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The map label for this gene is fruA [H]

Identifier: 83593305

GI number: 83593305

Start: 2277487

End: 2279214

Strand: Reverse

Name: fruA [H]

Synonym: Rru_A1970

Alternate gene names: 83593305

Gene position: 2279214-2277487 (Counterclockwise)

Preceding gene: 83593306

Following gene: 83593299

Centisome position: 52.36

GC content: 68.0

Gene sequence:

>1728_bases
ATGAGCCAGTTTATCGCGGTCGTCGGCGGGGGCGAGCGGAGCACCCAGGCGCTGCTGGTCGCCGAGGCCCTGCGCCGGGC
CGCCAGCGGGGCGGGGCACCGCATCGATATCGAGGTGCGCAGCGATCAGGGCGTGGTCAACGCCTTGAGCGACGACGCCA
TCGTGCGCGCCAGGGCGGTGATCCTGATCGGCACCGGCGATCTGGATGTCGGGCGCTTTCCCGGGTTGCCCAAGCTTGAA
ACCACCATCGAGGCGGTGCTGGCCGATGTGGGGGCGGTTCTCGGGCGGGCCGAGGGGGCCGAATTGGCCGGAAGCGTCGC
CGCCACTGACGACGGGGTGCGGCGCATCGTCGCCATCACCTCCTGCCCGACCGGCATCGCCCATACCTTCATGGCCGCCG
AGGGCATCACCCAGGCGGCCAAGGCTTTGGGCTATCAGGCCAGGGTCGAGACCCAGGGCTCGGTGGGATCGCGCGACACC
TTAAGCGACGACGAGATCGCCCAGGCCGATATCGTGCTGATCGCCGCCGATACCCAGATCGATCTGGCGCGCTTCGACGG
CAAGCGGGTGTTCCTGTCGGGCACCAAGCCGGCGATCGCCGATGGCAAGGCGCTGATCGCCCGCGCCCTGGCCGAGGCGA
CGCTGCAAGGCGGCAAGAAATCCCTGGTCGATACGGTGGAGGCGGGCAAGGCCCAGCGCTCGGCCCAGCGCACGGGGGCC
TATAAGCACCTGATGACCGGCGTGTCCTTCATGCTGCCCTTCGTCGTCGCCGGCGGGTTGCTGATCGCCCTGGCCTTCGC
CTTGGGCGGCATCAACGCCTTTGACGAGGCCAATAAGGGAACGCTGGCCTATGACCTGTTCCAGATCGGCGCCAAAAGCG
CCTTCGTGCTGATGGTTCCGGCCCTGGCCGGCTATATCGCCTTTTCCATCGCCGACCGGCCGGGCATCGCCCCGGGCATG
ATCGGCGGTCTGGTCGCGGCCAATCTGGGGGCGGGTTTCCTGGGCGGCATCATCGCCGGCTTCATCGCCGGCTATGTCAC
GGCTTGGTTCAATCGCACCATCCGGCTGCACCGCAATCTTGAAGGGTTGAAGCCGGTCCTGATCCTGCCCGTGCTGGGCA
CCGTCGTGACCGGCTTGCTGATGATCTATGTCGTCGGCACGCCGGTGGCCGGGCTGTTGTCGTGGTTGACCGAGGCCTTG
CGCGGCATGCAGGGCAGCAGCGCCATCGTGCTCGGGCTGTTGATCGGGGCGATGATGGCCTTCGATATGGGCGGCCCGGT
CAATAAGGCGGCCTATGCCTTTTCCACCGGCCTGCTGGCCAGCGAGGTCTATACGCCGATGGCGGCGGCCATGGTGGCGG
GGATGACCCCGGCCCTGGGCGTGGCCCTGGCCAGCCGGCTGTTTCGCAGCCGCTTCACCGCCAGCGAACGCGAGGCCGGC
GGGGCGGCGGCGGTGCTGGGGCTGGCCTTCATCACCGAAGGCGCCATTCCCTTCGCTGCCTCCGATCCCTTCCGCGTCAT
TCCGGCGCTGATGGCCGGATCGGCGGCGGCCGGGGCGATCTCGATGACGGTGGGAGCGGAGCTGAAAGTCCCCCACGGCG
GCATTTTCGTGCTGCCGATCCCCAATGCCGTCACCCATTTGCTGGGCTATATCGTCGCCCTGGTCGTTGGCACCCTGATC
ACCGCCCTGGTGCTGCGGATCACCAAACGCCCGGTGGCTGTTCTTTAG

Upstream 100 bases:

>100_bases
CGCGACGTCGTTCTCGCCCTGGCCGGGCAAACCCATATCGCGCGTCTTCAAGCCTAACGCGTTGCCAACGCGGGCGCAGA
CCCGCCGGGGAGGAGATATC

Downstream 100 bases:

>100_bases
CAGGGGGCTTTGGCGCCCAGTCCAGGATGGCACTGCGCCAGGAAGAAGCGGAGCATTTCAGCGCTGGCGTCGGGCCCCCG
GGGGTCGGTGAACGATCCCG

Product: PTS fructose IIC component

Products: NA

Alternate protein names: EIIBC-Fru; EII-Fru; Fructose-specific phosphotransferase enzyme IIB component; PTS system fructose-specific EIIB component; Fructose permease IIC component; PTS system fructose-specific EIIC component [H]

Number of amino acids: Translated: 575; Mature: 574

Protein sequence:

>575_residues
MSQFIAVVGGGERSTQALLVAEALRRAASGAGHRIDIEVRSDQGVVNALSDDAIVRARAVILIGTGDLDVGRFPGLPKLE
TTIEAVLADVGAVLGRAEGAELAGSVAATDDGVRRIVAITSCPTGIAHTFMAAEGITQAAKALGYQARVETQGSVGSRDT
LSDDEIAQADIVLIAADTQIDLARFDGKRVFLSGTKPAIADGKALIARALAEATLQGGKKSLVDTVEAGKAQRSAQRTGA
YKHLMTGVSFMLPFVVAGGLLIALAFALGGINAFDEANKGTLAYDLFQIGAKSAFVLMVPALAGYIAFSIADRPGIAPGM
IGGLVAANLGAGFLGGIIAGFIAGYVTAWFNRTIRLHRNLEGLKPVLILPVLGTVVTGLLMIYVVGTPVAGLLSWLTEAL
RGMQGSSAIVLGLLIGAMMAFDMGGPVNKAAYAFSTGLLASEVYTPMAAAMVAGMTPALGVALASRLFRSRFTASEREAG
GAAAVLGLAFITEGAIPFAASDPFRVIPALMAGSAAAGAISMTVGAELKVPHGGIFVLPIPNAVTHLLGYIVALVVGTLI
TALVLRITKRPVAVL

Sequences:

>Translated_575_residues
MSQFIAVVGGGERSTQALLVAEALRRAASGAGHRIDIEVRSDQGVVNALSDDAIVRARAVILIGTGDLDVGRFPGLPKLE
TTIEAVLADVGAVLGRAEGAELAGSVAATDDGVRRIVAITSCPTGIAHTFMAAEGITQAAKALGYQARVETQGSVGSRDT
LSDDEIAQADIVLIAADTQIDLARFDGKRVFLSGTKPAIADGKALIARALAEATLQGGKKSLVDTVEAGKAQRSAQRTGA
YKHLMTGVSFMLPFVVAGGLLIALAFALGGINAFDEANKGTLAYDLFQIGAKSAFVLMVPALAGYIAFSIADRPGIAPGM
IGGLVAANLGAGFLGGIIAGFIAGYVTAWFNRTIRLHRNLEGLKPVLILPVLGTVVTGLLMIYVVGTPVAGLLSWLTEAL
RGMQGSSAIVLGLLIGAMMAFDMGGPVNKAAYAFSTGLLASEVYTPMAAAMVAGMTPALGVALASRLFRSRFTASEREAG
GAAAVLGLAFITEGAIPFAASDPFRVIPALMAGSAAAGAISMTVGAELKVPHGGIFVLPIPNAVTHLLGYIVALVVGTLI
TALVLRITKRPVAVL
>Mature_574_residues
SQFIAVVGGGERSTQALLVAEALRRAASGAGHRIDIEVRSDQGVVNALSDDAIVRARAVILIGTGDLDVGRFPGLPKLET
TIEAVLADVGAVLGRAEGAELAGSVAATDDGVRRIVAITSCPTGIAHTFMAAEGITQAAKALGYQARVETQGSVGSRDTL
SDDEIAQADIVLIAADTQIDLARFDGKRVFLSGTKPAIADGKALIARALAEATLQGGKKSLVDTVEAGKAQRSAQRTGAY
KHLMTGVSFMLPFVVAGGLLIALAFALGGINAFDEANKGTLAYDLFQIGAKSAFVLMVPALAGYIAFSIADRPGIAPGMI
GGLVAANLGAGFLGGIIAGFIAGYVTAWFNRTIRLHRNLEGLKPVLILPVLGTVVTGLLMIYVVGTPVAGLLSWLTEALR
GMQGSSAIVLGLLIGAMMAFDMGGPVNKAAYAFSTGLLASEVYTPMAAAMVAGMTPALGVALASRLFRSRFTASEREAGG
AAAVLGLAFITEGAIPFAASDPFRVIPALMAGSAAAGAISMTVGAELKVPHGGIFVLPIPNAVTHLLGYIVALVVGTLIT
ALVLRITKRPVAVL

Specific function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This

COG id: COG1299

COG function: function code G; Phosphotransferase system, fructose-specific IIC component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIC type-2 domain [H]

Homologues:

Organism=Escherichia coli, GI1788492, Length=462, Percent_Identity=53.2467532467532, Blast_Score=478, Evalue=1e-136,
Organism=Escherichia coli, GI1786951, Length=471, Percent_Identity=39.2781316348195, Blast_Score=277, Evalue=1e-75,
Organism=Escherichia coli, GI1790386, Length=310, Percent_Identity=46.4516129032258, Blast_Score=250, Evalue=2e-67,
Organism=Escherichia coli, GI87082348, Length=435, Percent_Identity=36.551724137931, Blast_Score=234, Evalue=8e-63,
Organism=Escherichia coli, GI1788729, Length=403, Percent_Identity=29.2803970223325, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1790387, Length=95, Percent_Identity=40, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1788730, Length=94, Percent_Identity=36.1702127659575, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013011
- InterPro:   IPR003501
- InterPro:   IPR003352
- InterPro:   IPR013014
- InterPro:   IPR003353
- InterPro:   IPR006327 [H]

Pfam domain/function: PF02378 PTS_EIIC; PF02302 PTS_IIB [H]

EC number: =2.7.1.69 [H]

Molecular weight: Translated: 58694; Mature: 58563

Theoretical pI: Translated: 8.87; Mature: 8.87

Prosite motif: PS51099 PTS_EIIB_TYPE_2 ; PS51104 PTS_EIIC_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQFIAVVGGGERSTQALLVAEALRRAASGAGHRIDIEVRSDQGVVNALSDDAIVRARAV
CCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHCCCCEEEEEEE
ILIGTGDLDVGRFPGLPKLETTIEAVLADVGAVLGRAEGAELAGSVAATDDGVRRIVAIT
EEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCHHEEEEEEE
SCPTGIAHTFMAAEGITQAAKALGYQARVETQGSVGSRDTLSDDEIAQADIVLIAADTQI
CCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCCCEEEEEECCEE
DLARFDGKRVFLSGTKPAIADGKALIARALAEATLQGGKKSLVDTVEAGKAQRSAQRTGA
EEEEECCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
YKHLMTGVSFMLPFVVAGGLLIALAFALGGINAFDEANKGTLAYDLFQIGAKSAFVLMVP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCHHHHHHHHCCCCHHHHHHH
ALAGYIAFSIADRPGIAPGMIGGLVAANLGAGFLGGIIAGFIAGYVTAWFNRTIRLHRNL
HHHHHHHHEECCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
EGLKPVLILPVLGTVVTGLLMIYVVGTPVAGLLSWLTEALRGMQGSSAIVLGLLIGAMMA
CCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
FDMGGPVNKAAYAFSTGLLASEVYTPMAAAMVAGMTPALGVALASRLFRSRFTASEREAG
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHCCC
GAAAVLGLAFITEGAIPFAASDPFRVIPALMAGSAAAGAISMTVGAELKVPHGGIFVLPI
CHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCCEEEEEECCEEECCCCCEEEEEC
PNAVTHLLGYIVALVVGTLITALVLRITKRPVAVL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SQFIAVVGGGERSTQALLVAEALRRAASGAGHRIDIEVRSDQGVVNALSDDAIVRARAV
CCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHCCCCEEEEEEE
ILIGTGDLDVGRFPGLPKLETTIEAVLADVGAVLGRAEGAELAGSVAATDDGVRRIVAIT
EEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCHHEEEEEEE
SCPTGIAHTFMAAEGITQAAKALGYQARVETQGSVGSRDTLSDDEIAQADIVLIAADTQI
CCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCCCEEEEEECCEE
DLARFDGKRVFLSGTKPAIADGKALIARALAEATLQGGKKSLVDTVEAGKAQRSAQRTGA
EEEEECCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
YKHLMTGVSFMLPFVVAGGLLIALAFALGGINAFDEANKGTLAYDLFQIGAKSAFVLMVP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCHHHHHHHHCCCCHHHHHHH
ALAGYIAFSIADRPGIAPGMIGGLVAANLGAGFLGGIIAGFIAGYVTAWFNRTIRLHRNL
HHHHHHHHEECCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
EGLKPVLILPVLGTVVTGLLMIYVVGTPVAGLLSWLTEALRGMQGSSAIVLGLLIGAMMA
CCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
FDMGGPVNKAAYAFSTGLLASEVYTPMAAAMVAGMTPALGVALASRLFRSRFTASEREAG
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHCCC
GAAAVLGLAFITEGAIPFAASDPFRVIPALMAGSAAAGAISMTVGAELKVPHGGIFVLPI
CHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCCEEEEEECCEEECCCCCEEEEEC
PNAVTHLLGYIVALVVGTLITALVLRITKRPVAVL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1655739; 12024217; 1650911 [H]