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The map label for this gene is lolC [H]

Identifier: 83592913

GI number: 83592913

Start: 1858803

End: 1860056

Strand: Direct

Name: lolC [H]

Synonym: Rru_A1578

Alternate gene names: 83592913

Gene position: 1858803-1860056 (Clockwise)

Preceding gene: 83592912

Following gene: 83592914

Centisome position: 42.7

GC content: 63.96

Gene sequence:

>1254_bases
ATGATCTTCAACGCCTTTGAACGGATGATGGCCGGCCGCTACCTGCGGGCCCGGCGCAAGGAAGGCTTCGTTTCGGTGAT
CGCCGGATTTTCCCTGGCCGGCATCGGCCTGGGGGTGGCGACGCTGATCATCGTCATGGCGGTGATGAACGGCTTCCGCG
AGGATCTGATGGGCCGGATCTTCGGCCTGAACGGCCATCTCACCGTTCTTGGGCAATACGACGTGATGATGGATTACGAC
CGCGCCACCGATATCATTCGCGGCATTCCCGGGGTGCGGGCGGTGACGCCGACGGTTGAAGGGCAGGTGATGCTGACCGA
CAACGGCCGCTCGGTCGGCGGGCTGGTGCGCGGCGTGCGCCCCGAAGACCTGCGCCAGCGGCCGATGCTGGCCAATGCGG
TGATCGCCGGCTCGCTCGATGATCTGCGCGGCCAGGATTCGATCATGATCGGCAATCGTCTGGCCGAGAATTTCGGGCTG
CGGGTTGGCGACAAGCTGACCCTGGTTTCGCCCAAGGGCAAGGTGACGGCCATGGGCACCGTGCCCCGGGTGCGCGCCTA
TACGGTGCGCGTTATCTTTTCCATCGGCATGAGCGAATACGACAGCAGCTTCGTCTTCCTGCCCCTTGAGGCCGCCCAAA
CCTATTTCCAGGTGCCGACCGAAGGCGTCAACCATCTGGAGGTGGTGGTCGACCATCCCGACCGGGTGGGCGAGGTGGCG
GGCACCATCGCCTCGACCAATGGCCTGGGCGGCATCCGCCTGCGCGACTGGCGCCAGACCAACGCCACCTTCTTCAATGC
GCTGCAGGTCGAGCGCAACGTGATGTTCCTGATCCTGACCCTGATCATCGTCGTCGCCGCCTTCAATATCATCAGCGGCC
TGATCATGCTGGTGAAGGACAAGGGCCGCGATATCGCCATCTTGCGCACCATGGGCGCCTCGCGCGGGGCGATCATGCGC
ATCTTCTTCCTGGCCGGCGCCGCCGTCGGCGTGACCGGCACCCTGGCCGGCCTGCTGCTTGGCGTGCTGTTTTGCCAGAA
CATCGAAGCCATTCGTCAGGGCCTGCAAAGCCTGCTTGGCGTCGAATTGTTCAATGCCGAGATCTATTTCCTGGCGACGA
TGCCAGCGACCATGGACCCCCATGAGGTGATGAACGTCGTGCTGATGGCTTTGGGCCTGTCGTTCGCCGCCACCCTCTAT
CCAGCATGGCGGGCGGCGCGCACCGATCCCGTGGAGGCCCTGCGCAATGAGTAA

Upstream 100 bases:

>100_bases
TTTTGATCGGCTATGATCCCGAACCGCCGCTAGCCGCCGGAGACCTGTTCAAGGCCCCGGCGGAGCGCATCACCCTGGCT
CGCACCGGATTGGCCCACCC

Downstream 100 bases:

>100_bases
GTCCCCTTCCGTCTCCAGTCCGCAGACCGCCCCCGGTCCGCAGACCGCGCCCGGTCCGCAGGCCAGCAAGGTGCCGCAGG
CGGCCTTGCGCTTGGATAAG

Product: LolC/E family lipoprotein releasing system, transmembrane protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MIFNAFERMMAGRYLRARRKEGFVSVIAGFSLAGIGLGVATLIIVMAVMNGFREDLMGRIFGLNGHLTVLGQYDVMMDYD
RATDIIRGIPGVRAVTPTVEGQVMLTDNGRSVGGLVRGVRPEDLRQRPMLANAVIAGSLDDLRGQDSIMIGNRLAENFGL
RVGDKLTLVSPKGKVTAMGTVPRVRAYTVRVIFSIGMSEYDSSFVFLPLEAAQTYFQVPTEGVNHLEVVVDHPDRVGEVA
GTIASTNGLGGIRLRDWRQTNATFFNALQVERNVMFLILTLIIVVAAFNIISGLIMLVKDKGRDIAILRTMGASRGAIMR
IFFLAGAAVGVTGTLAGLLLGVLFCQNIEAIRQGLQSLLGVELFNAEIYFLATMPATMDPHEVMNVVLMALGLSFAATLY
PAWRAARTDPVEALRNE

Sequences:

>Translated_417_residues
MIFNAFERMMAGRYLRARRKEGFVSVIAGFSLAGIGLGVATLIIVMAVMNGFREDLMGRIFGLNGHLTVLGQYDVMMDYD
RATDIIRGIPGVRAVTPTVEGQVMLTDNGRSVGGLVRGVRPEDLRQRPMLANAVIAGSLDDLRGQDSIMIGNRLAENFGL
RVGDKLTLVSPKGKVTAMGTVPRVRAYTVRVIFSIGMSEYDSSFVFLPLEAAQTYFQVPTEGVNHLEVVVDHPDRVGEVA
GTIASTNGLGGIRLRDWRQTNATFFNALQVERNVMFLILTLIIVVAAFNIISGLIMLVKDKGRDIAILRTMGASRGAIMR
IFFLAGAAVGVTGTLAGLLLGVLFCQNIEAIRQGLQSLLGVELFNAEIYFLATMPATMDPHEVMNVVLMALGLSFAATLY
PAWRAARTDPVEALRNE
>Mature_417_residues
MIFNAFERMMAGRYLRARRKEGFVSVIAGFSLAGIGLGVATLIIVMAVMNGFREDLMGRIFGLNGHLTVLGQYDVMMDYD
RATDIIRGIPGVRAVTPTVEGQVMLTDNGRSVGGLVRGVRPEDLRQRPMLANAVIAGSLDDLRGQDSIMIGNRLAENFGL
RVGDKLTLVSPKGKVTAMGTVPRVRAYTVRVIFSIGMSEYDSSFVFLPLEAAQTYFQVPTEGVNHLEVVVDHPDRVGEVA
GTIASTNGLGGIRLRDWRQTNATFFNALQVERNVMFLILTLIIVVAAFNIISGLIMLVKDKGRDIAILRTMGASRGAIMR
IFFLAGAAVGVTGTLAGLLLGVLFCQNIEAIRQGLQSLLGVELFNAEIYFLATMPATMDPHEVMNVVLMALGLSFAATLY
PAWRAARTDPVEALRNE

Specific function: Part of an ATP-dependent transport system responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprotein) and

COG id: COG4591

COG function: function code M; ABC-type transport system, involved in lipoprotein release, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787360, Length=407, Percent_Identity=31.2039312039312, Blast_Score=173, Evalue=2e-44,
Organism=Escherichia coli, GI1787362, Length=400, Percent_Identity=30.5, Blast_Score=169, Evalue=3e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003838
- InterPro:   IPR011925 [H]

Pfam domain/function: PF02687 FtsX [H]

EC number: NA

Molecular weight: Translated: 45303; Mature: 45303

Theoretical pI: Translated: 9.30; Mature: 9.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIFNAFERMMAGRYLRARRKEGFVSVIAGFSLAGIGLGVATLIIVMAVMNGFREDLMGRI
CCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FGLNGHLTVLGQYDVMMDYDRATDIIRGIPGVRAVTPTVEGQVMLTDNGRSVGGLVRGVR
CCCCCCEEEEEEECEEECCHHHHHHHHCCCCCCEECCCCCCEEEEECCCCCHHHHHCCCC
PEDLRQRPMLANAVIAGSLDDLRGQDSIMIGNRLAENFGLRVGDKLTLVSPKGKVTAMGT
CHHHHHCCCHHHHHHCCCHHHHCCCCCEEECHHHHHHCCCCCCCEEEEECCCCCEEEECC
VPRVRAYTVRVIFSIGMSEYDSSFVFLPLEAAQTYFQVPTEGVNHLEVVVDHPDRVGEVA
CCCHHHHHHHHHHHHCHHHCCCCEEEEEHHHHHHHHCCCCCCCCEEEEEECCCHHHHHHH
GTIASTNGLGGIRLRDWRQTNATFFNALQVERNVMFLILTLIIVVAAFNIISGLIMLVKD
HHHCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEC
KGRDIAILRTMGASRGAIMRIFFLAGAAVGVTGTLAGLLLGVLFCQNIEAIRQGLQSLLG
CCCCEEEEEECCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHC
VELFNAEIYFLATMPATMDPHEVMNVVLMALGLSFAATLYPAWRAARTDPVEALRNE
EEEECCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCC
>Mature Secondary Structure
MIFNAFERMMAGRYLRARRKEGFVSVIAGFSLAGIGLGVATLIIVMAVMNGFREDLMGRI
CCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FGLNGHLTVLGQYDVMMDYDRATDIIRGIPGVRAVTPTVEGQVMLTDNGRSVGGLVRGVR
CCCCCCEEEEEEECEEECCHHHHHHHHCCCCCCEECCCCCCEEEEECCCCCHHHHHCCCC
PEDLRQRPMLANAVIAGSLDDLRGQDSIMIGNRLAENFGLRVGDKLTLVSPKGKVTAMGT
CHHHHHCCCHHHHHHCCCHHHHCCCCCEEECHHHHHHCCCCCCCEEEEECCCCCEEEECC
VPRVRAYTVRVIFSIGMSEYDSSFVFLPLEAAQTYFQVPTEGVNHLEVVVDHPDRVGEVA
CCCHHHHHHHHHHHHCHHHCCCCEEEEEHHHHHHHHCCCCCCCCEEEEEECCCHHHHHHH
GTIASTNGLGGIRLRDWRQTNATFFNALQVERNVMFLILTLIIVVAAFNIISGLIMLVKD
HHHCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEC
KGRDIAILRTMGASRGAIMRIFFLAGAAVGVTGTLAGLLLGVLFCQNIEAIRQGLQSLLG
CCCCEEEEEECCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHC
VELFNAEIYFLATMPATMDPHEVMNVVLMALGLSFAATLYPAWRAARTDPVEALRNE
EEEECCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]