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The map label for this gene is serS

Identifier: 83593105

GI number: 83593105

Start: 2062286

End: 2063557

Strand: Reverse

Name: serS

Synonym: Rru_A1770

Alternate gene names: 83593105

Gene position: 2063557-2062286 (Counterclockwise)

Preceding gene: 83593106

Following gene: 83593104

Centisome position: 47.41

GC content: 67.14

Gene sequence:

>1272_bases
ATGCACGACCTAAAAGCCATTCGCGAAACTCCCGAGGCCTTCGACCTCGCCCTGGCCCGTCGGCGGCTGGAGCCGCGCTC
GGCCCTGGTCCTTGATCTCGATAGCCAGCGTCGCGCCGTTCAGACCGAGTTGAACGATCTGCAGGCGCGACGCAACGAGG
CGTCCAAGCGCATCGGCCTGGTCAAGAAGGAGGGCGGCGACGCCCAGGCGTTGGTCGATGAGGTCGCCGGCATCAAGGCG
ACGATGGCCGCGTTGGAGGCGCGTCTGGGGGACCTCGATCGCGACCTCGACGGCCATCTGATGGGCCTGCCCAATATCCT
GGACGACGGCGTTCCCGAAGGCCCCGACGAAAGCGCCAATGTCGAGGTGCGCCGCTGGGGAACGCCGCGCGCCTTCGAGT
TCACCCCGCGTCAGCATTTCGAGATCGGCGAGAGCCTGGGCGGCATGGATTTCGAGGCCGCCGCCCGGCTGTCGGGGGCG
CGCTTCGTCGTGCTCAAGGGGCAGATCGCCCGCTTGGAACGCGCCCTTGGCCAGTTCATGCTGGATCTGCACATCACCGA
GCATGGCTATCAGGAGGTGCAGACCCCGGTTCTGGTCCGCGCCCCGGCCCTGCAGGGAACCGGCCAGCTGCCCAAATTCG
CCGAGGATCTGTTCCGCGTCGAGGGGGATTTCTTCTTGATCCCGACGGCCGAGGTCACCGTGACCAATCTGGTCGCCGGG
CAGGTGCTCGCCGCCACGGCCCTGCCGTTGCGCATGACCGCCTTCACCCAGTGCTTCCGCTCGGAAGCCGGGGCGGCGGG
CAAGGATACCCGGGGCATGATCCGCCAGCACCAGTTCGAGAAGGTCGAGATGGTGTCGATCGTCCATCCCGACGACTCGG
CGGCCGAACTGGAGCGGATGACCGCTTGCGCCGAGGATGTGCTCAAGCGCCTGGAGCTGCCTTATCGGGTGATGGCGCTC
TGCGCGGGCGATGTCGGGTTCAGCGCCCGCCAGACCTATGACCTGGAGGTCTGGCTGCCCGGCCAGGACCGCTACCGGGA
AATCTCGTCGTGCTCCAACACGGGCGACTTCCAGGCGCGGCGGATGAATGGCCGCTTCAAGGTCGAGGGCGAGAAGGGCA
CGCGCTTCGTTCACACGCTCAATGGCTCGGGCGTGGCCGTGGGCCGCTGTCTGGTGGCGGTGCTGGAGAATTATCAGAAC
GCCGATGGCACGGTGAGCGTCCCCGAGGCCCTGCGCGGCTATATGGGCGGACTTGAGCGGTTGGGGGACTGA

Upstream 100 bases:

>100_bases
ATGGGCATTAGCCCGCTATAAAGACGACCCTGCGCCTTTTTTCCGCCACACCTCTTGCCGCCTCGCAGACCCCCACACGC
CAGCCGACGGACGAACCGAG

Downstream 100 bases:

>100_bases
TGTTTTCGCCGCTGACCGATCTTTCCCGCGCGCGCATCCTGCTGTCCAATGACGACGGCTTCGAAGCCGAAGGTCTGGCC
GTGCTCGAACGGGTGGCGCG

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 423; Mature: 423

Protein sequence:

>423_residues
MHDLKAIRETPEAFDLALARRRLEPRSALVLDLDSQRRAVQTELNDLQARRNEASKRIGLVKKEGGDAQALVDEVAGIKA
TMAALEARLGDLDRDLDGHLMGLPNILDDGVPEGPDESANVEVRRWGTPRAFEFTPRQHFEIGESLGGMDFEAAARLSGA
RFVVLKGQIARLERALGQFMLDLHITEHGYQEVQTPVLVRAPALQGTGQLPKFAEDLFRVEGDFFLIPTAEVTVTNLVAG
QVLAATALPLRMTAFTQCFRSEAGAAGKDTRGMIRQHQFEKVEMVSIVHPDDSAAELERMTACAEDVLKRLELPYRVMAL
CAGDVGFSARQTYDLEVWLPGQDRYREISSCSNTGDFQARRMNGRFKVEGEKGTRFVHTLNGSGVAVGRCLVAVLENYQN
ADGTVSVPEALRGYMGGLERLGD

Sequences:

>Translated_423_residues
MHDLKAIRETPEAFDLALARRRLEPRSALVLDLDSQRRAVQTELNDLQARRNEASKRIGLVKKEGGDAQALVDEVAGIKA
TMAALEARLGDLDRDLDGHLMGLPNILDDGVPEGPDESANVEVRRWGTPRAFEFTPRQHFEIGESLGGMDFEAAARLSGA
RFVVLKGQIARLERALGQFMLDLHITEHGYQEVQTPVLVRAPALQGTGQLPKFAEDLFRVEGDFFLIPTAEVTVTNLVAG
QVLAATALPLRMTAFTQCFRSEAGAAGKDTRGMIRQHQFEKVEMVSIVHPDDSAAELERMTACAEDVLKRLELPYRVMAL
CAGDVGFSARQTYDLEVWLPGQDRYREISSCSNTGDFQARRMNGRFKVEGEKGTRFVHTLNGSGVAVGRCLVAVLENYQN
ADGTVSVPEALRGYMGGLERLGD
>Mature_423_residues
MHDLKAIRETPEAFDLALARRRLEPRSALVLDLDSQRRAVQTELNDLQARRNEASKRIGLVKKEGGDAQALVDEVAGIKA
TMAALEARLGDLDRDLDGHLMGLPNILDDGVPEGPDESANVEVRRWGTPRAFEFTPRQHFEIGESLGGMDFEAAARLSGA
RFVVLKGQIARLERALGQFMLDLHITEHGYQEVQTPVLVRAPALQGTGQLPKFAEDLFRVEGDFFLIPTAEVTVTNLVAG
QVLAATALPLRMTAFTQCFRSEAGAAGKDTRGMIRQHQFEKVEMVSIVHPDDSAAELERMTACAEDVLKRLELPYRVMAL
CAGDVGFSARQTYDLEVWLPGQDRYREISSCSNTGDFQARRMNGRFKVEGEKGTRFVHTLNGSGVAVGRCLVAVLENYQN
ADGTVSVPEALRGYMGGLERLGD

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=435, Percent_Identity=31.264367816092, Blast_Score=193, Evalue=3e-49,
Organism=Homo sapiens, GI8923421, Length=432, Percent_Identity=30.3240740740741, Blast_Score=184, Evalue=9e-47,
Organism=Homo sapiens, GI225579074, Length=434, Percent_Identity=30.4147465437788, Blast_Score=182, Evalue=4e-46,
Organism=Escherichia coli, GI1787120, Length=430, Percent_Identity=53.7209302325581, Blast_Score=449, Evalue=1e-127,
Organism=Caenorhabditis elegans, GI17539260, Length=337, Percent_Identity=32.6409495548961, Blast_Score=185, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI17542084, Length=380, Percent_Identity=29.7368421052632, Blast_Score=155, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6320226, Length=397, Percent_Identity=33.2493702770781, Blast_Score=221, Evalue=2e-58,
Organism=Saccharomyces cerevisiae, GI6321799, Length=399, Percent_Identity=28.5714285714286, Blast_Score=191, Evalue=2e-49,
Organism=Drosophila melanogaster, GI24581334, Length=327, Percent_Identity=33.9449541284404, Blast_Score=179, Evalue=3e-45,
Organism=Drosophila melanogaster, GI17737985, Length=355, Percent_Identity=32.3943661971831, Blast_Score=168, Evalue=8e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_RHORT (Q2RTH5)

Other databases:

- EMBL:   CP000230
- RefSeq:   YP_426857.1
- HSSP:   Q9N0F3
- ProteinModelPortal:   Q2RTH5
- SMR:   Q2RTH5
- STRING:   Q2RTH5
- GeneID:   3835192
- GenomeReviews:   CP000230_GR
- KEGG:   rru:Rru_A1770
- NMPDR:   fig|1085.1.peg.2345
- eggNOG:   COG0172
- HOGENOM:   HBG629391
- OMA:   PKFADDM
- PhylomeDB:   Q2RTH5
- ProtClustDB:   PRK05431
- BioCyc:   RRUB269796:RRU_A1770-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 46537; Mature: 46537

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 283-283 BINDING 383-383

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHDLKAIRETPEAFDLALARRRLEPRSALVLDLDSQRRAVQTELNDLQARRNEASKRIGL
CCCHHHHHCCHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCC
VKKEGGDAQALVDEVAGIKATMAALEARLGDLDRDLDGHLMGLPNILDDGVPEGPDESAN
EEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCHHHHCCCCCCCCCCCC
VEVRRWGTPRAFEFTPRQHFEIGESLGGMDFEAAARLSGARFVVLKGQIARLERALGQFM
EEEEECCCCCCEECCCHHHHHHHHHCCCCCHHHHHHCCCCEEEEECCHHHHHHHHHHHHH
LDLHITEHGYQEVQTPVLVRAPALQGTGQLPKFAEDLFRVEGDFFLIPTAEVTVTNLVAG
HHEEECCCCHHHHCCCEEEECCCCCCCCCCHHHHHHHHHHCCCEEEEECCHHHHHHHHHH
QVLAATALPLRMTAFTQCFRSEAGAAGKDTRGMIRQHQFEKVEMVSIVHPDDSAAELERM
HHHHHHHCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCEEEEEEECCCCHHHHHHHH
TACAEDVLKRLELPYRVMALCAGDVGFSARQTYDLEVWLPGQDRYREISSCSNTGDFQAR
HHHHHHHHHHHCCCHHHHHHHHCCCCCCCCEEEEEEEEECCHHHHHHHHHCCCCCCCEEE
RMNGRFKVEGEKGTRFVHTLNGSGVAVGRCLVAVLENYQNADGTVSVPEALRGYMGGLER
ECCCEEEEECCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHH
LGD
HCC
>Mature Secondary Structure
MHDLKAIRETPEAFDLALARRRLEPRSALVLDLDSQRRAVQTELNDLQARRNEASKRIGL
CCCHHHHHCCHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCC
VKKEGGDAQALVDEVAGIKATMAALEARLGDLDRDLDGHLMGLPNILDDGVPEGPDESAN
EEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCHHHHCCCCCCCCCCCC
VEVRRWGTPRAFEFTPRQHFEIGESLGGMDFEAAARLSGARFVVLKGQIARLERALGQFM
EEEEECCCCCCEECCCHHHHHHHHHCCCCCHHHHHHCCCCEEEEECCHHHHHHHHHHHHH
LDLHITEHGYQEVQTPVLVRAPALQGTGQLPKFAEDLFRVEGDFFLIPTAEVTVTNLVAG
HHEEECCCCHHHHCCCEEEECCCCCCCCCCHHHHHHHHHHCCCEEEEECCHHHHHHHHHH
QVLAATALPLRMTAFTQCFRSEAGAAGKDTRGMIRQHQFEKVEMVSIVHPDDSAAELERM
HHHHHHHCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCEEEEEEECCCCHHHHHHHH
TACAEDVLKRLELPYRVMALCAGDVGFSARQTYDLEVWLPGQDRYREISSCSNTGDFQAR
HHHHHHHHHHHCCCHHHHHHHHCCCCCCCCEEEEEEEEECCHHHHHHHHHCCCCCCCEEE
RMNGRFKVEGEKGTRFVHTLNGSGVAVGRCLVAVLENYQNADGTVSVPEALRGYMGGLER
ECCCEEEEECCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHH
LGD
HCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA