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The map label for this gene is clpA [C]

Identifier: 83593444

GI number: 83593444

Start: 2446474

End: 2448813

Strand: Reverse

Name: clpA [C]

Synonym: Rru_A2109

Alternate gene names: 83593444

Gene position: 2448813-2446474 (Counterclockwise)

Preceding gene: 83593445

Following gene: 83593443

Centisome position: 56.26

GC content: 61.54

Gene sequence:

>2340_bases
ATGCTGTCGCGTAATCTGGAACAGACTCTCCACCGGGCCCTCGCTCTCGCGTCCCAACGTCGACATGAGTATGCGACTCT
CGAACATCTTCTTCTTGCCCTGGTCGATGATCAGGACGCGGTTTCCGTGCTCAAGGCCTGCTCGGTGGATGTCGAGAAAC
TGCGCAAACAGCTTGCCGAGTTCGTCGAACACGAATTGACCGGTCTGGTCGTCGCCGCCCCGGAAGGGGATCCCAAGCCG
ACCGCCGGCTTCCAGCGGGTGGTCCAGCGCGCCGCCATTCACGTTCAGTCGTCGGGGCGCGAGCAGGTGACCGGCGCCAA
TATTCTTGTCGCCCTGTTTAGCGAACGGGAAAGCCACGCGGTCTATTTCCTGCAAATGCAGGATATGACCCGGCTCGATG
CCGTCAATTACATCAGCCATGGCATCGCCAAGGCCCCCGGCCACGGCCAAGCCCGCGCTCCGCGCGGCGCCGACGAGGAA
ACCAAATCCGAGGAGACGGCGACGGTGAAAAAAGGCCGGGAGGCACTCGATGCCTATTGCGTCAATCTCAACGAGAAGGC
CGCCGAGGGAAAGATCGACCCGCTGATCGGTCGCGATCAGGAAGTCGAGCGGACGATCCAGATCCTCTGCCGTCGCAACA
AGAACAACCCGCTGCTGGTTGGCGACCCCGGGGTTGGCAAGACGGCCATCGTCGAAGGGCTGGCCCGGCGCATCGTCCAC
AAGGAGGTGCCCGAGGTTCTGCACAACGCCACGATCTTTTCGCTTGATATGGGCGCCCTGCTTGCCGGAACCCGCTATCG
CGGCGATTTCGAAGAGCGGCTGAAGGCCGTGGTCGGCGAATTGGAGGCCTATGAGGGCGCGGTGCTGTTCATCGACGAGA
TCCACACGGTGATCGGCGCCGGCGCCACCTCGGGCGGCTCGATGGACGCCTCCAATCTGCTCAAGCCGGCCCTGGCCCAG
GGTCTGCTGCGCTGTGTCGGCTCGACCACCTATAAGGAATTCCGCAACCACTTCGAAAAGGACCGGGCGCTGGTCCGCCG
TTTTCAGAAGATCGACGTCAACGAGCCCAGCGTCGAGGATACGGTCAAGATCCTGCGCGGCATCAAGTCCTATTACGAAG
ATCACCACAAGGTGCGTTACACCAACGACGCCGTGCGCGCCGCCGTCGAGCTATCGAACAAATACATCAATGATCGCAAG
CTGCCCGACAAGGCGATCGACGTCATCGACGAGGTCGGCGCCGCCCGCATGCTGTTGCCCGAAAGCCGTCGGCGCAAGAC
GGTGACCGTGCGCGATATCGAAGAGATCGTCGCCAAGATCGCCCGCATCCCGCCGAAATCGGTGTCGCGCGACGATCAGG
CGGTTCTCAAATCCCTGGAGCGCGACCTCAAGACCATGGTCTTCGGTCAGGATCAGGCCATCGAGGCTTTGGCCAGCGCC
ATCAAGCTGGCCCGGGCCGGCTTGCGCGAACCGACCAAACCGATCGGCAATTATCTGTTTAGCGGCCCGACCGGCGTTGG
CAAGACCGAGGTGGCCCGCCAGCTCGCCCGCATCCTGGGCATCGAACTGGTCCGCTTCGACATGTCCGAATACATGGAGC
GCCATTCCGTTTCGCGGCTGATCGGCGCCCCGCCGGGCTATGTCGGCTTCGACCAGGGCGGCCTGCTGACCGACGCGGTG
GACCAGCAGCCCCATTGCGTGCTGTTGCTTGATGAAATCGAAAAGGCCCATCCCGACCTTTTCAATATTCTTCTTCAGGT
CATGGATCACGGCAAGCTGACCGATCACAATGGCAAGCACGTCGACTTCCGCAATGTCATCTTGATCATGACGACCAACG
CGGGGGCCCAGATGCTGGCCAAGAACGCCATGGGCTTTGGCCGCGAAACCCGCTCGGGCGATGACACCGAGGAAATCGAG
CGCTCGTTCTCGCCCGAATTCCGCAACCGGCTTGATGCCATCATTCCCTTTGCCAATCTGGCGGCGGAAACCGTGGGCAT
GGTGGTCGACAAATTCGTCATGGAACTGGAAGCCCAACTCGCCGACCGCAATGTCACGATCGAGCTGACCGACAAGGCGC
GCAGCTGGTTGGCCGAAAAGGGCTACGACCGCCGCATGGGGGCGCGGCCCTTGGCGCGGATCATTCAGGAAACGATCAAG
AAACCTTTGGCCGAAGAGCTGTTGTTTGGAAAACTGACCAAGGGCGGCAGGGTCAAGGTTGGCGTCAAGGATGGAAAGCC
CGATTTCGCCTTCTTCGATCTGCCGCCCAAGGACCTTCTCGAGAAAGAGGGGGAACGGGGCGATAACGACGAGTCACCCA
CCGAAGAGGTCGCTGACTGA

Upstream 100 bases:

>100_bases
GTCGCCGGAGAGATCCGGCATCCGGGTGGCGGTCCGGCACCAACCTCAGATCGCGGCCCGTCCTGGTCGTGGTCGAAACC
GGTTTAAGAAAGGAGCGGGC

Downstream 100 bases:

>100_bases
TCGACCTTATTGTCTCAGGGCTGCTAAGGTCTTTTCTTGAACTTGCGAGAGGCCCGTTTCTCCTAAGGAGAACGGGCCTT
TTGTGCGCGAAGGGATCGGA

Product: ATP-dependent Clp protease ATP-binding subunit ClpA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 779; Mature: 779

Protein sequence:

>779_residues
MLSRNLEQTLHRALALASQRRHEYATLEHLLLALVDDQDAVSVLKACSVDVEKLRKQLAEFVEHELTGLVVAAPEGDPKP
TAGFQRVVQRAAIHVQSSGREQVTGANILVALFSERESHAVYFLQMQDMTRLDAVNYISHGIAKAPGHGQARAPRGADEE
TKSEETATVKKGREALDAYCVNLNEKAAEGKIDPLIGRDQEVERTIQILCRRNKNNPLLVGDPGVGKTAIVEGLARRIVH
KEVPEVLHNATIFSLDMGALLAGTRYRGDFEERLKAVVGELEAYEGAVLFIDEIHTVIGAGATSGGSMDASNLLKPALAQ
GLLRCVGSTTYKEFRNHFEKDRALVRRFQKIDVNEPSVEDTVKILRGIKSYYEDHHKVRYTNDAVRAAVELSNKYINDRK
LPDKAIDVIDEVGAARMLLPESRRRKTVTVRDIEEIVAKIARIPPKSVSRDDQAVLKSLERDLKTMVFGQDQAIEALASA
IKLARAGLREPTKPIGNYLFSGPTGVGKTEVARQLARILGIELVRFDMSEYMERHSVSRLIGAPPGYVGFDQGGLLTDAV
DQQPHCVLLLDEIEKAHPDLFNILLQVMDHGKLTDHNGKHVDFRNVILIMTTNAGAQMLAKNAMGFGRETRSGDDTEEIE
RSFSPEFRNRLDAIIPFANLAAETVGMVVDKFVMELEAQLADRNVTIELTDKARSWLAEKGYDRRMGARPLARIIQETIK
KPLAEELLFGKLTKGGRVKVGVKDGKPDFAFFDLPPKDLLEKEGERGDNDESPTEEVAD

Sequences:

>Translated_779_residues
MLSRNLEQTLHRALALASQRRHEYATLEHLLLALVDDQDAVSVLKACSVDVEKLRKQLAEFVEHELTGLVVAAPEGDPKP
TAGFQRVVQRAAIHVQSSGREQVTGANILVALFSERESHAVYFLQMQDMTRLDAVNYISHGIAKAPGHGQARAPRGADEE
TKSEETATVKKGREALDAYCVNLNEKAAEGKIDPLIGRDQEVERTIQILCRRNKNNPLLVGDPGVGKTAIVEGLARRIVH
KEVPEVLHNATIFSLDMGALLAGTRYRGDFEERLKAVVGELEAYEGAVLFIDEIHTVIGAGATSGGSMDASNLLKPALAQ
GLLRCVGSTTYKEFRNHFEKDRALVRRFQKIDVNEPSVEDTVKILRGIKSYYEDHHKVRYTNDAVRAAVELSNKYINDRK
LPDKAIDVIDEVGAARMLLPESRRRKTVTVRDIEEIVAKIARIPPKSVSRDDQAVLKSLERDLKTMVFGQDQAIEALASA
IKLARAGLREPTKPIGNYLFSGPTGVGKTEVARQLARILGIELVRFDMSEYMERHSVSRLIGAPPGYVGFDQGGLLTDAV
DQQPHCVLLLDEIEKAHPDLFNILLQVMDHGKLTDHNGKHVDFRNVILIMTTNAGAQMLAKNAMGFGRETRSGDDTEEIE
RSFSPEFRNRLDAIIPFANLAAETVGMVVDKFVMELEAQLADRNVTIELTDKARSWLAEKGYDRRMGARPLARIIQETIK
KPLAEELLFGKLTKGGRVKVGVKDGKPDFAFFDLPPKDLLEKEGERGDNDESPTEEVAD
>Mature_779_residues
MLSRNLEQTLHRALALASQRRHEYATLEHLLLALVDDQDAVSVLKACSVDVEKLRKQLAEFVEHELTGLVVAAPEGDPKP
TAGFQRVVQRAAIHVQSSGREQVTGANILVALFSERESHAVYFLQMQDMTRLDAVNYISHGIAKAPGHGQARAPRGADEE
TKSEETATVKKGREALDAYCVNLNEKAAEGKIDPLIGRDQEVERTIQILCRRNKNNPLLVGDPGVGKTAIVEGLARRIVH
KEVPEVLHNATIFSLDMGALLAGTRYRGDFEERLKAVVGELEAYEGAVLFIDEIHTVIGAGATSGGSMDASNLLKPALAQ
GLLRCVGSTTYKEFRNHFEKDRALVRRFQKIDVNEPSVEDTVKILRGIKSYYEDHHKVRYTNDAVRAAVELSNKYINDRK
LPDKAIDVIDEVGAARMLLPESRRRKTVTVRDIEEIVAKIARIPPKSVSRDDQAVLKSLERDLKTMVFGQDQAIEALASA
IKLARAGLREPTKPIGNYLFSGPTGVGKTEVARQLARILGIELVRFDMSEYMERHSVSRLIGAPPGYVGFDQGGLLTDAV
DQQPHCVLLLDEIEKAHPDLFNILLQVMDHGKLTDHNGKHVDFRNVILIMTTNAGAQMLAKNAMGFGRETRSGDDTEEIE
RSFSPEFRNRLDAIIPFANLAAETVGMVVDKFVMELEAQLADRNVTIELTDKARSWLAEKGYDRRMGARPLARIIQETIK
KPLAEELLFGKLTKGGRVKVGVKDGKPDFAFFDLPPKDLLEKEGERGDNDESPTEEVAD

Specific function: ATP-Dependent Specificity Component Of The Clpp Protease. It Directs The Protease To Specific Substrates. The Primary Function Of The Clpa-Clpp Complex Appears To Be The Degradation Of Unfolded Or Abnormal Proteins. [C]

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=318, Percent_Identity=31.7610062893082, Blast_Score=160, Evalue=5e-39,
Organism=Escherichia coli, GI1787109, Length=751, Percent_Identity=60.5858854860186, Blast_Score=924, Evalue=0.0,
Organism=Escherichia coli, GI1788943, Length=421, Percent_Identity=43.7054631828979, Blast_Score=310, Evalue=2e-85,
Organism=Saccharomyces cerevisiae, GI6320464, Length=334, Percent_Identity=45.8083832335329, Blast_Score=294, Evalue=4e-80,
Organism=Saccharomyces cerevisiae, GI6323002, Length=455, Percent_Identity=36.9230769230769, Blast_Score=257, Evalue=5e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR013461
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 86323; Mature: 86323

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSRNLEQTLHRALALASQRRHEYATLEHLLLALVDDQDAVSVLKACSVDVEKLRKQLAE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHH
FVEHELTGLVVAAPEGDPKPTAGFQRVVQRAAIHVQSSGREQVTGANILVALFSERESHA
HHHHHHCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHCCHHHHHHHHCCCCCCE
VYFLQMQDMTRLDAVNYISHGIAKAPGHGQARAPRGADEETKSEETATVKKGREALDAYC
EEEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHCCHHHHHHHHHHHHHHHHH
VNLNEKAAEGKIDPLIGRDQEVERTIQILCRRNKNNPLLVGDPGVGKTAIVEGLARRIVH
HCCCCHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHH
KEVPEVLHNATIFSLDMGALLAGTRYRGDFEERLKAVVGELEAYEGAVLFIDEIHTVIGA
HHHHHHHHCCEEEEECHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHC
GATSGGSMDASNLLKPALAQGLLRCVGSTTYKEFRNHFEKDRALVRRFQKIDVNEPSVED
CCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
TVKILRGIKSYYEDHHKVRYTNDAVRAAVELSNKYINDRKLPDKAIDVIDEVGAARMLLP
HHHHHHHHHHHHHHHCCEEECHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCHHHHHCC
ESRRRKTVTVRDIEEIVAKIARIPPKSVSRDDQAVLKSLERDLKTMVFGQDQAIEALASA
CHHCCCEEHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
IKLARAGLREPTKPIGNYLFSGPTGVGKTEVARQLARILGIELVRFDMSEYMERHSVSRL
HHHHHHHCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGAPPGYVGFDQGGLLTDAVDQQPHCVLLLDEIEKAHPDLFNILLQVMDHGKLTDHNGKH
HCCCCCCCCCCCCCCCCHHCCCCCCEEEEHHHHHHHCHHHHHHHHHHHHCCCCCCCCCCE
VDFRNVILIMTTNAGAQMLAKNAMGFGRETRSGDDTEEIERSFSPEFRNRLDAIIPFANL
EECCCEEEEEECCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHH
AAETVGMVVDKFVMELEAQLADRNVTIELTDKARSWLAEKGYDRRMGARPLARIIQETIK
HHHHHHHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
KPLAEELLFGKLTKGGRVKVGVKDGKPDFAFFDLPPKDLLEKEGERGDNDESPTEEVAD
HHHHHHHHHHHCCCCCEEEEEECCCCCCEEEECCCHHHHHHHCCCCCCCCCCCHHHHCC
>Mature Secondary Structure
MLSRNLEQTLHRALALASQRRHEYATLEHLLLALVDDQDAVSVLKACSVDVEKLRKQLAE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHH
FVEHELTGLVVAAPEGDPKPTAGFQRVVQRAAIHVQSSGREQVTGANILVALFSERESHA
HHHHHHCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHCCHHHHHHHHCCCCCCE
VYFLQMQDMTRLDAVNYISHGIAKAPGHGQARAPRGADEETKSEETATVKKGREALDAYC
EEEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHCCHHHHHHHHHHHHHHHHH
VNLNEKAAEGKIDPLIGRDQEVERTIQILCRRNKNNPLLVGDPGVGKTAIVEGLARRIVH
HCCCCHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHH
KEVPEVLHNATIFSLDMGALLAGTRYRGDFEERLKAVVGELEAYEGAVLFIDEIHTVIGA
HHHHHHHHCCEEEEECHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHC
GATSGGSMDASNLLKPALAQGLLRCVGSTTYKEFRNHFEKDRALVRRFQKIDVNEPSVED
CCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
TVKILRGIKSYYEDHHKVRYTNDAVRAAVELSNKYINDRKLPDKAIDVIDEVGAARMLLP
HHHHHHHHHHHHHHHCCEEECHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCHHHHHCC
ESRRRKTVTVRDIEEIVAKIARIPPKSVSRDDQAVLKSLERDLKTMVFGQDQAIEALASA
CHHCCCEEHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
IKLARAGLREPTKPIGNYLFSGPTGVGKTEVARQLARILGIELVRFDMSEYMERHSVSRL
HHHHHHHCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGAPPGYVGFDQGGLLTDAVDQQPHCVLLLDEIEKAHPDLFNILLQVMDHGKLTDHNGKH
HCCCCCCCCCCCCCCCCHHCCCCCCEEEEHHHHHHHCHHHHHHHHHHHHCCCCCCCCCCE
VDFRNVILIMTTNAGAQMLAKNAMGFGRETRSGDDTEEIERSFSPEFRNRLDAIIPFANL
EECCCEEEEEECCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHH
AAETVGMVVDKFVMELEAQLADRNVTIELTDKARSWLAEKGYDRRMGARPLARIIQETIK
HHHHHHHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
KPLAEELLFGKLTKGGRVKVGVKDGKPDFAFFDLPPKDLLEKEGERGDNDESPTEEVAD
HHHHHHHHHHHCCCCCEEEEEECCCCCCEEEECCCHHHHHHHCCCCCCCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6209404 [H]