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The map label for this gene is fabH

Identifier: 83593002

GI number: 83593002

Start: 1957629

End: 1958603

Strand: Direct

Name: fabH

Synonym: Rru_A1667

Alternate gene names: 83593002

Gene position: 1957629-1958603 (Clockwise)

Preceding gene: 83593001

Following gene: 83593003

Centisome position: 44.97

GC content: 66.97

Gene sequence:

>975_bases
ATGTGGCGTTCCGTGATCGCGGGATGCGGGTCCTACCTGCCCGCGAACAAGGTGACCAACGCCAATTTGGCGGAGCGGGT
GGAGACCACCGATGCTTGGATCCGCGAAAGGACCGGCATTCTGGTGCGCCACTTCGCCGCCGAGGGGGAAAAGACCTCTG
ATCTGGCGATGGCCGCCGCTAGGGCCGCCCTGGCCGATGCCGGGGTCGACGCCGCCGAGGTCGATCTGATCGTTCTGGCG
ACCGCCACCCCCGACCAGACCTTCCCGGCCACCGCCACCCGGGTTCAGGCCGGACTGGGCTGTCGGCCCGGCGCGCCGGC
CTTCGATATCCAGGCGGTCTGTTCGGGTTTTCTCTATGCCCTCAGCGTCGCCGACGCCCTGATCAAGGCCGGTCAGGCGC
GTACCGCGCTGGTTATCGGCGCCGAAACCTTCTCGCGCATTCTTGATTTCACCGACCGCACCACCTGCGTGCTGTTTGGC
GATGGCGCCGGGGCGGTGGTTTTGCGGGCGACGCCCTCGACCGGCGACGGCGGCGAGCGCGGCATCTTGTCGACCCATCT
GCATGCCGATGGCCGCCACCATGATCTGCTCTATGTCGATGGCGGGCCGTCGTCGACCGGCACCGTGGGCCATCTGCGGA
TGCAGGGCCGCGAGGTTTTCCGCCATGCGGTGACCAATCTTTACGAGGTCGTCCTTGAAGCCCTGGCGGCCAATGGCCTT
CAGGCCGACGCCATCGACTGGGTGGTTCCCCATCAGGCCAATCAGCGCATCCTCGATGGCACCGCCAAGAAGCTGGGCAT
CGATCCGGCCAAGGTGATCAGCACCATCGCCCTTCACGCCAACACCTCGGCCGCCTCGGTGCCGCTGGCGCTTTGCGAGG
CCCGGCGCGATGGCCGCATTCAGCCCGGTCAGTTGATTTTGCTCGAAGCCATGGGCGGCGGTTTCACCTGGGGCTCGGCC
CTGGTCCGGCTGTAA

Upstream 100 bases:

>100_bases
GCCGTCTGATCCGACCCCCGCCCGCTAAGGCCGCGTGATAGCGGCCGACCGGACGGGGTCCTCAGGATATCAAAAGGCTG
TTTGACAAGGATATTTCCCC

Downstream 100 bases:

>100_bases
AAAGGCCAAAAACCCGACGGGGTCGATCGGATTTAGTTTTTTCATCGGCCCGTATGGTTTCCACCCCCCTGCGCAACGCT
TAAGGCCCAGTCTCGGGACC

Product: 3-oxoacyl-[acyl-carrier-protein] synthase III

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase III; Beta-ketoacyl-ACP synthase III; KAS III

Number of amino acids: Translated: 324; Mature: 324

Protein sequence:

>324_residues
MWRSVIAGCGSYLPANKVTNANLAERVETTDAWIRERTGILVRHFAAEGEKTSDLAMAAARAALADAGVDAAEVDLIVLA
TATPDQTFPATATRVQAGLGCRPGAPAFDIQAVCSGFLYALSVADALIKAGQARTALVIGAETFSRILDFTDRTTCVLFG
DGAGAVVLRATPSTGDGGERGILSTHLHADGRHHDLLYVDGGPSSTGTVGHLRMQGREVFRHAVTNLYEVVLEALAANGL
QADAIDWVVPHQANQRILDGTAKKLGIDPAKVISTIALHANTSAASVPLALCEARRDGRIQPGQLILLEAMGGGFTWGSA
LVRL

Sequences:

>Translated_324_residues
MWRSVIAGCGSYLPANKVTNANLAERVETTDAWIRERTGILVRHFAAEGEKTSDLAMAAARAALADAGVDAAEVDLIVLA
TATPDQTFPATATRVQAGLGCRPGAPAFDIQAVCSGFLYALSVADALIKAGQARTALVIGAETFSRILDFTDRTTCVLFG
DGAGAVVLRATPSTGDGGERGILSTHLHADGRHHDLLYVDGGPSSTGTVGHLRMQGREVFRHAVTNLYEVVLEALAANGL
QADAIDWVVPHQANQRILDGTAKKLGIDPAKVISTIALHANTSAASVPLALCEARRDGRIQPGQLILLEAMGGGFTWGSA
LVRL
>Mature_324_residues
MWRSVIAGCGSYLPANKVTNANLAERVETTDAWIRERTGILVRHFAAEGEKTSDLAMAAARAALADAGVDAAEVDLIVLA
TATPDQTFPATATRVQAGLGCRPGAPAFDIQAVCSGFLYALSVADALIKAGQARTALVIGAETFSRILDFTDRTTCVLFG
DGAGAVVLRATPSTGDGGERGILSTHLHADGRHHDLLYVDGGPSSTGTVGHLRMQGREVFRHAVTNLYEVVLEALAANGL
QADAIDWVVPHQANQRILDGTAKKLGIDPAKVISTIALHANTSAASVPLALCEARRDGRIQPGQLILLEAMGGGFTWGSA
LVRL

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the

COG id: COG0332

COG function: function code I; 3-oxoacyl-[acyl-carrier-protein] synthase III

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabH family

Homologues:

Organism=Escherichia coli, GI1787333, Length=328, Percent_Identity=51.5243902439024, Blast_Score=310, Evalue=7e-86,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FABH_RHORT (Q2RTS8)

Other databases:

- EMBL:   CP000230
- RefSeq:   YP_426754.1
- ProteinModelPortal:   Q2RTS8
- SMR:   Q2RTS8
- STRING:   Q2RTS8
- GeneID:   3835086
- GenomeReviews:   CP000230_GR
- KEGG:   rru:Rru_A1667
- NMPDR:   fig|1085.1.peg.2244
- eggNOG:   COG0332
- HOGENOM:   HBG649927
- OMA:   ICATSTP
- PhylomeDB:   Q2RTS8
- BioCyc:   RRUB269796:RRU_A1667-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01815
- InterPro:   IPR013751
- InterPro:   IPR013747
- InterPro:   IPR004655
- InterPro:   IPR016039
- InterPro:   IPR016038
- Gene3D:   G3DSA:3.40.47.10
- TIGRFAMs:   TIGR00747

Pfam domain/function: PF08545 ACP_syn_III; PF08541 ACP_syn_III_C; SSF53901 Thiolase-like

EC number: =2.3.1.180

Molecular weight: Translated: 33882; Mature: 33882

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: NA

Important sites: ACT_SITE 114-114 ACT_SITE 251-251 ACT_SITE 281-281

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWRSVIAGCGSYLPANKVTNANLAERVETTDAWIRERTGILVRHFAAEGEKTSDLAMAAA
CCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHEEEHHCCCCCCHHHHHHHH
RAALADAGVDAAEVDLIVLATATPDQTFPATATRVQAGLGCRPGAPAFDIQAVCSGFLYA
HHHHHHCCCCHHHEEEEEEEECCCCCCCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
LSVADALIKAGQARTALVIGAETFSRILDFTDRTTCVLFGDGAGAVVLRATPSTGDGGER
HHHHHHHHHCCCCCEEEEEEHHHHHHHHCCCCCEEEEEEECCCCEEEEEECCCCCCCCCC
GILSTHLHADGRHHDLLYVDGGPSSTGTVGHLRMQGREVFRHAVTNLYEVVLEALAANGL
CEEEEEECCCCCCCEEEEECCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCC
QADAIDWVVPHQANQRILDGTAKKLGIDPAKVISTIALHANTSAASVPLALCEARRDGRI
CCCCEEEECCCCCCCHHHCCCHHHHCCCHHHHHHHHHEECCCCCHHHHHHHHHHHCCCCC
QPGQLILLEAMGGGFTWGSALVRL
CCCCEEEEEECCCCEEHHHHHHCC
>Mature Secondary Structure
MWRSVIAGCGSYLPANKVTNANLAERVETTDAWIRERTGILVRHFAAEGEKTSDLAMAAA
CCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHEEEHHCCCCCCHHHHHHHH
RAALADAGVDAAEVDLIVLATATPDQTFPATATRVQAGLGCRPGAPAFDIQAVCSGFLYA
HHHHHHCCCCHHHEEEEEEEECCCCCCCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
LSVADALIKAGQARTALVIGAETFSRILDFTDRTTCVLFGDGAGAVVLRATPSTGDGGER
HHHHHHHHHCCCCCEEEEEEHHHHHHHHCCCCCEEEEEEECCCCEEEEEECCCCCCCCCC
GILSTHLHADGRHHDLLYVDGGPSSTGTVGHLRMQGREVFRHAVTNLYEVVLEALAANGL
CEEEEEECCCCCCCEEEEECCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCC
QADAIDWVVPHQANQRILDGTAKKLGIDPAKVISTIALHANTSAASVPLALCEARRDGRI
CCCCEEEECCCCCCCHHHCCCHHHHCCCHHHHHHHHHEECCCCCHHHHHHHHHHHCCCCC
QPGQLILLEAMGGGFTWGSALVRL
CCCCEEEEEECCCCEEHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA