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The map label for this gene is mmsB [H]

Identifier: 83593168

GI number: 83593168

Start: 2129911

End: 2130801

Strand: Reverse

Name: mmsB [H]

Synonym: Rru_A1833

Alternate gene names: 83593168

Gene position: 2130801-2129911 (Counterclockwise)

Preceding gene: 83593169

Following gene: 83593167

Centisome position: 48.95

GC content: 69.25

Gene sequence:

>891_bases
ATGGCCAAGATCGCTTTCATCGGCCTGGGCAATATGGGCGGACCGATGCTGCGCAACCTGCTCAAGGCCGGCCACGAGTG
CGTGGCCTTCGATCTGTCGGCCCCCGCCCTGGCGGCGGCCGAACAGGCGGGGGCCCGGCCGGCCGCCAGCCCCGGCGACG
CCGCGCGCGGGGTCGATGGGGTGATCACCATGCTGCCCGCCGGAACCATCGTCCGCGCCGTCTATGAGGGCCCGGGCGGG
GTGATCGCCAACGCCGCGCCGGGAACCTTGCTGATCGATTGCTCGACCATCGATGTCGCCAGCGCCCGGGCGGTGGCCGA
GGCGGCGACGGCGGCCGGGCTGTCGATGGTCGACGCCCCCGTATCGGGTGGGGTGGCCGGAGCGGCGGCGGCGACCTTAA
CTTTCATGGTTGGCGGTCCGCCGGAAACCTTCGAGGCGGCGCGGCCGATTCTGGCGGCGATGGGCGGGACCATCGTCCAT
GCCGGGGCGGCGGGAACCGGGCAGGCGGCCAAGATCTGCAACAACATGCTGCTGGGCATTTCGATGATCGGCACCTGCGA
GGCCTTCATGTTGGCCAAACGCCTGGGGCTCGACGCGCAAAAGTTGTTCGACATCAGTTCCAAGGCCTCGGGCCAATGCT
GGTCGCTGACCTCTTATTGTCCGGTTCCCGGACCGGTGGCCAGCGCGCCGTCCAACCGCGATTATCAACCGGGGTTCGCC
GCGGCGATGATGCTCAAGGACTTGAAGCTGGCCCAAGAGGCCGCCGCCGGCGTTGACGCGGCGACGCCCCTGGGGGCCGC
CGCCGCCGCCCTTTACAGCCTGTATTGTAACGCCGGCCATGCCGGAACCGACTTCTCGGGCATCATCGCCATGATCGACG
GCAGCGACTGA

Upstream 100 bases:

>100_bases
GAGGTCGAGGACGCCGCCGTCGGAGCGCTGTTCGCGCCGCGTGCCGATGGCGATCTGGAGTTTCGCGACCCTTAAAAAAC
CTTAAGCATGGGAGGAAGAT

Downstream 100 bases:

>100_bases
ACCCGGATGGGCGTGGAACGCGACAACACCAATAACGCTTTAAAAATACAATACGCACGATAAGGTTGCTTTTTTAACCC
CCCTTCCCATATCGTAGTCC

Product: 3-hydroxyisobutyrate dehydrogenase

Products: NA

Alternate protein names: HIBADH [H]

Number of amino acids: Translated: 296; Mature: 295

Protein sequence:

>296_residues
MAKIAFIGLGNMGGPMLRNLLKAGHECVAFDLSAPALAAAEQAGARPAASPGDAARGVDGVITMLPAGTIVRAVYEGPGG
VIANAAPGTLLIDCSTIDVASARAVAEAATAAGLSMVDAPVSGGVAGAAAATLTFMVGGPPETFEAARPILAAMGGTIVH
AGAAGTGQAAKICNNMLLGISMIGTCEAFMLAKRLGLDAQKLFDISSKASGQCWSLTSYCPVPGPVASAPSNRDYQPGFA
AAMMLKDLKLAQEAAAGVDAATPLGAAAAALYSLYCNAGHAGTDFSGIIAMIDGSD

Sequences:

>Translated_296_residues
MAKIAFIGLGNMGGPMLRNLLKAGHECVAFDLSAPALAAAEQAGARPAASPGDAARGVDGVITMLPAGTIVRAVYEGPGG
VIANAAPGTLLIDCSTIDVASARAVAEAATAAGLSMVDAPVSGGVAGAAAATLTFMVGGPPETFEAARPILAAMGGTIVH
AGAAGTGQAAKICNNMLLGISMIGTCEAFMLAKRLGLDAQKLFDISSKASGQCWSLTSYCPVPGPVASAPSNRDYQPGFA
AAMMLKDLKLAQEAAAGVDAATPLGAAAAALYSLYCNAGHAGTDFSGIIAMIDGSD
>Mature_295_residues
AKIAFIGLGNMGGPMLRNLLKAGHECVAFDLSAPALAAAEQAGARPAASPGDAARGVDGVITMLPAGTIVRAVYEGPGGV
IANAAPGTLLIDCSTIDVASARAVAEAATAAGLSMVDAPVSGGVAGAAAATLTFMVGGPPETFEAARPILAAMGGTIVHA
GAAGTGQAAKICNNMLLGISMIGTCEAFMLAKRLGLDAQKLFDISSKASGQCWSLTSYCPVPGPVASAPSNRDYQPGFAA
AMMLKDLKLAQEAAAGVDAATPLGAAAAALYSLYCNAGHAGTDFSGIIAMIDGSD

Specific function: D-galactarate metabolism; third step. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=289, Percent_Identity=45.3287197231834, Blast_Score=255, Evalue=3e-68,
Organism=Homo sapiens, GI40556376, Length=289, Percent_Identity=26.9896193771626, Blast_Score=101, Evalue=9e-22,
Organism=Escherichia coli, GI145693186, Length=265, Percent_Identity=36.9811320754717, Blast_Score=160, Evalue=9e-41,
Organism=Escherichia coli, GI1790315, Length=298, Percent_Identity=37.9194630872483, Blast_Score=159, Evalue=2e-40,
Organism=Escherichia coli, GI1786719, Length=291, Percent_Identity=28.1786941580756, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI1789092, Length=294, Percent_Identity=29.9319727891156, Blast_Score=108, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17557316, Length=275, Percent_Identity=46.1818181818182, Blast_Score=229, Evalue=1e-60,
Organism=Drosophila melanogaster, GI24655230, Length=290, Percent_Identity=44.8275862068966, Blast_Score=236, Evalue=1e-62,
Organism=Drosophila melanogaster, GI19922568, Length=290, Percent_Identity=44.8275862068966, Blast_Score=236, Evalue=1e-62,
Organism=Drosophila melanogaster, GI28574115, Length=289, Percent_Identity=21.7993079584775, Blast_Score=79, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR011548
- InterPro:   IPR016040 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.31 [H]

Molecular weight: Translated: 29098; Mature: 28967

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKIAFIGLGNMGGPMLRNLLKAGHECVAFDLSAPALAAAEQAGARPAASPGDAARGVDG
CCEEEEEECCCCCCHHHHHHHHCCCCEEEEECCCCHHHHHHHHCCCCCCCCCCHHCCCCH
VITMLPAGTIVRAVYEGPGGVIANAAPGTLLIDCSTIDVASARAVAEAATAAGLSMVDAP
HHHHCCCHHHHHHHHCCCCCEEECCCCCEEEEEECCCCHHHHHHHHHHHHHHCCHHCCCC
VSGGVAGAAAATLTFMVGGPPETFEAARPILAAMGGTIVHAGAAGTGQAAKICNNMLLGI
CCCCCHHHHHEEEEEEECCCCHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHH
SMIGTCEAFMLAKRLGLDAQKLFDISSKASGQCWSLTSYCPVPGPVASAPSNRDYQPGFA
HHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCHHH
AAMMLKDLKLAQEAAAGVDAATPLGAAAAALYSLYCNAGHAGTDFSGIIAMIDGSD
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCC
>Mature Secondary Structure 
AKIAFIGLGNMGGPMLRNLLKAGHECVAFDLSAPALAAAEQAGARPAASPGDAARGVDG
CEEEEEECCCCCCHHHHHHHHCCCCEEEEECCCCHHHHHHHHCCCCCCCCCCHHCCCCH
VITMLPAGTIVRAVYEGPGGVIANAAPGTLLIDCSTIDVASARAVAEAATAAGLSMVDAP
HHHHCCCHHHHHHHHCCCCCEEECCCCCEEEEEECCCCHHHHHHHHHHHHHHCCHHCCCC
VSGGVAGAAAATLTFMVGGPPETFEAARPILAAMGGTIVHAGAAGTGQAAKICNNMLLGI
CCCCCHHHHHEEEEEEECCCCHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHH
SMIGTCEAFMLAKRLGLDAQKLFDISSKASGQCWSLTSYCPVPGPVASAPSNRDYQPGFA
HHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCHHH
AAMMLKDLKLAQEAAAGVDAATPLGAAAAALYSLYCNAGHAGTDFSGIIAMIDGSD
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1339433; 10984043 [H]