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The map label for this gene is rcsC [H]

Identifier: 83593393

GI number: 83593393

Start: 2379699

End: 2381198

Strand: Direct

Name: rcsC [H]

Synonym: Rru_A2058

Alternate gene names: 83593393

Gene position: 2379699-2381198 (Clockwise)

Preceding gene: 83593392

Following gene: 83593394

Centisome position: 54.67

GC content: 65.4

Gene sequence:

>1500_bases
GTGAACGGCGCGCAAAAAGATGAAAAAGCCGATCTTCCCAAAAGCCGGCCCGTCGCCGGCTGGATGACCCGGCGCTATCT
TCTCGCCCTGTCGCTTATCGCCCTGCTGGCCCTATCTGGCTATCTGACCTTCGACAAGCTGGCGGCCCAGCATGACCGCA
CCCTGGGCTTGGTCAATATCAGCGGTCGCCAGCGCATGCTGTCCCAACGCACCGCCCTTTATGCCGAACGGCTTGTGCGC
GACGACTGCCCCGAGCCGGTCGATGTCTGCCATCGCATCTTGGGCGAAGCGACCGATCTTTTGGAGGACTCCCATAGGGC
GCTGACCCGGGGCAGCGCCGAAATGGGCCTGCCGGTCGCGAAAAGTCCCGAGATCCGGGCGCTGTACTTCGATGGCGCCC
CCAGTCTCGATCAACGGATGACCGACTATCTGGCGGCCCTGCGCCAGATCCTGACGGCGACCCGGGCCGGTGACGACACC
CTCGCCCTGGACGCCTATCGGCGCGTCGTCAGGGAATCCTCTGGTCCGTTGCTTGACGATCTCGACCGGCTGGTGGCGCG
CCACCAAAGCGAGGGCGAGGCGGCCTTGGAGCACCTCGATCGGGCGGAAAGCGCCATCCTCGCCCTAACCTTGCTCACGC
TTTTGCTAGAGATCGTGCTGATCTTCCGCCCGATGGTCACCCAGATCCACCGGCAATTCGCCGCCCTTGACCATATGACC
GCCGCCCTGCGCCGCTCCCGCGACGGTCTTGAAGACATCGTCGAGCAACGCACCGCCGATATCGACCGCGCCCGGGCCGA
GGCGGTCAAGGCCAGTCACTCGAAATCACGCTTTCTCGCCGCCGCCGGCCACGATCTGATGCAACCCTTGGAAGGGGCGA
TGATGTACGCTGGCGCCCTGGGGCGTCAGGCCGAAACCGACAGGGCCCGTCAGGCGGTGGCCGAGCTGAAGAACGCCCAT
CAGGCGATGAGCCGGCTGATCCGCTCGATTCTGGAAATCTCCAAACTCGATTGCGGGGCGGTTGAGCCGCTGCCCCGCGT
TTTCGCCCTTGGTCCTTTGCTCGACCAACTCGTTGGCGAGGTTCAGCCCCAGGCCCAAGCCAAGGGACTGCGGGTGCGCC
GGGTATGGACCAGCGCGCGGCTGGAGACCGATCCTTTGCTGCTCGAGCGCATCTTGCGCAATCTGCTGGCCAATGCCCTG
CGCCATACCCACAAGGGCGGCATCGTCTTGGGCGTGCGTCGCCGCGCCGATGGACTGGACATCGCCGTCGCCGACAGCGG
CATTGGCATCGCCGCCCAGAACCTGGGCCGGATCTTCGAGGCGTTCATCCAGATCGACGGCGGGCAGCTTGATCGCAGCG
AAGGGTTGGGGCTGGGGCTGGCCATCGTTGACCGCCTGTCCCGGCTGCTTGGCCTGGATGTTTCGGTGCGCTCGCGGCTT
GGCAAGGGCACCGTCTTTTCCCTCCACATCCCGTCTGGAGCCCTGGCCGATGACCGATGA

Upstream 100 bases:

>100_bases
GCCTTCCCGCCGGGGCGCGCCGCCGCTATCATGGCGGGCACGCCCCGAACTCGGGGGCCGGTGCGGCCTTTGTTGGACTT
GCTGATCGTGAAAGAAGGTC

Downstream 100 bases:

>100_bases
CCCGACCCTGTGGGCACAAAGGCTGGAAGAGGCCGTCGTCGGCCTTGGTGCCAATGGGGACCGCTCCCACGACCTCGCCC
ACGCCAAGCGCGTCCTGCGC

Product: histidine kinase

Products: NA

Alternate protein names: Capsular synthesis regulator component C [H]

Number of amino acids: Translated: 499; Mature: 499

Protein sequence:

>499_residues
MNGAQKDEKADLPKSRPVAGWMTRRYLLALSLIALLALSGYLTFDKLAAQHDRTLGLVNISGRQRMLSQRTALYAERLVR
DDCPEPVDVCHRILGEATDLLEDSHRALTRGSAEMGLPVAKSPEIRALYFDGAPSLDQRMTDYLAALRQILTATRAGDDT
LALDAYRRVVRESSGPLLDDLDRLVARHQSEGEAALEHLDRAESAILALTLLTLLLEIVLIFRPMVTQIHRQFAALDHMT
AALRRSRDGLEDIVEQRTADIDRARAEAVKASHSKSRFLAAAGHDLMQPLEGAMMYAGALGRQAETDRARQAVAELKNAH
QAMSRLIRSILEISKLDCGAVEPLPRVFALGPLLDQLVGEVQPQAQAKGLRVRRVWTSARLETDPLLLERILRNLLANAL
RHTHKGGIVLGVRRRADGLDIAVADSGIGIAAQNLGRIFEAFIQIDGGQLDRSEGLGLGLAIVDRLSRLLGLDVSVRSRL
GKGTVFSLHIPSGALADDR

Sequences:

>Translated_499_residues
MNGAQKDEKADLPKSRPVAGWMTRRYLLALSLIALLALSGYLTFDKLAAQHDRTLGLVNISGRQRMLSQRTALYAERLVR
DDCPEPVDVCHRILGEATDLLEDSHRALTRGSAEMGLPVAKSPEIRALYFDGAPSLDQRMTDYLAALRQILTATRAGDDT
LALDAYRRVVRESSGPLLDDLDRLVARHQSEGEAALEHLDRAESAILALTLLTLLLEIVLIFRPMVTQIHRQFAALDHMT
AALRRSRDGLEDIVEQRTADIDRARAEAVKASHSKSRFLAAAGHDLMQPLEGAMMYAGALGRQAETDRARQAVAELKNAH
QAMSRLIRSILEISKLDCGAVEPLPRVFALGPLLDQLVGEVQPQAQAKGLRVRRVWTSARLETDPLLLERILRNLLANAL
RHTHKGGIVLGVRRRADGLDIAVADSGIGIAAQNLGRIFEAFIQIDGGQLDRSEGLGLGLAIVDRLSRLLGLDVSVRSRL
GKGTVFSLHIPSGALADDR
>Mature_499_residues
MNGAQKDEKADLPKSRPVAGWMTRRYLLALSLIALLALSGYLTFDKLAAQHDRTLGLVNISGRQRMLSQRTALYAERLVR
DDCPEPVDVCHRILGEATDLLEDSHRALTRGSAEMGLPVAKSPEIRALYFDGAPSLDQRMTDYLAALRQILTATRAGDDT
LALDAYRRVVRESSGPLLDDLDRLVARHQSEGEAALEHLDRAESAILALTLLTLLLEIVLIFRPMVTQIHRQFAALDHMT
AALRRSRDGLEDIVEQRTADIDRARAEAVKASHSKSRFLAAAGHDLMQPLEGAMMYAGALGRQAETDRARQAVAELKNAH
QAMSRLIRSILEISKLDCGAVEPLPRVFALGPLLDQLVGEVQPQAQAKGLRVRRVWTSARLETDPLLLERILRNLLANAL
RHTHKGGIVLGVRRRADGLDIAVADSGIGIAAQNLGRIFEAFIQIDGGQLDRSEGLGLGLAIVDRLSRLLGLDVSVRSRL
GKGTVFSLHIPSGALADDR

Specific function: Member of the two-component regulatory system rcsC/rcsB involved in the regulation of the expression of genes involved in colanic acid capsule synthesis. Together with rcsF, rcsC probably functions as a membrane-associated protein kinase that phosphorylat

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI145693157, Length=227, Percent_Identity=33.0396475770925, Blast_Score=122, Evalue=6e-29,
Organism=Escherichia coli, GI1789149, Length=265, Percent_Identity=30.188679245283, Blast_Score=113, Evalue=3e-26,
Organism=Escherichia coli, GI87081816, Length=262, Percent_Identity=31.2977099236641, Blast_Score=108, Evalue=6e-25,
Organism=Escherichia coli, GI48994928, Length=239, Percent_Identity=30.5439330543933, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1788713, Length=254, Percent_Identity=25.5905511811024, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1786600, Length=227, Percent_Identity=26.8722466960352, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1786783, Length=221, Percent_Identity=26.2443438914027, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1790436, Length=216, Percent_Identity=26.8518518518519, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1790551, Length=229, Percent_Identity=27.0742358078603, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1787894, Length=137, Percent_Identity=32.1167883211679, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR000014
- InterPro:   IPR004358
- InterPro:   IPR019017
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF09456 RcsC; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 54662; Mature: 54662

Theoretical pI: Translated: 8.48; Mature: 8.48

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGAQKDEKADLPKSRPVAGWMTRRYLLALSLIALLALSGYLTFDKLAAQHDRTLGLVNI
CCCCCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEEEC
SGRQRMLSQRTALYAERLVRDDCPEPVDVCHRILGEATDLLEDSHRALTRGSAEMGLPVA
CHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCC
KSPEIRALYFDGAPSLDQRMTDYLAALRQILTATRAGDDTLALDAYRRVVRESSGPLLDD
CCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHH
LDRLVARHQSEGEAALEHLDRAESAILALTLLTLLLEIVLIFRPMVTQIHRQFAALDHMT
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AALRRSRDGLEDIVEQRTADIDRARAEAVKASHSKSRFLAAAGHDLMQPLEGAMMYAGAL
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHH
GRQAETDRARQAVAELKNAHQAMSRLIRSILEISKLDCGAVEPLPRVFALGPLLDQLVGE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
VQPQAQAKGLRVRRVWTSARLETDPLLLERILRNLLANALRHTHKGGIVLGVRRRADGLD
CCCHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCE
IAVADSGIGIAAQNLGRIFEAFIQIDGGQLDRSEGLGLGLAIVDRLSRLLGLDVSVRSRL
EEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHC
GKGTVFSLHIPSGALADDR
CCCCEEEEECCCCCCCCCC
>Mature Secondary Structure
MNGAQKDEKADLPKSRPVAGWMTRRYLLALSLIALLALSGYLTFDKLAAQHDRTLGLVNI
CCCCCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEEEC
SGRQRMLSQRTALYAERLVRDDCPEPVDVCHRILGEATDLLEDSHRALTRGSAEMGLPVA
CHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCC
KSPEIRALYFDGAPSLDQRMTDYLAALRQILTATRAGDDTLALDAYRRVVRESSGPLLDD
CCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHH
LDRLVARHQSEGEAALEHLDRAESAILALTLLTLLLEIVLIFRPMVTQIHRQFAALDHMT
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AALRRSRDGLEDIVEQRTADIDRARAEAVKASHSKSRFLAAAGHDLMQPLEGAMMYAGAL
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHH
GRQAETDRARQAVAELKNAHQAMSRLIRSILEISKLDCGAVEPLPRVFALGPLLDQLVGE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
VQPQAQAKGLRVRRVWTSARLETDPLLLERILRNLLANALRHTHKGGIVLGVRRRADGLD
CCCHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCE
IAVADSGIGIAAQNLGRIFEAFIQIDGGQLDRSEGLGLGLAIVDRLSRLLGLDVSVRSRL
EEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHC
GKGTVFSLHIPSGALADDR
CCCCEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504; 8626298 [H]