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The map label for this gene is pdhR [H]

Identifier: 83592750

GI number: 83592750

Start: 1672026

End: 1672802

Strand: Direct

Name: pdhR [H]

Synonym: Rru_A1414

Alternate gene names: 83592750

Gene position: 1672026-1672802 (Clockwise)

Preceding gene: 83592743

Following gene: 83592751

Centisome position: 38.41

GC content: 67.05

Gene sequence:

>777_bases
ATGATCATGAGCGAGCCGATCAGGGCGACGCGCCTAGCCGAAACGATCGCCGATCATCTGGAGCGACTGATCGCCGAGGG
GGCCCTTCGTCCGGGGGAACGTCTGTTGCCCGAGCGCGAACTGGCCCTGAAGCTCAATGTCTCGCGGCCGTCCTTGCGCG
ACGGCTTGGCGGCGATGGAACGCCGGGGGCTGATCGTCACCGATCGCCAGGGCTCGCGCGTCGCCGAATTCCTGCGGCCG
CTGACCGAGCCGCTGGAACTGCTGATCCAGAACAACACCCAGGCGACCTTCGATTATCTGGAGTTCCGCTTCGTCGTCGA
GGGGGCGGCGGCGGAAATGGCCGCCAAGCGCGCCACCGACCTTGATCGGGCGGCGATCCGCGCCATCCTGGATCGCATGG
CGGCCGTCCATGGCGACGATGACTCGGCGGCCGAGGCCGAAGCCGACGCCGATCTGCACAGCGCCACCTATGAGGCGACC
TATAACGTTATGATTTTGCACATCATGCGCGGCTTCTCGCAGCTTTTGCGCCGCGATGTCTTTTATAACCGCGAACGGCT
TTACGCCCGGCCCGGCGTGCGTGATCTGCTGCTTGGCCATCATCAGGCGATCGGCGAAGCGATCATCGCCGGCGACGGCC
CCGCCGCCCGCCGCGCCGCCGAGGAGCACATCACCGTCACCCGCGAAACCCTGGAAGAGATCCGCGACGCCGACGCCCGC
TTGGCCATGTCGCTGCGCCGCATCGGCCGCCGCGATCTGGTGGCCCCTGAGCGGTAG

Upstream 100 bases:

>100_bases
GGCGGTCGCGGCCGTGGTGATGGGGCCGGGGGTGACAAGGCGGGCCCCGCTGCCTAAACTAAGGCCGTCGGGCGGGGTGG
GGTGACCCGGAGCGAAAAGG

Downstream 100 bases:

>100_bases
AATGGTAGTGTTTGGGTCGGTTTTTCTCCCTTTGTCTGTTGCCTTGACTATTCGTACATAGAAAAGCTCTTCCGAAGCGG
AGCAAATTTGTGAGATCGCT

Product: GntR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 258; Mature: 258

Protein sequence:

>258_residues
MIMSEPIRATRLAETIADHLERLIAEGALRPGERLLPERELALKLNVSRPSLRDGLAAMERRGLIVTDRQGSRVAEFLRP
LTEPLELLIQNNTQATFDYLEFRFVVEGAAAEMAAKRATDLDRAAIRAILDRMAAVHGDDDSAAEAEADADLHSATYEAT
YNVMILHIMRGFSQLLRRDVFYNRERLYARPGVRDLLLGHHQAIGEAIIAGDGPAARRAAEEHITVTRETLEEIRDADAR
LAMSLRRIGRRDLVAPER

Sequences:

>Translated_258_residues
MIMSEPIRATRLAETIADHLERLIAEGALRPGERLLPERELALKLNVSRPSLRDGLAAMERRGLIVTDRQGSRVAEFLRP
LTEPLELLIQNNTQATFDYLEFRFVVEGAAAEMAAKRATDLDRAAIRAILDRMAAVHGDDDSAAEAEADADLHSATYEAT
YNVMILHIMRGFSQLLRRDVFYNRERLYARPGVRDLLLGHHQAIGEAIIAGDGPAARRAAEEHITVTRETLEEIRDADAR
LAMSLRRIGRRDLVAPER
>Mature_258_residues
MIMSEPIRATRLAETIADHLERLIAEGALRPGERLLPERELALKLNVSRPSLRDGLAAMERRGLIVTDRQGSRVAEFLRP
LTEPLELLIQNNTQATFDYLEFRFVVEGAAAEMAAKRATDLDRAAIRAILDRMAAVHGDDDSAAEAEADADLHSATYEAT
YNVMILHIMRGFSQLLRRDVFYNRERLYARPGVRDLLLGHHQAIGEAIIAGDGPAARRAAEEHITVTRETLEEIRDADAR
LAMSLRRIGRRDLVAPER

Specific function: Transcriptional repressor for the pyruvate dehydrogenase complex genes aceEF and lpd [H]

COG id: COG2186

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786303, Length=227, Percent_Identity=37.4449339207048, Blast_Score=139, Evalue=1e-34,
Organism=Escherichia coli, GI1790032, Length=248, Percent_Identity=34.2741935483871, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1789353, Length=229, Percent_Identity=31.4410480349345, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1790780, Length=251, Percent_Identity=27.4900398406374, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1789621, Length=248, Percent_Identity=28.2258064516129, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011711
- InterPro:   IPR000524
- InterPro:   IPR011991 [H]

Pfam domain/function: PF07729 FCD; PF00392 GntR [H]

EC number: NA

Molecular weight: Translated: 28908; Mature: 28908

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIMSEPIRATRLAETIADHLERLIAEGALRPGERLLPERELALKLNVSRPSLRDGLAAME
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCEEEEEECCCCCHHHHHHHHH
RRGLIVTDRQGSRVAEFLRPLTEPLELLIQNNTQATFDYLEFRFVVEGAAAEMAAKRATD
HCCEEEECCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LDRAAIRAILDRMAAVHGDDDSAAEAEADADLHSATYEATYNVMILHIMRGFSQLLRRDV
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FYNRERLYARPGVRDLLLGHHQAIGEAIIAGDGPAARRAAEEHITVTRETLEEIRDADAR
HHCHHHHHCCCCHHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAMSLRRIGRRDLVAPER
HHHHHHHHCHHCCCCCCC
>Mature Secondary Structure
MIMSEPIRATRLAETIADHLERLIAEGALRPGERLLPERELALKLNVSRPSLRDGLAAME
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCEEEEEECCCCCHHHHHHHHH
RRGLIVTDRQGSRVAEFLRPLTEPLELLIQNNTQATFDYLEFRFVVEGAAAEMAAKRATD
HCCEEEECCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LDRAAIRAILDRMAAVHGDDDSAAEAEADADLHSATYEATYNVMILHIMRGFSQLLRRDV
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FYNRERLYARPGVRDLLLGHHQAIGEAIIAGDGPAARRAAEEHITVTRETLEEIRDADAR
HHCHHHHHCCCCHHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAMSLRRIGRRDLVAPER
HHHHHHHHCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]