BacMap

Definition	Rhodospirillum rubrum ATCC 11170 chromosome, complete genome.
Accession	NC_007643
Length	4,352,825

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The map label for this gene is ppi [H]

Identifier: 83593077

GI number: 83593077

Start: 2033249

End: 2033755

Strand: Reverse

Name: ppi [H]

Synonym: Rru_A1742

Alternate gene names: 83593077

Gene position: 2033755-2033249 (Counterclockwise)

Preceding gene: 83593078

Following gene: 83593074

Centisome position: 46.72

GC content: 64.5

Gene sequence:

>507_bases
ATGACCGACACCAAGGCCGCCGACCCTGAAAACACCCTCTACATGGACCTCAAAGATGGTCGCGTGGTGATCGAGCTGCG
GCCCGATCTTGCGCCCAAGCATGTGGAGCGCATCAAGCTGCTGGTCCGCAAGGGCTTTTACGATGGCACGCCGTTCCATC
GGGTGATCGATGGCTTCATGGTCCAGGGCGGCGACCCGACCGGGACCGGCCGTGGCGGCTCCGATCTGCCCGATCTGCCC
GCCGAGTTCAGCCCGCCGTCGAAGGCCCGCCATCTGCGCGGCGTGACCTCGATGGCCCGCACCGCCGATCCCGACAGCGC
CAACAGCCAGTTCTTCATCATGCTGGCCCCGTCGTCGCATCTGGATGGCCAGTACACCATCTGGGGCCAGGTGACCAAGG
GCATGGACTTCGTGGACATGATCAAGAAGGGCGATTCGCGGGCCAATGGCTCGGTGAGCGATCCCGACCGCATCGTCAAG
GTTCAGGTCGCCGCCGACGTGAAGTAG

Upstream 100 bases:

>100_bases
CTGAGCCAAGCCCCCTCCCTCCCTCAAGAGGTCAAGGAAACGCCATATGCGCCGCATCCTGATCAGTTTATTCGCTCTAC
TCGCCTGCATGGGAACTGTC

Downstream 100 bases:

>100_bases
GATTTCCCCACGGAGGGCGTCCCGGGCGCGGTCGCGCCATGGGAGGCCCCCTTGGGAAACCAGCCTTTTCGGGTCTTGTC
GCTATCAAGGTTGACAAGAG

Product: peptidylprolyl isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 168; Mature: 167

Protein sequence:

>168_residues
MTDTKAADPENTLYMDLKDGRVVIELRPDLAPKHVERIKLLVRKGFYDGTPFHRVIDGFMVQGGDPTGTGRGGSDLPDLP
AEFSPPSKARHLRGVTSMARTADPDSANSQFFIMLAPSSHLDGQYTIWGQVTKGMDFVDMIKKGDSRANGSVSDPDRIVK
VQVAADVK

Sequences:

>Translated_168_residues
MTDTKAADPENTLYMDLKDGRVVIELRPDLAPKHVERIKLLVRKGFYDGTPFHRVIDGFMVQGGDPTGTGRGGSDLPDLP
AEFSPPSKARHLRGVTSMARTADPDSANSQFFIMLAPSSHLDGQYTIWGQVTKGMDFVDMIKKGDSRANGSVSDPDRIVK
VQVAADVK
>Mature_167_residues
TDTKAADPENTLYMDLKDGRVVIELRPDLAPKHVERIKLLVRKGFYDGTPFHRVIDGFMVQGGDPTGTGRGGSDLPDLPA
EFSPPSKARHLRGVTSMARTADPDSANSQFFIMLAPSSHLDGQYTIWGQVTKGMDFVDMIKKGDSRANGSVSDPDRIVKV
QVAADVK

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI7706339, Length=151, Percent_Identity=39.7350993377483, Blast_Score=111, Evalue=3e-25,
Organism=Homo sapiens, GI19557636, Length=134, Percent_Identity=41.7910447761194, Blast_Score=101, Evalue=4e-22,
Organism=Homo sapiens, GI24308049, Length=144, Percent_Identity=38.8888888888889, Blast_Score=97, Evalue=6e-21,
Organism=Homo sapiens, GI64276486, Length=114, Percent_Identity=42.1052631578947, Blast_Score=87, Evalue=7e-18,
Organism=Homo sapiens, GI10863927, Length=138, Percent_Identity=40.5797101449275, Blast_Score=84, Evalue=6e-17,
Organism=Homo sapiens, GI5031987, Length=139, Percent_Identity=42.4460431654676, Blast_Score=84, Evalue=7e-17,
Organism=Homo sapiens, GI4826932, Length=128, Percent_Identity=37.5, Blast_Score=80, Evalue=9e-16,
Organism=Homo sapiens, GI45439316, Length=160, Percent_Identity=33.125, Blast_Score=77, Evalue=5e-15,
Organism=Homo sapiens, GI4505991, Length=130, Percent_Identity=43.0769230769231, Blast_Score=77, Evalue=7e-15,
Organism=Homo sapiens, GI310129267, Length=139, Percent_Identity=38.8489208633094, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI310120620, Length=139, Percent_Identity=38.8489208633094, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI303305009, Length=172, Percent_Identity=32.5581395348837, Blast_Score=75, Evalue=2e-14,
Organism=Homo sapiens, GI5174637, Length=152, Percent_Identity=33.5526315789474, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI310110104, Length=139, Percent_Identity=38.8489208633094, Blast_Score=74, Evalue=4e-14,
Organism=Homo sapiens, GI256017253, Length=128, Percent_Identity=39.0625, Blast_Score=74, Evalue=8e-14,
Organism=Homo sapiens, GI221139811, Length=128, Percent_Identity=39.0625, Blast_Score=74, Evalue=8e-14,
Organism=Homo sapiens, GI256017251, Length=128, Percent_Identity=39.0625, Blast_Score=74, Evalue=8e-14,
Organism=Homo sapiens, GI4758950, Length=161, Percent_Identity=38.5093167701863, Blast_Score=73, Evalue=1e-13,
Organism=Homo sapiens, GI178057341, Length=131, Percent_Identity=37.4045801526718, Blast_Score=71, Evalue=4e-13,
Organism=Homo sapiens, GI310127646, Length=145, Percent_Identity=37.9310344827586, Blast_Score=71, Evalue=5e-13,
Organism=Homo sapiens, GI310114371, Length=145, Percent_Identity=37.9310344827586, Blast_Score=71, Evalue=5e-13,
Organism=Homo sapiens, GI310119221, Length=145, Percent_Identity=37.9310344827586, Blast_Score=71, Evalue=5e-13,
Organism=Homo sapiens, GI169214050, Length=184, Percent_Identity=33.1521739130435, Blast_Score=71, Evalue=5e-13,
Organism=Homo sapiens, GI239751853, Length=154, Percent_Identity=35.0649350649351, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI113428306, Length=154, Percent_Identity=35.0649350649351, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI42560244, Length=141, Percent_Identity=36.8794326241135, Blast_Score=69, Evalue=1e-12,
Organism=Homo sapiens, GI20911035, Length=134, Percent_Identity=33.5820895522388, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI169164185, Length=138, Percent_Identity=36.231884057971, Blast_Score=68, Evalue=4e-12,
Organism=Homo sapiens, GI169163623, Length=138, Percent_Identity=36.231884057971, Blast_Score=68, Evalue=4e-12,
Organism=Homo sapiens, GI22547212, Length=129, Percent_Identity=42.6356589147287, Blast_Score=67, Evalue=5e-12,
Organism=Homo sapiens, GI7657473, Length=129, Percent_Identity=42.6356589147287, Blast_Score=67, Evalue=5e-12,
Organism=Homo sapiens, GI169163387, Length=138, Percent_Identity=36.231884057971, Blast_Score=67, Evalue=6e-12,
Organism=Homo sapiens, GI22547215, Length=129, Percent_Identity=42.6356589147287, Blast_Score=67, Evalue=9e-12,
Organism=Escherichia coli, GI1789763, Length=129, Percent_Identity=43.4108527131783, Blast_Score=94, Evalue=6e-21,
Organism=Escherichia coli, GI1786736, Length=133, Percent_Identity=36.0902255639098, Blast_Score=80, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17539496, Length=133, Percent_Identity=40.6015037593985, Blast_Score=108, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI71980594, Length=124, Percent_Identity=44.3548387096774, Blast_Score=99, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI71980590, Length=124, Percent_Identity=44.3548387096774, Blast_Score=98, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17506311, Length=127, Percent_Identity=41.7322834645669, Blast_Score=94, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17532641, Length=125, Percent_Identity=40.8, Blast_Score=86, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17539498, Length=153, Percent_Identity=33.3333333333333, Blast_Score=84, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17566266, Length=146, Percent_Identity=36.3013698630137, Blast_Score=79, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17559074, Length=149, Percent_Identity=34.8993288590604, Blast_Score=77, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17552782, Length=168, Percent_Identity=33.3333333333333, Blast_Score=76, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17552780, Length=127, Percent_Identity=38.5826771653543, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17551282, Length=161, Percent_Identity=32.2981366459627, Blast_Score=74, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17551284, Length=161, Percent_Identity=32.2981366459627, Blast_Score=74, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17565860, Length=167, Percent_Identity=33.5329341317365, Blast_Score=73, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17552784, Length=135, Percent_Identity=35.5555555555556, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71997782, Length=128, Percent_Identity=36.71875, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI32563659, Length=140, Percent_Identity=33.5714285714286, Blast_Score=70, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17506307, Length=152, Percent_Identity=35.5263157894737, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320359, Length=147, Percent_Identity=42.8571428571429, Blast_Score=86, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6323562, Length=129, Percent_Identity=41.0852713178295, Blast_Score=84, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6321848, Length=153, Percent_Identity=39.2156862745098, Blast_Score=74, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6323246, Length=155, Percent_Identity=32.9032258064516, Blast_Score=73, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6320510, Length=158, Percent_Identity=36.7088607594937, Blast_Score=65, Evalue=7e-12,
Organism=Drosophila melanogaster, GI17986117, Length=162, Percent_Identity=40.7407407407407, Blast_Score=111, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24664125, Length=149, Percent_Identity=38.9261744966443, Blast_Score=87, Evalue=5e-18,
Organism=Drosophila melanogaster, GI21357783, Length=149, Percent_Identity=38.9261744966443, Blast_Score=87, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24652460, Length=133, Percent_Identity=38.3458646616541, Blast_Score=85, Evalue=2e-17,
Organism=Drosophila melanogaster, GI45549139, Length=138, Percent_Identity=39.1304347826087, Blast_Score=85, Evalue=2e-17,
Organism=Drosophila melanogaster, GI19922376, Length=143, Percent_Identity=35.6643356643357, Blast_Score=84, Evalue=3e-17,
Organism=Drosophila melanogaster, GI21357249, Length=127, Percent_Identity=37.007874015748, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI19922912, Length=135, Percent_Identity=42.2222222222222, Blast_Score=74, Evalue=6e-14,
Organism=Drosophila melanogaster, GI20130249, Length=151, Percent_Identity=37.0860927152318, Blast_Score=74, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24650807, Length=137, Percent_Identity=37.2262773722628, Blast_Score=70, Evalue=4e-13,
Organism=Drosophila melanogaster, GI17136360, Length=149, Percent_Identity=34.8993288590604, Blast_Score=70, Evalue=5e-13,
Organism=Drosophila melanogaster, GI17647301, Length=133, Percent_Identity=33.0827067669173, Blast_Score=70, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24661775, Length=156, Percent_Identity=32.0512820512821, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21355237, Length=156, Percent_Identity=32.0512820512821, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24661771, Length=156, Percent_Identity=32.0512820512821, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 18330; Mature: 18199

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDTKAADPENTLYMDLKDGRVVIELRPDLAPKHVERIKLLVRKGFYDGTPFHRVIDGFM
CCCCCCCCCCCEEEEEECCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHEE
VQGGDPTGTGRGGSDLPDLPAEFSPPSKARHLRGVTSMARTADPDSANSQFFIMLAPSSH
EECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCC
LDGQYTIWGQVTKGMDFVDMIKKGDSRANGSVSDPDRIVKVQVAADVK
CCCEEEEEEEECCCCHHHHHHHCCCCCCCCCCCCCCCEEEEEEEECCC
>Mature Secondary Structure 
TDTKAADPENTLYMDLKDGRVVIELRPDLAPKHVERIKLLVRKGFYDGTPFHRVIDGFM
CCCCCCCCCCEEEEEECCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHEE
VQGGDPTGTGRGGSDLPDLPAEFSPPSKARHLRGVTSMARTADPDSANSQFFIMLAPSSH
EECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCC
LDGQYTIWGQVTKGMDFVDMIKKGDSRANGSVSDPDRIVKVQVAADVK
CCCEEEEEEEECCCCHHHHHHHCCCCCCCCCCCCCCCEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA