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The map label for this gene is tyrS

Identifier: 83593367

GI number: 83593367

Start: 2344729

End: 2345985

Strand: Direct

Name: tyrS

Synonym: Rru_A2032

Alternate gene names: 83593367

Gene position: 2344729-2345985 (Clockwise)

Preceding gene: 83593365

Following gene: 83593368

Centisome position: 53.87

GC content: 66.67

Gene sequence:

>1257_bases
ATGACCGCTCCGAAATCGGAATTCCTCGCGGTCGTTCGCGATCGCGGCTTCATCCACCAATGCACCGACCTCGACGGGTT
GGACGCGCTGTTGGCCAAGGGCCCGGTTTCGGCCTATATCGGCTTTGACTGCACCGCCGACAGCCTGCATGTCGGCAGCC
TGATCCAGATCATGCTGCTCCACTGGCTTCAGCGCACCGGCCATCGTCCGGTGGTGTTGATGGGCGGCGGCACGACGCGC
ATCGGCGATCCCTCGTTCCGCGACGAGGCCCGGCCTTTGCTGACCGACGAGAAGATCGGCCAAAACATGGCCGGCATCCG
TCAGGTGTTTTCGCGCTTCCTGAGCTTTGGCGAGGGCGCCACCGACGCGGTGATGGTCAATAACGCCGATTGGCTCGACG
GTCTGGCCTATATCCCCTTCCTGCGCGACTTCGGCCGGCACTTCTCGGTCAACCGCATGCTGACCTTCGATTCGGTACGC
CTGCGCCTCGACCGCGAGCAGCCGCTGTCGTTCCTTGAATTCAACTACATGATCTTGCAGGCCTATGACTTCCTTGAACT
GGGGCGCCGCACCGGCGTGCGCCTGCAGATGGGCGGCTCGGACCAGTGGGGCAACATCGTCAATGGCGTCGAACTGGGGC
GCCGCGTCGATGGCTTGGAACTGTTCGGGCTGACCAGCCCGCTGATCACCACCGCCTCGGGCGCCAAGATGGGCAAGACG
GCCCAGGGCGCGGTGTGGCTGAACGAGGCGCGGCTGCCCGCCTATGATTACTGGCAGTTCTGGCGCAATACGGAAGACGC
CGACGTCGGGCGCTTCCTGCGCCTGTTCACCGATCTGCCGCTCGACGAGGTCGCCCGCCTGGAGGCCCTGGGCGGGGCCG
AGATCAACGAGGCCAAGAAGATCCTGGCCGAACGGGCGACGACCATGGCCCATGGGCCGGAAGCCGCCCTGACGGCGGCG
GAAACCGCCCGCAAGGTCTTCGAGCAGGGCGGCACCGGCGACGCCTTGCCGACCCATGACGTGGCGGCCGAAGCCTTGGC
CGCCGGGCTGCCCTTGGCCGAGATGATGCGGGCCACCGGCCTTGCCGCCAGCGGCAAGGAGGTCAAGCGTCTGGTGTCCG
AGGGCGGGGCGCGGATCAATGACGTCGCAGTGAGCGACGCCGCCCGCCTGCTGGGGCCCGCCGATGTGCAAGACGGCGCC
ATCAAGCTGAGCGCGGGGAAGAAACGCCACGCCCTGATCCGCGTTCTTCCCGGCTAA

Upstream 100 bases:

>100_bases
TGGTGATTTTCGCCCCTTGCCCAAGATTGTTCCCTGGGCGGCAGTGTGCTAAACGAGCCTCCCACCACGCAAGTCATCGT
TTTTCACAAGGACGGGGATC

Downstream 100 bases:

>100_bases
CCTCGGGAAAGCCTTCTCGGCTTTGCGGGAAGTGATGTAGACTTTCGGTCGCGTTTCGGGTTTTCCCGCTATGGACCGGA
GGATTGCGCTTGCCCCGCCG

Product: tyrosyl-tRNA synthetase

Products: NA

Alternate protein names: Tyrosine--tRNA ligase; TyrRS

Number of amino acids: Translated: 418; Mature: 417

Protein sequence:

>418_residues
MTAPKSEFLAVVRDRGFIHQCTDLDGLDALLAKGPVSAYIGFDCTADSLHVGSLIQIMLLHWLQRTGHRPVVLMGGGTTR
IGDPSFRDEARPLLTDEKIGQNMAGIRQVFSRFLSFGEGATDAVMVNNADWLDGLAYIPFLRDFGRHFSVNRMLTFDSVR
LRLDREQPLSFLEFNYMILQAYDFLELGRRTGVRLQMGGSDQWGNIVNGVELGRRVDGLELFGLTSPLITTASGAKMGKT
AQGAVWLNEARLPAYDYWQFWRNTEDADVGRFLRLFTDLPLDEVARLEALGGAEINEAKKILAERATTMAHGPEAALTAA
ETARKVFEQGGTGDALPTHDVAAEALAAGLPLAEMMRATGLAASGKEVKRLVSEGGARINDVAVSDAARLLGPADVQDGA
IKLSAGKKRHALIRVLPG

Sequences:

>Translated_418_residues
MTAPKSEFLAVVRDRGFIHQCTDLDGLDALLAKGPVSAYIGFDCTADSLHVGSLIQIMLLHWLQRTGHRPVVLMGGGTTR
IGDPSFRDEARPLLTDEKIGQNMAGIRQVFSRFLSFGEGATDAVMVNNADWLDGLAYIPFLRDFGRHFSVNRMLTFDSVR
LRLDREQPLSFLEFNYMILQAYDFLELGRRTGVRLQMGGSDQWGNIVNGVELGRRVDGLELFGLTSPLITTASGAKMGKT
AQGAVWLNEARLPAYDYWQFWRNTEDADVGRFLRLFTDLPLDEVARLEALGGAEINEAKKILAERATTMAHGPEAALTAA
ETARKVFEQGGTGDALPTHDVAAEALAAGLPLAEMMRATGLAASGKEVKRLVSEGGARINDVAVSDAARLLGPADVQDGA
IKLSAGKKRHALIRVLPG
>Mature_417_residues
TAPKSEFLAVVRDRGFIHQCTDLDGLDALLAKGPVSAYIGFDCTADSLHVGSLIQIMLLHWLQRTGHRPVVLMGGGTTRI
GDPSFRDEARPLLTDEKIGQNMAGIRQVFSRFLSFGEGATDAVMVNNADWLDGLAYIPFLRDFGRHFSVNRMLTFDSVRL
RLDREQPLSFLEFNYMILQAYDFLELGRRTGVRLQMGGSDQWGNIVNGVELGRRVDGLELFGLTSPLITTASGAKMGKTA
QGAVWLNEARLPAYDYWQFWRNTEDADVGRFLRLFTDLPLDEVARLEALGGAEINEAKKILAERATTMAHGPEAALTAAE
TARKVFEQGGTGDALPTHDVAAEALAAGLPLAEMMRATGLAASGKEVKRLVSEGGARINDVAVSDAARLLGPADVQDGAI
KLSAGKKRHALIRVLPG

Specific function: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction:tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)

COG id: COG0162

COG function: function code J; Tyrosyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S4 RNA-binding domain

Homologues:

Organism=Homo sapiens, GI94681057, Length=412, Percent_Identity=34.9514563106796, Blast_Score=214, Evalue=1e-55,
Organism=Escherichia coli, GI1787925, Length=422, Percent_Identity=40.521327014218, Blast_Score=306, Evalue=2e-84,
Organism=Caenorhabditis elegans, GI25145802, Length=420, Percent_Identity=28.3333333333333, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI25145805, Length=318, Percent_Identity=27.0440251572327, Blast_Score=101, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6325160, Length=432, Percent_Identity=31.4814814814815, Blast_Score=207, Evalue=2e-54,
Organism=Drosophila melanogaster, GI20130383, Length=431, Percent_Identity=36.1948955916473, Blast_Score=241, Evalue=6e-64,

Paralogues:

None

Copy number: 892 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYY_RHORT (Q2RSR3)

Other databases:

- EMBL:   CP000230
- RefSeq:   YP_427119.1
- ProteinModelPortal:   Q2RSR3
- SMR:   Q2RSR3
- STRING:   Q2RSR3
- GeneID:   3835458
- GenomeReviews:   CP000230_GR
- KEGG:   rru:Rru_A2032
- NMPDR:   fig|1085.1.peg.2609
- eggNOG:   COG0162
- HOGENOM:   HBG288125
- OMA:   TFYIGFD
- PhylomeDB:   Q2RSR3
- BioCyc:   RRUB269796:RRU_A2032-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_02006
- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002942
- InterPro:   IPR002307
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR11766
- PRINTS:   PR01040
- TIGRFAMs:   TIGR00234

Pfam domain/function: PF00579 tRNA-synt_1b

EC number: =6.1.1.1

Molecular weight: Translated: 45437; Mature: 45305

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS00178 AA_TRNA_LIGASE_I; PS50889 S4

Important sites: BINDING 39-39 BINDING 176-176 BINDING 180-180 BINDING 239-239

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAPKSEFLAVVRDRGFIHQCTDLDGLDALLAKGPVSAYIGFDCTADSLHVGSLIQIMLL
CCCCHHHHHHHHHCCCCEEECCCCCHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHH
HWLQRTGHRPVVLMGGGTTRIGDPSFRDEARPLLTDEKIGQNMAGIRQVFSRFLSFGEGA
HHHHHCCCCCEEEECCCCCCCCCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHCCCCC
TDAVMVNNADWLDGLAYIPFLRDFGRHFSVNRMLTFDSVRLRLDREQPLSFLEFNYMILQ
CCEEEECCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHEEEECCCCCCHHHHHHHHHHH
AYDFLELGRRTGVRLQMGGSDQWGNIVNGVELGRRVDGLELFGLTSPLITTASGAKMGKT
HHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHCCCCCCEEEECCCCHHHCCCCCCCCCCC
AQGAVWLNEARLPAYDYWQFWRNTEDADVGRFLRLFTDLPLDEVARLEALGGAEINEAKK
CCCEEEEECCCCCHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHH
ILAERATTMAHGPEAALTAAETARKVFEQGGTGDALPTHDVAAEALAAGLPLAEMMRATG
HHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHC
LAASGKEVKRLVSEGGARINDVAVSDAARLLGPADVQDGAIKLSAGKKRHALIRVLPG
CCCCCHHHHHHHHHCCCEEEHHHHHHHHHHCCCCCCCCCEEEECCCCCCCEEEEECCC
>Mature Secondary Structure 
TAPKSEFLAVVRDRGFIHQCTDLDGLDALLAKGPVSAYIGFDCTADSLHVGSLIQIMLL
CCCHHHHHHHHHCCCCEEECCCCCHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHH
HWLQRTGHRPVVLMGGGTTRIGDPSFRDEARPLLTDEKIGQNMAGIRQVFSRFLSFGEGA
HHHHHCCCCCEEEECCCCCCCCCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHCCCCC
TDAVMVNNADWLDGLAYIPFLRDFGRHFSVNRMLTFDSVRLRLDREQPLSFLEFNYMILQ
CCEEEECCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHEEEECCCCCCHHHHHHHHHHH
AYDFLELGRRTGVRLQMGGSDQWGNIVNGVELGRRVDGLELFGLTSPLITTASGAKMGKT
HHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHCCCCCCEEEECCCCHHHCCCCCCCCCCC
AQGAVWLNEARLPAYDYWQFWRNTEDADVGRFLRLFTDLPLDEVARLEALGGAEINEAKK
CCCEEEEECCCCCHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHH
ILAERATTMAHGPEAALTAAETARKVFEQGGTGDALPTHDVAAEALAAGLPLAEMMRATG
HHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHC
LAASGKEVKRLVSEGGARINDVAVSDAARLLGPADVQDGAIKLSAGKKRHALIRVLPG
CCCCCHHHHHHHHHCCCEEEHHHHHHHHHHCCCCCCCCCEEEECCCCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA