Click here to switch to the map view.

The map label for this gene is msrA

Identifier: 83593697

GI number: 83593697

Start: 2752996

End: 2753478

Strand: Reverse

Name: msrA

Synonym: Rru_A2362

Alternate gene names: 83593697

Gene position: 2753478-2752996 (Counterclockwise)

Preceding gene: 83593698

Following gene: 83593696

Centisome position: 63.26

GC content: 66.05

Gene sequence:

>483_bases
ATGGCTACCGCAACCTTCGCCGCCGGCTGCTTCTGGGGCGTGGAAGAAACCTTCCGCAAGATCCCCGGGGTAACCGGCAC
GACCGTCGGTTATACCGGCGGGCATTTCAAGGAACCGACCTACCGTCAGGTCTGCGCCGGCGATACCGGCCATGCCGAAG
CGGTGCGCGTTGATTACGATCCCGATAAAGTGACCTACGAACAGTTGCTGGACGTGTTCTGGGCCGCCCATGATCCGACC
CAGGTCGACCGCCAGGGGCCCGATATCGGCGATCAGTACCGCAGCGCCATCTTCTATCACGACGCCGGCCAGGAAGCCGC
CGCCGGGGCCAGCCGCGCCCGGCTTGAACAGTCGGGCGCCCTGTCGCGGGCCATCGCCACCCGCATCGAACCCGCCGGCC
CCTTCTGGCCGGCCGAAGAGTATCACCAGCGCTATATCGACAAACAACGGGCCCGCACCGGCGTCGCCCCGGCCTGTCAT
TAA

Upstream 100 bases:

>100_bases
TTCCGCTTCGAGGGCGCCGACGTCTTGTCCGAGGATGCCGCCTAACCCCATGTTGAGGAAAGCCGCTCGGCCCCACCCGC
TTTCGAGGAGAGCTTTCACC

Downstream 100 bases:

>100_bases
CTCCTGCCCGTTCGCCGTTCGCCGTTCGCCGCCCGATTGCGGCGCGCGGCGGGCGCCGGTTTATCCGTCGCTCAATAACC
GCCCGCCTTCTGGTCTGCAA

Product: protein-methionine-S-oxide reductase

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase

Number of amino acids: Translated: 160; Mature: 159

Protein sequence:

>160_residues
MATATFAAGCFWGVEETFRKIPGVTGTTVGYTGGHFKEPTYRQVCAGDTGHAEAVRVDYDPDKVTYEQLLDVFWAAHDPT
QVDRQGPDIGDQYRSAIFYHDAGQEAAAGASRARLEQSGALSRAIATRIEPAGPFWPAEEYHQRYIDKQRARTGVAPACH

Sequences:

>Translated_160_residues
MATATFAAGCFWGVEETFRKIPGVTGTTVGYTGGHFKEPTYRQVCAGDTGHAEAVRVDYDPDKVTYEQLLDVFWAAHDPT
QVDRQGPDIGDQYRSAIFYHDAGQEAAAGASRARLEQSGALSRAIATRIEPAGPFWPAEEYHQRYIDKQRARTGVAPACH
>Mature_159_residues
ATATFAAGCFWGVEETFRKIPGVTGTTVGYTGGHFKEPTYRQVCAGDTGHAEAVRVDYDPDKVTYEQLLDVFWAAHDPTQ
VDRQGPDIGDQYRSAIFYHDAGQEAAAGASRARLEQSGALSRAIATRIEPAGPFWPAEEYHQRYIDKQRARTGVAPACH

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family

Homologues:

Organism=Homo sapiens, GI6912516, Length=150, Percent_Identity=47.3333333333333, Blast_Score=137, Evalue=5e-33,
Organism=Homo sapiens, GI208609995, Length=150, Percent_Identity=47.3333333333333, Blast_Score=136, Evalue=7e-33,
Organism=Homo sapiens, GI208609993, Length=106, Percent_Identity=47.1698113207547, Blast_Score=91, Evalue=6e-19,
Organism=Escherichia coli, GI1790665, Length=153, Percent_Identity=55.5555555555556, Blast_Score=161, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17533973, Length=150, Percent_Identity=34, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6320881, Length=154, Percent_Identity=41.5584415584416, Blast_Score=116, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24664627, Length=147, Percent_Identity=43.5374149659864, Blast_Score=113, Evalue=6e-26,
Organism=Drosophila melanogaster, GI24664631, Length=147, Percent_Identity=42.1768707482993, Blast_Score=105, Evalue=1e-23,
Organism=Drosophila melanogaster, GI45553131, Length=140, Percent_Identity=42.1428571428571, Blast_Score=103, Evalue=5e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MSRA_RHORT (Q2RRT3)

Other databases:

- EMBL:   CP000230
- RefSeq:   YP_427449.1
- ProteinModelPortal:   Q2RRT3
- SMR:   Q2RRT3
- STRING:   Q2RRT3
- GeneID:   3835796
- GenomeReviews:   CP000230_GR
- KEGG:   rru:Rru_A2362
- NMPDR:   fig|1085.1.peg.11
- eggNOG:   COG0225
- HOGENOM:   HBG748152
- OMA:   PSCHIEY
- PhylomeDB:   Q2RRT3
- BioCyc:   RRUB269796:RRU_A2362-MONOMER
- HAMAP:   MF_01401
- InterPro:   IPR002569
- Gene3D:   G3DSA:3.30.1060.10
- TIGRFAMs:   TIGR00401

Pfam domain/function: PF01625 PMSR; SSF55068 MsrA

EC number: =1.8.4.11

Molecular weight: Translated: 17551; Mature: 17420

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: NA

Important sites: ACT_SITE 10-10

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATATFAAGCFWGVEETFRKIPGVTGTTVGYTGGHFKEPTYRQVCAGDTGHAEAVRVDYD
CCCCHHHHHHHHCHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCEEEEECCC
PDKVTYEQLLDVFWAAHDPTQVDRQGPDIGDQYRSAIFYHDAGQEAAAGASRARLEQSGA
CCHHHHHHHHHHHHHCCCCCHHCCCCCCCCHHHHHEEEECCCCCHHHHHHHHHHHHHHHH
LSRAIATRIEPAGPFWPAEEYHQRYIDKQRARTGVAPACH
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
ATATFAAGCFWGVEETFRKIPGVTGTTVGYTGGHFKEPTYRQVCAGDTGHAEAVRVDYD
CCCHHHHHHHHCHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCEEEEECCC
PDKVTYEQLLDVFWAAHDPTQVDRQGPDIGDQYRSAIFYHDAGQEAAAGASRARLEQSGA
CCHHHHHHHHHHHHHCCCCCHHCCCCCCCCHHHHHEEEECCCCCHHHHHHHHHHHHHHHH
LSRAIATRIEPAGPFWPAEEYHQRYIDKQRARTGVAPACH
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA