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The map label for this gene is degP [H]

Identifier: 83593994

GI number: 83593994

Start: 3092389

End: 3093864

Strand: Reverse

Name: degP [H]

Synonym: Rru_A2662

Alternate gene names: 83593994

Gene position: 3093864-3092389 (Counterclockwise)

Preceding gene: 83593995

Following gene: 83593993

Centisome position: 71.08

GC content: 68.77

Gene sequence:

>1476_bases
ATGATCAAAGCGGGGGAGGACCGGATGGACCAATCGGGGCGGTGGGCCAGGGGCGTTCTGGCCGGGGCGAGCGTCGCGGT
CTTGCTGGCGTTCGGGGGACCGGCGGCGGGGGCGGCCGAACAGGTGCCAGGGGCCGGGACGGCCGAACAGGTGCCGATGG
CGGCGGCCGAGATCAAGCTGACCTTCGCGCCGGTGGTCCGCGCCGTCGCTCCGGCGGTGGTCAATATCTTCAGCCAGCGC
GTCATCACCGAGTCGCAAGTTCCGCCGATGTTCGCCGACCCGCTGTTCCGCCGCTTCCTCGAGGAGCGCGGCATGCTGGG
CAAGCCGCGCGAGCGGGTTCAGCGGTCCTTGGGCTCGGGGGTGATCTTGCGCTCCGAGGGCGTGGTGGTGACCAATGCCC
ATGTGGTCAATGGCGCGAGCGAAATCACCGTGGCCCTCAACGATCGCCGGGAATTCCCCGCCGAACTGGTCGGGCTTGAT
CCGCGGGCCGATCTGGCGGTGCTGCGGATCAAATCCGATACGCCGCTGCCGTCGCTGGCCCTGGCCGACGGCGAGCCGCC
CGAGGTTGGCGATCTGGTTTTGGCCATCGGCAATCCCTTTGGCGTCGGTCAAACGGTCACCAGCGGCATCGTTTCGGCCC
AGGCGCGGACCACGGCGGGAATTTCCGATTACCGCTTCTTCATTCAGACCGACGCGGCGATCAACCCCGGCAATTCCGGC
GGCGCCCTGGTCGATCTGAGCGGCCGGCTGGTCGGCATCAACACCGCCATTTATTCGCGCGACGGCGGCAGCGTCGGCAT
CGGCTTCGCCATTCCGGTCGAAATGGTGCGCTCGGTGGTCGAGGGGATCTTGGAAGACGGCAAGGTCCGCCACCCCTGGC
TGGGCGCCGATGGCCAGTCGGTGACGACCGAACTGGCAAGCCACATGGGCTTGGATCGCCCGCTGGGCGTCGCCATCACC
GATGTGGCCAAGGGCGGGCCGGCGGCCAAGGCCGGGCTTGCCGAAGGCGATGTCATCCTGGCGCTTGATGGCCGGCCGGT
GTTCGAGGGGGAAACCCTGCGCTATCGCATCGCCACCCACCGCCCCGGCGACAAGGTGGTGTTGGGGATCCGCCGCGACG
GCAAAGATACCACCCTGGCCGTCACCCTGGAGGCGCCGCCGGAGGATCCGCCGCGCGATACCACCTTGCTCAAAGGCTCC
CATCCGTTCGACGGGGCGGAGGTTTCCAATATGAATCCGGCCCTGGCCGAAGAACTGGGGTTGGAGAAGGCCTCCCGGGG
GGTGACGGTCACCGGCCTGGGCGATGGCGTCGCCGCGCGGATCGGCATCCGCCCCGGGGACCGGGTCATCGAGGTCAACG
GCAAGGCCATTGACGCGGTTAGGGACCTGAAGGCGGCGATCAGCAAACCCAGCCGGGTGTGGCAGGTGGTGGTCGATCGC
GACGGTCGGGCGGTGCGGCTGGTGCTCGGCGGCTGA

Upstream 100 bases:

>100_bases
CCGCGAGGAGAGGCGCCCCTTTCCTTTGGGCGAGGTGGTTTTATTTTCAGAGAGACCGGCGATGCCCGGGCATCGGGGCC
GGTTGGCGGAGGAGGGCGAC

Downstream 100 bases:

>100_bases
GGGCGGCGTCGTCTTTAGGTCTTTGGGCTTCATTCAGGCCTTTCGGATTGACCGTCCCTGGGATAGGGTCGGTCCTTTCG
AACAGGGATAGGTCGGTCAT

Product: peptidase S1C, Do

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 491; Mature: 491

Protein sequence:

>491_residues
MIKAGEDRMDQSGRWARGVLAGASVAVLLAFGGPAAGAAEQVPGAGTAEQVPMAAAEIKLTFAPVVRAVAPAVVNIFSQR
VITESQVPPMFADPLFRRFLEERGMLGKPRERVQRSLGSGVILRSEGVVVTNAHVVNGASEITVALNDRREFPAELVGLD
PRADLAVLRIKSDTPLPSLALADGEPPEVGDLVLAIGNPFGVGQTVTSGIVSAQARTTAGISDYRFFIQTDAAINPGNSG
GALVDLSGRLVGINTAIYSRDGGSVGIGFAIPVEMVRSVVEGILEDGKVRHPWLGADGQSVTTELASHMGLDRPLGVAIT
DVAKGGPAAKAGLAEGDVILALDGRPVFEGETLRYRIATHRPGDKVVLGIRRDGKDTTLAVTLEAPPEDPPRDTTLLKGS
HPFDGAEVSNMNPALAEELGLEKASRGVTVTGLGDGVAARIGIRPGDRVIEVNGKAIDAVRDLKAAISKPSRVWQVVVDR
DGRAVRLVLGG

Sequences:

>Translated_491_residues
MIKAGEDRMDQSGRWARGVLAGASVAVLLAFGGPAAGAAEQVPGAGTAEQVPMAAAEIKLTFAPVVRAVAPAVVNIFSQR
VITESQVPPMFADPLFRRFLEERGMLGKPRERVQRSLGSGVILRSEGVVVTNAHVVNGASEITVALNDRREFPAELVGLD
PRADLAVLRIKSDTPLPSLALADGEPPEVGDLVLAIGNPFGVGQTVTSGIVSAQARTTAGISDYRFFIQTDAAINPGNSG
GALVDLSGRLVGINTAIYSRDGGSVGIGFAIPVEMVRSVVEGILEDGKVRHPWLGADGQSVTTELASHMGLDRPLGVAIT
DVAKGGPAAKAGLAEGDVILALDGRPVFEGETLRYRIATHRPGDKVVLGIRRDGKDTTLAVTLEAPPEDPPRDTTLLKGS
HPFDGAEVSNMNPALAEELGLEKASRGVTVTGLGDGVAARIGIRPGDRVIEVNGKAIDAVRDLKAAISKPSRVWQVVVDR
DGRAVRLVLGG
>Mature_491_residues
MIKAGEDRMDQSGRWARGVLAGASVAVLLAFGGPAAGAAEQVPGAGTAEQVPMAAAEIKLTFAPVVRAVAPAVVNIFSQR
VITESQVPPMFADPLFRRFLEERGMLGKPRERVQRSLGSGVILRSEGVVVTNAHVVNGASEITVALNDRREFPAELVGLD
PRADLAVLRIKSDTPLPSLALADGEPPEVGDLVLAIGNPFGVGQTVTSGIVSAQARTTAGISDYRFFIQTDAAINPGNSG
GALVDLSGRLVGINTAIYSRDGGSVGIGFAIPVEMVRSVVEGILEDGKVRHPWLGADGQSVTTELASHMGLDRPLGVAIT
DVAKGGPAAKAGLAEGDVILALDGRPVFEGETLRYRIATHRPGDKVVLGIRRDGKDTTLAVTLEAPPEDPPRDTTLLKGS
HPFDGAEVSNMNPALAEELGLEKASRGVTVTGLGDGVAARIGIRPGDRVIEVNGKAIDAVRDLKAAISKPSRVWQVVVDR
DGRAVRLVLGG

Specific function: Serine protease that is required at high temperature. Involved in the degradation of damaged proteins. Shared specificity with hhoA/degQ [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI22129776, Length=352, Percent_Identity=30.9659090909091, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI24308541, Length=333, Percent_Identity=31.2312312312312, Blast_Score=134, Evalue=3e-31,
Organism=Homo sapiens, GI4506141, Length=354, Percent_Identity=31.3559322033898, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI7019477, Length=309, Percent_Identity=34.3042071197411, Blast_Score=130, Evalue=2e-30,
Organism=Escherichia coli, GI1786356, Length=479, Percent_Identity=37.160751565762, Blast_Score=280, Evalue=2e-76,
Organism=Escherichia coli, GI1789629, Length=454, Percent_Identity=35.6828193832599, Blast_Score=261, Evalue=5e-71,
Organism=Escherichia coli, GI1789630, Length=334, Percent_Identity=38.0239520958084, Blast_Score=214, Evalue=1e-56,
Organism=Drosophila melanogaster, GI24646839, Length=296, Percent_Identity=30.7432432432432, Blast_Score=115, Evalue=7e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 51110; Mature: 51110

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKAGEDRMDQSGRWARGVLAGASVAVLLAFGGPAAGAAEQVPGAGTAEQVPMAAAEIKL
CCCCCCCCCCCCCCCHHHHHCCCCEEEEEEECCCCCCCHHCCCCCCCHHHCCCEEHEEEE
TFAPVVRAVAPAVVNIFSQRVITESQVPPMFADPLFRRFLEERGMLGKPRERVQRSLGSG
EHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCC
VILRSEGVVVTNAHVVNGASEITVALNDRREFPAELVGLDPRADLAVLRIKSDTPLPSLA
EEEECCCEEEEEEEEECCCCEEEEEECCCCCCCHHHCCCCCCCCEEEEEEECCCCCCCEE
LADGEPPEVGDLVLAIGNPFGVGQTVTSGIVSAQARTTAGISDYRFFIQTDAAINPGNSG
ECCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHCCHHCCCCCCEEEEEEECCEECCCCCC
GALVDLSGRLVGINTAIYSRDGGSVGIGFAIPVEMVRSVVEGILEDGKVRHPWLGADGQS
CEEEEECCEEEEEEEEEEECCCCCEEEEEECHHHHHHHHHHHHHHCCCCCCCEECCCCCH
VTTELASHMGLDRPLGVAITDVAKGGPAAKAGLAEGDVILALDGRPVFEGETLRYRIATH
HHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCCEEEEECCEEEECCCEEEEEEEEC
RPGDKVVLGIRRDGKDTTLAVTLEAPPEDPPRDTTLLKGSHPFDGAEVSNMNPALAEELG
CCCCEEEEEEEECCCCCEEEEEEECCCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHC
LEKASRGVTVTGLGDGVAARIGIRPGDRVIEVNGKAIDAVRDLKAAISKPSRVWQVVVDR
CHHHHCCEEEEECCCCEEEEEECCCCCEEEEECCCHHHHHHHHHHHHCCCCEEEEEEEEC
DGRAVRLVLGG
CCCEEEEEECC
>Mature Secondary Structure
MIKAGEDRMDQSGRWARGVLAGASVAVLLAFGGPAAGAAEQVPGAGTAEQVPMAAAEIKL
CCCCCCCCCCCCCCCHHHHHCCCCEEEEEEECCCCCCCHHCCCCCCCHHHCCCEEHEEEE
TFAPVVRAVAPAVVNIFSQRVITESQVPPMFADPLFRRFLEERGMLGKPRERVQRSLGSG
EHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCC
VILRSEGVVVTNAHVVNGASEITVALNDRREFPAELVGLDPRADLAVLRIKSDTPLPSLA
EEEECCCEEEEEEEEECCCCEEEEEECCCCCCCHHHCCCCCCCCEEEEEEECCCCCCCEE
LADGEPPEVGDLVLAIGNPFGVGQTVTSGIVSAQARTTAGISDYRFFIQTDAAINPGNSG
ECCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHCCHHCCCCCCEEEEEEECCEECCCCCC
GALVDLSGRLVGINTAIYSRDGGSVGIGFAIPVEMVRSVVEGILEDGKVRHPWLGADGQS
CEEEEECCEEEEEEEEEEECCCCCEEEEEECHHHHHHHHHHHHHHCCCCCCCEECCCCCH
VTTELASHMGLDRPLGVAITDVAKGGPAAKAGLAEGDVILALDGRPVFEGETLRYRIATH
HHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCCEEEEECCEEEECCCEEEEEEEEC
RPGDKVVLGIRRDGKDTTLAVTLEAPPEDPPRDTTLLKGSHPFDGAEVSNMNPALAEELG
CCCCEEEEEEEECCCCCEEEEEEECCCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHC
LEKASRGVTVTGLGDGVAARIGIRPGDRVIEVNGKAIDAVRDLKAAISKPSRVWQVVVDR
CHHHHCCEEEEECCCCEEEEEECCCCCEEEEECCCHHHHHHHHHHHHCCCCEEEEEEEEC
DGRAVRLVLGG
CCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1645840; 11677609 [H]