Click here to switch to the map view.

The map label for this gene is serA [H]

Identifier: 83593791

GI number: 83593791

Start: 2854500

End: 2855735

Strand: Reverse

Name: serA [H]

Synonym: Rru_A2456

Alternate gene names: 83593791

Gene position: 2855735-2854500 (Counterclockwise)

Preceding gene: 83593797

Following gene: 83593784

Centisome position: 65.61

GC content: 62.54

Gene sequence:

>1236_bases
GTGAGCAATCTTTCACTGCCCAAGGACAAGATCCGGGTCGTGCTGTTCGAGAACATCCATGACAGCGCCGTCGAGTATTT
TCACAGTCGCGGTTACCACAACATCGAGCGGCTGACCGGGGCTCTGGACGGTGAGGCGCTGAAGGACAAGATCCGTGACG
CCCATATGGTCGGGATCCGATCGCGAACCCGCTTGACTCGCGACGTCTTGGAATCAGCCGAAAAGCTGATGGCGGTCGGC
TGCTTTTGCATCGGCACCAATCAGGTCGATCTTGACGCCGCCGAGCTTCTGGGGATCCCCGTTTTCAACGCCCCCTATTC
CAATACCCGCTCGGTCGCCGAACTGGTGGTCGCCGAGGCGGTGATGATGATGCGCGATATCCCACGGCGCAATTGGGATA
CCCACGAGGGCGGGTGGAACAAGGCGGCGACCGGCTGTCACGAGGTGCGCGGCAAGACCCTGGGCATCGTCGGCTATGGC
CATATCGGCACCCAGGTGTCCGTTCTCGCCGAAAGCATGGGCATGTCGGTGCGCTATTTCGACATCGTCGAAAAGCTGGC
GATCGGCAACGCCCAGCCCTGCGCCACCCTGAACGAGCTGATGGCGGTGGCCGATGTCGTCACCTTGCATGTGCCCGATA
CCGCCGATACCCGCGATATGATCCGCGCGCCGCAGATCGCGGCGATGAAGGACGGGGCCTATCTGATCAACGCCTCGCGC
GGCAAGGTGGTTGATATCGACGCCCTGGCCGAAGCCCTGACGGCGGGCAAGCTGCGCGGCGCCGCCGTCGACGTGTTCCC
CAAGGAGCCGGCCAGCCTGGGCGATCCGTTCGAAAGCCCGTTGCGCGGCATGCGCAATGTTCTGCTGACCCCCCATATCG
GCGGCTCGACCGAAGAGGCGCAGATGGGGATCGGCCGCGAAGTGGCCGAAAAGCTGGTGAAATATTCCGATGACGGCTCG
ACTCTGGGCGCCGTCAACTTCCCCGAGGTGGCCTTGCCCCAGCAGGCCAGCGTGACCCGCTTCTTGCACATTCACCGCAA
TGTGCCCGGGGTGATGAGCGCGCTCAACGAGGTGTTTTCCAGCCACCACATCAATATCCGCGGCCAGTATCTGATGACCA
ATCCCCGGGTCGGCTATGTGGTGGTCGATGTGGAAAAGGACCTGAAGGCCGGCGAGGGCTTCCGTCAGGCTTTGGCGGCG
ATCAACGGCACGCTGCGCTTCCGCTTCCTGAATTAA

Upstream 100 bases:

>100_bases
CTCCTTTTCCACACCGGTTCGTTCCATGGTAACCAGAGCCCCGCCACCGGTGGCCGTTTGGGGGCACCGGACCAGCCTCG
CATATCGGAAGGGAATGGTC

Downstream 100 bases:

>100_bases
GCGGCTTCACGGCGGCGGAGAGCCTTGAAAAAACAAGAAAGCCCCGGAGCTTGGGTTCCGGGGCTTTCAGGCGTCCAGCG
CGGAGGGTTTGTCTCCGGCT

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 411; Mature: 410

Protein sequence:

>411_residues
MSNLSLPKDKIRVVLFENIHDSAVEYFHSRGYHNIERLTGALDGEALKDKIRDAHMVGIRSRTRLTRDVLESAEKLMAVG
CFCIGTNQVDLDAAELLGIPVFNAPYSNTRSVAELVVAEAVMMMRDIPRRNWDTHEGGWNKAATGCHEVRGKTLGIVGYG
HIGTQVSVLAESMGMSVRYFDIVEKLAIGNAQPCATLNELMAVADVVTLHVPDTADTRDMIRAPQIAAMKDGAYLINASR
GKVVDIDALAEALTAGKLRGAAVDVFPKEPASLGDPFESPLRGMRNVLLTPHIGGSTEEAQMGIGREVAEKLVKYSDDGS
TLGAVNFPEVALPQQASVTRFLHIHRNVPGVMSALNEVFSSHHINIRGQYLMTNPRVGYVVVDVEKDLKAGEGFRQALAA
INGTLRFRFLN

Sequences:

>Translated_411_residues
MSNLSLPKDKIRVVLFENIHDSAVEYFHSRGYHNIERLTGALDGEALKDKIRDAHMVGIRSRTRLTRDVLESAEKLMAVG
CFCIGTNQVDLDAAELLGIPVFNAPYSNTRSVAELVVAEAVMMMRDIPRRNWDTHEGGWNKAATGCHEVRGKTLGIVGYG
HIGTQVSVLAESMGMSVRYFDIVEKLAIGNAQPCATLNELMAVADVVTLHVPDTADTRDMIRAPQIAAMKDGAYLINASR
GKVVDIDALAEALTAGKLRGAAVDVFPKEPASLGDPFESPLRGMRNVLLTPHIGGSTEEAQMGIGREVAEKLVKYSDDGS
TLGAVNFPEVALPQQASVTRFLHIHRNVPGVMSALNEVFSSHHINIRGQYLMTNPRVGYVVVDVEKDLKAGEGFRQALAA
INGTLRFRFLN
>Mature_410_residues
SNLSLPKDKIRVVLFENIHDSAVEYFHSRGYHNIERLTGALDGEALKDKIRDAHMVGIRSRTRLTRDVLESAEKLMAVGC
FCIGTNQVDLDAAELLGIPVFNAPYSNTRSVAELVVAEAVMMMRDIPRRNWDTHEGGWNKAATGCHEVRGKTLGIVGYGH
IGTQVSVLAESMGMSVRYFDIVEKLAIGNAQPCATLNELMAVADVVTLHVPDTADTRDMIRAPQIAAMKDGAYLINASRG
KVVDIDALAEALTAGKLRGAAVDVFPKEPASLGDPFESPLRGMRNVLLTPHIGGSTEEAQMGIGREVAEKLVKYSDDGST
LGAVNFPEVALPQQASVTRFLHIHRNVPGVMSALNEVFSSHHINIRGQYLMTNPRVGYVVVDVEKDLKAGEGFRQALAAI
NGTLRFRFLN

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=317, Percent_Identity=33.1230283911672, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI145580578, Length=268, Percent_Identity=32.8358208955224, Blast_Score=126, Evalue=5e-29,
Organism=Homo sapiens, GI4557499, Length=268, Percent_Identity=32.8358208955224, Blast_Score=126, Evalue=5e-29,
Organism=Homo sapiens, GI145580575, Length=268, Percent_Identity=32.8358208955224, Blast_Score=123, Evalue=4e-28,
Organism=Homo sapiens, GI4557497, Length=258, Percent_Identity=31.0077519379845, Blast_Score=122, Evalue=6e-28,
Organism=Homo sapiens, GI61743967, Length=258, Percent_Identity=31.0077519379845, Blast_Score=122, Evalue=7e-28,
Organism=Homo sapiens, GI6912396, Length=240, Percent_Identity=29.5833333333333, Blast_Score=83, Evalue=4e-16,
Organism=Escherichia coli, GI1789279, Length=410, Percent_Identity=58.0487804878049, Blast_Score=485, Evalue=1e-138,
Organism=Escherichia coli, GI87082289, Length=256, Percent_Identity=33.59375, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1787645, Length=259, Percent_Identity=28.5714285714286, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI87081824, Length=163, Percent_Identity=34.9693251533742, Blast_Score=76, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17532191, Length=330, Percent_Identity=32.7272727272727, Blast_Score=159, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI25147481, Length=269, Percent_Identity=28.2527881040892, Blast_Score=97, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6320925, Length=414, Percent_Identity=50, Blast_Score=411, Evalue=1e-115,
Organism=Saccharomyces cerevisiae, GI6322116, Length=386, Percent_Identity=50.5181347150259, Blast_Score=398, Evalue=1e-112,
Organism=Saccharomyces cerevisiae, GI6324964, Length=275, Percent_Identity=30.9090909090909, Blast_Score=102, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6324055, Length=233, Percent_Identity=29.1845493562232, Blast_Score=97, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6324980, Length=191, Percent_Identity=31.9371727748691, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6325144, Length=152, Percent_Identity=30.9210526315789, Blast_Score=70, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6321253, Length=162, Percent_Identity=30.8641975308642, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI19921140, Length=311, Percent_Identity=30.5466237942122, Blast_Score=144, Evalue=8e-35,
Organism=Drosophila melanogaster, GI24646446, Length=244, Percent_Identity=32.7868852459016, Blast_Score=112, Evalue=7e-25,
Organism=Drosophila melanogaster, GI24646448, Length=244, Percent_Identity=32.7868852459016, Blast_Score=112, Evalue=7e-25,
Organism=Drosophila melanogaster, GI24646452, Length=244, Percent_Identity=32.7868852459016, Blast_Score=112, Evalue=7e-25,
Organism=Drosophila melanogaster, GI24646450, Length=244, Percent_Identity=32.7868852459016, Blast_Score=112, Evalue=7e-25,
Organism=Drosophila melanogaster, GI62472511, Length=244, Percent_Identity=32.7868852459016, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI28574286, Length=270, Percent_Identity=30.3703703703704, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI28571528, Length=259, Percent_Identity=27.4131274131274, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI28574284, Length=274, Percent_Identity=27.007299270073, Blast_Score=82, Evalue=9e-16,
Organism=Drosophila melanogaster, GI45551003, Length=287, Percent_Identity=26.1324041811847, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI45552429, Length=274, Percent_Identity=27.007299270073, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24585514, Length=274, Percent_Identity=27.007299270073, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI28574282, Length=274, Percent_Identity=27.007299270073, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24585516, Length=306, Percent_Identity=22.8758169934641, Blast_Score=78, Evalue=1e-14,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR010771
- InterPro:   IPR016040
- ProDom:   PD147088 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 44771; Mature: 44640

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNLSLPKDKIRVVLFENIHDSAVEYFHSRGYHNIERLTGALDGEALKDKIRDAHMVGIR
CCCCCCCHHHEEEEEECCCHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHHHCCH
SRTRLTRDVLESAEKLMAVGCFCIGTNQVDLDAAELLGIPVFNAPYSNTRSVAELVVAEA
HHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHH
VMMMRDIPRRNWDTHEGGWNKAATGCHEVRGKTLGIVGYGHIGTQVSVLAESMGMSVRYF
HHHHHHCCCCCCCCCCCCCCHHHCCHHHHCCCEEEEEEECCCCHHHHHHHHHHCCEEHHH
DIVEKLAIGNAQPCATLNELMAVADVVTLHVPDTADTRDMIRAPQIAAMKDGAYLINASR
HHHHHHHCCCCCCHHHHHHHHHHHHHHEEECCCCCCHHHHHCCCCCEEECCCEEEEECCC
GKVVDIDALAEALTAGKLRGAAVDVFPKEPASLGDPFESPLRGMRNVLLTPHIGGSTEEA
CCEEEHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHEEECCCCCCCCCHH
QMGIGREVAEKLVKYSDDGSTLGAVNFPEVALPQQASVTRFLHIHRNVPGVMSALNEVFS
HHCCCHHHHHHHHHCCCCCCEECCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHH
SHHINIRGQYLMTNPRVGYVVVDVEKDLKAGEGFRQALAAINGTLRFRFLN
CCCEEEEEEEEEECCCEEEEEEEECCCCCCCHHHHHHHHHHCCEEEEEEEC
>Mature Secondary Structure 
SNLSLPKDKIRVVLFENIHDSAVEYFHSRGYHNIERLTGALDGEALKDKIRDAHMVGIR
CCCCCCHHHEEEEEECCCHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHHHCCH
SRTRLTRDVLESAEKLMAVGCFCIGTNQVDLDAAELLGIPVFNAPYSNTRSVAELVVAEA
HHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHH
VMMMRDIPRRNWDTHEGGWNKAATGCHEVRGKTLGIVGYGHIGTQVSVLAESMGMSVRYF
HHHHHHCCCCCCCCCCCCCCHHHCCHHHHCCCEEEEEEECCCCHHHHHHHHHHCCEEHHH
DIVEKLAIGNAQPCATLNELMAVADVVTLHVPDTADTRDMIRAPQIAAMKDGAYLINASR
HHHHHHHCCCCCCHHHHHHHHHHHHHHEEECCCCCCHHHHHCCCCCEEECCCEEEEECCC
GKVVDIDALAEALTAGKLRGAAVDVFPKEPASLGDPFESPLRGMRNVLLTPHIGGSTEEA
CCEEEHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHEEECCCCCCCCCHH
QMGIGREVAEKLVKYSDDGSTLGAVNFPEVALPQQASVTRFLHIHRNVPGVMSALNEVFS
HHCCCHHHHHHHHHCCCCCCEECCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHH
SHHINIRGQYLMTNPRVGYVVVDVEKDLKAGEGFRQALAAINGTLRFRFLN
CCCEEEEEEEEEECCCEEEEEEEECCCCCCCHHHHHHHHHHCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]