTTGACGCCGTGACCAGGGA
ACTTGAGGGAATTCTTGGCGACTGCTAA

Upstream 100 bases:

>100_bases
TCACGGTGACGATGGACACGGTCGCGCAGATTCAGTCTCACCTGTTGGCCCATCAGTACGAGGGCCTTATCAAGAAGTCG
AAGTTGCGGGGGAAACGCGG

Downstream 100 bases:

>100_bases
GGGGGCTTACCGAGGTTGACTCAGGCGGGATTGTCCCTATAATCCCGCGCCTCGGTTTCCCTTACGGGCCAAGGCTGCGC
GAGACCGCGTTTCGCGTTTT

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 195; Mature: 194

Protein sequence:

>195_residues
MTGKRVIFMGPPGGGKGTQAQRLEKKYQLKQLSTGDMLRAAVAAGTDLGRQAKAIIDAGKLVSDDIMVGMIAERIDETDC
ANGFVLDGFPRTVPQAEALDVMLADKGLKLDAVIELRVDDSILFDRIRKRAAEADAGSVRADDNEDTLRKRLDIYHGMTA
PILPYYGQKGLLHVVDGTLPVDAVTRELEGILGDC

Sequences:

>Translated_195_residues
MTGKRVIFMGPPGGGKGTQAQRLEKKYQLKQLSTGDMLRAAVAAGTDLGRQAKAIIDAGKLVSDDIMVGMIAERIDETDC
ANGFVLDGFPRTVPQAEALDVMLADKGLKLDAVIELRVDDSILFDRIRKRAAEADAGSVRADDNEDTLRKRLDIYHGMTA
PILPYYGQKGLLHVVDGTLPVDAVTRELEGILGDC
>Mature_194_residues
TGKRVIFMGPPGGGKGTQAQRLEKKYQLKQLSTGDMLRAAVAAGTDLGRQAKAIIDAGKLVSDDIMVGMIAERIDETDCA
NGFVLDGFPRTVPQAEALDVMLADKGLKLDAVIELRVDDSILFDRIRKRAAEADAGSVRADDNEDTLRKRLDIYHGMTAP
ILPYYGQKGLLHVVDGTLPVDAVTRELEGILGDC

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI7524346, Length=205, Percent_Identity=42.4390243902439, Blast_Score=167, Evalue=4e-42,
Organism=Homo sapiens, GI4502013, Length=205, Percent_Identity=42.4390243902439, Blast_Score=167, Evalue=5e-42,
Organism=Homo sapiens, GI19923437, Length=197, Percent_Identity=37.0558375634518, Blast_Score=128, Evalue=3e-30,
Organism=Homo sapiens, GI4502011, Length=182, Percent_Identity=32.4175824175824, Blast_Score=110, Evalue=7e-25,
Organism=Homo sapiens, GI310110345, Length=197, Percent_Identity=31.9796954314721, Blast_Score=105, Evalue=2e-23,
Organism=Homo sapiens, GI53832003, Length=197, Percent_Identity=31.9796954314721, Blast_Score=105, Evalue=2e-23,
Organism=Homo sapiens, GI8051579, Length=197, Percent_Identity=31.9796954314721, Blast_Score=105, Evalue=2e-23,
Organism=Homo sapiens, GI53832001, Length=197, Percent_Identity=31.9796954314721, Blast_Score=105, Evalue=2e-23,
Organism=Homo sapiens, GI28144899, Length=175, Percent_Identity=31.4285714285714, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI28144897, Length=175, Percent_Identity=31.4285714285714, Blast_Score=91, Evalue=5e-19,
Organism=Homo sapiens, GI7706497, Length=192, Percent_Identity=30.2083333333333, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI22749187, Length=179, Percent_Identity=26.8156424581006, Blast_Score=73, Evalue=2e-13,
Organism=Escherichia coli, GI1786680, Length=217, Percent_Identity=46.0829493087558, Blast_Score=182, Evalue=9e-48,
Organism=Caenorhabditis elegans, GI17552384, Length=214, Percent_Identity=40.6542056074766, Blast_Score=166, Evalue=5e-42,
Organism=Caenorhabditis elegans, GI17567503, Length=178, Percent_Identity=35.3932584269663, Blast_Score=103, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI17533833, Length=188, Percent_Identity=31.3829787234043, Blast_Score=100, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17550688, Length=184, Percent_Identity=29.8913043478261, Blast_Score=90, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI17537943, Length=192, Percent_Identity=25.5208333333333, Blast_Score=73, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6320432, Length=213, Percent_Identity=43.6619718309859, Blast_Score=175, Evalue=3e-45,
Organism=Saccharomyces cerevisiae, GI6321018, Length=195, Percent_Identity=34.3589743589744, Blast_Score=110, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6322828, Length=193, Percent_Identity=29.5336787564767, Blast_Score=88, Evalue=9e-19,
Organism=Drosophila melanogaster, GI22026816, Length=213, Percent_Identity=43.6619718309859, Blast_Score=172, Evalue=1e-43,
Organism=Drosophila melanogaster, GI17737899, Length=196, Percent_Identity=34.1836734693878, Blast_Score=112, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24645822, Length=196, Percent_Identity=34.1836734693878, Blast_Score=112, Evalue=1e-25,
Organism=Drosophila melanogaster, GI17647141, Length=168, Percent_Identity=36.9047619047619, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24663208, Length=168, Percent_Identity=36.9047619047619, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI221459597, Length=190, Percent_Identity=28.4210526315789, Blast_Score=87, Evalue=7e-18,
Organism=Drosophila melanogaster, GI21356893, Length=190, Percent_Identity=28.4210526315789, Blast_Score=87, Evalue=7e-18,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006259
- InterPro:   IPR000850 [H]

Pfam domain/function: PF00406 ADK [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 21055; Mature: 20923

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGKRVIFMGPPGGGKGTQAQRLEKKYQLKQLSTGDMLRAAVAAGTDLGRQAKAIIDAGK
CCCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHCC
LVSDDIMVGMIAERIDETDCANGFVLDGFPRTVPQAEALDVMLADKGLKLDAVIELRVDD
HHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCHHHHEEEECCCCCCEEEEEEEEECH
SILFDRIRKRAAEADAGSVRADDNEDTLRKRLDIYHGMTAPILPYYGQKGLLHVVDGTLP
HHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCC
VDAVTRELEGILGDC
HHHHHHHHHHHHCCC
>Mature Secondary Structure 
TGKRVIFMGPPGGGKGTQAQRLEKKYQLKQLSTGDMLRAAVAAGTDLGRQAKAIIDAGK
CCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHCC
LVSDDIMVGMIAERIDETDCANGFVLDGFPRTVPQAEALDVMLADKGLKLDAVIELRVDD
HHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCHHHHEEEECCCCCCEEEEEEEEECH
SILFDRIRKRAAEADAGSVRADDNEDTLRKRLDIYHGMTAPILPYYGQKGLLHVVDGTLP
HHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCC
VDAVTRELEGILGDC
HHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA