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The map label for this gene is trpE [H]

Identifier: 83593226

GI number: 83593226

Start: 2191371

End: 2192885

Strand: Direct

Name: trpE [H]

Synonym: Rru_A1891

Alternate gene names: 83593226

Gene position: 2191371-2192885 (Clockwise)

Preceding gene: 83593225

Following gene: 83593230

Centisome position: 50.34

GC content: 66.86

Gene sequence:

>1515_bases
ATGCCGACCACCCTGCCCGTCCTGGATCGCGCTTTCGTCACCGCCTATGACGCCGGCACGCCCCAGGTCGTCTGGACCCG
TCTGGTCGCCGATCTCGAAACGCCCGTATCGGCGATGCTGAAACTGGCCGATGGCCGGCCCTATTCCTTCCTGCTCGATT
CGGTGGAAGGCGGGGCGGTGCGCGGACGCTATTCGATCATCGGCCTCAAGCCCGATGTGCTGTGGCGGGCGCGGTCCGGT
CAGGCCGAGATCAACCGGTCGGTCCGCCACGATCCCACGGCCTTCGTCGCCGATGGCCCGGCGCTCGATTCCTTGCGCCG
CCTAGTCGAGGAAAGCCGCATCGACCTGCCCGCCGGCTTGCCGCCGATGGCGGCGATGGTCGCGGGCTATCTTGGCTATG
ACGTGGTGCGTCTGGTCGAACCCCAGATCGCCGATACCAACCCCGATCCCATCGACGTTCCCGACGGCATCTTCCTGCGC
CCGACGCTGATGGCGATTTTCGACAATGTCGAGCATATGGTGACCCTGGTCACCCCCGTGCGCCGCGAAGACGGCGTGAG
CGCGGCGGCGGCTTATACCCTGGCCCAGGAGCGTCTGGCCGACGCCGTCACCGATTTCCAGCGCACCCTGCCCTATCGCC
GCGAGGCCTTCGACACCTTGTCGACGCCGCCGGCGCCGATGGGCACCATGGCCCCGGCGACCTATTGCGAGATGGTGAAG
AAGGCCAAGGAGTACATCCTGGCCGGCGACATCTTCCAGGTGGTGCTGTCCCAGCGCTTCACCGTGCCCTTCCGCCTGCC
GCCGTTCTCGCTCTATCGCTCGCTGCGCCGCACCAACCCCTCGCCCTTCATGTTCTATCTCGATATGGGGGCGTTCCATA
TCGTCGGGGCGAGCCCGGAGATTCTGGTCCGCCTGCGCGATGGTCAGGTCACCATCCGGCCGATCGCCGGCACCCGCAAG
CGCGGCGCCACCCCCGACGAGGACAAGGCCCTGGCCGCCGATTTGCTGGCCGATCCCAAGGAACTGGCCGAGCATCTGAT
GCTGCTGGATCTGGGGCGCAACGATGTCGGCCGGGTGGCCAAGGTCGGCACGGTCGGCGTGCGGGCCGACGAAAAGATGT
TTGTCGAATACTACAGCCACGTCATGCATATCGTGTCGAACGTCACCGGCGAGATCGCGCCCGGCCACGATGCCCTTGAC
GCCCTGTTCGCCGGGTTTCCCGCCGGGACGGTCTCGGGCGCGCCCAAGGTGCGGGCGATGGAAATCATCGACGAGCTCGA
GCCGGTGCGGCGCGGCTTCTACGCCGGAACCGTCGGCTATTTCGCCGCCAACGGGTCGATGGACACCTGTATTTCGCTGC
GCACCTGTCTGGTCAAGGACGGGGTCATGCATGTCCAGGCCGGGGCCGGCATCGTCGCCGACAGCGATCCGATGGCCGAA
TACGAGGAATGCCTGAACAAGGCCAAGGCCCTGGTCCGCGCCGCCGAGGAAGCCGTGCGCTACGCCGCCGGCTAA

Upstream 100 bases:

>100_bases
GCCAAAGGGGGTGCCTTTTGGCGCGGGTTTTCGCCTTCCAAGCCTAACGCGCAACCCCCAAAACCGCCGTCCCGATCCAT
CCTCCTTGCGGAGAGTTCCG

Downstream 100 bases:

>100_bases
ACAAATCCTCTCCCCGCCCCCTGGCTTCAAGGGGCGGGGGGGCAGGCTTAGGCGGCCTTGGGGCCCAGGTAATCGAAGCC
GGCGCCATCGACGGCGGCTT

Product: anthranilate synthase component I

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 504; Mature: 503

Protein sequence:

>504_residues
MPTTLPVLDRAFVTAYDAGTPQVVWTRLVADLETPVSAMLKLADGRPYSFLLDSVEGGAVRGRYSIIGLKPDVLWRARSG
QAEINRSVRHDPTAFVADGPALDSLRRLVEESRIDLPAGLPPMAAMVAGYLGYDVVRLVEPQIADTNPDPIDVPDGIFLR
PTLMAIFDNVEHMVTLVTPVRREDGVSAAAAYTLAQERLADAVTDFQRTLPYRREAFDTLSTPPAPMGTMAPATYCEMVK
KAKEYILAGDIFQVVLSQRFTVPFRLPPFSLYRSLRRTNPSPFMFYLDMGAFHIVGASPEILVRLRDGQVTIRPIAGTRK
RGATPDEDKALAADLLADPKELAEHLMLLDLGRNDVGRVAKVGTVGVRADEKMFVEYYSHVMHIVSNVTGEIAPGHDALD
ALFAGFPAGTVSGAPKVRAMEIIDELEPVRRGFYAGTVGYFAANGSMDTCISLRTCLVKDGVMHVQAGAGIVADSDPMAE
YEECLNKAKALVRAAEEAVRYAAG

Sequences:

>Translated_504_residues
MPTTLPVLDRAFVTAYDAGTPQVVWTRLVADLETPVSAMLKLADGRPYSFLLDSVEGGAVRGRYSIIGLKPDVLWRARSG
QAEINRSVRHDPTAFVADGPALDSLRRLVEESRIDLPAGLPPMAAMVAGYLGYDVVRLVEPQIADTNPDPIDVPDGIFLR
PTLMAIFDNVEHMVTLVTPVRREDGVSAAAAYTLAQERLADAVTDFQRTLPYRREAFDTLSTPPAPMGTMAPATYCEMVK
KAKEYILAGDIFQVVLSQRFTVPFRLPPFSLYRSLRRTNPSPFMFYLDMGAFHIVGASPEILVRLRDGQVTIRPIAGTRK
RGATPDEDKALAADLLADPKELAEHLMLLDLGRNDVGRVAKVGTVGVRADEKMFVEYYSHVMHIVSNVTGEIAPGHDALD
ALFAGFPAGTVSGAPKVRAMEIIDELEPVRRGFYAGTVGYFAANGSMDTCISLRTCLVKDGVMHVQAGAGIVADSDPMAE
YEECLNKAKALVRAAEEAVRYAAG
>Mature_503_residues
PTTLPVLDRAFVTAYDAGTPQVVWTRLVADLETPVSAMLKLADGRPYSFLLDSVEGGAVRGRYSIIGLKPDVLWRARSGQ
AEINRSVRHDPTAFVADGPALDSLRRLVEESRIDLPAGLPPMAAMVAGYLGYDVVRLVEPQIADTNPDPIDVPDGIFLRP
TLMAIFDNVEHMVTLVTPVRREDGVSAAAAYTLAQERLADAVTDFQRTLPYRREAFDTLSTPPAPMGTMAPATYCEMVKK
AKEYILAGDIFQVVLSQRFTVPFRLPPFSLYRSLRRTNPSPFMFYLDMGAFHIVGASPEILVRLRDGQVTIRPIAGTRKR
GATPDEDKALAADLLADPKELAEHLMLLDLGRNDVGRVAKVGTVGVRADEKMFVEYYSHVMHIVSNVTGEIAPGHDALDA
LFAGFPAGTVSGAPKVRAMEIIDELEPVRRGFYAGTVGYFAANGSMDTCISLRTCLVKDGVMHVQAGAGIVADSDPMAEY
EECLNKAKALVRAAEEAVRYAAG

Specific function: Tryptophan biosynthesis; first step. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1787518, Length=395, Percent_Identity=39.2405063291139, Blast_Score=230, Evalue=1e-61,
Organism=Escherichia coli, GI1788114, Length=378, Percent_Identity=35.1851851851852, Blast_Score=214, Evalue=8e-57,
Organism=Escherichia coli, GI87082077, Length=262, Percent_Identity=27.8625954198473, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI1786809, Length=257, Percent_Identity=27.6264591439689, Blast_Score=81, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6320935, Length=483, Percent_Identity=38.9233954451346, Blast_Score=293, Evalue=3e-80,
Organism=Saccharomyces cerevisiae, GI6324361, Length=420, Percent_Identity=25.2380952380952, Blast_Score=114, Evalue=3e-26,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR005256
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 54814; Mature: 54682

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTTLPVLDRAFVTAYDAGTPQVVWTRLVADLETPVSAMLKLADGRPYSFLLDSVEGGAV
CCCCHHHHHHHHHEEECCCCHHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHCCCCCCEE
RGRYSIIGLKPDVLWRARSGQAEINRSVRHDPTAFVADGPALDSLRRLVEESRIDLPAGL
ECEEEEEECCHHHEEECCCCHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHCCCCCCCC
PPMAAMVAGYLGYDVVRLVEPQIADTNPDPIDVPDGIFLRPTLMAIFDNVEHMVTLVTPV
CHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCH
RREDGVSAAAAYTLAQERLADAVTDFQRTLPYRREAFDTLSTPPAPMGTMAPATYCEMVK
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHH
KAKEYILAGDIFQVVLSQRFTVPFRLPPFSLYRSLRRTNPSPFMFYLDMGAFHIVGASPE
HHHHHHHHHHHHHHHHHCCCCCCEECCCHHHHHHHHHCCCCCEEEEEECCCEEEECCCCE
ILVRLRDGQVTIRPIAGTRKRGATPDEDKALAADLLADPKELAEHLMLLDLGRNDVGRVA
EEEEEECCEEEEEECCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHH
KVGTVGVRADEKMFVEYYSHVMHIVSNVTGEIAPGHDALDALFAGFPAGTVSGAPKVRAM
HHCEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHH
EIIDELEPVRRGFYAGTVGYFAANGSMDTCISLRTCLVKDGVMHVQAGAGIVADSDPMAE
HHHHHHHHHHHHHHHCCHHHEEECCCHHHHHHHHHHHHHCCCEEEECCCCEEECCCCHHH
YEECLNKAKALVRAAEEAVRYAAG
HHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PTTLPVLDRAFVTAYDAGTPQVVWTRLVADLETPVSAMLKLADGRPYSFLLDSVEGGAV
CCCHHHHHHHHHEEECCCCHHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHCCCCCCEE
RGRYSIIGLKPDVLWRARSGQAEINRSVRHDPTAFVADGPALDSLRRLVEESRIDLPAGL
ECEEEEEECCHHHEEECCCCHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHCCCCCCCC
PPMAAMVAGYLGYDVVRLVEPQIADTNPDPIDVPDGIFLRPTLMAIFDNVEHMVTLVTPV
CHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCH
RREDGVSAAAAYTLAQERLADAVTDFQRTLPYRREAFDTLSTPPAPMGTMAPATYCEMVK
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHH
KAKEYILAGDIFQVVLSQRFTVPFRLPPFSLYRSLRRTNPSPFMFYLDMGAFHIVGASPE
HHHHHHHHHHHHHHHHHCCCCCCEECCCHHHHHHHHHCCCCCEEEEEECCCEEEECCCCE
ILVRLRDGQVTIRPIAGTRKRGATPDEDKALAADLLADPKELAEHLMLLDLGRNDVGRVA
EEEEEECCEEEEEECCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHH
KVGTVGVRADEKMFVEYYSHVMHIVSNVTGEIAPGHDALDALFAGFPAGTVSGAPKVRAM
HHCEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHH
EIIDELEPVRRGFYAGTVGYFAANGSMDTCISLRTCLVKDGVMHVQAGAGIVADSDPMAE
HHHHHHHHHHHHHHHCCHHHEEECCCHHHHHHHHHHHHHCCCEEEECCCCEEECCCCHHH
YEECLNKAKALVRAAEEAVRYAAG
HHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA