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The map label for this gene is phbA [H]

Identifier: 83592716

GI number: 83592716

Start: 1628125

End: 1629300

Strand: Reverse

Name: phbA [H]

Synonym: Rru_A1380

Alternate gene names: 83592716

Gene position: 1629300-1628125 (Counterclockwise)

Preceding gene: 83592717

Following gene: 83592715

Centisome position: 37.43

GC content: 67.52

Gene sequence:

>1176_bases
ATGAATGACGTTGTGATCGCGGGCGCCGCCCGCACGGCCATCGGTGCGTTCAATGGCGCCTTTGGCGCCGTCCCCGCCCA
CACCCTGGGTGAAGTCGCCATCCGCGAGGCCCTGAACCGGGCCAAGGTCGAGGCCGGCGATGTCGATGAAGTGGTGCTTG
GTCATGTGCTGACCGCCGGCCAGGGCCAAAATCCGGCCCGTCAGGCCGCCGTCAACGCCGGCATTCCGGTGGAAAGAACC
GCCTATTGCATCAATCAGCTTTGCGGTTCGGGGCTGCGCACCGTGGCCTTGGGCTTCCAGGCGATCCGCAATGGCGATGC
GAAGATCGTCGTCGCCGGCGGCCAGGAAAGCATGAGCATGGCCCCCCACGCCAGCCACCTGCGCGCCGGCATCAAGATGG
GCCCGGGCGAGCTGGTCGACACCATGATCAAGGACGGCCTGTGGGATGCCTTCAACGGCTACCACATGGGCACCACCGCC
GAGAACATCGCCGACAAATGGCAGATCAGCCGGGCCGAGCAGGATGAATTCGCCTGCGCCTCGCAGAACAAGGCCGAGGC
CGCCATCGCCGCGGGCAAATTCAAGGACGAGATCGCCGCCGTCACCCTCAAAACCCGCAAAGGCGATGTCGTCGTCGATA
CCGACGAGCACCCCAAGGCCGGGGTGACGATCGAGAGCCTGGCCAAGGCGCGGGCCGCCTTCCGCAAGGATGGCACGGTC
ACCGCCGGCAACGCCTCGGGCATCAACGACGGCGCCGCCGCCCTGGTGCTGATGAGCGCCGATAACGCCCGCCTGCGCGG
CATCGCCCCGCTCGCCCGCATCGTGTCGTGGGCCACGGCTGGCGTCGATCCGGCGATCATGGGCAGCGGCCCGATCCCCG
CCTCGCGTCTGGCCCTGAAAAAAGCCGGCTGGACCATCGACGACCTGGATCTGATCGAAGCCAACGAGGCCTTCGCCGCC
CAGGCGATCGCCGTCAACCGCGACATGGGCTGGGACACGGCCAAGGTCAACGTCAACGGCGGCGCCATCGCCCTTGGTCA
TCCGATCGGCGCCTCGGGCGCGCGCGTCCTGGTCACCTTGCTCCACGAGATGATCAAGCGCGACGCCAAGAAGGGCCTGA
CGACGCTGTGCATCGGCGGCGGCATGGGCATCGCGCTTTGCGTTGAGCGCGGCTAA

Upstream 100 bases:

>100_bases
TCCCTCGCCAACCGGGGATGCGGGCCGGGTTCATCCCCCCGCCCGCCTCTCCCCCGCTCCCCGGTTGGCGTCCCCTTTGG
ATCATCGAAAGAGACCCGTC

Downstream 100 bases:

>100_bases
GCCGCCCGATCCCGGCCGGACCCTTTGGCGATCCTCGCCACAGGGTCCGGCCGCCCCCACCCGCCGCTTGTGTCTTATCC
CCCGGAGCGCGCCATCATGC

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 391; Mature: 391

Protein sequence:

>391_residues
MNDVVIAGAARTAIGAFNGAFGAVPAHTLGEVAIREALNRAKVEAGDVDEVVLGHVLTAGQGQNPARQAAVNAGIPVERT
AYCINQLCGSGLRTVALGFQAIRNGDAKIVVAGGQESMSMAPHASHLRAGIKMGPGELVDTMIKDGLWDAFNGYHMGTTA
ENIADKWQISRAEQDEFACASQNKAEAAIAAGKFKDEIAAVTLKTRKGDVVVDTDEHPKAGVTIESLAKARAAFRKDGTV
TAGNASGINDGAAALVLMSADNARLRGIAPLARIVSWATAGVDPAIMGSGPIPASRLALKKAGWTIDDLDLIEANEAFAA
QAIAVNRDMGWDTAKVNVNGGAIALGHPIGASGARVLVTLLHEMIKRDAKKGLTTLCIGGGMGIALCVERG

Sequences:

>Translated_391_residues
MNDVVIAGAARTAIGAFNGAFGAVPAHTLGEVAIREALNRAKVEAGDVDEVVLGHVLTAGQGQNPARQAAVNAGIPVERT
AYCINQLCGSGLRTVALGFQAIRNGDAKIVVAGGQESMSMAPHASHLRAGIKMGPGELVDTMIKDGLWDAFNGYHMGTTA
ENIADKWQISRAEQDEFACASQNKAEAAIAAGKFKDEIAAVTLKTRKGDVVVDTDEHPKAGVTIESLAKARAAFRKDGTV
TAGNASGINDGAAALVLMSADNARLRGIAPLARIVSWATAGVDPAIMGSGPIPASRLALKKAGWTIDDLDLIEANEAFAA
QAIAVNRDMGWDTAKVNVNGGAIALGHPIGASGARVLVTLLHEMIKRDAKKGLTTLCIGGGMGIALCVERG
>Mature_391_residues
MNDVVIAGAARTAIGAFNGAFGAVPAHTLGEVAIREALNRAKVEAGDVDEVVLGHVLTAGQGQNPARQAAVNAGIPVERT
AYCINQLCGSGLRTVALGFQAIRNGDAKIVVAGGQESMSMAPHASHLRAGIKMGPGELVDTMIKDGLWDAFNGYHMGTTA
ENIADKWQISRAEQDEFACASQNKAEAAIAAGKFKDEIAAVTLKTRKGDVVVDTDEHPKAGVTIESLAKARAAFRKDGTV
TAGNASGINDGAAALVLMSADNARLRGIAPLARIVSWATAGVDPAIMGSGPIPASRLALKKAGWTIDDLDLIEANEAFAA
QAIAVNRDMGWDTAKVNVNGGAIALGHPIGASGARVLVTLLHEMIKRDAKKGLTTLCIGGGMGIALCVERG

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=391, Percent_Identity=55.7544757033248, Blast_Score=439, Evalue=1e-123,
Organism=Homo sapiens, GI167614485, Length=395, Percent_Identity=44.5569620253165, Blast_Score=327, Evalue=1e-89,
Organism=Homo sapiens, GI4557237, Length=392, Percent_Identity=41.8367346938776, Blast_Score=300, Evalue=2e-81,
Organism=Homo sapiens, GI4501853, Length=395, Percent_Identity=39.2405063291139, Blast_Score=231, Evalue=7e-61,
Organism=Homo sapiens, GI4504327, Length=426, Percent_Identity=29.3427230046948, Blast_Score=152, Evalue=4e-37,
Organism=Homo sapiens, GI194353979, Length=389, Percent_Identity=29.0488431876607, Blast_Score=121, Evalue=1e-27,
Organism=Escherichia coli, GI87082165, Length=391, Percent_Identity=55.4987212276215, Blast_Score=433, Evalue=1e-122,
Organism=Escherichia coli, GI1788554, Length=392, Percent_Identity=55.6122448979592, Blast_Score=410, Evalue=1e-116,
Organism=Escherichia coli, GI1787663, Length=400, Percent_Identity=44.25, Blast_Score=306, Evalue=1e-84,
Organism=Escherichia coli, GI48994986, Length=400, Percent_Identity=42, Blast_Score=243, Evalue=2e-65,
Organism=Escherichia coli, GI1788683, Length=410, Percent_Identity=31.7073170731707, Blast_Score=183, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI133906874, Length=389, Percent_Identity=46.5295629820051, Blast_Score=336, Evalue=1e-92,
Organism=Caenorhabditis elegans, GI25147385, Length=385, Percent_Identity=37.4025974025974, Blast_Score=261, Evalue=6e-70,
Organism=Caenorhabditis elegans, GI17535921, Length=395, Percent_Identity=37.2151898734177, Blast_Score=237, Evalue=7e-63,
Organism=Caenorhabditis elegans, GI17535917, Length=392, Percent_Identity=29.3367346938776, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17551802, Length=430, Percent_Identity=28.6046511627907, Blast_Score=154, Evalue=7e-38,
Organism=Saccharomyces cerevisiae, GI6325229, Length=398, Percent_Identity=43.4673366834171, Blast_Score=281, Evalue=1e-76,
Organism=Saccharomyces cerevisiae, GI6322031, Length=390, Percent_Identity=38.7179487179487, Blast_Score=215, Evalue=8e-57,
Organism=Drosophila melanogaster, GI24655093, Length=390, Percent_Identity=59.4871794871795, Blast_Score=479, Evalue=1e-135,
Organism=Drosophila melanogaster, GI17648125, Length=389, Percent_Identity=42.6735218508997, Blast_Score=297, Evalue=6e-81,
Organism=Drosophila melanogaster, GI24640423, Length=391, Percent_Identity=43.2225063938619, Blast_Score=295, Evalue=4e-80,
Organism=Drosophila melanogaster, GI17137578, Length=425, Percent_Identity=30.3529411764706, Blast_Score=170, Evalue=2e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 40238; Mature: 40238

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDVVIAGAARTAIGAFNGAFGAVPAHTLGEVAIREALNRAKVEAGDVDEVVLGHVLTAG
CCCEEEECCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCC
QGQNPARQAAVNAGIPVERTAYCINQLCGSGLRTVALGFQAIRNGDAKIVVAGGQESMSM
CCCCHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCC
APHASHLRAGIKMGPGELVDTMIKDGLWDAFNGYHMGTTAENIADKWQISRAEQDEFACA
CCCHHHHHCCCCCCCHHHHHHHHHCCCHHHCCCEECCCCHHHHHHHHHCCCCCCHHHHHC
SQNKAEAAIAAGKFKDEIAAVTLKTRKGDVVVDTDEHPKAGVTIESLAKARAAFRKDGTV
CCCCHHHHHHHCCCCCCEEEEEEEECCCCEEEECCCCCCCCCCHHHHHHHHHHHHCCCCE
TAGNASGINDGAAALVLMSADNARLRGIAPLARIVSWATAGVDPAIMGSGPIPASRLALK
EECCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHH
KAGWTIDDLDLIEANEAFAAQAIAVNRDMGWDTAKVNVNGGAIALGHPIGASGARVLVTL
HCCCCCCCCCEEECCCHHHHHEEEEECCCCCCEEEEEECCCEEEECCCCCCCHHHHHHHH
LHEMIKRDAKKGLTTLCIGGGMGIALCVERG
HHHHHHHHHHCCCEEEEEECCCEEEEEEECC
>Mature Secondary Structure
MNDVVIAGAARTAIGAFNGAFGAVPAHTLGEVAIREALNRAKVEAGDVDEVVLGHVLTAG
CCCEEEECCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCC
QGQNPARQAAVNAGIPVERTAYCINQLCGSGLRTVALGFQAIRNGDAKIVVAGGQESMSM
CCCCHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCC
APHASHLRAGIKMGPGELVDTMIKDGLWDAFNGYHMGTTAENIADKWQISRAEQDEFACA
CCCHHHHHCCCCCCCHHHHHHHHHCCCHHHCCCEECCCCHHHHHHHHHCCCCCCHHHHHC
SQNKAEAAIAAGKFKDEIAAVTLKTRKGDVVVDTDEHPKAGVTIESLAKARAAFRKDGTV
CCCCHHHHHHHCCCCCCEEEEEEEECCCCEEEECCCCCCCCCCHHHHHHHHHHHHCCCCE
TAGNASGINDGAAALVLMSADNARLRGIAPLARIVSWATAGVDPAIMGSGPIPASRLALK
EECCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHH
KAGWTIDDLDLIEANEAFAAQAIAVNRDMGWDTAKVNVNGGAIALGHPIGASGARVLVTL
HCCCCCCCCCEEECCCHHHHHEEEEECCCCCCEEEEEECCCEEEECCCCCCCHHHHHHHH
LHEMIKRDAKKGLTTLCIGGGMGIALCVERG
HHHHHHHHHHCCCEEEEEECCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7582015; 11481430 [H]