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The map label for this gene is cobC [H]

Identifier: 83593983

GI number: 83593983

Start: 3080618

End: 3081643

Strand: Reverse

Name: cobC [H]

Synonym: Rru_A2651

Alternate gene names: 83593983

Gene position: 3081643-3080618 (Counterclockwise)

Preceding gene: 83593984

Following gene: 83593982

Centisome position: 70.8

GC content: 73.1

Gene sequence:

>1026_bases
GTGACCCTCCCTTTTCTGTGGCACGGCGGCGCCATCGCCGCCGCCCGGGAGCGCTTTGGCGATCCCGGCCCGCAAGGCTG
GCTTGATCTGTCAACGGGGATAGCCCCCGTCGCCTATCCATACAGCCGCCTGCCGGCGCAGGCCTGGACCCGCCTGCCCG
ATAGCGATCTTGCCGAGGCCTTTATCGGCGCCGTGCGCGCCGCCCACCACCTGCCGACGGCGGCGGCGGTTCTGCCGATC
GCCGGAGAACAGGCCATCCTCGGCCTGCTGCCGCTGTGCGACGCCCCCAGCGGCGCGGTCCGCGTGCCCAAGCCGGGCTA
TCGCGGCCACGCCGAGGCCTGGGCGGCGGCCGGCCGCTGTGTTCACGATTGCGCCGATCCGCTGGAGACGGCCGGCGAGG
GCGGCGTTATCGTGGTCATCAACCCCAACAACCCCAGCGGCCGGCGCTGGTCGGCGGAGTCGCTGCTGGCCGCCGCCGCG
GCCCAGGCGGCGGCGGGCGGCTGGCTGATCGTTGACGAGGCGTTTGGCGAAGTCACCCCCGATCTCAGCGTTCTGGCTGA
CAGCGGCCGGCCGGGGCTGCTGGTGCTGCGCTCCTTTGGCAAGTTTTTCGGATTGCCCGGTCTGCGCCTGGGATGGCTGG
CCGGGCCGCCCGAGGTGGTCGAGCCCTTGGCCCGGCGTCTCGGCCCCTGGGCGGTTTCCGGCCCGGCGCTGGCCCTGGGC
GCGCGGGCCGAGGCCGATGAGCTTTGGCGGGCCGGCCAGCGGCGCAGGCTGGCGCGTCTGGCGCTCAAACTGGATGGGGT
TCTGAGTCGCGCTGGCTTGGTGGGACTGGGCGGCACCGATCTGTTCCGGCTGGTCGAGGTTCCCGCCGGCACCCGCGCCC
TGGACTGGTTCGAGGGGTTGGCCGCCCAGGGGATCCTGGTCCGTCCCTTCGCCGAGGCCGAGCGCGCCTTGCGCTTTGGT
CTGCCCGGCACGCAAGCGGCGCGCGATCGCCTAAGCGCCGCCCTGGCCCGGATGACCTTGAAATGA

Upstream 100 bases:

>100_bases
AGGGCGGTTCTGGGCAATCGCCTGCGCGGCGATGGCGGAACCCGGGGGGCCCATTTGCTGGCCGAACTGGCCTTGACCAC
GCCTTCGGCCGCGTGACCCG

Downstream 100 bases:

>100_bases
AAAACATTAAATCCAAAGCGTTTATTGGTGCGGAGTGATCGCTGTCAACGGGCTTTCGGTCATAATCTTACCTCATTGAT
TTCATCCCACTGTCACCATT

Product: aminotransferase

Products: NA

Alternate protein names: L-threonine-O-3-phosphate decarboxylase [H]

Number of amino acids: Translated: 341; Mature: 340

Protein sequence:

>341_residues
MTLPFLWHGGAIAAARERFGDPGPQGWLDLSTGIAPVAYPYSRLPAQAWTRLPDSDLAEAFIGAVRAAHHLPTAAAVLPI
AGEQAILGLLPLCDAPSGAVRVPKPGYRGHAEAWAAAGRCVHDCADPLETAGEGGVIVVINPNNPSGRRWSAESLLAAAA
AQAAAGGWLIVDEAFGEVTPDLSVLADSGRPGLLVLRSFGKFFGLPGLRLGWLAGPPEVVEPLARRLGPWAVSGPALALG
ARAEADELWRAGQRRRLARLALKLDGVLSRAGLVGLGGTDLFRLVEVPAGTRALDWFEGLAAQGILVRPFAEAERALRFG
LPGTQAARDRLSAALARMTLK

Sequences:

>Translated_341_residues
MTLPFLWHGGAIAAARERFGDPGPQGWLDLSTGIAPVAYPYSRLPAQAWTRLPDSDLAEAFIGAVRAAHHLPTAAAVLPI
AGEQAILGLLPLCDAPSGAVRVPKPGYRGHAEAWAAAGRCVHDCADPLETAGEGGVIVVINPNNPSGRRWSAESLLAAAA
AQAAAGGWLIVDEAFGEVTPDLSVLADSGRPGLLVLRSFGKFFGLPGLRLGWLAGPPEVVEPLARRLGPWAVSGPALALG
ARAEADELWRAGQRRRLARLALKLDGVLSRAGLVGLGGTDLFRLVEVPAGTRALDWFEGLAAQGILVRPFAEAERALRFG
LPGTQAARDRLSAALARMTLK
>Mature_340_residues
TLPFLWHGGAIAAARERFGDPGPQGWLDLSTGIAPVAYPYSRLPAQAWTRLPDSDLAEAFIGAVRAAHHLPTAAAVLPIA
GEQAILGLLPLCDAPSGAVRVPKPGYRGHAEAWAAAGRCVHDCADPLETAGEGGVIVVINPNNPSGRRWSAESLLAAAAA
QAAAGGWLIVDEAFGEVTPDLSVLADSGRPGLLVLRSFGKFFGLPGLRLGWLAGPPEVVEPLARRLGPWAVSGPALALGA
RAEADELWRAGQRRRLARLALKLDGVLSRAGLVGLGGTDLFRLVEVPAGTRALDWFEGLAAQGILVRPFAEAERALRFGL
PGTQAARDRLSAALARMTLK

Specific function: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1- amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin [H]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005860
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.1.1.81 [H]

Molecular weight: Translated: 35648; Mature: 35517

Theoretical pI: Translated: 8.50; Mature: 8.50

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLPFLWHGGAIAAARERFGDPGPQGWLDLSTGIAPVAYPYSRLPAQAWTRLPDSDLAEA
CCCCEEECCCHHHHHHHHCCCCCCCCCEECCCCCCCCCCCHHHCCHHHHHCCCCHHHHHH
FIGAVRAAHHLPTAAAVLPIAGEQAILGLLPLCDAPSGAVRVPKPGYRGHAEAWAAAGRC
HHHHHHHHHHCCHHHHEEECCCCHHHHHHHHCCCCCCCCEECCCCCCCCCHHHHHHHHHH
VHDCADPLETAGEGGVIVVINPNNPSGRRWSAESLLAAAAAQAAAGGWLIVDEAFGEVTP
HHHHHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCC
DLSVLADSGRPGLLVLRSFGKFFGLPGLRLGWLAGPPEVVEPLARRLGPWAVSGPALALG
CHHEEECCCCCCCHHHHHHHHHHCCCCCEECCCCCCHHHHHHHHHHCCCCCCCCCCEEEC
ARAEADELWRAGQRRRLARLALKLDGVLSRAGLVGLGGTDLFRLVEVPAGTRALDWFEGL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCHHHHHHHCCCCCCHHHHHHHHH
AAQGILVRPFAEAERALRFGLPGTQAARDRLSAALARMTLK
HHCCEEECCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TLPFLWHGGAIAAARERFGDPGPQGWLDLSTGIAPVAYPYSRLPAQAWTRLPDSDLAEA
CCCEEECCCHHHHHHHHCCCCCCCCCEECCCCCCCCCCCHHHCCHHHHHCCCCHHHHHH
FIGAVRAAHHLPTAAAVLPIAGEQAILGLLPLCDAPSGAVRVPKPGYRGHAEAWAAAGRC
HHHHHHHHHHCCHHHHEEECCCCHHHHHHHHCCCCCCCCEECCCCCCCCCHHHHHHHHHH
VHDCADPLETAGEGGVIVVINPNNPSGRRWSAESLLAAAAAQAAAGGWLIVDEAFGEVTP
HHHHHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCC
DLSVLADSGRPGLLVLRSFGKFFGLPGLRLGWLAGPPEVVEPLARRLGPWAVSGPALALG
CHHEEECCCCCCCHHHHHHHHHHCCCCCEECCCCCCHHHHHHHHHHCCCCCCCCCCEEEC
ARAEADELWRAGQRRRLARLALKLDGVLSRAGLVGLGGTDLFRLVEVPAGTRALDWFEGL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCHHHHHHHCCCCCCHHHHHHHHH
AAQGILVRPFAEAERALRFGLPGTQAARDRLSAALARMTLK
HHCCEEECCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2211520 [H]