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The map label for this gene is purM [H]

Identifier: 83593502

GI number: 83593502

Start: 2516259

End: 2517425

Strand: Direct

Name: purM [H]

Synonym: Rru_A2167

Alternate gene names: 83593502

Gene position: 2516259-2517425 (Clockwise)

Preceding gene: 83593497

Following gene: 83593503

Centisome position: 57.81

GC content: 66.67

Gene sequence:

>1167_bases
ATGGTCCGGGGAACCGCACCGGCTGCGGGCGCCCACCCGCCGCGACGAACACCAGTGAAGAACGAGGTTGCCATTTCCAC
TTCCCATCTCGACGCCGGCGCCACGGGCACCGGCCTGACCTATAAAGATGCCGGTGTTGACATAGACAGCGGCAATGCTC
TCGTGCAAGCGATCAAACCGCTTGCCGCATCGACAAAGCGCCCGGGGGCCGACGCGTCCCTCGGCGGCTTCGGCGCGATC
TTCGATCTTGCCGCCGCCGGCTATTCCGATCCCCTTCTTATCACGGCGACGGACGGTGTTGGCACAAAGCTGAAGATCGC
CCTCGACTCGGGCATCCATGATAGCGTCGGCATCGACCTCGTGGCCATGTGCGTCAATGATCTGGTCGTCCAGGGCGGCG
AGCCGCTGCTGTTTCTCGACTACTTCGCCACCTCGCGCCTGCAGGTGCCGGTGGCCAGCGCCGTGGTCAAGGGCATCGCC
GAGGGCTGCCTTCAGGCCGGTTGCGCCCTGGTCGGCGGCGAGACCGCCGAAATGCCCGGCATGTATGGCAATAACGACTA
TGATCTGGCCGGCTTCGCCGTTGGCGCCGTCGAGCGCTCGCAGCTTCTGACCGATGACCGCATCGGCCTGGGCGACGTTC
TGCTCGGCCTCGCCAGCTCGGGCGTCCATTCCAACGGCTTCTCGCTGGTCCGGCGCATCGTCGAGCGCAGCGGCTTGGCC
TGGGACGCCCCGGCGCCCTTCGCCCCCGAAACCACCCTGGCCCGCGCCCTGCTGACGCCCACGCGCATCTATGTGAAATC
CTGTCTGGCCCTGCACCGCGCTGGGCTGGTTCATGGCTTCGCCCATATCACCGGCGGCGGCTTCTGGGAGAATATCCCGC
GTGTTCTGCCCCAGGGGGCTTGCGCCCACCTTGACGGCCTGTCCTGGCCCTTCCCGCCGGTCTTCCGCTGGCTGATGGAT
CAGGGCGGCGTCAGCGCCCATGAAATGGCCCGCACCTTCAACTGCGGCATCGGCATGGTGGTTGCCGTTCCCGCCGACAA
GGCCGAAGCCGCCATCGCTTTGCTTGGCGAACACGGTGAAACCGTTCATCGCCTGGGCACCATCGCCGCGCGCGGCGAGG
GCGAGGCGGTGATCATCGATCACCTGGACGAAGCCTTCGCCCGATGA

Upstream 100 bases:

>100_bases
ATCGGCGGCCCAGGCCGGAGCGGTCGCCATCGGCCCAAGCGGGGCAAGGGCCATCAGCAAAGCCGCGACCACCAGGATTG
CAAAGCGGCGCGCTTCGGGT

Downstream 100 bases:

>100_bases
ACGCTCCCCAATCGACCGCGCCCCGCAAGCGCGTGGCGGTACTGATCAGCGGGCGCGGCAGCAATATGGAAGCGCTGATC
GCGGCTTGCGCCGATCCCGC

Product: phosphoribosylformylglycinamidine cyclo-ligase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 388; Mature: 388

Protein sequence:

>388_residues
MVRGTAPAAGAHPPRRTPVKNEVAISTSHLDAGATGTGLTYKDAGVDIDSGNALVQAIKPLAASTKRPGADASLGGFGAI
FDLAAAGYSDPLLITATDGVGTKLKIALDSGIHDSVGIDLVAMCVNDLVVQGGEPLLFLDYFATSRLQVPVASAVVKGIA
EGCLQAGCALVGGETAEMPGMYGNNDYDLAGFAVGAVERSQLLTDDRIGLGDVLLGLASSGVHSNGFSLVRRIVERSGLA
WDAPAPFAPETTLARALLTPTRIYVKSCLALHRAGLVHGFAHITGGGFWENIPRVLPQGACAHLDGLSWPFPPVFRWLMD
QGGVSAHEMARTFNCGIGMVVAVPADKAEAAIALLGEHGETVHRLGTIAARGEGEAVIIDHLDEAFAR

Sequences:

>Translated_388_residues
MVRGTAPAAGAHPPRRTPVKNEVAISTSHLDAGATGTGLTYKDAGVDIDSGNALVQAIKPLAASTKRPGADASLGGFGAI
FDLAAAGYSDPLLITATDGVGTKLKIALDSGIHDSVGIDLVAMCVNDLVVQGGEPLLFLDYFATSRLQVPVASAVVKGIA
EGCLQAGCALVGGETAEMPGMYGNNDYDLAGFAVGAVERSQLLTDDRIGLGDVLLGLASSGVHSNGFSLVRRIVERSGLA
WDAPAPFAPETTLARALLTPTRIYVKSCLALHRAGLVHGFAHITGGGFWENIPRVLPQGACAHLDGLSWPFPPVFRWLMD
QGGVSAHEMARTFNCGIGMVVAVPADKAEAAIALLGEHGETVHRLGTIAARGEGEAVIIDHLDEAFAR
>Mature_388_residues
MVRGTAPAAGAHPPRRTPVKNEVAISTSHLDAGATGTGLTYKDAGVDIDSGNALVQAIKPLAASTKRPGADASLGGFGAI
FDLAAAGYSDPLLITATDGVGTKLKIALDSGIHDSVGIDLVAMCVNDLVVQGGEPLLFLDYFATSRLQVPVASAVVKGIA
EGCLQAGCALVGGETAEMPGMYGNNDYDLAGFAVGAVERSQLLTDDRIGLGDVLLGLASSGVHSNGFSLVRRIVERSGLA
WDAPAPFAPETTLARALLTPTRIYVKSCLALHRAGLVHGFAHITGGGFWENIPRVLPQGACAHLDGLSWPFPPVFRWLMD
QGGVSAHEMARTFNCGIGMVVAVPADKAEAAIALLGEHGETVHRLGTIAARGEGEAVIIDHLDEAFAR

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=338, Percent_Identity=56.508875739645, Blast_Score=379, Evalue=1e-105,
Organism=Homo sapiens, GI209869995, Length=338, Percent_Identity=56.508875739645, Blast_Score=379, Evalue=1e-105,
Organism=Homo sapiens, GI209869993, Length=338, Percent_Identity=56.508875739645, Blast_Score=379, Evalue=1e-105,
Organism=Escherichia coli, GI1788845, Length=350, Percent_Identity=56.8571428571429, Blast_Score=391, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI17567511, Length=355, Percent_Identity=44.7887323943662, Blast_Score=299, Evalue=1e-81,
Organism=Saccharomyces cerevisiae, GI6321203, Length=345, Percent_Identity=54.4927536231884, Blast_Score=370, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24582400, Length=306, Percent_Identity=44.4444444444444, Blast_Score=244, Evalue=7e-65,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 40055; Mature: 40055

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVRGTAPAAGAHPPRRTPVKNEVAISTSHLDAGATGTGLTYKDAGVDIDSGNALVQAIKP
CCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCEEECCCCEECCCHHHHHHHHH
LAASTKRPGADASLGGFGAIFDLAAAGYSDPLLITATDGVGTKLKIALDSGIHDSVGIDL
HHHCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCEEEEEECCCCCCHHHHHH
VAMCVNDLVVQGGEPLLFLDYFATSRLQVPVASAVVKGIAEGCLQAGCALVGGETAEMPG
HHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCEEECCCHHHCCC
MYGNNDYDLAGFAVGAVERSQLLTDDRIGLGDVLLGLASSGVHSNGFSLVRRIVERSGLA
CCCCCCCCHHHEEEHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCC
WDAPAPFAPETTLARALLTPTRIYVKSCLALHRAGLVHGFAHITGGGFWENIPRVLPQGA
CCCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCC
CAHLDGLSWPFPPVFRWLMDQGGVSAHEMARTFNCGIGMVVAVPADKAEAAIALLGEHGE
HHHCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCCEEEEEECCCCHHHEEEEECCCCH
TVHRLGTIAARGEGEAVIIDHLDEAFAR
HHHHHHHHEECCCCCEEEEECHHHHHCC
>Mature Secondary Structure
MVRGTAPAAGAHPPRRTPVKNEVAISTSHLDAGATGTGLTYKDAGVDIDSGNALVQAIKP
CCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCEEECCCCEECCCHHHHHHHHH
LAASTKRPGADASLGGFGAIFDLAAAGYSDPLLITATDGVGTKLKIALDSGIHDSVGIDL
HHHCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCEEEEEECCCCCCHHHHHH
VAMCVNDLVVQGGEPLLFLDYFATSRLQVPVASAVVKGIAEGCLQAGCALVGGETAEMPG
HHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCEEECCCHHHCCC
MYGNNDYDLAGFAVGAVERSQLLTDDRIGLGDVLLGLASSGVHSNGFSLVRRIVERSGLA
CCCCCCCCHHHEEEHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCC
WDAPAPFAPETTLARALLTPTRIYVKSCLALHRAGLVHGFAHITGGGFWENIPRVLPQGA
CCCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCC
CAHLDGLSWPFPPVFRWLMDQGGVSAHEMARTFNCGIGMVVAVPADKAEAAIALLGEHGE
HHHCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCCEEEEEECCCCHHHEEEEECCCCH
TVHRLGTIAARGEGEAVIIDHLDEAFAR
HHHHHHHHEECCCCCEEEEECHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA